{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:40:04Z","timestamp":1793259604623,"version":"4.5.0"},"reference-count":198,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01687","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T04:32:13Z","timestamp":1563337933000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":262,"title":["Platelets in Sepsis: An Update on Experimental Models and Clinical Data"],"prefix":"10.3389","volume":"10","author":[{"given":"Alice","family":"Assinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waltraud C.","family":"Schrottmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Salzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Rayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1586\/eri.12.50","article-title":"Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes","volume":"10","author":"Martin","year":"2012","journal-title":"Expert Rev Anti Infect Ther"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"B6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-kappaB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/imr.12453","article-title":"Clearance of apoptotic neutrophils and resolution of inflammation","volume":"273","author":"Greenlee-Wacker","year":"2016","journal-title":"Immunol Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis","volume":"5","author":"Mayr","year":"2014","journal-title":"Virulence"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.chest.2016.08.1460","article-title":"Culture-negative severe sepsis: nationwide trends and outcomes","volume":"150","author":"Gupta","year":"2016","journal-title":"Chest"},{"key":"B11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/joim.12331","article-title":"Endothelial barrier dysfunction in septic shock","volume":"277","author":"Opal","year":"2015","journal-title":"J Intern Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1164\/ajrccm.157.2.9611103","article-title":"Red blood cell deformability in sepsis","volume":"157","author":"Baskurt","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ebiom.2014.10.003","article-title":"An endotoxin tolerance signature predicts sepsis and organ dysfunction at initial clinical presentation","volume":"1","author":"Pena","year":"2014","journal-title":"EBioMedicine"},{"key":"B14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10495-016-1325-3","article-title":"Apoptosis-induced lymphopenia in sepsis and other severe injuries","volume":"22","author":"Girardot","year":"2017","journal-title":"Apoptosis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"JAMA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1080\/15548627.2016.1179410","article-title":"Autophagy in sepsis: degradation into exhaustion?","volume":"12","author":"Ho","year":"2016","journal-title":"Autophagy."},{"key":"B17","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful molecular mechanisms in sepsis","volume":"8","author":"Rittirsch","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1182\/blood-2018-08-867267","article-title":"Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps","volume":"133","author":"Beristain-Covarrubias","year":"2018","journal-title":"Blood."},{"key":"B19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1055\/s-0028-1092871","article-title":"Thrombocytopenia in critically ill patients","volume":"34","author":"Levi","year":"2008","journal-title":"Semin Thromb Hemost."},{"key":"B21","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1128\/IAI.64.12.5290-5294.1996","article-title":"Biphasic, organ-specific, and strain-specific accumulation of platelets induced in mice by a lipopolysaccharide from Escherichia coli and its possible involvement in shock","volume":"64","author":"Shibazaki","year":"1996","journal-title":"Infect Immun"},{"key":"B22","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1097\/00003246-199204000-00005","article-title":"Intestinal platelet trapping after traumatic and septic shock","volume":"20","author":"Sigurdsson","year":"1992","journal-title":"Crit Care Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1182\/blood-2005-03-0916","article-title":"Platelets express functional Toll-like receptor-4","volume":"106","author":"Andonegui","year":"2005","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"341","author":"Levi","year":"1999","journal-title":"N Engl J Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1182\/blood-2015-11-680744","article-title":"Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients","volume":"127","author":"Claushuis","year":"2016","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jcrc.2015.11.010","article-title":"Thrombocytopenia in critically ill patients with severe sepsis\/septic shock: prognostic value and association with a distinct serum cytokine profile","volume":"32","author":"Tsirigotis","year":"2016","journal-title":"J Crit Care"},{"key":"B27","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/00003246-200002000-00027","article-title":"Coagulation system and platelets are fully activated in uncomplicated sepsis","volume":"28","author":"Mavrommatis","year":"2000","journal-title":"Crit Care Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1378\/chest.104.4.1243","article-title":"Thrombocytopenia in the intensive care unit","volume":"104","author":"Baughman","year":"1993","journal-title":"Chest"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1164\/ajrccm.161.6.9812004","article-title":"Effects of nitric oxide in septic shock","volume":"161","author":"Vincent","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1182\/blood-2002-06-1887","article-title":"The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome","volume":"101","author":"Aird","year":"2003","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S2468-1253(16)30119-4","article-title":"The role of the gut microbiota in