{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:32:29Z","timestamp":1790674349245,"version":"4.1.0"},"reference-count":210,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"publisher","award":["108517-002"],"award-info":[{"award-number":["108517-002"]}],"id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01605","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T04:29:14Z","timestamp":1563337754000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":82,"title":["Innovative Mucosal Vaccine Formulations Against Influenza A Virus Infections"],"prefix":"10.3389","volume":"10","author":[{"given":"Cynthia","family":"Calzas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fmicb.2018.00123","article-title":"Universal vaccines and vaccine platforms to protect against influenza viruses in humans and agriculture","volume":"9","author":"Rajao","year":"2018","journal-title":"Front Microbiol"},{"key":"B2","unstructured":"OrganizationWH Influenza (Seasonal) Fact Sheet2017"},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.20506\/rst.28.1.1869","article-title":"Pathogenesis and pathobiology of avian influenza virus infection in birds","volume":"28","author":"Pantin-Jackwood","year":"2009","journal-title":"Rev Sci Tech."},{"key":"B4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.7883\/yoken.JJID.2015.560","article-title":"Intranasal inactivated influenza vaccines: a reasonable approach to improve the efficacy of influenza vaccine?","volume":"69","author":"Tamura","year":"2016","journal-title":"Jpn J Infect Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev-immunol-031210-101317","article-title":"Immunoglobulin responses at the mucosal interface","volume":"29","author":"Cerutti","year":"2011","journal-title":"Annu Rev Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/01652176.2012.711956","article-title":"Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines","volume":"32","author":"de Geus","year":"2012","journal-title":"Vet Q."},{"key":"B7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/82_2014_405","article-title":"Innate immune sensing and response to influenza","volume":"386","author":"Pulendran","year":"2015","journal-title":"Curr Top Microbiol Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.3389\/fimmu.2018.01521","article-title":"Respiratory mononuclear phagocytes in human influenza A virus infection: their role in immune protection and as targets of the virus","volume":"9","author":"Vangeti","year":"2018","journal-title":"Front Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1189\/jlb.1011506","article-title":"The human side of influenza","volume":"92","author":"Oshansky","year":"2012","journal-title":"J Leukoc Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1084\/jem.20071365","article-title":"Clearance of influenza virus from the lung depends on migratory langerin+CD11b\u2212 but not plasmacytoid dendritic cells","volume":"205","author":"GeurtsvanKessel","year":"2008","journal-title":"J Exp Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1172\/JCI60659","article-title":"Cross-presenting CD103+ dendritic cells are protected from influenza virus infection","volume":"122","author":"Helft","year":"2012","journal-title":"J Clin Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.4049\/jimmunol.1100987","article-title":"Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells","volume":"187","author":"Ho","year":"2011","journal-title":"J Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e4204","DOI":"10.1371\/journal.pone.0004204","article-title":"Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses","volume":"4","author":"Kim","year":"2009","journal-title":"PLoS ONE."},{"key":"B14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/ni.1838","article-title":"Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza","volume":"11","author":"Ballesteros-Tato","year":"2010","journal-title":"Nat Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"8670","DOI":"10.1073\/pnas.0402644101","article-title":"Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus","volume":"101","author":"Belz","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5306","DOI":"10.1073\/pnas.0900655106","article-title":"TNF\/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection","volume":"106","author":"Aldridge","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S1074-7613(03)00208-5","article-title":"Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6","volume":"19","author":"Jego","year":"2003","journal-title":"Immunity."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1128\/JVI.02546-15","article-title":"Plasmacytoid dendritic cells require direct infection to sustain the pulmonary influenza A virus-specific CD8 T Cell Response","volume":"90","author":"Hemann","year":"2015","journal-title":"J Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1084\/jem.20080314","article-title":"Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs","volume":"205","author":"McGill","year":"2008","journal-title":"J Exp Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1042\/CS20160484","article-title":"Contribution of innate immune cells to pathogenesis of severe influenza virus infection","volume":"131","author":"Cole","year":"2017","journal-title":"Clin Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.4049\/jimmunol.173.2.1209","article-title":"Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection","volume":"173","author":"Lawrence","year":"2004","journal-title":"J Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1084\/jem.20021052","article-title":"CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function","volume":"196","author":"Roman","year":"2002","journal-title":"J Exp Med."},{"key":"B23","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.4049\/jimmunol.159.11.5197","article-title":"CD8+ T cells clear influenza virus by perforin or Fas-dependent processes","volume":"159","author":"Topham","year":"1997","journal-title":"J Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.4049\/jimmunol.181.7.4918","article-title":"CD8 T cells utilize TRAIL to control influenza virus infection","volume":"181","author":"Brincks","year":"2008","journal-title":"J Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"11884","DOI":"10.1128\/JVI.01461-13","article-title":"Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection","volume":"87","author":"Hua","year":"2013","journal-title":"J Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"6792","DOI":"10.1128\/JVI.07172-11","article-title":"Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection","volume":"86","author":"Brown","year":"2012","journal-title":"J