{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:09:31Z","timestamp":1792638571686,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01658","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T04:39:56Z","timestamp":1563856796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Elevated Gestational IL-13 During Fetal Development Is Associated With Hyperactivity and Inattention in Eight-Year-Old Children"],"prefix":"10.3389","volume":"10","author":[{"given":"Loreen","family":"Th\u00fcrmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunda","family":"Herberth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Rolle-Kampczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"R\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Borte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"von Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Trump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.3389\/fimmu.2018.02186","article-title":"Prenatal immune and endocrine modulators of offspring's brain development and cognitive functions later in life","volume":"9","author":"Schepanski","year":"2018","journal-title":"Front Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/sj.mp.4001748","article-title":"The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia","volume":"11","author":"Ashdown","year":"2006","journal-title":"Mol Psychiatry."},{"key":"B4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.molmed.2011.03.001","article-title":"Maternal infection and immune involvement in autism","volume":"17","author":"Patterson","year":"2011","journal-title":"Trends Mol Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/jcpp.12480","article-title":"Fever and infections in pregnancy and risk of attention deficit\/hyperactivity disorder in the offspring","volume":"57","author":"Werenberg Dreier","year":"2016","journal-title":"J Child Psychol Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1037\/a0013801","article-title":"An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze","volume":"123","author":"Fedorova","year":"2009","journal-title":"Behav Neurosci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat Rev Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1093\/schbul\/sbn022","article-title":"A review of the fetal brain cytokine imbalance hypothesis of schizophrenia","volume":"35","author":"Meyer","year":"2009","journal-title":"Schizophr Bull."},{"key":"B9","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1176\/appi.ajp.161.5.889","article-title":"Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring","volume":"161","author":"Brown","year":"2004","journal-title":"Am J Psychiatry."},{"key":"B10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1006\/brbi.2001.0644","article-title":"Maternal cytokine levels during pregnancy and adult psychosis","volume":"15","author":"Buka","year":"2001","journal-title":"Brain Behav Immun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41398-018-0112-z","article-title":"Gestational cytokine concentrations and neurocognitive development at 7 years","volume":"8","author":"Ghassabian","year":"2018","journal-title":"Transl Psychiatry."},{"key":"B12","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/s41593-018-0128-y","article-title":"Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring","volume":"21","author":"Rudolph","year":"2018","journal-title":"Nat Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0028","DOI":"10.5041\/RMMJ.10305","article-title":"Maternal inflammation, fetal brain implications and suggested neuroprotection: a summary of 10 years of research in animal models","volume":"8","author":"Ginsberg","year":"2017","journal-title":"Rambam Maimonides Med J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbi.2016.11.007","article-title":"The placental interleukin-6 signaling controls fetal brain development and behavior","volume":"62","author":"Wu","year":"2017","journal-title":"Brain Behav Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jaac.2016.12.010","article-title":"Associations between autoimmune diseases and attention-deficit\/hyperactivity disorder: a nationwide study","volume":"56","author":"Nielsen","year":"2017","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1001\/archpedi.159.2.151","article-title":"Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study","volume":"159","author":"Croen","year":"2005","journal-title":"Arch Pediatr Adolesc Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/nu8010006","article-title":"DHA effects in brain development and function","volume":"8","author":"Lauritzen","year":"2016","journal-title":"Nutrients."},{"key":"B19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.plefa.2006.07.010","article-title":"Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology","volume":"75","author":"McNamara","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B20","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/jn\/108.3.358","article-title":"Learning behavior and brain lipid composition in rats subjected to essential fatty acid deficiency during gestation, lactation and growth","volume":"108","author":"Lamptey","year":"1978","journal-title":"J Nutr"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e1229","DOI":"10.1038\/tp.2017.182","article-title":"Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes","volume":"7","author":"Maekawa","year":"2017","journal-title":"Transl Psychiatry."},{"key":"B22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1203\/01.PDR.0000180547.46725.CC","article-title":"N-3 fatty acid deficiency induced by a modified artificial rearing method leads to poorer performance in spatial learning tasks","volume":"58","author":"Lim","year":"2005","journal-title":"Pediatr Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1017\/S0007114500000544","article-title":"Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice","volume":"83","author":"Carrie","year":"2000","journal-title":"Br J Nutr"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e011465","DOI":"10.1136\/bmjopen-2016-011465","article-title":"Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial","volume":"6","author":"Gould","year":"2016","journal-title":"BMJ Open."