{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:33:17Z","timestamp":1792225997805,"version":"4.4.0"},"reference-count":273,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01744","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T04:30:47Z","timestamp":1563942647000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":289,"title":["Glucocorticoids\u2014All-Rounders Tackling the Versatile Players of the Immune System"],"prefix":"10.3389","volume":"10","author":[{"given":"Cindy","family":"Strehl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ehlers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Gaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Buttgereit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1136\/ard.61.8.718","article-title":"Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology","volume":"61","author":"Buttgereit","year":"2002","journal-title":"Ann Rheum Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.tem.2017.09.002","article-title":"Steroidogenesis: unanswered questions","volume":"28","author":"Miller","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1136\/ard.2008.092502","article-title":"Arthritis and endogenous glucocorticoids: the emerging role of the 11\u03b2-HSD enzymes","volume":"67","author":"Buttgereit","year":"2008","journal-title":"Ann Rheum Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1749-6632.1994.tb39221.x","article-title":"Glucocorticoids and stress: permissive and suppressive actions","volume":"746","author":"Munck","year":"1994","journal-title":"Ann N Y Acad Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1189\/jlb.71.1.9","article-title":"Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor","volume":"71","author":"Almawi","year":"2002","journal-title":"J Leukoc Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1021\/bi00066a015","article-title":"FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function","volume":"32","author":"Hutchison","year":"1993","journal-title":"Biochemistry."},{"key":"B7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3181\/00379727-217-44252","article-title":"The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors","volume":"217","author":"Pratt","year":"1998","journal-title":"Proc Soc Exp Biol Med."},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1007\/3-540-29717-0_5","article-title":"Chaperoning of glucocorticoid receptors","volume-title":"Molecular Chaperones in Health and Disease. Handbook of Experimental Pharmacology","author":"Pratt","year":"2006"},{"key":"B9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1677\/joe.0.1780331","article-title":"Glucocorticoid action and novel mechanisms of steroid resistance: role of glucocorticoid receptor-interacting proteins for glucocorticoid responsiveness","volume":"178","author":"Wikstrom","year":"2003","journal-title":"J Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1007\/s00198-016-3623-6","article-title":"GRAND-4: the German retrospective analysis of long-term persistence in women with osteoporosis treated with bisphosphonates or denosumab","volume":"27","author":"Hadji","year":"2016","journal-title":"Osteoporosis Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/0092-8674(88)90145-6","article-title":"Multiple and cooperative trans-activation domains of the human glucocorticoid receptor","volume":"55","author":"Hollenberg","year":"1988","journal-title":"Cell."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1074\/jbc.R110.179325","article-title":"Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue specific actions of glucocorticoids","volume":"286","author":"Oakley","year":"2010","journal-title":"J Biol Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"9550","DOI":"10.1074\/jbc.271.16.9550","article-title":"The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function","volume":"271","author":"Oakley","year":"1996","journal-title":"J Biol Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1196\/annals.1321.007","article-title":"Modulation of glucocorticoid receptor function via phosphorylation","volume":"1024","author":"Ismaili","year":"2004","journal-title":"Ann N Y Acad Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/ncprheum0898","article-title":"Genomic and nongenomic effects of glucocorticoids","volume":"4","author":"Stahn","year":"2008","journal-title":"Nat Clin Pract Rheumatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.mce.2007.05.019","article-title":"Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists","volume":"275","author":"Stahn","year":"2007","journal-title":"Mol Cell Endocrinol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1586\/1744666X.2014.864236","article-title":"The intelligent use of systemic glucocorticoids in rheumatoid arthritis","volume":"10","author":"Mercieca","year":"2014","journal-title":"Expert Rev Clin Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1136\/annrheumdis-2015-208916","article-title":"Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force","volume":"75","author":"Strehl","year":"2016","journal-title":"Ann Rheum Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.4049\/jimmunol.166.3.1975","article-title":"Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity","volume":"166","author":"Belvisi","year":"2001","journal-title":"J Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1073\/pnas.0300372101","article-title":"Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects","volume":"101","author":"Schacke","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1073\/pnas.0308334100","article-title":"The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane","volume":"101","author":"Song","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B22","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1210\/en.2012-2045","article-title":"New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation","volume":"154","author":"Vandevyver","year":"2013","journal-title":"Endocrinology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.mce.2012.12.014","article-title":"How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering","volume":"380","author":"Ratman","year":"2013","journal-title":"Mol Cell Endocrinol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"7168","DOI":"10.1093\/emboj\/20.24.7168","article-title":"Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor","volume":"20","author":"Reichardt","year":"2001","journal-title":"EMBO J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.mce.2007.05.009","article-title":"Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice","volume":"275","author":"Kleiman","year":"2007","journal-title":"Mol Cell Endocrinol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1172\/JCI28034","article-title":"Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy","volume":"117","author":"Tuckermann","year":"2007","journal-title":"J Clin Invest."