sepsis","volume":"2","author":"Haak","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2741\/3236","article-title":"The role of platelets in acute lung injury (ALI)","volume":"14","author":"Zarbock","year":"2009","journal-title":"Front Biosci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3109\/08830185.2014.889129","article-title":"The role of the liver in sepsis","volume":"33","author":"Yan","year":"2014","journal-title":"Int Rev Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1097\/MCC.0000000000000356","article-title":"Sepsis-induced acute kidney injury","volume":"22","author":"Gomez","year":"2016","journal-title":"Curr Opin Crit Care"},{"key":"B35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/2110-5820-3-15","article-title":"Understanding brain dysfunction in sepsis","volume":"3","author":"Sonneville","year":"2013","journal-title":"Ann Intensive Care"},{"key":"B36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1159\/000444807","article-title":"Platelet Interaction with Innate Immune Cells","volume":"43","author":"Kral","year":"2016","journal-title":"Transfus Med Hemother"},{"key":"B37","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1160\/TH14-11-0943","article-title":"Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes","volume":"114","author":"Schrottmaier","year":"2015","journal-title":"Thromb Haemost."},{"key":"B38","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","article-title":"Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo","volume":"107","author":"Aslam","year":"2006","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fmed.2018.00017","article-title":"Toward the relevance of platelet subpopulations for transfusion medicine","volume":"5","author":"Handtke","year":"2018","journal-title":"Front Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1161\/ATVBAHA.114.304954","article-title":"Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors","volume":"35","author":"Koupenova","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e73","DOI":"10.1182\/blood-2012-04-416594","article-title":"The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways","volume":"120","author":"Burkhart","year":"2012","journal-title":"Blood."},{"key":"B42","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fimmu.2015.00083","article-title":"The inflammatory role of platelets via their TLRs and siglec receptors","volume":"6","author":"Cognasse","year":"2015","journal-title":"Front Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1074\/mcp.M114.038513","article-title":"Copy number analysis of the murine platelet proteome spanning the complete abundance range","volume":"13","author":"Zeiler","year":"2014","journal-title":"Mol Cell Proteomics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1600-065X.2008.00701.x","article-title":"The interleukin-1 receptor\/Toll-like receptor superfamily: 10 years of progress","volume":"226","author":"O'Neill","year":"2008","journal-title":"Immunol Rev"},{"key":"B45","doi-asserted-by":"publisher","first-page":"5963","DOI":"10.1182\/blood-2010-09-304949","article-title":"Regulatory effects of TLR2 on megakaryocytic cell function","volume":"117","author":"Beaulieu","year":"2011","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1161\/CIRCRESAHA.108.185785","article-title":"Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase","volume":"104","author":"Blair","year":"2009","journal-title":"Circ Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/j.thromres.2010.10.023","article-title":"Periodontopathogens induce soluble P-selectin release by endothelial cells and platelets","volume":"127","author":"Assinger","year":"2011","journal-title":"Thromb Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1182\/blood-2013-11-536003","article-title":"Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis","volume":"124","author":"Koupenova","year":"2014","journal-title":"Blood"},{"key":"B49","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1083\/jcb.201111136","article-title":"T granules in human platelets function in TLR9 organization and signaling","volume":"198","author":"Thon","year":"2012","journal-title":"J Cell Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4803","DOI":"10.1182\/blood-2006-12-062695","article-title":"Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets","volume":"109","author":"Semple","year":"2007","journal-title":"Blood"},{"key":"B52","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/00024382-200212000-00013","article-title":"Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide","volume":"18","author":"Bentala","year":"2002","journal-title":"Shock."},{"key":"B53","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.4049\/jimmunol.161.10.5464","article-title":"The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity","volume":"161","author":"Schromm","year":"1998","journal-title":"J Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.chom.2018.09.011","article-title":"Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis","volume":"24","author":"Yang","year":"2018","journal-title":"Cell Host Microbe."},{"key":"B55","doi-asserted-by":"publisher","first-page":"20218","DOI":"10.1073\/pnas.1313905110","article-title":"Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor","volume":"110","author":"Grewal","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B56","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1080\/09537104.2018.1445841","article-title":"Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis","volume":"30","author":"Claushuis","year":"2018","journal-title":"Platelets."