Virol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.4049\/jimmunol.177.5.2888","article-title":"CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch","volume":"177","author":"Brown","year":"2006","journal-title":"J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nm.2612","article-title":"Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans","volume":"18","author":"Wilkinson","year":"2012","journal-title":"Nat Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/nm.3350","article-title":"Cellular immune correlates of protection against symptomatic pandemic influenza","volume":"19","author":"Sridhar","year":"2013","journal-title":"Nat Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJM198307073090103","article-title":"Cytotoxic T-cell immunity to influenza","volume":"309","author":"McMichael","year":"1983","journal-title":"N Engl J Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3389\/fimmu.2018.00600","article-title":"Novel platforms for the development of a universal influenza vaccine","volume":"9","author":"Kumar","year":"2018","journal-title":"Front Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/imr.12662","article-title":"CD4 T cells in protection from influenza virus: viral antigen specificity and functional potential","volume":"284","author":"Sant","year":"2018","journal-title":"Immunol Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.coi.2018.03.019","article-title":"Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus","volume":"53","author":"Sant","year":"2018","journal-title":"Curr Opin Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1089\/vim.2017.0025","article-title":"Adaptive B cell responses to influenza virus infection in the lung","volume":"30","author":"Takahashi","year":"2017","journal-title":"Viral Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e40733","DOI":"10.1371\/journal.pone.0040733","article-title":"Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses","volume":"7","author":"Boyden","year":"2012","journal-title":"PLoS ONE."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1073\/pnas.0800003105","article-title":"Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia","volume":"105","author":"Joo","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B37","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/82_2014_402","article-title":"Mucosal immunization and adjuvants","volume":"386","author":"Hasegawa","year":"2015","journal-title":"Curr Top Microbiol Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3610","DOI":"10.1128\/JVI.03099-14","article-title":"Broadly neutralizing anti-influenza virus antibodies: enhancement of neutralizing potency in polyclonal mixtures and IgA backbones","volume":"89","author":"He","year":"2015","journal-title":"J Virol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.4049\/jimmunol.173.3.1978","article-title":"Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract","volume":"173","author":"Renegar","year":"2004","journal-title":"J Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3389\/fmicb.2017.00900","article-title":"Nasal IgA provides protection against human influenza challenge in volunteers with low serum influenza antibody titre","volume":"8","author":"Gould","year":"2017","journal-title":"Front Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41577-019-0143-6","article-title":"The human antibody response to influenza A virus infection and vaccination","volume":"19","author":"Krammer","year":"2019","journal-title":"Nat Rev Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.coviro.2017.03.002","article-title":"Tackling influenza with broadly neutralizing antibodies","volume":"24","author":"Corti","year":"2017","journal-title":"Curr Opin Virol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/vaccines6020027","article-title":"The potential role of Fc-receptor functions in the development of a universal influenza vaccine","volume":"6","author":"Jegaskanda","year":"2018","journal-title":"Vaccines."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21645515.2017.1290018","article-title":"Fc or not Fc; that is the question: antibody Fc-receptor interactions are key to universal influenza vaccine design","volume":"13","author":"Jegaskanda","year":"2017","journal-title":"Hum Vaccin Immunother."},{"key":"B45","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.coviro.2016.12.002","article-title":"Antibody-dependent cellular cytotoxicity and influenza virus","volume":"22","author":"Vanderven","year":"2017","journal-title":"Curr Opin Virol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1189\/jlb.0313180","article-title":"Lung-resident memory CD8 T cells","volume":"95","author":"Wu","year":"2014","journal-title":"J Leukoc Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"eaag2031","DOI":"10.1126\/sciimmunol.aag2031","article-title":"Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity","volume":"2","author":"Slutter","year":"2017","journal-title":"Sci Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"eaam6970","DOI":"10.1126\/sciimmunol.aam6970","article-title":"Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection","volume":"2","author":"Pizzolla","year":"2017","journal-title":"Sci Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/mi.2013.67","article-title":"Lung niches for the generation and maintenance of tissue-resident memory T cells","volume":"7","author":"Turner","year":"2014","journal-title":"Mucosal Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.4049\/jimmunol.1102243","article-title":"Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection","volume":"187","author":"Teijaro","year":"2011","journal-title":"J Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3389\/fimmu.2016.00195","article-title":"Heterosubtypic T-Cell immunity to influenza in humans: challenges for universal T-cell influenza vaccines","volume":"7","author":"Sridhar","year":"2016","journal-title":"Front Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1084\/jem.20142284","article-title":"Distinct germinal center selection at local sites shapes memory B cell response to viral escape","volume":"212","author":"Adachi","year":"2015","journal-title":"J Exp Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e85832","DOI":"10.1172\/jci.insight.85832","article-title":"Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza infection","volume":"1","author":"Zens","year":"2016","journal-title":"JCI Insight."},{"key":"B54","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.vetmic.2016.11.025","article-title":"Recombinant viral-vectored vaccines for the control of avian influenza in poultry","volume":"206","author":"Suarez","year":"2017","journal-title":"Vet Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1080\/21645515.2016.1210729","article-title":"Viral vector-based influenza vaccines","volume":"12","author":"de Vries","year":"2016","journal-title":"Hum Vaccin Immunother."