{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:17:17Z","timestamp":1760577437930,"version":"3.41.2"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L009374\/1","MRNO2995X\/1"],"award-info":[{"award-number":["MR\/L009374\/1","MRNO2995X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000351","name":"British Lung Foundation","doi-asserted-by":"publisher","award":["PPRG16-11","RG14-4"],"award-info":[{"award-number":["PPRG16-11","RG14-4"]}],"id":[{"id":"10.13039\/501100000351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01721","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T13:35:52Z","timestamp":1564580152000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Bethany M.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte S.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisha F.","family":"Jabeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nika","family":"Khoshaein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth K.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Peachell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao C.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Dockrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen M.","family":"Marriott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Sabroe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Condliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne R.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"B1","unstructured":"World Health Statistics2008"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1164\/rccm.200506-859OC","article-title":"Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations","volume":"173","author":"Papi","year":"2006","journal-title":"Am J Respirat Crit Care Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/01.mcp.0000208451.50231.8f","article-title":"Role of nontypeable Haemophilus influenzae in exacerbations and progression of chronic obstructive pulmonary disease","volume":"12","author":"Eldika","year":"2006","journal-title":"Curr Opin Pulm Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1053\/srin.2000.0150041","article-title":"Haemophilus influenzae in chronic bronchitis","volume":"15","author":"Murphy","year":"2000","journal-title":"Semin Respir Infect"},{"key":"B5","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1034\/j.1399-3003.2000.15e12.x","article-title":"Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency","volume":"15","author":"Hill","year":"2000","journal-title":"Eur Respir J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.3389\/fimmu.2018.02530","article-title":"The interplay between immune response and bacterial infection in COPD: focus upon non-typeable haemophilus influenzae","volume":"9","author":"Su","year":"2018","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1093\/infdis\/jit400","article-title":"Phagocytic dysfunction of human alveolar macrophages and severity of chronic obstructive pulmonary disease","volume":"208","author":"Berenson","year":"2013","journal-title":"J Infect Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"706376","DOI":"10.1155\/2015\/706376","article-title":"The lung immune response to nontypeable haemophilus influenzae (lung immunity to NTHi)","volume":"2015","author":"King","year":"2015","journal-title":"J Immunol Res"},{"key":"B9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/IAI.50.1.207-212.1985","article-title":"Role of C5 and recruited neutrophils in early clearance of nontypable Haemophilus influenzae from murine lungs","volume":"50","author":"Toews","year":"1985","journal-title":"Infect Immun"},{"key":"B10","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nri3599","article-title":"The roles of Pellino E3 ubiquitin ligases in immunity","volume":"14","author":"Moynagh","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jaci.2010.10.024","article-title":"Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples","volume":"127","author":"Baines","year":"2011","journal-title":"J Aller Clin Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"19218","DOI":"10.1074\/jbc.M115.640128","article-title":"Pellino-1 positively regulates toll-like receptor (TLR) 2 and TLR4 signaling and is suppressed upon induction of endotoxin tolerance","volume":"290","author":"Murphy","year":"2015","journal-title":"J Biol Chem"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ni.1777","article-title":"Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production","volume":"10","author":"Chang","year":"2009","journal-title":"Nat Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"L931","DOI":"10.1152\/ajplung.00150.2009","article-title":"Elastase- and LPS-exposed mice display altered responses to rhinovirus infection","volume":"297","author":"Sajjan","year":"2009","journal-title":"Am J Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1567-1348(02)00152-1","article-title":"High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae","volume":"3","author":"Cody","year":"2003","journal-title":"Infect Genet Evol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e1001262","DOI":"10.1371\/journal.ppat.1001262","article-title":"A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci","volume":"7","author":"Bewley","year":"2011","journal-title":"PLoS Pathog"},{"key":"B17","first-page":"101","article-title":"Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide","volume":"119","author":"Haslett","year":"1985","journal-title":"Am J Pathol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1164\/rccm.200612-1804OC","article-title":"Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa","volume":"177","author":"Bianchi","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1111\/bph.13565","article-title":"The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor","volume":"173","author":"Gill","year":"2016","journal-title":"Br J Pharmacol"},{"key":"B20","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1128\/IAI.58.9.2862-2868.1990","article-title":"Inactivation of suppressor T cell activity by the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides","volume":"58","author":"Baker","year":"1990","journal-title":"Infect Immun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"6401","DOI":"10.4049\/jimmunol.169.11.6401","article-title":"Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury","volume":"169","author":"Rowe","year":"2002","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1179\/096805106X102219","article-title":"TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent","volume":"12","author":"Shoenfelt","year":"2006","journal-title":"J Endotoxin Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.molcel.2018.05.016","article-title":"PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation","volume":"70","author":"Choi","year":"2018","journal-title":"Mol Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/imr.12306","article-title":"Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity","volume":"266","author":"Humphries","year":"2015","journal-title":"Immunol Rev"},{"key":"B27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/imr.12298","article-title":"E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses","volume":"266","author":"Medvedev","year":"2015","journal-title":"Immunol Rev"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/ni.2090","article-title":"The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity","volume":"12","author":"Chang","year":"2011","journal-title":"Nat Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"6595","DOI":"10.1128\/JVI.06755-11","article-title":"Pellino-1 selectively regulates epithelial cell responses to rhinovirus","volume":"86","author":"Bennett","year":"2012","journal-title":"J Virol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1172\/JCI99902","article-title":"Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection","volume":"128","author":"Luo","year":"2018","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1002244","DOI":"10.1371\/journal.ppat.1002244","article-title":"Hansbro. haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease","volume":"7","author":"Essilfie","year":"2011","journal-title":"PLoS Pathog"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1086\/508428","article-title":"Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease","volume":"194","author":"Berenson","year":"2006","journal-title":"J Infect Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ajpath.2011.09.029","article-title":"Elastase\/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A","volume":"180","author":"Ganesan","year":"2012","journal-title":"Am J Pathol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1164\/rccm.200509-1525OC","article-title":"Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease","volume":"173","author":"Sethi","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1038\/mi.2015.128","article-title":"Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection","volume":"9","author":"Dudek","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1038\/ncomms4458","article-title":"Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila","volume":"5","author":"Ji","year":"2014","journal-title":"Nat Commun"},{"key":"B37","unstructured":"Increased survivability of ischemic skin flap tissue in Flk-1(+\/-) mice by Pellino-1 interventione12362 RednamCK WilsonRL SelvarajuV RishiMT ThirunavukkarasuM Coca-SolizV 10.1111\/micc.1236228177171Microcirculation242017"},{"key":"B38","doi-asserted-by":"publisher","first-page":"577","DOI":"10.15252\/emmm.201404653","article-title":"Park. Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide","volume":"7","author":"Lee","year":"2015","journal-title":"EMBO Mol Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.celrep.2017.06.088","article-title":"Cytosolic pellino-1-mediated K63-linked ubiquitination of IRF5 in M1 macrophages regulates glucose intolerance in obesity","volume":"20","author":"Kim","year":"2017","journal-title":"Cell Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"6042","DOI":"10.4049\/jimmunol.175.9.6042","article-title":"The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung","volume":"175","author":"Wieland","year":"2005","journal-title":"J Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"810","DOI":"10.4049\/jimmunol.168.2.810","article-title":"Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung","volume":"168","author":"Wang","year":"2002","journal-title":"J Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette spatzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01721\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T15:59:19Z","timestamp":1610726359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01721\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":42,"alternative-id":["10.3389\/fimmu.2019.01721"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01721","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2019,7,31]]},"article-number":"1721"}}