},{"key":"B25","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/npp.2017.160","article-title":"Omega-3 polyunsaturated fatty acids in youths with attention deficit hyperactivity disorder: a systematic review and meta-analysis of clinical trials and biological studies","volume":"43","author":"Chang","year":"2018","journal-title":"Neuropsychopharmacology."},{"key":"B26","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00787-015-0815-0","article-title":"Diagnostic efficiency of the SDQ for parents to identify ADHD in the UK: a ROC analysis","volume":"25","author":"Algorta","year":"2016","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B27","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1080\/j.1440-1614.2004.01428.x","article-title":"Comparing psychiatric diagnoses generated by the Strengths and Difficulties Questionnaire with diagnoses made by clinicians","volume":"38","author":"Mathai","year":"2004","journal-title":"Aust N Z J Psychiatry."},{"key":"B28","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.jaac.2018.03.008","article-title":"Attention-deficit\/hyperactivity disorder in preschoolers: the accuracy of a short screener","volume":"57","author":"Overgaard","year":"2018","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e80247","DOI":"10.1371\/journal.pone.0080247","article-title":"The strengths and difficulties questionnaire as a predictor of parent-reported diagnosis of autism spectrum disorder and attention deficit hyperactivity disorder","volume":"8","author":"Russell","year":"2013","journal-title":"PLoS ONE."},{"key":"B30","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00787-011-0198-9","article-title":"Screening for the attention deficit hyperactivity disorder phenotype using the strength and difficulties questionnaire","volume":"20","author":"Ullebo","year":"2011","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B31","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/j.1469-7610.1997.tb01545.x","article-title":"The strengths and difficulties questionnaire: a research note","volume":"38","author":"Goodman","year":"1997","journal-title":"J Child Psychol Psychiatry."},{"key":"B32","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00787-018-1226-9","article-title":"The predictive validity of the Strengths and Difficulties Questionnaire for child attention-deficit\/hyperactivity disorder","volume":"28","author":"Overgaard","year":"2018","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1024\/1422-4917.30.2.105","article-title":"Normal values and evaluation of the German parents' version of Strengths and Difficulties Questionnaire (SDQ): results of a representative field study","volume":"30","author":"Woerner","year":"2002","journal-title":"Z Kinder Jugendpsychiatr Psychother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1111\/j.1398-9995.2011.02587.x","article-title":"Maternal immune status in pregnancy is related to offspring's immune responses and atopy risk","volume":"66","author":"Herberth","year":"2011","journal-title":"Allergy."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.jaci.2017.11.018","article-title":"Early-onset childhood atopic dermatitis is related to NLRP2 repression","volume":"141","author":"Thurmann","year":"2018","journal-title":"J Allergy Clin Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jaci.2015.01.022","article-title":"Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases","volume":"136","author":"Herberth","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B37","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach.","author":"Hayes","year":"2013"},{"key":"B38","doi-asserted-by":"publisher","first-page":"I56","DOI":"10.1007\/s00787-006-1008-7","article-title":"Psychopathological screening of children with ADHD: Strengths and Difficulties Questionnaire in a pan-European study","volume":"15","author":"Becker","year":"2006","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e0133604","DOI":"10.1371\/journal.pone.0133604","article-title":"Postnatal environmental tobacco smoke exposure related to behavioral problems in children","volume":"10","author":"Chastang","year":"2015","journal-title":"PLoS ONE."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e0197961","DOI":"10.1371\/journal.pone.0197961","article-title":"Effect of socioeconomic status on behavioral problems from preschool to early elementary school - A Japanese longitudinal study","volume":"13","author":"Hosokawa","year":"2018","journal-title":"PLoS ONE."},{"key":"B41","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1136\/archdischild-2014-306288","article-title":"Socioeconomic inequalities in parent-reported and teacher-reported psychological well-being","volume":"100","author":"Lewis","year":"2015","journal-title":"Arch Dis Child."},{"key":"B42","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1136\/jech-2013-202956","article-title":"Prenatal exposure to alcohol, and gender differences on child mental health at age seven years","volume":"68","author":"Niclasen","year":"2014","journal-title":"J Epidemiol Community Health."},{"key":"B43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neuro.2016.03.014","article-title":"Bisphenol A, phthalates and lead and learning and behavioral problems in Canadian children 6\u201311 years of age: CHMS 2007-2009","volume":"54","author":"Arbuckle","year":"2016","journal-title":"Neurotoxicology."},{"key":"B44","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3390\/nu10050582","article-title":"Dietary acid load and mental health outcomes in children and adolescents: results from the GINIplus and LISA birth cohort studies","volume":"10","author":"Buhlmeier","year":"2018","journal-title":"Nutrients."},{"key":"B45","doi-asserted-by":"publisher","first-page":"D527","DOI":"10.1093\/nar\/gkl838","article-title":"LMSD: LIPID MAPS structure database","volume":"35","author":"Sud","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2040-2392-2-13","article-title":"Increased midgestational IFN-gamma, IL-4 and IL-5 in women bearing a child with autism: a case-control study","volume":"2","author":"Goines","year":"2011","journal-title":"Mol Autism."