{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:17:36Z","timestamp":1790299056585,"version":"4.1.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BL 953\/5-2"],"award-info":[{"award-number":["BL 953\/5-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STE 1971\/4-2"],"award-info":[{"award-number":["STE 1971\/4-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","award":["HiLF to MB"],"award-info":[{"award-number":["HiLF to MB"]}],"id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01708","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T04:55:41Z","timestamp":1563857741000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["Composition of the Intestinal Microbiota Determines the Outcome of Virus-Triggered Colitis in Mice"],"prefix":"10.3389","volume":"10","author":[{"given":"Silvia","family":"Bolsega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Basic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Smoczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Buettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Eberl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodwo Appoh","family":"Odum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e4rbel","family":"Stecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Bleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur J Nutr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2015.07.007","article-title":"Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome","volume":"22","author":"Ussar","year":"2015","journal-title":"Cell Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.ccell.2018.03.004","article-title":"The intestinal microbiota in colorectal cancer","volume":"33","author":"Tilg","year":"2018","journal-title":"Cancer Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/JIR.S116088","article-title":"The microbiota in inflammatory bowel disease: current and therapeutic insights","volume":"10","author":"Lane","year":"2017","journal-title":"J Inflamm Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/ilar\/ilv031","article-title":"The mammalian microbiome and its importance in laboratory animal research","volume":"56","author":"Bleich","year":"2015","journal-title":"ILAR J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ijmm.2016.03.004","article-title":"Analysis of factors contributing to variation in the C57BL\/6J fecal microbiota across German animal facilities","volume":"306","author":"Rausch","year":"2016","journal-title":"Int J Med Microbiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/cmi.2010.67","article-title":"The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases","volume":"8","author":"Tlaskalova-Hogenova","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N Engl J Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/ilar\/ilv030","article-title":"The intestinal microbiota in inflammatory bowel disease","volume":"56","author":"Becker","year":"2015","journal-title":"ILAR J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/ibd.3780060407","article-title":"Heritable susceptibility for colitis in mice induced by IL-10 deficiency","volume":"6","author":"Bristol","year":"2000","journal-title":"Inflamm Bowel Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"13820","DOI":"10.1073\/pnas.241258698","article-title":"A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice","volume":"98","author":"Farmer","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1097\/MIB.0000000000000468","article-title":"A Multihit model: colitis lessons from the interleukin-10-deficient mouse","volume":"21","author":"Keubler","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"B19","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","article-title":"Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice","volume":"66","author":"Sellon","year":"1998","journal-title":"Infect Immun"},{"key":"B20","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3389\/fmicb.2017.00792","article-title":"Differing complex microbiota alter disease severity of the IL-10(-\/-) mouse model of inflammatory bowel disease","volume":"8","author":"Hart","year":"2017","journal-title":"Front Microbiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/s41385-019-0133-9","article-title":"Analysis of Cdcs1 colitogenic effects in the hematopoietic compartment reveals distinct microbiome interaction and a new subcongenic interval active in T cells","volume":"12","author":"Bruesch","year":"2019","journal-title":"Mucosal Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1097\/01.MIB.0000441346.86827.ed","article-title":"Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice","volume":"20","author":"Basic","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"B23","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1128\/AEM.65.8.3287-3292.1999","article-title":"Phylogeny of the defined murine microbiota: altered Schaedler Flora","volume":"65","author":"Dewhirst","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/ilar\/ilv012","article-title":"The altered Schaedler Flora: continued applications of a defined murine microbial community","volume":"56","author":"Wymore Brand","year":"2015","journal-title":"ILAR J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e0195310","DOI":"10.1371\/journal.pone.0195310","article-title":"Mice harboring pathobiont-free microbiota do not develop intestinal inflammation that normally results from an innate immune deficiency","volume":"13","author":"Chassaing","year":"2018","journal-title":"PLoS ONE"},{"key":"B26","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1258\/la.2009.0080075","article-title":"Charles river altered Schaedler Flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages","volume":"43","author":"Stehr","year":"2009","journal-title":"Lab Anim"},{"key":"B27","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1136\/gut.2006.099242","article-title":"Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H\/HeN