},{"key":"B27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/BOR.0b013e3282f51031","article-title":"The epidemiology of glucocorticoid-associated adverse events","volume":"20","author":"McDonough","year":"2008","journal-title":"Curr Opin Rheumatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0163-7258(02)00297-8","article-title":"Mechanisms involved in the side effects of glucocorticoids","volume":"96","author":"Schacke","year":"2002","journal-title":"Pharmacol Ther."},{"key":"B29","first-page":"275","volume-title":"Janeway's Immunobiology.","author":"Murphy","year":"2012"},{"key":"B30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1042\/EBC20160017","article-title":"The immune system","volume":"60","author":"Nicholson","year":"2016","journal-title":"Essays Biochem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-1-4939-2895-8_9","article-title":"Effects of glucocorticoids in the immune system","volume":"872","author":"Oppong","year":"2015","journal-title":"Adv Exp Med Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1084\/jem.20180595","article-title":"Immune regulation by glucocorticoids can be linked to cell type\u2013dependent transcriptional responses","volume":"216","author":"Franco","year":"2019","journal-title":"J Exp Med."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215672","article-title":"2018 Update of the EULAR recommendations for the management of large vessel vasculitis","author":"Hellmich","year":"2019","journal-title":"Ann Rheum Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1001\/jama.2016.5444","article-title":"Polymyalgia rheumatica and giant cell arteritis: a systematic review","volume":"315","author":"Buttgereit","year":"2016","journal-title":"JAMA."},{"key":"B35","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1136\/annrheumdis-2016-210715","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann Rheum Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1136\/annrheumdis-2019-215089","article-title":"2019 update of the EULAR recommendations for the management of systemic lupus erythematosus","volume":"78","author":"Fanouriakis","year":"2019","journal-title":"Ann Rheum Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/jdv.14891","article-title":"Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I","volume":"32","author":"Wollenberg","year":"2018","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/9780203908877-2","article-title":"The atopic eczema\/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated (\u201cextrinsic\u201d) and the nonallergic (\u201cintrinsic\u201d) AEDS","volume":"13","author":"Wuthrich","year":"2003","journal-title":"J Investig Allergol Clin Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/jdv.13599","article-title":"ETFAD\/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients","volume":"30","author":"Wollenberg","year":"2016","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1056\/NEJMcp1412282","article-title":"Clinical practice. Allergic rhinitis","volume":"372","author":"Wheatley","year":"2015","journal-title":"N Engl J Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/S0140-6736(11)60130-X","article-title":"Allergic rhinitis","volume":"378","author":"Greiner","year":"2011","journal-title":"Lancet."},{"key":"B42","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Brozek","year":"2017","journal-title":"J Allergy Clin Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1056\/NEJMoa1715274","article-title":"Inhaled combined budesonide-formoterol as needed in mild asthma","volume":"378","author":"O'Byrne","year":"2018","journal-title":"N Engl J Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1378\/chest.08-1018","article-title":"Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control","volume":"134","author":"O'Byrne","year":"2008","journal-title":"Chest."},{"key":"B45","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J."},{"key":"B46","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.jaci.2012.11.038","article-title":"The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials","volume":"131","author":"Rank","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/all.12368","article-title":"The risk of asthma exacerbation after reducing inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials","volume":"69","author":"Hagan","year":"2014","journal-title":"Allergy."},{"key":"B48","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.jaci.2011.07.014","article-title":"Approaches to stepping up and stepping down care in asthmatic patients","volume":"128","author":"Thomas","year":"2011","journal-title":"J Allergy Clin Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"794","DOI":"10.2169\/internalmedicine.39.794","article-title":"Duration of systemic corticosteroids in the treatment of asthma exacerbation; a randomized study","volume":"39","author":"Hasegawa","year":"2000","journal-title":"Intern Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1053\/rmed.2002.1369","article-title":"Prospective, placebo-controlled trial of 5 vs 10 days of oral prednisolone in acute adult asthma","volume":"96","author":"Jones","year":"2002","journal-title":"Respir Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/j.1398-9995.2010.02424.x","article-title":"Glucocorticoids for the treatment of anaphylaxis: cochrane systematic review","volume":"65","author":"Choo","year":"2010","journal-title":"Allergy."