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.3389\/fimmu.2018.01568","article-title":"A review of DNA vaccines against influenza","volume":"9","author":"Lee","year":"2018","journal-title":"Front Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines-a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat Rev Drug Discov."},{"key":"B58","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3389\/fimmu.2019.00594","article-title":"Advances in mRNA vaccines for infectious diseases","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fimmu.2013.00114","article-title":"Mechanisms of action of adjuvants","volume":"4","author":"Awate","year":"2013","journal-title":"Front Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1089\/vim.2017.0026","article-title":"Modes of action for mucosal vaccine adjuvants","volume":"30","author":"Aoshi","year":"2017","journal-title":"Viral Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1459394","DOI":"10.1155\/2016\/1459394","article-title":"Adjuvants: classification, modus operandi, and licensing","volume":"2016","author":"Apostolico Jde","year":"2016","journal-title":"J Immunol Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev-bioeng-071811-150054","article-title":"Mucosal vaccine design and delivery","volume":"14","author":"Woodrow","year":"2012","journal-title":"Annu Rev Biomed Eng."},{"key":"B63","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.coph.2018.03.015","article-title":"ADP-ribosylating enterotoxins as vaccine adjuvants","volume":"41","author":"Lycke","year":"2018","journal-title":"Curr Opin Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/vim.2013.0013","article-title":"Mucosal adjuvants for influenza virus-like particle vaccine","volume":"26","author":"Quan","year":"2013","journal-title":"Viral Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1128\/JVI.01615-07","article-title":"Induction of heterosubtypic immunity to influenza virus by intranasal immunization","volume":"82","author":"Quan","year":"2008","journal-title":"J Virol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"5141","DOI":"10.1128\/JVI.75.11.5141-5150.2001","article-title":"Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection","volume":"75","author":"Tumpey","year":"2001","journal-title":"J Virol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1128\/JVI.02035-08","article-title":"Kinetics of immune responses to influenza virus-like particles and dose-dependence of protection with a single vaccination","volume":"83","author":"Quan","year":"2009","journal-title":"J Virol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.pep.2017.08.010","article-title":"CTA1: Purified and display onto gram-positive enhancer matrix (GEM) particles as mucosal adjuvant","volume":"141","author":"Zhang","year":"2018","journal-title":"Protein Expr Purif."},{"key":"B69","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.vetmic.2017.01.020","article-title":"Mucosal vaccination of conserved sM2, HA2 and cholera toxin subunit A1 (CTA1) fusion protein with poly gamma-glutamate\/chitosan nanoparticles (PC NPs) induces protection against divergent influenza subtypes","volume":"201","author":"Chowdhury","year":"2017","journal-title":"Vet Microbiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.4049\/jimmunol.176.6.3697","article-title":"The combined CTA1-DD\/ISCOM adjuvant vector promotes priming of mucosal and systemic immunity to incorporated antigens by specific targeting of B cells","volume":"176","author":"Helgeby","year":"2006","journal-title":"J Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.vaccine.2007.12.027","article-title":"CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine","volume":"26","author":"Eliasson","year":"2008","journal-title":"Vaccine."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.3389\/fimmu.2018.02060","article-title":"Porous nanoparticles with self-adjuvanting M2e-fusion protein and recombinant hemagglutinin provide strong and broadly protective immunity against influenza virus infections","volume":"9","author":"Bernasconi","year":"2018","journal-title":"Front Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.vaccine.2005.08.061","article-title":"The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection","volume":"24","author":"De Filette","year":"2006","journal-title":"Vaccine."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e373","DOI":"10.1038\/emm.2017.172","article-title":"Bacterial flagellin-a potent immunomodulatory agent","volume":"49","author":"Hajam","year":"2017","journal-title":"Exp Mol Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1086\/591056","article-title":"Effects of flagellin on the functions of follicle-associated epithelium","volume":"198","author":"Chabot","year":"2008","journal-title":"J Infect Dis."},{"key":"B76","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1016\/j.vaccine.2009.07.058","article-title":"Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine","volume":"28","author":"Skountzou","year":"2010","journal-title":"Vaccine."},{"key":"B77","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.vaccine.2011.10.058","article-title":"Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection","volume":"30","author":"Hong","year":"2012","journal-title":"Vaccine."},{"key":"B78","doi-asserted-by":"publisher","first-page":"e13972","DOI":"10.1371\/journal.pone.0013972","article-title":"Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS ONE."},{"key":"B79","doi-asserted-by":"publisher","first-page":"686549","DOI":"10.1155\/2013\/686549","article-title":"Virus-like particles containing the tetrameric ectodomain of influenza matrix protein 2 and flagellin induce heterosubtypic protection in mice","volume":"2013","author":"Wang","year":"2013","journal-title":"Biomed Res Int."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2014.01.002","article-title":"Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity","volume":"178","author":"Wang","year":"2014","journal-title":"J Control Release."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.nano.2018.03.007","article-title":"Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity","volume":"14","author":"Wang","year":"2018","journal-title":"Nanomedicine."},{"key":"B82","doi-asserted-by":"publisher","first-page":"4747","DOI":"10.2147\/IJN.S137222","article-title":"Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro","volume":"12","author":"Wang","year":"2017","journal-title":"Int J Nanomedicine."},{"key":"B83","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.vetmic.2011.12.014","article-title":"Salmonella flagellin enhances mucosal immunity of avian influenza vaccine in chickens","volume":"157","author":"Chaung","year":"2012","journal-title":"Vet Microbiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fimmu.2017.00326","article-title":"Mucosal and systemic immune responses to influenza H7N9 antigen HA1-2 co-delivered intranasally with flagellin or polyethyleneimine in mice and chickens","volume":"8","author":"Song","year":"2017","journal-title":"Front Immunol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1080\/21645515.2017.1415684","article-title":"Adjuvanted influenza vaccines","volume":"14","author":"Tregoning","year":"2018","journal-title":"Hum Vaccin Immunother."