{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:32Z","timestamp":1787312672911,"version":"build-2736575974"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01604","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T04:59:31Z","timestamp":1562821171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Poly-\u03b3-Glutamic Acid Complexed With Alum Induces Cross-Protective Immunity of Pandemic H1N1 Vaccine"],"prefix":"10.3389","volume":"10","author":[{"given":"Quyen Thi","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaewon","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaemoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyoung","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Hee","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haryoung","family":"Poo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"800","DOI":"10.2105\/AJPH.2004.039438","article-title":"Evaluating the safety of new vaccines: summary of a workshop","volume":"95","author":"Ellenberg","year":"2005","journal-title":"Am J Public Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1172\/JCI81083","article-title":"Beyond antigens and adjuvants: formulating future vaccines","volume":"126","author":"Moyer","year":"2016","journal-title":"J Clin Invest"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1590\/S0100-879X2012007500142","article-title":"Recombinant vaccines and the development of new vaccine strategies","volume":"45","author":"Nascimento","year":"2012","journal-title":"Braz J Med Biol Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.celrep.2013.03.034","article-title":"Neuraminidase-mediated, NKp46-dependent immune-evasion mechanism of influenza viruses","volume":"3","author":"Bar-On","year":"2013","journal-title":"Cell Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrmicro1681","article-title":"The perfect mix: recent progress in adjuvant research","volume":"5","author":"Guy","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/vaccines3020320","article-title":"Vaccine adjuvants: from 1920 to 2015 and beyond","volume":"3","author":"Di Pasquale","year":"2015","journal-title":"Vaccines"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.1128\/JVI.03030-12","article-title":"Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaques","volume":"87","author":"Jegaskanda","year":"2013","journal-title":"J Virol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"45552","DOI":"10.1038\/srep45552","article-title":"Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.virol.2016.08.010","article-title":"Cross-protective efficacies of highly-pathogenic avian influenza H5N1 vaccines against a recent H5N8 virus","volume":"498","author":"Park","year":"2016","journal-title":"Virology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.chom.2015.03.002","article-title":"Passively acquired antibody-dependent cellular cytotoxicity (ADCC) activity in HIV-infected infants is associated with reduced mortality","volume":"17","author":"Milligan","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/jmv.23630","article-title":"Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine","volume":"85","author":"Song","year":"2013","journal-title":"J Med Virol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jsps.2011.06.003","article-title":"Vaccine adjuvants - current status and prospects on controlled release adjuvancity","volume":"19","author":"Sivakumar","year":"2011","journal-title":"Saudi Pharm J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fimmu.2017.00225","article-title":"Toll-like receptor ligand-based vaccine adjuvants require intact MyD88 signaling in antigen-presenting cells for germinal center formation and antibody production","volume":"8","author":"Mosaheb","year":"2017","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.cell.2012.02.012","article-title":"Beyond empiricism: informing vaccine development through innate immunity research","volume":"148","author":"Levitz","year":"2012","journal-title":"Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/tcr.20061","article-title":"Natural and edible biopolymer poly-gamma-glutamic acid: synthesis, production, and applications","volume":"5","author":"Sung","year":"2005","journal-title":"Chem Rec"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1007\/s00262-009-0689-4","article-title":"Oral administration of poly-gamma-glutamate induces TLR4- and dendritic cell-dependent antitumor effect","volume":"58","author":"Lee","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"B18","doi-asserted-by":"publisher","first-page":"44839","DOI":"10.1038\/srep44839","article-title":"Poly-gamma-glutamic acid\/chitosan nanogel greatly enhances the efficacy and heterosubtypic cross-reactivity of H1N1 pandemic influenza vaccine","volume":"7","author":"Yang","year":"2017","journal-title":"Sci Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1002\/smll.201101836","article-title":"Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects","volume":"7","author":"Lim","year":"2011","journal-title":"Small"},{"key":"B20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method for estimating fifty percent endpoint","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Hygiene."},{"key":"B21","doi-asserted-by":"publisher","first-page":"31578","DOI":"10.1038\/srep31578","article-title":"Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations","volume":"6","author":"Mold","year":"2016","journal-title":"Sci Rep"},{"key":"B22","volume-title":"Light Scattering From Polymer Solutions and Nanoparticle Dispersions","author":"Sch\u00e4rtl","year":"2007"},{"key":"B23","doi-asserted-by":"publisher","first-page":"11085","DOI":"10.1039\/C6RA26419K","article-title":"Preparation of \u03b3-PGA hydrogels and swelling behaviors in salt solutions with different ionic valence numbers","volume":"7","author":"Li","year":"2017","journal-title":"RSC Adv"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.2166\/wst.2017.037","article-title":"Coagulation-adsorption of reactive orange from aqueous solution by freshly formed magnesium hydroxide: mixing time and mechanistic study","volume":"75","author":"Zhao","year":"2017","journal-title":"Water Sci Technol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1039\/C5NJ02407B","article-title":"Facile one-pot electrosynthesis of Al (OH) 3\u2013kinetics and equilibrium modeling for adsorption of 2:4:5\u2013trichlorophenoxyacetic acid from aqueous solution","volume":"40","author":"Kamaraj","year":"2016","journal-title":"N J Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.polymdegradstab.2012.05.011","article-title":"On the use of magnesium hydroxide towards halogen-free flame-retarded polyamide-6\/polypropylene blends","volume":"97","author":"Balakrishnan","year":"2012","journal-title":"Polymer Degrad Stabil"},{"key":"B27","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.immuni.2008.08.006","article-title":"Mechanisms and consequences of dendritic cell