{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:36:21Z","timestamp":1792164981214,"version":"4.4.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01594","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T07:39:51Z","timestamp":1562830791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":171,"title":["The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer"],"prefix":"10.3389","volume":"10","author":[{"given":"Inna M.","family":"Yasinska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana S.","family":"Sakhnevych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Pavlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Teo Hansen Seln\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Teuscher Abeleira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouafa","family":"Benlaouer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gon\u00e7alves Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Mosimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Varani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohanah","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Siligardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Cholewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen M.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard F.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri A.","family":"Ushkaryov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Fasler-Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Klenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim V.","family":"Sumbayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02330-y","article-title":"Unlocking the therapeutic potential of primary tumor-draining lymph nodes","author":"Rotman","year":"2019","journal-title":"Cancer Immunol Immunother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ebiom.2017.07.018","article-title":"The Tim-3-galectin-9 secretory pathway is involved in the immune escape of human acute myeloid leukemia cells","volume":"22","author":"Gon\u00e7alves Silva","year":"2017","journal-title":"EBioMed."},{"key":"B3","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/s41423-018-0053-8","article-title":"Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression","volume":"15","author":"Sakhnevych","year":"2018","journal-title":"Cell Mol Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1195535","DOI":"10.1080\/2162402X.2016.1195535","article-title":"The immune receptor Tim-3 acts as a trafficker in a Tim-3\/galectin-9 autocrine loop in human myeloid leukaemia cells","volume":"5","author":"Gon\u00e7alves Silva","year":"2016","journal-title":"OncoImmunology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1111\/j.1600-0854.2009.00960.x","article-title":"The role of galectins in protein trafficking","volume":"10","author":"Delacour","year":"2009","journal-title":"Traffic."},{"key":"B6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.stem.2015.07.011","article-title":"A TIM-3\/Gal-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemic progression","volume":"17","author":"Kikushige","year":"2015","journal-title":"Cell Stem Cell."},{"key":"B7","doi-asserted-by":"publisher","first-page":"45575","DOI":"10.18632\/oncotarget.10039","article-title":"Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukemia cells","volume":"7","author":"Sumbayev","year":"2016","journal-title":"Oncotarget."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e431","DOI":"10.1038\/bcj.2016.36","article-title":"Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets","volume":"6","author":"Maiga","year":"2016","journal-title":"Blood Cancer J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1038\/sj.onc.1202487","article-title":"Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31","volume":"17","author":"White","year":"1998","journal-title":"Oncogene."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1016\/S0960-9776(05)80073-6","article-title":"Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer","volume":"11","author":"Irie","year":"2005","journal-title":"Clin Cancer Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"15659","DOI":"10.1038\/srep15659","article-title":"Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer","volume":"5","author":"Kang","year":"2015","journal-title":"Sci Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s10517-010-0838-y","article-title":"Prediction of epitopes in closely related proteins using a new algorithm","volume":"148","author":"Davydov","year":"2009","journal-title":"Bull Exp Biol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.biocel.2014.11.017","article-title":"The immune receptor Tim-3 mediates activation of PI3 kinase\/mTOR and HIF-1 pathways in human myeloid leukemia cells","volume":"59","author":"Prokhorov","year":"2015","journal-title":"Int J Biochem Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0091-6749(03)80727-3","article-title":"Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma\/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI","volume":"27","author":"Kirshenbaum","year":"2003","journal-title":"Leuk Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/sj.bjc.6604181","article-title":"BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours","volume":"98","author":"D'Arcy","year":"2008","journal-title":"Br J Cancer."},{"key":"B16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00018-013-1421-2","article-title":"The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation","volume":"71","author":"Yasinska","year":"2014","journal-title":"Cell Mol Life Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3389\/fphar.2019.00342","article-title":"Mitochondrial Defunctionalisation supresses tim-3-galectin-9 secretory pathway in human colorectal cancer cells and thus can possibly affect tumour immune escape","volume":"10","author":"Sakhnevych","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1080\/21505594.2017.1385692","article-title":"IP3\u20134 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model","volume":"8","author":"Li","year":"2017","journal-title":"Virulence."},{"key":"B19","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/S0006-3495(99)77255-3","article-title":"Correlation between protein kinase C alpha activity and membrane phase behavior","volume":"76","author":"Micol","year":"1999","journal-title":"Biophys J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1038\/srep06307","article-title":"Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function","volume":"4","author":"Abooali","year":"2014","journal-title":"Sci Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5827","DOI":"10.1039\/C7NR09436A","article-title":"Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates","volume":"10","author":"Yasinska","year":"2018","journal-title":"Nanoscale."},{"key":"B22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fphar.2019.00333","article-title":"Specific targeting of basophil and mast cell pro-allergic reactivity using functionalised gold nanoparticles","volume":"10","author":"Yasinska","year":"2019","journal-title":"Front Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"27480","DOI":"10.1074\/jbc.M113.491803","article-title":"Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells","volume":"288","author":"Fan","year":"2013","journal-title":"J Biol Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1016\/j.str.2015.06.024","article-title":"Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion","volume":"23","author":"Lu","year":"2015","journal-title":"Structure."},{"key":"B25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1074\/jbc.M113.504779","article-title":"Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing","volume":"289","author":"Boucard","year":"2014","journal-title":"J Biol Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.neuron.2012.01.018","article-title":"FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development","volume":"73","author":"O'Sullivan","year":"2012","journal-title":"Neuron."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/hep.25777","article-title":"Tim-3\/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma","volume":"56","author":"Li","year":"2012","journal-title":"Hepatology."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.3892\/or.2018.6627","article-title":"Association between Tim3 and Gal9 expression and gastric cancer prognosis","volume":"40","author":"Wang","year":"2018","journal-title":"Oncol Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1074\/jbc.272.9.6078","article-title":"Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin","volume":"272","author":"Wada","year":"1997","journal-title":"J Biol Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1080\/15548627.2015.1063767","article-title":"The epithelial polarity regulator LGALS9\/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux","volume":"11","author":"Wiersma","year":"2018","journal-title":"Autophagy."},{"key":"B31","doi-asserted-by":"publisher","first-page":"17633","DOI":"10.1073\/pnas.1012424107","article-title":"Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells","volume":"107","author":"Mishra","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e0193498","DOI":"10.1371\/journal.pone.0193498","article-title":"In vitro immunotherapy potency assays using real-time cell analysis","volume":"13","author":"Cerignoli","year":"2018","journal-title":"PLoS ONE."},{"key":"B33","doi-asserted-by":"publisher","first-page":"S196","DOI":"10.1111\/j.1075-122X.2006.00334.x","article-title":"Galectin-9, a novel prognostic factor with antimetastatic potential in breast cancer","volume":"12","author":"Yamauchi","year":"2006","journal-title":"Breast J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jmb.2007.09.060","article-title":"Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue","volume":"375","author":"Nagae","year":"2008","journal-title":"J Mol Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.1182\/blood-2011-06-360321","article-title":"Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9","volume":"119","author":"Gleason","year":"2012","journal-title":"Blood."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01594\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T07:39:53Z","timestamp":1562830793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01594\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":35,"alternative-id":["10.3389\/fimmu.2019.01594"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01594","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]},"article-number":"1594"}}