},{"key":"B86","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.1016\/j.vaccine.2011.05.041","article-title":"Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults","volume":"29","author":"Turley","year":"2011","journal-title":"Vaccine."},{"key":"B87","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1586\/erv.10.172","article-title":"Proteosome-adjuvanted intranasal influenza vaccines: advantages, progress and future considerations","volume":"10","author":"Burt","year":"2011","journal-title":"Expert Rev Vaccines."},{"key":"B88","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S0264-410X(01)00268-7","article-title":"Nasal immunization with subunit proteosome influenza vaccines induces serum HAI, mucosal IgA and protection against influenza challenge","volume":"20","author":"Plante","year":"2001","journal-title":"Vaccine."},{"key":"B89","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1016\/j.vaccine.2004.03.035","article-title":"Protollin: a novel adjuvant for intranasal vaccines","volume":"22","author":"Jones","year":"2004","journal-title":"Vaccine."},{"key":"B90","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1016\/S0264-410X(03)00387-6","article-title":"A nasal Proteosome influenza vaccine containing baculovirus-derived hemagglutinin induces protective mucosal and systemic immunity","volume":"21","author":"Jones","year":"2003","journal-title":"Vaccine."},{"key":"B91","doi-asserted-by":"publisher","first-page":"e0163089","DOI":"10.1371\/journal.pone.0163089","article-title":"An intranasal proteosome-adjuvanted trivalent influenza vaccine is safe, immunogenic & efficacious in the human viral influenza challenge model. Serum IgG & mucosal IgA are important correlates of protection against illness associated with infection","volume":"11","author":"Lambkin-Williams","year":"2016","journal-title":"PLoS ONE."},{"key":"B92","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fimmu.2013.00282","article-title":"Bacterium-like particles for efficient immune stimulation of existing vaccines and new subunit vaccines in mucosal applications","volume":"4","author":"Van","year":"2013","journal-title":"Front Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1208\/s12248-009-9168-2","article-title":"Intranasal delivery of influenza subunit vaccine formulated with GEM particles as an adjuvant","volume":"12","author":"Saluja","year":"2010","journal-title":"AAPS J."},{"key":"B94","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.1016\/j.vaccine.2012.04.032","article-title":"Bacterium-like particles supplemented with inactivated influenza antigen induce cross-protective influenza-specific antibody responses through intranasal administration","volume":"30","author":"de Haan","year":"2012","journal-title":"Vaccine."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1016\/j.vaccine.2014.02.019","article-title":"Inactivated influenza vaccine adjuvanted with bacterium-like particles induce systemic and mucosal influenza A virus specific T-cell and B-cell responses after nasal administration in a TLR2 dependent fashion","volume":"32","author":"Keijzer","year":"2014","journal-title":"Vaccine."},{"key":"B96","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.vaccine.2016.12.025","article-title":"Outer membrane vesicles harboring modified lipid A moiety augment the efficacy of an influenza vaccine exhibiting reduced endotoxicity in a mouse model","volume":"35","author":"Lee","year":"2017","journal-title":"Vaccine."},{"key":"B97","doi-asserted-by":"publisher","first-page":"5482087","DOI":"10.1155\/2016\/5482087","article-title":"Mucosal vaccine development based on liposome technology","volume":"2016","author":"Bernasconi","year":"2016","journal-title":"J Immunol Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3389\/fimmu.2018.00431","article-title":"Lipid-Based Particles: versatile delivery systems for mucosal vaccination against infection","volume":"9","author":"Corthesy","year":"2018","journal-title":"Front Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1016\/S0264-410X(02)00295-5","article-title":"Liposomal immunostimulatory DNA sequence (ISS-ODN): an efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines","volume":"20","author":"Joseph","year":"2002","journal-title":"Vaccine."},{"key":"B100","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1080\/21691401.2018.1438450","article-title":"Cationic DDA\/TDB liposome as a mucosal vaccine adjuvant for uptake by dendritic cells in vitro induces potent humoural immunity","volume":"46","author":"Qu","year":"","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ijpharm.2009.10.043","article-title":"CAF01 liposomes as a mucosal vaccine adjuvant: in vitro and in vivo investigations","volume":"390","author":"Christensen","year":"2010","journal-title":"Int J Pharm."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1016\/j.vaccine.2011.01.009","article-title":"A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity","volume":"29","author":"Even-Or","year":"2011","journal-title":"Vaccine."},{"key":"B103","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1016\/j.vaccine.2005.12.017","article-title":"A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice","volume":"24","author":"Joseph","year":"2006","journal-title":"Vaccine."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1586\/14760584.2013.825445","article-title":"Adjuvanted influenza vaccines","volume":"12","author":"Even-Or","year":"2013","journal-title":"Expert Rev Vaccines."},{"key":"B105","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1016\/j.jcv.2004.09.013","article-title":"Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses","volume":"31","author":"Wang","year":"2004","journal-title":"J Clin Virol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1016\/S0264-410X(02)00261-X","article-title":"Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice","volume":"20","author":"Ninomiya","year":"2002","journal-title":"Vaccine."},{"key":"B107","doi-asserted-by":"publisher","first-page":"4460","DOI":"10.1016\/j.vaccine.2011.04.040","article-title":"Characterization of the murine Th2 response to immunization with liposomal M2e influenza vaccine","volume":"29","author":"Adler-Moore","year":"2011","journal-title":"Vaccine."},{"key":"B108","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/vaccines6020020","article-title":"New kids on the block: RNA-based influenza virus vaccines","volume":"6","author":"Scorza","year":"2018","journal-title":"Vaccines."