mice","volume":"56","author":"Jergens","year":"2007","journal-title":"Gut"},{"key":"B28","doi-asserted-by":"publisher","first-page":"16215","DOI":"10.1038\/nmicrobiol.2016.215","article-title":"Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium","volume":"2","author":"Brugiroux","year":"2016","journal-title":"Nat Microbiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e00758","DOI":"10.1128\/genomeA.00758-17","article-title":"High-quality whole-genome sequences of the oligo-mouse-microbiota bacterial community","volume":"5","author":"Garzetti","year":"2017","journal-title":"Genome Announc"},{"key":"B30","doi-asserted-by":"publisher","first-page":"16131","DOI":"10.1038\/nmicrobiol.2016.219","article-title":"The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota","volume":"1","author":"Lagkouvardos","year":"2016","journal-title":"Nat Microbiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B32","first-page":"90","article-title":"Segmented filamentous bacteria: commensal microbes with potential effects on research","volume":"64","author":"Ericsson","year":"2014","journal-title":"Comp Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/ilar\/ilv029","article-title":"Maintaining and monitoring the defined microbiota status of gnotobiotic rodents","volume":"56","author":"Nicklas","year":"2015","journal-title":"ILAR J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1177\/0023677213516312","article-title":"FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units","volume":"48","author":"M\u00e4hler","year":"2014","journal-title":"Lab Anim"},{"key":"B35","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/1743-422X-6-196","article-title":"Enhanced detection and study of murine norovirus-1 using a more efficient microglial cell line","volume":"6","author":"Cox","year":"2009","journal-title":"Virol J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1128\/AEM.70.5.2791-2800.2004","article-title":"Spatial distribution and stability of the eight microbial species of the altered Schaedler Flora in the mouse gastrointestinal tract","volume":"70","author":"Sarma-Rupavtarm","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00335-004-2392-2","article-title":"Refined histopathologic scoring system improves power to detect colitis QTL in mice","volume":"15","author":"Bleich","year":"2004","journal-title":"Mamm Genome"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1128\/AEM.69.5.2875-2878.2003","article-title":"Protocol for rapid fluorescence in situ hybridization of bacteria in cryosections of microarthropods","volume":"69","author":"Thimm","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41598-017-19062-7","article-title":"Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation","volume":"8","author":"Basic","year":"2018","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3945\/jn.110.137588","article-title":"Transforming growth factor-beta, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29\/B6 cells","volume":"141","author":"Hering","year":"2011","journal-title":"J Nutr"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1007\/s00535-017-1309-2","article-title":"Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and\u22128","volume":"52","author":"Barmeyer","year":"2017","journal-title":"J Gastroenterol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1177\/0300985815618439","article-title":"Histologic lesions induced by murine norovirus infection in laboratory mice","volume":"53","author":"Hsu","year":"2016","journal-title":"Vet Pathol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1086\/314525","article-title":"Molecular epidemiology of \u201cNorwalk-like viruses\u201d in outbreaks of gastroenteritis in the United States","volume":"178","author":"Fankhauser","year":"1998","journal-title":"J Infect Dis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3390\/v2030748","article-title":"Pathogenesis of noroviruses, emerging RNA viruses","volume":"2","author":"Karst","year":"2010","journal-title":"Viruses"},{"key":"B45","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/MPG.0b013e31818255cc","article-title":"Gastrointestinal norovirus infection associated with exacerbation of inflammatory bowel disease","volume":"48","author":"Khan","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.cell.2010.05.009","article-title":"Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine","volume":"141","author":"Cadwell","year":"2010","journal-title":"Cell"},{"key":"B47","first-page":"522","article-title":"Murine norovirus: an intercurrent variable in a mouse model of bacteria-induced inflammatory bowel disease","volume":"58","author":"Lencioni","year":"2008","journal-title":"Comp Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3390\/v3071281","article-title":"Viruses, autophagy genes, and Crohn's disease","volume":"3","author":"Hubbard","year":"2011","journal-title":"Viruses"},{"key":"B49","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature13960","article-title":"An enteric virus can replace the beneficial function of commensal bacteria","volume":"516","author":"Kernbauer","year":"2014","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses","volume":"98","author":"Berg","year":"1996","journal-title":"J Clin Invest"},{"key":"B51","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1128\/IAI.10.4.948-956.1974","article-title":"Habitat, succession, attachment, and morphology of segmented, filamentous microbes indigenous to the murine gastrointestinal tract","volume":"10","author":"Davis","year":"1974","journal-title":"Infect Immun"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1111\/j.1462-2920.2012.02731.x","article-title":"'Candidatus Arthromitus' revised: segmented filamentous bacteria in arthropod guts are members of Lachnospiraceae","volume":"14","author":"Thompson","year":"2012","journal-title":"Environ Microbiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3389\/fmicb.2018.01403","article-title":"Presence of segmented filamentous bacteria in human children and its potential role in the modulation of human gut immunity","volume":"9","author":"Chen","year":"2018","journal-title":"Front