},{"key":"B57","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1538-7836.2006.01749.x","article-title":"Lentivirus degradation and DC-SIGN expression by human platelets and megakaryocytes","volume":"4","author":"Boukour","year":"2006","journal-title":"J Thromb Haemost"},{"key":"B58","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1046\/j.1365-2222.2000.00871.x","article-title":"The role of CD23 in allergic disease","volume":"30","author":"Tsicopoulos","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1002\/eji.1830270914","article-title":"Expression and functions of the high-affinity IgE receptor on human platelets and megakaryocyte precursors","volume":"27","author":"Joseph","year":"1997","journal-title":"Eur J Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0091-6749(97)70230-6","article-title":"Endocytosis, storage, and release of IgE by human platelets: differences in patients with type I allergy and nonatopic subjects","volume":"100","author":"Klouche","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nri3565","article-title":"NOD proteins: regulators of inflammation in health and disease","volume":"14","author":"Philpott","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/CIRCULATIONAHA.114.013743","article-title":"Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis","volume":"131","author":"Zhang","year":"2015","journal-title":"Circulation"},{"key":"B63","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1365-2141.2005.05421.x","article-title":"A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb","volume":"129","author":"Plummer","year":"2005","journal-title":"Br J Haematol."},{"key":"B64","first-page":"2149","article-title":"Protein A is the von Willebrand factor binding protein on Staphylococcus aureus","volume":"96","author":"Hartleib","year":"2000","journal-title":"Blood"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1172\/JCI26989","article-title":"Structure and function of the platelet integrin alphaIIbbeta3","volume":"115","author":"Bennett","year":"2005","journal-title":"J Clin Invest"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1111\/j.1538-7836.2009.03495.x","article-title":"Elucidating the role of Staphylococcus epidermidis serine-aspartate repeat protein G in platelet activation","volume":"7","author":"Brennan","year":"2009","journal-title":"J Thromb Haemost"},{"key":"B67","doi-asserted-by":"publisher","first-page":"7059","DOI":"10.1073\/pnas.90.15.7059","article-title":"Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets","volume":"90","author":"Coburn","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1128\/IAI.69.5.3120-3127.2001","article-title":"Clumping factor A mediates binding of Staphylococcus aureus to human platelets","volume":"69","author":"Siboo","year":"2001","journal-title":"Infect Immun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/29325","article-title":"A dual thrombin receptor system for platelet activation","volume":"394","author":"Kahn","year":"1998","journal-title":"Nature."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1189\/jlb.0508327","article-title":"Functional expression of IgA receptor FcalphaRI on human platelets","volume":"84","author":"Qian","year":"2008","journal-title":"J Leukoc Biol."},{"key":"B71","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood.V93.8.2543","article-title":"Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its' intracellular expression in human megakaryocytes","volume":"93","author":"Hasegawa","year":"1999","journal-title":"Blood."},{"key":"B72","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1182\/blood.V80.9.2261.2261","article-title":"Response of human platelets to activating monoclonal antibodies: importance of Fc gamma RII (CD32) phenotype and level of expression","volume":"80","author":"Tomiyama","year":"1992","journal-title":"Blood."},{"key":"B73","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/jth.12905","article-title":"Human platelet IgG Fc receptor FcgammaRIIA in immunity and thrombosis","volume":"13","author":"Arman","year":"2015","journal-title":"J Thromb Haemost."},{"key":"B74","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1574-695X.2012.00945.x","article-title":"Human platelets efficiently kill IgG-opsonized E. coli","volume":"65","author":"Riaz","year":"2012","journal-title":"FEMS Immunol Med Microbiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1161\/01.ATV.0000092127.16125.E6","article-title":"Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity","volume":"23","author":"Leon","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0049-3848(99)00046-8","article-title":"Changes of platelet surface antigens in patients suffering from abdominal septic shock","volume":"95","author":"Salat","year":"1999","journal-title":"Thromb Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s001340050344","article-title":"Platelet function in septic multiple organ dysfunction syndrome","volume":"23","author":"Gawaz","year":"1997","journal-title":"Intensive Care Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40635-017-0145-2","article-title":"Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study","volume":"5","author":"Layios","year":"2017","journal-title":"Intensive Care Med Exp"},{"key":"B79","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1182\/bloodadvances.2017011171","article-title":"Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI","volume":"2","author":"Montague","year":"2018","journal-title":"Blood Adv."