},{"key":"B109","doi-asserted-by":"publisher","first-page":"319","DOI":"10.4155\/tde-2016-0006","article-title":"mRNA vaccine delivery using lipid nanoparticles","volume":"7","author":"Reichmuth","year":"2016","journal-title":"Ther Deliv."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e0161193","DOI":"10.1371\/journal.pone.0161193","article-title":"Self-amplifying mRNA vaccines expressing multiple conserved influenza antigens confer protection against homologous and heterosubtypic viral challenge","volume":"11","author":"Magini","year":"2016","journal-title":"PLoS ONE."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.ymthe.2017.03.035","article-title":"Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 influenza viruses","volume":"25","author":"Bahl","year":"2017","journal-title":"Mol Ther."},{"key":"B112","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1038\/s41467-018-05482-0","article-title":"Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies","volume":"9","author":"Pardi","year":"2018","journal-title":"Nat Commun."},{"key":"B113","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1038\/srep05128","article-title":"Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity","volume":"4","author":"Phua","year":"2014","journal-title":"Sci Rep."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3389\/fimmu.2017.01223","article-title":"Mucosal administration of cycle-di-nucleotide-adjuvanted virosomes efficiently induces protection against influenza H5N1 in mice","volume":"8","author":"Ebensen","year":"2017","journal-title":"Front Immunol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1586\/14760584.2013.811195","article-title":"Influenza virosomes as vaccine adjuvant and carrier system","volume":"12","author":"Moser","year":"2013","journal-title":"Expert Rev Vaccines."},{"key":"B116","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1586\/14760584.6.5.761","article-title":"ISCOMATRIX adjuvant for prophylactic and therapeutic vaccines","volume":"6","author":"Drane","year":"2007","journal-title":"Expert Rev Vaccines."},{"key":"B117","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1016\/j.vaccine.2011.03.090","article-title":"A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus","volume":"29","author":"Eliasson","year":"2011","journal-title":"Vaccine."},{"key":"B118","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/S0264-410X(02)00545-5","article-title":"Intranasal vaccination with ISCOMATRIX adjuvanted influenza vaccine","volume":"21","author":"Coulter","year":"2003","journal-title":"Vaccine."},{"key":"B119","doi-asserted-by":"publisher","first-page":"221","DOI":"10.14202\/vetworld.2018.221-226","article-title":"Intranasal administration of inactivated avian influenza virus of H5N1 subtype vaccine-induced systemic immune response in chicken and mice","volume":"11","author":"Suartha","year":"2018","journal-title":"Vet World."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.4049\/jimmunol.176.2.1122","article-title":"Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen","volume":"176","author":"Mizuno","year":"2006","journal-title":"J Immunol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"5368","DOI":"10.1016\/j.vaccine.2011.05.090","article-title":"Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity","volume":"29","author":"Mizuno","year":"2011","journal-title":"Vaccine."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1111\/irv.12124","article-title":"Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF-10: induction of potent local and systemic immunity with balanced Th1 and Th2 responses","volume":"7","author":"Kimoto","year":"2013","journal-title":"Influenza Other Respir Viruses."},{"key":"B123","doi-asserted-by":"publisher","first-page":"e0191133","DOI":"10.1371\/journal.pone.0191133","article-title":"Adjuvanting influenza hemagglutinin vaccine with a human pulmonary surfactant-mimicking synthetic compound SF-10 induces local and systemic cell-mediated immunity in mice","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS ONE."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1016\/j.vaccine.2016.02.061","article-title":"Induction of systemic and mucosal immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys","volume":"34","author":"Mizuno","year":"2016","journal-title":"Vaccine."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1016\/j.vaccine.2014.03.061","article-title":"Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets","volume":"32","author":"Maltais","year":"2014","journal-title":"Vaccine."},{"key":"B126","doi-asserted-by":"publisher","first-page":"e70527","DOI":"10.1371\/journal.pone.0070527","article-title":"Endocine, N3OA and N3OASq; three mucosal adjuvants that enhance the immune response to nasal influenza vaccination","volume":"8","author":"Falkeborn","year":"2013","journal-title":"PLoS ONE."},{"key":"B127","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12985-017-0698-4","article-title":"The intranasal adjuvant Endocine enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen","volume":"14","author":"Falkeborn","year":"2017","journal-title":"Virol J."},{"key":"B128","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1002\/eji.201142346","article-title":"Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking","volume":"42","author":"Makidon","year":"2012","journal-title":"Eur J Immunol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.vaccine.2012.12.033","article-title":"Nanoemulsion nasal adjuvant W805EC induces dendritic cell engulfment of antigen-primed epithelial cells","volume":"31","author":"Myc","year":"2013","journal-title":"Vaccine."},{"key":"B130","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1615\/CritRevImmunol.v30.i2.60","article-title":"Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant","volume":"30","author":"Bielinska","year":"2010","journal-title":"Crit Rev Immunol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.4049\/jimmunol.1301424","article-title":"Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant","volume":"192","author":"Bielinska","year":"2014","journal-title":"J Immunol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"6871","DOI":"10.1016\/j.vaccine.2012.09.007","article-title":"Nanoemulsion W805EC improves immune responses upon intranasal delivery of an inactivated pandemic H1N1 influenza vaccine","volume":"30","author":"Das","year":"2012","journal-title":"Vaccine."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1128\/CVI.00035-11","article-title":"Intranasal immunization of ferrets with commercial trivalent influenza vaccines formulated in a nanoemulsion-based adjuvant","volume":"18","author":"Hamouda","year":"2011","journal-title":"Clin Vaccine Immunol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.vaccine.2011.10.094","article-title":"Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens","volume":"30","author":"Stanberry","year":"2012","journal-title":"Vaccine."