},{"key":"B47","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s40259-018-0280-7","article-title":"Therapeutic targeting of the interleukin-4\/interleukin-13 signaling pathway: in allergy and beyond","volume":"32","author":"Karo-Atar","year":"2018","journal-title":"Biodrugs."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.4049\/jimmunol.1601546","article-title":"IL-13-mediated regulation of learning and memory","volume":"198","author":"Brombacher","year":"2017","journal-title":"J Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/brainsci6020018","article-title":"Neuroimmunology of the Interleukins 13 and 4","volume":"6","author":"Mori","year":"2016","journal-title":"Brain Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.bbi.2010.09.002","article-title":"Altered T cell responses in children with autism","volume":"25","author":"Ashwood","year":"2011","journal-title":"Brain Behav Immun."},{"key":"B51","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1744-9081-6-32","article-title":"Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention","volume":"6","author":"Oades","year":"2010","journal-title":"Behav Brain Funct."},{"key":"B52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jns.2010.06.004","article-title":"Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide","volume":"296","author":"Yu","year":"2010","journal-title":"J Neurol Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/glia.10357","article-title":"Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo","volume":"46","author":"Shin","year":"2004","journal-title":"Glia."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.4049\/jimmunol.177.2.1323","article-title":"Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia","volume":"177","author":"Yang","year":"2006","journal-title":"J Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/glia.10057","article-title":"Interleukin-13 and\u22124 induce death of activated microglia","volume":"38","author":"Yang","year":"2002","journal-title":"Glia."},{"key":"B56","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bbi.2018.06.001","article-title":"Controversies and prospects about microglia in maternal immune activation models for neurodevelopmental disorders","volume":"73","author":"Smolders","year":"2018","journal-title":"Brain Behav Immun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"4666","DOI":"10.4049\/jimmunol.0803392","article-title":"IL-13-induced oxidative stress via microglial NADPH oxidase contributes to death of hippocampal neurons in vivo","volume":"183","author":"Park","year":"2009","journal-title":"J Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000497383","article-title":"Atopic dermatitis: Collegium Internationale Allergologicum (CIA) update","volume":"178","author":"Simon","year":"2019","journal-title":"Int Arch Allergy Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s12016-010-8239-6","article-title":"A modular view of cytokine networks in atopic dermatitis","volume":"41","author":"Carmi-Levy","year":"2011","journal-title":"Clin Rev Allergy Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4172\/2155-9899.1000110","article-title":"Th2 cytokines and atopic dermatitis","volume":"2","author":"Brandt","year":"2011","journal-title":"J Clin Cell Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br J Clin Pharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.jaci.2007.09.018","article-title":"Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women","volume":"121","author":"Krauss-Etschmann","year":"2008","journal-title":"J Allergy Clin Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.cpr.2014.05.005","article-title":"Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials","volume":"34","author":"Hawkey","year":"2014","journal-title":"Clin Psychol Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00787-016-0932-4","article-title":"The potential relevance of docosahexaenoic acid and eicosapentaenoic acid to the etiopathogenesis of childhood neuropsychiatric disorders","volume":"26","author":"Tesei","year":"2017","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.2903\/j.efsa.2010.1461","article-title":"Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol","volume":"8","year":"2010","journal-title":"EFSA J."},{"key":"B66","volume-title":"Fats and Fatty Acids in Human Nutrition: Report of An Expert Consultation","year":"2010"},{"key":"B67","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000448271","article-title":"Docosahexaenoic acid and neurodevelopmental outcomes of term infants","volume":"69","author":"Meldrum","year":"2016","journal-title":"Ann Nutr Metab."},{"key":"B68","doi-asserted-by":"publisher","first-page":"CD003402","DOI":"10.1002\/14651858.CD003402.pub3","article-title":"Omega-3 fatty acid addition during pregnancy","volume":"11","author":"Middleton","year":"2018","journal-title":"Cochrane Database Syst Rev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/gene.2016.35","article-title":"Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms","volume":"17","author":"Djuardi","year":"2016","journal-title":"Genes Immun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3945\/ajcn.112.045781","article-title":"The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials","volume":"97","author":"Gould","year":"2013","journal-title":"Am J Clin Nutr."},{"key":"B71","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s007870050008","article-title":"Predicting type of psychiatric disorder from Strengths and Difficulties Questionnaire (SDQ) scores in child mental health clinics in London and Dhaka","volume":"9","author":"Goodman","year":"2000","journal-title":"Eur Child Adolesc Psychiatry."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01658\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T04:40:00Z","timestamp":1563856800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01658\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":71,"alternative-id":["10.3389\/fimmu.2019.01658"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01658","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"article-number":"1658"}}