Microbiol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.immuni.2009.08.020","article-title":"The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses","volume":"31","author":"Gaboriau-Routhiau","year":"2009","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1002\/ibd.20221","article-title":"Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells","volume":"13","author":"Stepankova","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"B56","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1073\/pnas.1000082107","article-title":"Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis","volume":"108","author":"Lee","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B58","doi-asserted-by":"crossref","first-page":"158.2","DOI":"10.4049\/jimmunol.198.Supp.158.2","article-title":"The host response to murine norovirus infection induces significant engagement of IFN and TNF-a immunological programs","volume":"198","author":"Levenson","year":"2017","journal-title":"J Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1128\/JVI.02096-06","article-title":"Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses","volume":"81","author":"Mumphrey","year":"2007","journal-title":"J Virol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1126\/science.1077905","article-title":"STAT1-dependent innate immunity to a Norwalk-like virus","volume":"299","author":"Karst","year":"2003","journal-title":"Science"},{"key":"B61","doi-asserted-by":"publisher","first-page":"12655","DOI":"10.1128\/JVI.01564-12","article-title":"Essential cell-autonomous role for interferon (IFN) regulatory factor 1 in IFN-gamma-mediated inhibition of norovirus replication in macrophages","volume":"86","author":"Maloney","year":"2012","journal-title":"J Virol"},{"key":"B62","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.4049\/jimmunol.157.10.4521","article-title":"IFN-gamma-independent production of IL-12 during murine endotoxemia","volume":"157","author":"Heinzel","year":"1996","journal-title":"J Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature14452","article-title":"Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation","volume":"523","author":"Gagliani","year":"2015","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.mib.2017.03.004","article-title":"Segmented filamentous bacteria, Th17 inducers and helpers in a hostile world","volume":"35","author":"Schnupf","year":"2017","journal-title":"Curr Opin Microbiol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"eaat4042","DOI":"10.1126\/science.aat4042","article-title":"Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis","volume":"363","author":"Ladinsky","year":"2019","journal-title":"Science"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1038\/emm.2017.20","article-title":"Roles of intestinal epithelial cells in the maintenance of gut homeostasis","volume":"49","author":"Okumura","year":"2017","journal-title":"Exp Mol Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1136\/gut.2006.094375","article-title":"Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease","volume":"56","author":"Zeissig","year":"2007","journal-title":"Gut"},{"key":"B68","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1053\/gast.2002.34784","article-title":"Mechanisms of diarrhea in collagenous colitis","volume":"123","author":"Burgel","year":"2002","journal-title":"Gastroenterology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"70","author":"Suzuki","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1590\/S1517-83822011000300043","article-title":"Expression of mouse beta defensin 2 in escherichia coli and its broad-spectrum antimicrobial activity","volume":"42","author":"Gong","year":"2011","journal-title":"Braz J Microbiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"7722","DOI":"10.1073\/pnas.0909449107","article-title":"Molecular basis for peptidoglycan recognition by a bactericidal lectin","volume":"107","author":"Lehotzky","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1371\/journal.pmed.0050054","article-title":"Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis","volume":"5","author":"Heazlewood","year":"2008","journal-title":"PLoS Med"},{"key":"B73","doi-asserted-by":"publisher","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"B74","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/mi.2013.109","article-title":"REG3\u03b3-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum","volume":"7","author":"Loonen","year":"2013","journal-title":"Mucosal Immunol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000342079","article-title":"Probiotic mechanisms of action","volume":"61","author":"Bermudez-Brito","year":"2012","journal-title":"Ann Nutr Metab"},{"key":"B76","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2567.2012.03616.x","article-title":"Intestinal colonization resistance","volume":"138","author":"Lawley","year":"2013","journal-title":"Immunology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/ni.3821","article-title":"IFN-lambda suppresses intestinal inflammation by non-translational regulation of neutrophil function","volume":"18","author":"Broggi","year":"2017","journal-title":"Nat Immunol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.3389\/fimmu.2017.01661","article-title":"Interferon (IFN)-lambda takes the helm: immunomodulatory roles of type III IFNs","volume":"8","author":"Zanoni","year":"2017","journal-title":"Front Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.3389\/fimmu.2017.01302","article-title":"Identification of a predominantly interferon-lambda-induced transcriptional profile in murine intestinal epithelial cells","volume":"8","author":"Selvakumar","year":"2017","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01708\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:02:09Z","timestamp":1695042129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01708\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":80,"alternative-id":["10.3389\/fimmu.2019.01708"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01708","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"article-number":"1708"}}