},{"key":"B135","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1128\/JVI.01786-15","article-title":"Induction of broad-based immunity and protective efficacy by self-amplifying mRNA vaccines encoding influenza virus hemagglutinin","volume":"90","author":"Brazzoli","year":"2016","journal-title":"J Virol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1080\/14760584.2016.1175942","article-title":"Progress in developing virus-like particle influenza vaccines","volume":"15","author":"Quan","year":"2016","journal-title":"Expert Rev Vaccines."},{"key":"B137","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.virusres.2009.04.005","article-title":"Influenza vaccines based on virus-like particles","volume":"143","author":"Kang","year":"2009","journal-title":"Virus Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"7670","DOI":"10.1016\/j.vaccine.2011.07.139","article-title":"A candidate dual vaccine against influenza and noroviruses","volume":"29","author":"Xia","year":"2011","journal-title":"Vaccine."},{"key":"B139","doi-asserted-by":"publisher","first-page":"5726","DOI":"10.1128\/JVI.00207-09","article-title":"Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge","volume":"83","author":"Perrone","year":"2009","journal-title":"J Virol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1128\/JVI.02052-06","article-title":"Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus","volume":"81","author":"Quan","year":"2007","journal-title":"J Virol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"e14538","DOI":"10.1371\/journal.pone.0014538","article-title":"Influenza virus-like particles containing M2 induce broadly cross protective immunity","volume":"6","author":"Song","year":"2011","journal-title":"PLoS ONE."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e01044","DOI":"10.1128\/mBio.01044-15","article-title":"An intranasal virus-like particle vaccine broadly protects mice from multiple subtypes of influenza A virus","volume":"6","author":"Schwartzman","year":"2015","journal-title":"MBio."},{"key":"B143","doi-asserted-by":"publisher","first-page":"901817","DOI":"10.1155\/2015\/901817","article-title":"Protection against multiple subtypes of influenza viruses by virus-like particle vaccines based on a hemagglutinin conserved epitope","volume":"2015","author":"Chen","year":"2015","journal-title":"Biomed Res Int."},{"key":"B144","doi-asserted-by":"publisher","first-page":"6464","DOI":"10.1016\/j.vaccine.2016.11.026","article-title":"Influenza H7N9 LAH-HBc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses","volume":"34","author":"Zheng","year":"2016","journal-title":"Vaccine."},{"key":"B145","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/eji.200636959","article-title":"Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design","volume":"38","author":"Bessa","year":"2008","journal-title":"Eur J Immunol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1016\/j.vaccine.2015.07.049","article-title":"Immunogenicity and protective efficacy of the norovirus P particle-M2e chimeric vaccine in chickens","volume":"33","author":"Elaish","year":"2015","journal-title":"Vaccine."},{"key":"B147","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1128\/JVI.01141-13","article-title":"A novel subnucleocapsid nanoplatform for mucosal vaccination against influenza virus that targets the ectodomain of matrix protein 2","volume":"88","author":"Herve","year":"2014","journal-title":"J Virol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.4049\/jimmunol.0804004","article-title":"Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses","volume":"183","author":"Bessa","year":"2009","journal-title":"J Immunol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"20566","DOI":"10.1073\/pnas.1206970109","article-title":"Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses","volume":"109","author":"Bessa","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B150","doi-asserted-by":"publisher","first-page":"9081","DOI":"10.1016\/j.vaccine.2011.09.051","article-title":"Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice","volume":"29","author":"Schneider-Ohrum","year":"2011","journal-title":"Vaccine."},{"key":"B151","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.intimp.2017.08.012","article-title":"CCL28 chemokine: an anchoring point bridging innate and adaptive immunity","volume":"51","author":"Mohan","year":"2017","journal-title":"Int Immunopharmacol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1016\/j.vaccine.2015.07.101","article-title":"Chitosan-based mucosal adjuvants: sunrise on the ocean","volume":"33","author":"Xia","year":"2015","journal-title":"Vaccine."},{"key":"B153","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.immuni.2016.02.004","article-title":"The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferons","volume":"44","author":"Carroll","year":"2016","journal-title":"Immunity."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1002\/jmv.24253","article-title":"Conjugating influenza A. (H1N1) antigen to N-trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration","volume":"87","author":"Liu","year":"2015","journal-title":"J Med Virol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.vaccine.2006.06.086","article-title":"N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model","volume":"25","author":"Amidi","year":"2007","journal-title":"Vaccine."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1016\/j.biomaterials.2011.11.068","article-title":"Thermal-sensitive hydrogel as adjuvant-free vaccine delivery system for H5N1 intranasal immunization","volume":"33","author":"Wu","year":"2012","journal-title":"Biomaterials."},{"key":"B157","doi-asserted-by":"publisher","first-page":"e93761","DOI":"10.1371\/journal.pone.0093761","article-title":"Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge","volume":"9","author":"Mann","year":"2014","journal-title":"PLoS ONE."},{"key":"B158","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ijpharm.2014.07.005","article-title":"Intranasal chitosan-DNA vaccines that protect across influenza virus subtypes","volume":"473","author":"Sawaengsak","year":"2014","journal-title":"Int J Pharm."},{"key":"B159","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00705-010-0621-4","article-title":"Cross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant","volume":"155","author":"Sui","year":"2010","journal-title":"Arch Virol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.vetmic.2012.05.035","article-title":"Mucosal immunization with recombinant influenza hemagglutinin protein and poly gamma-glutamate\/chitosan nanoparticles induces protection against highly pathogenic influenza A virus","volume":"160","author":"Moon","year":"2012","journal-title":"Vet Microbiol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"9026","DOI":"10.1016\/j.vaccine.2011.09.033","article-title":"Development and characterization of chitosan coated poly-(\u03b5-caprolactone) nanoparticulate system for effective immunization against influenza","volume":"29","author":"Gupta","year":"2011","journal-title":"Vaccine."