},{"key":"B80","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1080\/09537104.2018.1442567","article-title":"Platelet function in disseminated intravascular coagulation: a systematic review","volume":"29","author":"Laursen","year":"2018","journal-title":"Platelets"},{"key":"B81","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11239-010-0486-0","article-title":"Platelet aggregation in severe sepsis","volume":"31","author":"Woth","year":"2011","journal-title":"J Thromb Thrombolysis"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1111\/j.1538-7836.2004.01009.x","article-title":"Platelet function in sepsis","volume":"2","author":"Yaguchi","year":"2004","journal-title":"J Thromb Haemost"},{"key":"B83","doi-asserted-by":"publisher","first-page":"S313","DOI":"10.1097\/00003246-200205001-00022","article-title":"Platelet function in sepsis","volume":"30","author":"Vincent","year":"2002","journal-title":"Crit Care Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1365-2362.1995.tb01694.x","article-title":"Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure","volume":"25","author":"Gawaz","year":"1995","journal-title":"Eur J Clin Invest"},{"key":"B85","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/gerona\/glu082","article-title":"Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock","volume":"70","author":"Rondina","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1182\/blood-2013-11-540526","article-title":"Amplification of bacteria-induced platelet activation is triggered by FcgammaRIIA, integrin alphaIIbbeta3, and platelet factor 4","volume":"123","author":"Arman","year":"2014","journal-title":"Blood"},{"key":"B87","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fimmu.2015.00082","article-title":"Platelets and infections - complex interactions with bacteria","volume":"6","author":"Hamzeh-Cognasse","year":"2015","journal-title":"Front Immunol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1111\/j.1538-7836.2011.04264.x","article-title":"Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation","volume":"9","author":"Cox","year":"2011","journal-title":"J Thromb Haemost"},{"key":"B89","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1080\/09537104.2017.1420152","article-title":"Mucor circinelloides induces platelet aggregation through integrin alphaIIbbeta3 and FcgammaRIIA","volume":"30","author":"Ghuman","year":"2018","journal-title":"Platelets"},{"key":"B90","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1128\/IAI.02020-14","article-title":"Platelet activation by Streptococcus pyogenes leads to entrapment in platelet aggregates, from which bacteria subsequently escape","volume":"82","author":"Svensson","year":"2014","journal-title":"Infect Immun"},{"key":"B91","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1111\/j.1582-4934.2008.00504.x","article-title":"Complexity of complement activation in sepsis","volume":"12","author":"Markiewski","year":"2008","journal-title":"J Cell Mol Med"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1097\/00003246-200006000-00031","article-title":"Thrombocytopenia and prognosis in intensive care","volume":"28","author":"Vanderschueren","year":"2000","journal-title":"Crit Care Med"},{"key":"B93","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1177\/0310057X0703500604","article-title":"Thrombocytopenia in septic shock patients\u2013a prospective observational study of incidence, risk factors and correlation with clinical outcome","volume":"35","author":"Sharma","year":"2007","journal-title":"Anaesth Intensive Care."},{"key":"B94","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1378\/chest.10-2243","article-title":"The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review","volume":"139","author":"Hui","year":"2011","journal-title":"Chest"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1007\/s00134-013-2963-3","article-title":"Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study","volume":"39","author":"Thiolliere","year":"2013","journal-title":"Intensive Care Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2052-0492-1-9","article-title":"Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome","volume":"1","author":"Venkata","year":"2013","journal-title":"J Intensive Care."},{"key":"B97","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/00003246-200204000-00005","article-title":"Time course of platelet counts in critically ill patients","volume":"30","author":"Akca","year":"2002","journal-title":"Crit Care Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1164\/ajrccm.162.2.ncc3-00","article-title":"Thrombocytopenic disorders in critically ill patients","volume":"162","author":"Drews","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13613-017-0337-7","article-title":"Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?","volume":"7","author":"Dewitte","year":"2017","journal-title":"Ann Intensive Care"},{"key":"B100","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s13054-018-2073-2","article-title":"Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies-what intensivists need to know","volume":"22","author":"Vincent","year":"2018","journal-title":"Crit Care"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1097\/00003246-200208000-00015","article-title":"Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome","volume":"30","author":"Strauss","year":"2002","journal-title":"Crit Care Med"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e0192064","DOI":"10.1371\/journal.pone.0192064","article-title":"Time course of immature platelet count and its relation to thrombocytopenia and mortality in patients with sepsis","volume":"13","author":"Koyama","year":"2018","journal-title":"PLoS ONE"},{"key":"B103","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s00134-012-2725-7","article-title":"Immature platelet fraction in predicting sepsis in critically ill patients","volume":"39","author":"De Blasi","year":"2013","journal-title":"Intensive Care Med"},{"key":"B104","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.thromres.2018.06.017","article-title":"Phosphatidylserine expressing platelet microparticle levels at hospital presentation are decreased in sepsis non-survivors and correlate with thrombocytopenia","volume":"168","author":"Puskarich","year":"2018","journal-title":"Thromb Res"},{"key":"B105","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12964-018-0235-0","article-title":"Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones","volume":"16","author":"Elaskalani","year":"2018","journal-title":"Cell