{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:44:03Z","timestamp":1790286243832,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01391","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:44:41Z","timestamp":1560905081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of a Novel Non-desmoglein Autoantigen in Pemphigus Vulgaris"],"prefix":"10.3389","volume":"10","author":[{"given":"Giulia","family":"Di Lullo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliciana","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zambruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lanzavecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Zenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00281-015-0541-1","article-title":"Immune response in pemphigus and beyond: progresses and emerging concepts","volume":"38","author":"Di Zenzo","year":"2016","journal-title":"Semin Immunopathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1172\/JCI64413","article-title":"Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface","volume":"122","author":"Di Zenzo","year":"2012","journal-title":"J Clin Invest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3389\/fimmu.2018.01190","article-title":"Non-desmoglein antibodies in patients with pemphigus vulgaris","volume":"9","author":"Amber","year":"2018","journal-title":"Front Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3389\/fmed.2018.00218","article-title":"The evolving story of autoantibodies in pemphigus vulgaris: development of the \u201csuper compensation hypothesis\u201d","volume":"5","author":"Sinha","year":"2018","journal-title":"Front Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.ajpath.2010.10.016","article-title":"IgG autoantidodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion","volume":"178","author":"Rafei","year":"2011","journal-title":"Am J Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0002-9440(10)64651-2","article-title":"Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity","volume":"157","author":"Nguyen","year":"2000","journal-title":"Am J Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"29466","DOI":"10.1074\/jbc.M003174200","article-title":"Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexinlike molecule binding acetylcholine","volume":"275","author":"Nguyen","year":"2000","journal-title":"J Biol Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1074\/jbc.M109.081570","article-title":"Antimitochondrial autoantidodies in pemphigus vulgaris: a missing link in disease pathophysiology","volume":"285","author":"Marchenko","year":"2010","journal-title":"J Biol Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e57587","DOI":"10.1371\/journal.pone.0057587","article-title":"Pemphigus vulgaris autoantibody profiling by proteomic technique","volume":"8","author":"Kalantari-Dehaghi","year":"2013","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nm1080","article-title":"An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus","volume":"10","author":"Traggiai","year":"2004","journal-title":"Nat Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1111\/bjd.12816","article-title":"A truncating mutation in the laminin-332\u03b1 chain highlights the role of the LG45 proteolytic domain in regulating keratinocyte adhesion and migration","volume":"170","author":"Di Zenzo","year":"2014","journal-title":"Br J Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"768","DOI":"10.2340\/00015555-2311","article-title":"Autoantibody profile of a cohort of 78 italian patients with mucous membrane pemphigoid: correlation between reactivity profile and clinical involvement","volume":"96","author":"Cozzani","year":"2016","journal-title":"Acta Derm Venereol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantidodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J Invest Dermatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1046\/j.1523-1747.1998.00449.x","article-title":"Envoplakin and periplakin are components of the paraneoplastic pemphigus antigen complex","volume":"111","author":"Kiyokawa","year":"1998","journal-title":"J Invest Dermatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jaad.2003.11.051","article-title":"Mucosal dominant pemphigus vulgaris with anti-desmoplakin autoantibodies","volume":"51","author":"Mimouni","year":"2004","journal-title":"J Am Acad Dermatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/096120339700600103","article-title":"The penetrating potential of autoantibodies into live cells in vitro coincides with the in vivo staining of epidermal nuclei","volume":"6","author":"Golan","year":"1997","journal-title":"Lupus."},{"key":"B17","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1006\/jaut.1998.0238","article-title":"Proceedings of the second international conference on the penetration of autoantibodies into living cells","volume":"11","author":"Alasc\u00f3n-Segovia","year":"1998","journal-title":"J Autoimmun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0092-8674(92)90103-J","article-title":"Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization","volume":"70","author":"Hirano","year":"1992","journal-title":"Cell."},{"key":"B20","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/nrm1433","article-title":"Alpha-catenin: at the junction of intercellular adhesion and actin dynamics","volume":"5","author":"Kobielak","year":"2004","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3892\/ijmm.16.6.1003","article-title":"Identification of regions of alpha-catenin required for desmosome organization in epithelial cells","volume":"16","author":"Taniguchi","year":"2005","journal-title":"Int J Mol Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1038\/sj.jid.5701260","article-title":"E-cadherin is an additional immunological target for pemphigus autoantibodies","volume":"128","author":"Evangelista","year":"2008","journal-title":"J Invest Dermatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1111\/j.1346-8138.1994.tb03294.x","article-title":"Cadherins in cutaneous biology","volume":"21","author":"Furukawa","year":"1994","journal-title":"J Dermatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1002\/(SICI)1521-4141(199907)29:07&lt;2233::AID-IMMU2233&gt;3.0.CO;2-4","article-title":"A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes","volume":"29","author":"Aoyama","year":"1999","journal-title":"Eur J Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"23826","DOI":"10.1074\/jbc.M115.668061","article-title":"Critical role of the neonatal Fc receptor (FcRn) in the pathogenic action of antimitochondrial autoantibodies synergizing with anti-desmoglein autoantibodies in pemphigus vulgaris","volume":"290","author":"Chernyavsky","year":"2015","journal-title":"J Biol Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.1074\/jbc.RA118.006743","article-title":"Synergy among non-desmoglein antibodies contributes to the immunopathology of desmoglein antibody-negative pemphigus vulgaris","volume":"294","author":"Chernyavsky","year":"2019","journal-title":"J Biol Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.jid.5701132","article-title":"Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantidodies","volume":"128","author":"Ishii","year":"2008","journal-title":"J Invest Dermatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.4049\/jimmunol.0901691","article-title":"Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus","volume":"183","author":"Yamagami","year":"2009","journal-title":"J Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3389\/fimmu.2018.00779","article-title":"Humoral epitope spreading in autoimmune bullous diseases","volume":"9","author":"Didona","year":"2018","journal-title":"Front Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nature03724","article-title":"Groth B, Vinuesa CG. Cellular and genetic mechanisms of self tolerance and autoimmunity","volume":"435","author":"Goodnow","year":"2005","journal-title":"Nature."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01391\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:44:42Z","timestamp":1560905082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01391\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":31,"alternative-id":["10.3389\/fimmu.2019.01391"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01391","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"article-number":"1391"}}