},{"key":"B162","doi-asserted-by":"publisher","first-page":"e0206324","DOI":"10.1371\/journal.pone.0206324","article-title":"Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens","volume":"13","author":"Alkie","year":"2018","journal-title":"PLoS ONE."},{"key":"B163","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1038\/mtna.2014.24","article-title":"Self-replicating replicon-RNA delivery to dendritic cells by chitosan-nanoparticles for translation in vitro and in vivo","volume":"3","author":"McCullough","year":"2014","journal-title":"Mol Ther Nucleic Acids."},{"key":"B164","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.1016\/j.vaccine.2005.04.021","article-title":"Effective nasal influenza vaccine delivery using chitosan","volume":"23","author":"Read","year":"2005","journal-title":"Vaccine."},{"key":"B165","doi-asserted-by":"publisher","first-page":"797","DOI":"10.4161\/hv.27449","article-title":"Chitosan: a promising safe and immune-enhancing adjuvant for intranasal vaccines","volume":"10","author":"Smith","year":"2014","journal-title":"Hum Vaccin Immunother."},{"key":"B166","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1517\/17425247.2015.1044435","article-title":"Nasal and pulmonary vaccine delivery using particulate carriers","volume":"12","author":"Jia","year":"2015","journal-title":"Expert Opin Drug Deliv."},{"key":"B167","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.4049\/jimmunol.1500492","article-title":"Programming of influenza vaccine broadness and persistence by mucoadhesive polymer-based adjuvant systems","volume":"195","author":"Noh","year":"2015","journal-title":"J Immunol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"5896","DOI":"10.1016\/j.vaccine.2009.07.037","article-title":"Poly(\u03b3-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice","volume":"27","author":"Okamoto","year":"2009","journal-title":"Vaccine."},{"key":"B169","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/mt.2010.222","article-title":"Intranasal DNA vaccination induces potent mucosal and systemic immune responses and cross-protective immunity against influenza viruses","volume":"19","author":"Torrieri-Dramard","year":"2011","journal-title":"Mol Ther."},{"key":"B170","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jconrel.2016.02.043","article-title":"Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways","volume":"228","author":"Li","year":"2016","journal-title":"J Control Release."},{"key":"B171","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.nano.2015.11.001","article-title":"Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines","volume":"12","author":"Demoulins","year":"2016","journal-title":"Nanomedicine."},{"key":"B172","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ymthe.2017.11.017","article-title":"Self-Amplifying RNA vaccines give equivalent protection against influenza to mRNA vaccines but at much lower doses","volume":"26","author":"Vogel","year":"2018","journal-title":"Mol Ther."},{"key":"B173","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1128\/CVI.00778-14","article-title":"H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice","volume":"22","author":"Qin","year":"2015","journal-title":"Clin Vaccine Immunol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.jconrel.2013.06.004","article-title":"Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection","volume":"170","author":"Mann","year":"2013","journal-title":"J Control Release."},{"key":"B175","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.addr.2008.09.005","article-title":"Nanoparticles for nasal vaccination","volume":"61","author":"Csaba","year":"2009","journal-title":"Adv Drug Deliv Rev."},{"key":"B176","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1089\/vim.2015.0144","article-title":"Characterization of immune responses to an inactivated avian influenza virus vaccine adjuvanted with nanoparticles containing CpG ODN","volume":"29","author":"Singh","year":"2016","journal-title":"Viral Immunol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ejpb.2012.01.008","article-title":"Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes","volume":"81","author":"Sakuma","year":"2012","journal-title":"Eur J Pharm Biopharm."},{"key":"B178","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1021\/mp300329r","article-title":"Cell-penetrating peptide-linked polymers as carriers for mucosal vaccine delivery","volume":"9","author":"Sakuma","year":"2012","journal-title":"Mol Pharm."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1021\/acs.bioconjchem.6b00283","article-title":"Demonstration of D-octaarginine-linked polymers as promising adjuvants for mucosal vaccination through influenza virus challenge","volume":"27","author":"Miyata","year":"2016","journal-title":"Bioconjug Chem."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1586\/14760584.2015.1064772","article-title":"Gold nanoparticles and vaccine development","volume":"14","author":"Salazar-Gonzalez","year":"2015","journal-title":"Expert Rev Vaccines."},{"key":"B181","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2217\/nnm.13.58","article-title":"Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza A virus","volume":"9","author":"Tao","year":"2014","journal-title":"Nanomedicine."},{"key":"B182","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.antiviral.2017.01.021","article-title":"Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses","volume":"141","author":"Tao","year":"2017","journal-title":"Antiviral Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/mi.2017.48","article-title":"Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production","volume":"11","author":"Takaki","year":"2018","journal-title":"Mucosal Immunol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1128\/JVI.79.5.2910-2919.2005","article-title":"Synthetic double-stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection","volume":"79","author":"Ichinohe","year":"2005","journal-title":"J Virol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"e79194","DOI":"10.1371\/journal.pone.0079194","article-title":"Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies","volume":"8","author":"Goff","year":"2013","journal-title":"PLoS ONE."},{"key":"B186","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.3382\/ps.2013-03193","article-title":"Comparison of 3 kinds of Toll-like receptor ligands for inactivated avian H5N1 influenza virus intranasal immunization in chicken","volume":"92","author":"Liang","year":"2013","journal-title":"Poult Sci."