migration","volume":"29","author":"Alvarez","year":"2008","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1034\/j.1600-065X.2000.17717.x","article-title":"Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression","volume":"177","author":"Sallusto","year":"2000","journal-title":"Immunol Rev"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jlb.66.1.1","article-title":"The role of chemokines in the regulation of dendritic cell trafficking","volume":"66","author":"Sozzani","year":"1999","journal-title":"J Leukoc Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0092-8674(00)80059-8","article-title":"CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs","volume":"99","author":"Forster","year":"1999","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"469","DOI":"10.4049\/jimmunol.1400432","article-title":"Influenza-specific antibody-dependent cellular cytotoxicity: toward a universal influenza vaccine","volume":"193","author":"Jegaskanda","year":"2014","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fimmu.2013.00076","article-title":"Natural killer cell mediated antibody-dependent cellular cytotoxicity in tumor immunotherapy with therapeutic antibodies","volume":"4","author":"Seidel","year":"2013","journal-title":"Front Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1128\/JVI.01615-07","article-title":"Induction of heterosubtypic immunity to influenza virus by intranasal immunization","volume":"82","author":"Quan","year":"2008","journal-title":"J Virol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/mt.2012.246","article-title":"Virus-like particles containing multiple M2 extracellular domains confer improved cross-protection against various subtypes of influenza virus","volume":"21","author":"Kim","year":"2013","journal-title":"Mol Ther"},{"key":"B36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nm.3443","article-title":"Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo","volume":"20","author":"DiLillo","year":"2014","journal-title":"Nat Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.4049\/jimmunol.1400948","article-title":"Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells","volume":"193","author":"Didierlaurent","year":"2014","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"6186","DOI":"10.4049\/jimmunol.0901474","article-title":"AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity","volume":"183","author":"Didierlaurent","year":"2009","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7331","DOI":"10.1016\/j.vaccine.2010.08.075","article-title":"Safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents: an integrated analysis","volume":"28","author":"Black","year":"2010","journal-title":"Vaccine"},{"key":"B40","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.vaccine.2015.12.024","article-title":"A systematic review and meta-analysis on the safety of newly adjuvanted vaccines among children","volume":"34","author":"Stassijns","year":"2016","journal-title":"Vaccine"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/cti.2016.6","article-title":"Targeting dendritic cells: a promising strategy to improve vaccine effectiveness","volume":"5","author":"Macri","year":"2016","journal-title":"Clin Transl Immunology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/j.vaccine.2011.01.011","article-title":"Adjuvant System AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity","volume":"29","author":"Morel","year":"2011","journal-title":"Vaccine"},{"key":"B43","doi-asserted-by":"publisher","first-page":"8672","DOI":"10.1128\/JVI.00287-12","article-title":"Antibody-dependent cellular cytotoxicity against primary HIV-infected CD4+ T cells is directly associated with the magnitude of surface IgG binding","volume":"86","author":"Smalls-Mantey","year":"2012","journal-title":"J Virol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1089\/vim.2010.0108","article-title":"Activation of NK cells by ADCC responses during early HIV infection","volume":"24","author":"Chung","year":"2011","journal-title":"Viral Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"9923","DOI":"10.1038\/s41598-017-10265-6","article-title":"TCR\u2013like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus\u2013transformed B lymphoblastoid cells expressing different HLA-A* 02 microvariants","volume":"7","author":"Lai","year":"2017","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"5206","DOI":"10.1016\/j.biomaterials.2011.03.052","article-title":"The induction of innate and adaptive immunity by biodegradable poly(gamma-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway","volume":"32","author":"Uto","year":"2011","journal-title":"Biomaterials"},{"key":"B47","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12985-015-0387-0","article-title":"Intranasal administration of poly-gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection","volume":"12","author":"Kim","year":"2015","journal-title":"Virol J"},{"key":"B48","doi-asserted-by":"publisher","first-page":"775","DOI":"10.4049\/jimmunol.179.2.775","article-title":"Oral administration of high molecular mass poly-gamma-glutamate induces NK cell-mediated antitumor immunity","volume":"179","author":"Kim","year":"2007","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/eji.1830250329","article-title":"Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo","volume":"25","author":"Germann","year":"1995","journal-title":"Eur J Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.4049\/jimmunol.172.4.2453","article-title":"Recognition of homo- and heterosubtypic variants of influenza A viruses by human CD8+ T lymphocytes","volume":"172","author":"Boon","year":"2004","journal-title":"J Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"11931","DOI":"10.1073\/pnas.1609316113","article-title":"Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus","volume":"113","author":"He","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e01044","DOI":"10.1128\/mBio.01044-15","article-title":"An intranasal virus-like particle vaccine broadly protects mice from multiple subtypes of influenza A virus","volume":"6","author":"Schwartzman","year":"2015","journal-title":"MBio"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.4049\/jimmunol.172.6.3437","article-title":"Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly","volume":"172","author":"Deng","year":"2004","journal-title":"J Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/infdis\/jit294","article-title":"Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1","volume":"208","author":"Jegaskanda","year":"2013","journal-title":"J Infect Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01604\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:39:14Z","timestamp":1569026354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01604\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":54,"alternative-id":["10.3389\/fimmu.2019.01604"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01604","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]},"article-number":"1604"}}