Commun Signal"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e19190","DOI":"10.1371\/journal.pone.0019190","article-title":"GPVI and GPIbalpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors","volume":"6","author":"Hu","year":"2011","journal-title":"PLoS ONE"},{"key":"B107","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.1182\/blood-2012-04-420661","article-title":"Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets","volume":"120","author":"Kraemer","year":"2012","journal-title":"Blood"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1182\/blood-2014-05-579110","article-title":"C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia","volume":"125","author":"Kapur","year":"2015","journal-title":"Blood"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1017\/S0950268818001206","article-title":"Thrombocytopenia in bacteraemia and association with bacterial species","volume":"146","author":"Johansson","year":"2018","journal-title":"Epidemiol Infect"},{"key":"B110","doi-asserted-by":"publisher","first-page":"e41254","DOI":"10.1371\/journal.pone.0041254","article-title":"Platelet-derived Toll-like receptor 4 (Tlr-4) is sufficient to promote microvascular thrombosis in endotoxemia","volume":"7","author":"Stark","year":"2012","journal-title":"PLoS ONE."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1182\/blood-2011-03-343061","article-title":"Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4","volume":"118","author":"Semeraro","year":"2011","journal-title":"Blood"},{"key":"B112","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40560-014-0065-0","article-title":"PAMPs and DAMPs as triggers for DIC","volume":"2","author":"Ito","year":"2014","journal-title":"J Intensive Care."},{"key":"B113","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1172\/JCI81660","article-title":"Platelet-derived HMGB1 is a critical mediator of thrombosis","volume":"125","author":"Vogel","year":"2015","journal-title":"J Clin Invest"},{"key":"B114","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13045-017-0476-1","article-title":"Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial","volume":"10","author":"Li","year":"2017","journal-title":"J Hematol Oncol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"e00213","DOI":"10.1128\/IAI.00213-18","article-title":"Desialylation of platelets by pneumococcal neuraminidase A induces ADP-dependent platelet hyperreactivity","volume":"86","author":"Kullaya","year":"2018","journal-title":"Infect Immun."},{"key":"B116","first-page":"31","article-title":"Platelet auto-antibodies in septicaemic patients","volume":"42","author":"Ghosh","year":"1999","journal-title":"Indian J Pathol Microbiol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1378\/chest.115.5.1363","article-title":"Thrombocytopenia in a surgical ICU","volume":"115","author":"Stephan","year":"1999","journal-title":"Chest"},{"key":"B118","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.thromres.2018.09.060","article-title":"Anti-PF4\/heparin antibodies are increased in hospitalized patients with bacterial sepsis","volume":"171","author":"Maharaj","year":"2018","journal-title":"Thromb Res"},{"key":"B119","doi-asserted-by":"publisher","first-page":"E1550","DOI":"10.1073\/pnas.1720553115","article-title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","volume":"115","author":"Cloutier","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"B120","doi-asserted-by":"publisher","first-page":"869","DOI":"10.4065\/78.7.869","article-title":"The hematologic system as a marker of organ dysfunction in sepsis","volume":"78","author":"Aird","year":"2003","journal-title":"Mayo Clin Proc"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1126\/science.aam8897","article-title":"Host DNases prevent vascular occlusion by neutrophil extracellular traps","volume":"358","author":"Jimenez-Alcazar","year":"2017","journal-title":"Science"},{"key":"B122","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.thromres.2016.06.002","article-title":"Immature platelet fraction predicts coagulopathy-related platelet consumption and mortality in patients with sepsis","volume":"144","author":"Muronoi","year":"2016","journal-title":"Thromb Res"},{"key":"B123","doi-asserted-by":"publisher","first-page":"390892","DOI":"10.1155\/2012\/390892","article-title":"Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases","volume":"2012","author":"Lupia","year":"2012","journal-title":"Mediators Inflamm."},{"key":"B124","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0002-9343(97)00136-8","article-title":"Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor","volume":"103","author":"Francois","year":"1997","journal-title":"Am J Med"},{"key":"B125","doi-asserted-by":"publisher","first-page":"720254","DOI":"10.1155\/2012\/720254","article-title":"Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients?","volume":"2012","author":"Losche","year":"2012","journal-title":"Thrombosis"},{"key":"B126","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/CCM.0b013e3181b4275c","article-title":"Antiplatelet drugs and outcome in mixed admissions to an intensive care unit","volume":"38","author":"Winning","year":"2010","journal-title":"Crit Care Med"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1161\/ATVBAHA.115.306528","article-title":"Platelet P2Y12 inhibitors reduce systemic inflammation and its prothrombotic effects in an experimental human model","volume":"35","author":"Thomas","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/cc11886","article-title":"Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients","volume":"17","author":"Sossdorf","year":"2013","journal-title":"Crit Care"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1097\/CCM.0b013e318246b9df","article-title":"Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis","volume":"40","author":"Eisen","year":"2012","journal-title":"Crit