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1086\/521304","article-title":"Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine","volume":"196","author":"Ichinohe","year":"2007","journal-title":"J Infect Dis."},{"key":"B188","doi-asserted-by":"publisher","first-page":"5490","DOI":"10.1016\/j.vaccine.2014.07.078","article-title":"Intranasal seasonal influenza vaccine and a TLR-3 agonist, rintatolimod, induced cross-reactive IgA antibody formation against avian H5N1 and H7N9 influenza HA in humans","volume":"32","author":"Overton","year":"2014","journal-title":"Vaccine."},{"key":"B189","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/medsci5040035","article-title":"cGAMP promotes germinal center formation and production of IgA in nasal-associated lymphoid tissue","volume":"5","author":"Takaki","year":"2017","journal-title":"Med Sci."},{"key":"B190","doi-asserted-by":"publisher","first-page":"4973","DOI":"10.1016\/j.vaccine.2011.04.094","article-title":"Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice","volume":"29","author":"Madhun","year":"2011","journal-title":"Vaccine."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/irv.12056","article-title":"A study of chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine","volume":"7","author":"Svindland","year":"2013","journal-title":"Influenza Other Respir Viruses."},{"key":"B192","doi-asserted-by":"publisher","first-page":"e104824","DOI":"10.1371\/journal.pone.0104824","article-title":"Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge","volume":"9","author":"Sanchez","year":"2014","journal-title":"PLoS ONE."},{"key":"B193","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nri1329","article-title":"Immunotherapeutic uses of CpG oligodeoxynucleotides","volume":"4","author":"Klinman","year":"2004","journal-title":"Nat Rev Immunol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/S0264-410X(98)80122-9","article-title":"CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus","volume":"16","author":"Moldoveanu","year":"1998","journal-title":"Vaccine."},{"key":"B195","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.3382\/ps.2013-03205","article-title":"Effects of different CpG oligodeoxynucleotides with inactivated avian H5N1 influenza virus on mucosal immunity of chickens","volume":"92","author":"Fu","year":"2013","journal-title":"Poult Sci."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3389\/fimmu.2018.01953","article-title":"Polyanhydride nanovaccine induces robust pulmonary B and T cell immunity and confers protection against homologous and heterologous influenza A virus infections","volume":"9","author":"Zacharias","year":"2018","journal-title":"Front Immunol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.1128\/JVI.00296-15","article-title":"CpG oligodeoxynucleotides facilitate delivery of whole inactivated H9N2 influenza virus via transepithelial dendrites of dendritic cells in nasal mucosa","volume":"89","author":"Qin","year":"2015","journal-title":"J Virol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s13238-014-0125-1","article-title":"Innate endogenous adjuvants prime to desirable immune responses via mucosal routes","volume":"6","author":"Wang","year":"2015","journal-title":"Protein Cell."},{"key":"B199","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1086\/314996","article-title":"Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity","volume":"180","author":"Arulanandam","year":"1999","journal-title":"J Infect Dis."},{"key":"B200","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1016\/j.vaccine.2004.12.006","article-title":"Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level","volume":"23","author":"Bracci","year":"2005","journal-title":"Vaccine."},{"key":"B201","doi-asserted-by":"publisher","first-page":"12703","DOI":"10.1128\/JVI.01182-10","article-title":"Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus","volume":"84","author":"Kayamuro","year":"2010","journal-title":"J Virol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1743-422X-11-78","article-title":"Membrane-bound IL-12 and IL-23 serve as potent mucosal adjuvants when co-presented on whole inactivated influenza vaccines","volume":"11","author":"Khan","year":"2014","journal-title":"Virol J."},{"key":"B203","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jconrel.2016.05.021","article-title":"Co-delivery of GPI-anchored CCL28 and influenza HA in chimeric virus-like particles induces cross-protective immunity against H3N2 viruses","volume":"233","author":"Mohan","year":"2016","journal-title":"J Control Release."},{"key":"B204","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.intimp.2018.07.011","article-title":"Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28\/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses","volume":"63","author":"Liu","year":"2018","journal-title":"Int Immunopharmacol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1016\/j.vaccine.2009.06.084","article-title":"Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans","volume":"27","author":"Couch","year":"2009","journal-title":"Vaccine."},{"key":"B206","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.3389\/fimmu.2018.02936","article-title":"Trained immunity-based vaccines: a new paradigm for the development of broad-spectrum anti-infectious formulations","volume":"9","author":"Sanchez-Ramon","year":"2018","journal-title":"Front Immunol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1128\/JVI.01805-09","article-title":"Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model","volume":"84","author":"Norton","year":"2010","journal-title":"J Virol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.bbrc.2007.02.019","article-title":"Protection from lethal influenza virus challenge by oral type 1 interferon","volume":"355","author":"Beilharz","year":"2007","journal-title":"Biochem Biophys Res Commun."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.vaccine.2008.12.048","article-title":"A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic","volume":"27","author":"Lau","year":"2009","journal-title":"Vaccine."},{"key":"B210","doi-asserted-by":"publisher","first-page":"28729","DOI":"10.1038\/srep28729","article-title":"Intranasal administration of chitosan against influenza A (H7N9) virus infection in a mouse model","volume":"6","author":"Zheng","year":"2016","journal-title":"Sci Rep."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01605\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T09:24:00Z","timestamp":1695029040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01605\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":210,"alternative-id":["10.3389\/fimmu.2019.01605"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01605","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"article-number":"1605"}}