{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:42:59Z","timestamp":1781811779322,"version":"3.54.5"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01624","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T12:49:06Z","timestamp":1563367746000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Melissa","family":"Mavers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Simonetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Nishikii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica V.","family":"Ribado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Maas-Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihito","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Turkoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Negrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.it.2011.10.004","article-title":"TNF superfamily in inflammatory disease: translating basic insights","volume":"33","author":"Croft","year":"2012","journal-title":"Trends Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.immuni.2016.04.019","article-title":"The TNF receptor superfamily in co-stimulating and co-inhibitory responses","volume":"44","author":"Ward-Kavanagh","year":"2016","journal-title":"Immunity."},{"key":"B3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nri2526","article-title":"The role of TNF superfamily members in T-cell function and diseases","volume":"9","author":"Croft","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1126\/science.274.5289.990","article-title":"Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95","volume":"274","author":"Chinnaiyan","year":"1996","journal-title":"Science."},{"key":"B5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S1074-7613(00)80244-7","article-title":"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1\/CD95)","volume":"6","author":"Bodmer","year":"1997","journal-title":"Immunity."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1084\/jem.20072528","article-title":"Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation","volume":"205","author":"Fang","year":"2008","journal-title":"J Exp Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/mi.2013.114","article-title":"The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells","volume":"7","author":"Meylan","year":"2014","journal-title":"Mucosal Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1002\/eji.201445213","article-title":"Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation","volume":"45","author":"Ahn","year":"2015","journal-title":"Eur J Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"258164","DOI":"10.1155\/2013\/258164","article-title":"The role of TL1A and DR3 in autoimmune and inflammatory diseases","volume":"2013","author":"Aiba","year":"2013","journal-title":"Mediat Inflamm."},{"key":"B10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2008.04.021","article-title":"The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases","volume":"29","author":"Meylan","year":"2008","journal-title":"Immunity."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1172\/JCI42933","article-title":"Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation","volume":"120","author":"Schreiber","year":"2010","journal-title":"J Clin Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1182\/blood-2015-04-637587","article-title":"Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease","volume":"126","author":"Kim","year":"2015","journal-title":"Blood."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1182\/blood-2016-06-723783","article-title":"DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease","volume":"128","author":"Nishikii","year":"2016","journal-title":"Blood."},{"key":"B14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.bbmt.2008.10.014","article-title":"GVHD: a continuing barrier to the safety of allogeneic transplantation","volume":"15","author":"Reddy","year":"2009","journal-title":"Biol Blood Marrow Transplant."},{"key":"B15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5966\/sctm.2012-0115","article-title":"Concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment","volume":"2","author":"Sung","year":"2013","journal-title":"Stem Cells Transl Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1084\/jem.20020399","article-title":"Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation","volume":"196","author":"Hoffmann","year":"2002","journal-title":"J Exp Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1182\/blood.V99.10.3493","article-title":"The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality","volume":"99","author":"Taylor","year":"2002","journal-title":"Blood."},{"key":"B18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.clim.2009.06.001","article-title":"First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127\u2212 T regulatory cells","volume":"133","author":"Trzonkowski","year":"2009","journal-title":"Clin Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1182\/blood-2010-07-293795","article-title":"Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics","volume":"117","author":"Brunstein","year":"2011","journal-title":"Blood."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1182\/blood-2013-08-453126","article-title":"Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation","volume":"122","author":"Schneidawind","year":"2013","journal-title":"Blood."},{"key":"B21","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/TP.0b013e318264d3ef","article-title":"Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival","volume":"94","author":"Wolf","year":"2012","journal-title":"Transplantation."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.4049\/jimmunol.1201908","article-title":"Cloning, expression, and functional characterization of TL1A-Ig","volume":"190","author":"Khan","year":"2013","journal-title":"J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"eaao4910","DOI":"10.1126\/scisignal.aao4910","article-title":"Structural principles of tumor necrosis factor superfamily signaling","volume":"11","author":"Vanamee","year":"2018","journal-title":"Sci Signal."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.4049\/jimmunol.0902420","article-title":"Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3","volume":"184","author":"Suffner","year":"2010","journal-title":"J Immunol."},{"key":"B25","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"Van der Maaten","year":"2008","journal-title":"J Mach Learn Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics."},{"key":"B28","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1182\/blood-2010-08-303008","article-title":"Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4\u2013dependent mechanism","volume":"117","author":"Leveson-Gower","year":"2011","journal-title":"Blood."},{"key":"B30","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230","article-title":"An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin","volume":"88","author":"Cooke","year":"1996","journal-title":"Blood."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nm915","article-title":"CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation","volume":"9","author":"Edinger","year":"2003","journal-title":"Nat Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1002\/eji.201141764","article-title":"The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins","volume":"41","author":"Dom\u00ednguez-Luis","year":"2011","journal-title":"Eur J Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.4049\/jimmunol.178.1.301","article-title":"FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissues","volume":"178","author":"Lee","year":"2007","journal-title":"J Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"12885","DOI":"10.1073\/pnas.0812530106","article-title":"IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells","volume":"106","author":"Elyaman","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.4049\/jimmunol.1400481","article-title":"IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R\/ST2+ regulatory T cells","volume":"193","author":"Matta","year":"2014","journal-title":"J Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"308ra160","DOI":"10.1126\/scitranslmed.aab0166","article-title":"ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease","volume":"7","author":"Zhang","year":"2015","journal-title":"Sci Transl Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.4049\/jimmunol.1103768","article-title":"IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells","volume":"189","author":"Cheng","year":"2012","journal-title":"J Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.bbmt.2017.02.013","article-title":"Marked in vivo donor regulatory T cell expansion via interleukin-2 and TL1A-Ig stimulation ameliorates graft-versus-host disease but preserves graft-versus-leukemia in recipients after hematopoietic stem cell transplantation","volume":"23","author":"Wolf","year":"2017","journal-title":"Biol Blood Marrow Transplant."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/j.bbmt.2018.04.026","article-title":"Very low numbers of CD4+ FoxP3+ tregs expanded in donors via TL1A-Ig and low-dose IL-2 exhibit a distinct activation\/functional profile and suppress GVHD in a preclinical model","volume":"24","author":"Copsel","year":"2018","journal-title":"Biol Blood Marrow Transplant."},{"key":"B40","doi-asserted-by":"publisher","first-page":"6145","DOI":"10.1182\/blood-2011-12-395970","article-title":"Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence","volume":"119","author":"Arai","year":"2012","journal-title":"Blood."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1182\/blood-2010-10-311894","article-title":"Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation","volume":"117","author":"Di Ianni","year":"2011","journal-title":"Blood."},{"key":"B42","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1182\/blood-2014-03-564401","article-title":"HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse","volume":"124","author":"Martelli","year":"2014","journal-title":"Blood."},{"key":"B43","doi-asserted-by":"publisher","first-page":"35611","DOI":"10.18632\/oncotarget.26242","article-title":"Third party, umbilical cord blood derived regulatory T-cells for prevention of graft versus host disease in allogeneic hematopoietic stem cell transplantation: feasibility, safety and immune reconstitution","volume":"9","author":"Kellner","year":"2018","journal-title":"Oncotarget."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01624\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T02:43:39Z","timestamp":1575427419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01624\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2019.01624"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01624","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"article-number":"1624"}}