Care Med"},{"key":"B130","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1172\/JCI122955","article-title":"Functional significance of the platelet immune receptors GPVI and CLEC-2","volume":"129","author":"Rayes","year":"2019","journal-title":"J Clin Invest"},{"key":"B131","doi-asserted-by":"publisher","first-page":"7997","DOI":"10.4049\/jimmunol.0802884","article-title":"Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4\/MyD88 and the cGMP-dependent protein kinase pathway","volume":"182","author":"Zhang","year":"2009","journal-title":"J Immunol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1111\/jth.13048","article-title":"The role of platelet MyD88 in host response during gram-negative sepsis","volume":"13","author":"de Stoppelaar","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B133","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0049-3848(03)00092-6","article-title":"In vivo platelet response to lipopolysaccharide in mice: proposed method for evaluating new antiplatelet drugs","volume":"108","author":"Ohtaki","year":"2002","journal-title":"Thromb Res"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/S0002-9440(10)62329-2","article-title":"Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models","volume":"166","author":"Corral","year":"2005","journal-title":"Am J Pathol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1182\/blood-2002-01-0252","article-title":"LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system","volume":"100","author":"Zhao","year":"2002","journal-title":"Blood"},{"key":"B136","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1128\/IAI.67.10.5186-5191.1999","article-title":"Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharides","volume":"67","author":"Shibazaki","year":"1999","journal-title":"Infect Immun"},{"key":"B137","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/ilar\/ilx007","article-title":"Murine models of sepsis and trauma: can we bridge the gap?","volume":"58","author":"Stortz","year":"2017","journal-title":"ILAR J"},{"key":"B138","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/SHK.0b013e3181ea4476","article-title":"Streptococcal M1 protein-induced lung injury is independent of platelets in mice","volume":"35","author":"Zhang","year":"2011","journal-title":"Shock"},{"key":"B139","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1365-3083.1990.tb02925.x","article-title":"Tumour necrosis factor alpha (TNF-alpha) and interleukin 6 in a zymosan-induced shock model","volume":"32","author":"von Asmuth","year":"1990","journal-title":"Scand J Immunol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1038\/ncomms3657","article-title":"Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway","volume":"4","author":"Xiang","year":"2013","journal-title":"Nat Commun"},{"key":"B141","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1182\/blood-2014-05-573915","article-title":"Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice","volume":"124","author":"de Stoppelaar","year":"2014","journal-title":"Blood"},{"key":"B142","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.chom.2015.05.011","article-title":"Synergistic action of Staphylococcus aureus alpha-toxin on platelets and myeloid lineage cells contributes to lethal sepsis","volume":"17","author":"Powers","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B143","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.micinf.2013.05.003","article-title":"Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis","volume":"15","author":"Kahn","year":"2013","journal-title":"Microbes Infect"},{"key":"B144","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1097\/CCM.0000000000000853","article-title":"Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia","volume":"43","author":"van den Boogaard","year":"2015","journal-title":"Crit Care Med."},{"key":"B145","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/IAI.61.7.2741-2747.1993","article-title":"Choice of bacteria in animal models of sepsis","volume":"61","author":"Cross","year":"1993","journal-title":"Infect Immun"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1555040","article-title":"Epidemiology of lower respiratory tract infections in adults","author":"Feldman","year":"2018","journal-title":"Expert Rev Respir Med."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1099\/mic.0.000499","article-title":"Microbe profile: Candida albicans: a shape-changing, opportunistic pathogenic fungus of humans","volume":"163","author":"Gow","year":"2017","journal-title":"Microbiology"},{"key":"B148","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1080\/21505594.2016.1138201","article-title":"Innate immune cell response upon Candida albicans infection","volume":"7","author":"Qin","year":"2016","journal-title":"Virulence"},{"key":"B149","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1128\/IAI.7.3.468-472.1973","article-title":"Effect in mice of injection of viable Candida albicans and a cell-free sonic extract on circulating platelets","volume":"7","author":"Holder","year":"1973","journal-title":"Infect Immun"},{"key":"B150","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1177\/0300060518764717","article-title":"Assessment of clinical sepsis-associated biomarkers in a septic mouse model","volume":"46","author":"Li","year":"2018","journal-title":"J Int Med Res"},{"key":"B151","doi-asserted-by":"publisher","first-page":"13536","DOI":"10.1038\/s41598-018-31910-8","article-title":"Platelet activation and prothrombotic properties in a mouse model of peritoneal sepsis","volume":"8","author":"Vardon Bounes","year":"2018","journal-title":"Sci Rep"},{"key":"B152","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models of sepsis: setting the stage","volume":"4","author":"Buras","year":"2005","journal-title":"Nat Rev Drug Discov."},{"key":"B154","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.jhep.2007.07.021","article-title":"Role of LPS in the hepatic microvascular dysfunction elicited by cecal ligation and puncture in mice","volume":"47","author":"Singer","year":"2007","journal-title":"J Hepatol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/00024382-200013020-00004","article-title":"Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs","volume":"13","author":"Remick","year":"2000","journal-title":"Shock"},{"key":"B156","doi-asserted-by":"publisher","first-page":"e94404","DOI":"10.1371\/journal.pone.0094404","article-title":"Host responses to sepsis vary in different low-lethality murine models","volume":"9","author":"Gentile","year":"2014","journal-title":"PLoS ONE."},{"key":"B157","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1182\/blood-2017-06-788067","article-title":"Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria","volume":"131","author":"Claushuis","year":"2018","journal-title":"Blood"},{"key":"B158","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1172\/JCI29499","article-title":"Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation","volume":"116","author":"Zarbock","year":"2006","journal-title":"J Clin Invest"},{"key":"B159","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/jth.12795","article-title":"A novel conditional platelet depletion mouse model reveals the importance of platelets in protection against Staphylococcus aureus bacteremia","volume":"13","author":"Wuescher","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B160","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1182\/blood-2005-08-3130","article-title":"Roles of protease-activated receptors in a mouse model of endotoxemia","volume":"107","author":"Camerer","year":"2006","journal-title":"Blood"},{"key":"B161","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1160\/TH13-01-0052","article-title":"Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice","volume":"110","author":"de Stoppelaar","year":"2013","journal-title":"Thromb Haemost"},{"key":"B162","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1111\/jth.12893","article-title":"Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis","volume":"13","author":"de Stoppelaar","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B163","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1476-5381.2008.00021.x","article-title":"P-selectin glycoprotein-ligand-1 regulates pulmonary recruitment of neutrophils in a platelet-independent manner in abdominal sepsis","volume":"156","author":"Asaduzzaman","year":"2009","journal-title":"Br J Pharmacol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1111\/jth.12273","article-title":"Platelet shedding of CD40L is regulated by matrix metalloproteinase-9 in abdominal sepsis","volume":"11","author":"Rahman","year":"2013","journal-title":"J Thromb Haemost"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1097\/CCM.0b013e31819ceb71","article-title":"Platelets support pulmonary recruitment of neutrophils in abdominal sepsis","volume":"37","author":"Asaduzzaman","year":"2009","journal-title":"Crit Care Med"},{"key":"B166","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1161\/ATVBAHA.113.302339","article-title":"Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality","volume":"33","author":"Yin","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1161\/ATVBAHA.113.303113","article-title":"Platelet glycoprotein Ib-IX as a regulator of systemic inflammation","volume":"34","author":"Corken","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B168","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1038\/s41467-017-02402-6","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","volume":"8","author":"Rayes","year":"2017","journal-title":"Nat Commun"},{"key":"B169","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1172\/JCI79070","article-title":"Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets","volume":"125","author":"Hitchcock","year":"2015","journal-title":"J Clin Invest."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/ATVBAHA.118.311332","article-title":"Nbeal2 deficiency increases organ damage but does not affect host defense during gram-negative pneumonia-derived sepsis","volume":"38","author":"Claushuis","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1111\/bph.13325","article-title":"Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage","volume":"172","author":"Hwaiz","year":"2015","journal-title":"Br J Pharmacol"},{"key":"B172","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1189\/jlb.4A1214-603R","article-title":"Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury","volume":"97","author":"Hwaiz","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1164\/rccm.201108-1533OC","article-title":"Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury","volume":"185","author":"Grommes","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1182\/blood-2007-03-081901","article-title":"Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge","volume":"110","author":"Kowalska","year":"2007","journal-title":"Blood"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1182\/blood-2012-06-437392","article-title":"Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice","volume":"121","author":"Duerschmied","year":"2013","journal-title":"Blood"},{"key":"B176","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1182\/bloodadvances.2017011817","article-title":"Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice","volume":"2","author":"Zhou","year":"2018","journal-title":"Blood Adv"},{"key":"B177","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1164\/rccm.200807-1085OC","article-title":"Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity","volume":"179","author":"Freishtat","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"B178","doi-asserted-by":"publisher","first-page":"e41549","DOI":"10.1371\/journal.pone.0041549","article-title":"Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb\/IIIa blockade","volume":"7","author":"Sharron","year":"2012","journal-title":"PLoS ONE"},{"key":"B179","doi-asserted-by":"publisher","first-page":"F332","DOI":"10.1152\/ajprenal.00567.2014","article-title":"Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice","volume":"309","author":"Mederle","year":"2015","journal-title":"Am J Physiol Renal Physiol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1189\/jlb.1012518","article-title":"LPS-induced systemic inflammation is more severe in P2Y12 null mice","volume":"95","author":"Liverani","year":"2014","journal-title":"J Leukoc Biol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/ATVBAHA.116.307401","article-title":"P2Y12 Receptor modulates sepsis-induced inflammation","volume":"36","author":"Liverani","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3109\/09537104.2013.809520","article-title":"Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis","volume":"25","author":"Rahman","year":"2014","journal-title":"Platelets"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1160\/TH11-12-0867","article-title":"Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse","volume":"107","author":"Totani","year":"2012","journal-title":"Thromb Haemost"},{"key":"B184","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/09537104.2017.1392499","article-title":"The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury","volume":"30","author":"Li","year":"2018","journal-title":"Platelets."},{"key":"B185","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1159\/000494147","article-title":"Platelet-dense granules worsen pre-infection thrombocytopenia during gram-negative pneumonia-derived sepsis","volume":"11","author":"Claushuis","year":"2018","journal-title":"J Innate Immun."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/j.1538-7836.2009.03352.x","article-title":"Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis","volume":"7","author":"Seidel","year":"2009","journal-title":"J Thromb Haemost"},{"key":"B187","doi-asserted-by":"publisher","first-page":"e14073","DOI":"10.14814\/phy2.14073","article-title":"NLRP3 inflammasome activation in platelets in response to sepsis","volume":"7","author":"Cornelius","year":"2019","journal-title":"Physiol Rep."},{"key":"B188","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/bcpt.13148","article-title":"Signalling pathways involved in p47(phox) -dependent reactive oxygen species in platelets of endotoxemic rats","volume":"124","author":"Lopes Pires","year":"2019","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"B189","doi-asserted-by":"publisher","first-page":"e0195379","DOI":"10.1371\/journal.pone.0195379","article-title":"Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis","volume":"13","author":"Liverani","year":"2018","journal-title":"PLoS ONE."},{"key":"B190","doi-asserted-by":"publisher","first-page":"E2176","DOI":"10.3390\/ijms18102176","article-title":"Time response of oxidative\/nitrosative stress and inflammation in LPS-induced endotoxaemia-A comparative study of mice and rats","volume":"18","author":"Steven","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1177\/0300985811429314","article-title":"Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice","volume":"49","author":"Sellers","year":"2012","journal-title":"Vet Pathol"},{"key":"B192","doi-asserted-by":"publisher","first-page":"e12995","DOI":"10.1111\/cmi.12995","article-title":"Discordant susceptibility of inbred C57BL\/6 versus outbred CD1 mice to experimental fungal sepsis","volume":"21","author":"Carreras","year":"2018","journal-title":"Cell Microbiol."},{"key":"B193","first-page":"59","article-title":"Complete blood count, clinical chemistry, and serology profile by using a single tube of whole blood from mice","volume":"46","author":"Wiedmeyer","year":"2007","journal-title":"J Am Assoc Lab Anim Sci."},{"key":"B194","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.4049\/jimmunol.162.7.4311","article-title":"The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model","volume":"162","author":"McKenzie","year":"1999","journal-title":"J Immunol"},{"key":"B195","doi-asserted-by":"publisher","first-page":"e0165565","DOI":"10.1371\/journal.pone.0165565","article-title":"Humanizing the protease-activated receptor (PAR) expression profile in mouse platelets by knocking PAR1 into the Par3 locus reveals PAR1 expression is not tolerated in mouse platelets","volume":"11","author":"French","year":"2016","journal-title":"PLoS ONE"},{"key":"B196","doi-asserted-by":"publisher","first-page":"e97724","DOI":"10.1371\/journal.pone.0097724","article-title":"Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets","volume":"9","author":"Arachiche","year":"2014","journal-title":"PLoS ONE."},{"key":"B197","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1128\/CDLI.12.1.60-67.2005","article-title":"Acute inflammatory response to endotoxin in mice and humans","volume":"12","author":"Copeland","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1086\/649557","article-title":"Resilience to bacterial infection: difference between species could be due to proteins in serum","volume":"201","author":"Warren","year":"2010","journal-title":"J Infect Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01687\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T09:24:04Z","timestamp":1695029044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01687\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":198,"alternative-id":["10.3389\/fimmu.2019.01687"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01687","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"article-number":"1687"}}