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1111\/all.12429","article-title":"EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy","volume":"69","author":"Muraro","year":"2014","journal-title":"Allergy."},{"key":"B53","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s40629-014-0009-1","article-title":"Guideline for acute therapy and management of anaphylaxis: S2 Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Association of German Allergologists (AeDA), the Society of Pediatric Allergy and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Austrian Society for Allergology and Immunology (OGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Society for Psychosomatic Medicine (DGPM), the German Working Group of Anaphylaxis Training and Education (AGATE) and the patient organization German Allergy and Asthma Association (DAAB)","volume":"23","author":"Ring","year":"2014","journal-title":"Allergo J Int."},{"key":"B54","doi-asserted-by":"publisher","first-page":"v78","DOI":"10.1093\/annonc\/mdv303","article-title":"Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Eichhorst","year":"2015","journal-title":"Ann Oncol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"iv30","DOI":"10.1093\/annonc\/mdy133","article-title":"Primary cutaneous lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Willemze","year":"2018","journal-title":"Ann Oncol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"iv19","DOI":"10.1093\/annonc\/mdy080","article-title":"Hodgkin lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Eichenauer","year":"2018","journal-title":"Ann Oncol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"v69","DOI":"10.1093\/annonc\/mdw025","article-title":"Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Hoelzer","year":"2016","journal-title":"Ann Oncol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum."},{"key":"B59","doi-asserted-by":"publisher","first-page":"ii51","DOI":"10.1093\/rheumatology\/kex423","article-title":"Pathogenesis of giant-cell arteritis: how targeted therapies are influencing our understanding of the mechanisms involved","volume":"57","author":"Terrades-Garcia","year":"2018","journal-title":"Rheumatology."},{"key":"B60","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s40123-019-0171-0","article-title":"Reviewing the pathophysiology behind the advances in the management of giant cell arteritis","volume":"8","author":"Al-Mousawi","year":"2019","journal-title":"Ophthalmol Ther."},{"key":"B61","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1093\/rheumatology\/keh058","article-title":"Tissue production of pro-inflammatory cytokines (IL-1beta, TNFalpha and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis","volume":"43","author":"Hernandez-Rodriguez","year":"2004","journal-title":"Rheumatology."},{"key":"B62","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1161\/CIRCRESAHA.118.313206","article-title":"MMP (Matrix Metalloprotease)-9-producing monocytes enable T cells to invade the vessel wall and cause vasculitis","volume":"123","author":"Watanabe","year":"2018","journal-title":"Circ Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1056\/NEJMoa1613849","article-title":"Trial of tocilizumab in giant-cell arteritis","volume":"377","author":"Stone","year":"2017","journal-title":"N Engl J Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.rdc.2015.08.009","article-title":"Glucocorticoids for management of polymyalgia rheumatica and giant cell arteritis","volume":"42","author":"Matteson","year":"2016","journal-title":"Rheum Dis Clin North Am."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1172\/JCI119477","article-title":"Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras","volume":"99","author":"Brack","year":"1997","journal-title":"J Clin Invest."},{"key":"B66","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/art.10071","article-title":"Therapeutic effects of acetylsalicylic acid in giant cell arteritis","volume":"46","author":"Weyand","year":"2002","journal-title":"Arthritis Rheum."},{"key":"B67","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1172\/JCI11914","article-title":"Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer","volume":"107","author":"Yamamoto","year":"2001","journal-title":"J Clin Invest."},{"key":"B68","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1006\/pulp.1994.1004","article-title":"Effects of a corticosteroid, budesonide, on alveolar macrophage and blood monocyte secretion of cytokines: differential sensitivity of GM-CSF, IL-1 beta, and IL-6","volume":"7","author":"Linden","year":"1994","journal-title":"Pulm Pharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"9991","DOI":"10.1073\/pnas.89.21.9991","article-title":"A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1","volume":"89","author":"Cronstein","year":"1992","journal-title":"Proc Natl Acad Sci USA."},{"key":"B70","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.4049\/jimmunol.158.12.5589","article-title":"Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes","volume":"158","author":"Blotta","year":"1997","journal-title":"J Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1161\/CIRCULATIONAHA.109.872903","article-title":"Th17 and Th1 T-cell responses in giant cell arteritis","volume":"121","author":"Deng","year":"2010","journal-title":"Circulation."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1136\/annrheumdis-2012-201836","article-title":"Increased IL-17A expression in temporal artery lesions is a predictor of sustained response to glucocorticoid treatment in patients with giant-cell arteritis","volume":"72","author":"Espigol-Frigole","year":"2013","journal-title":"Ann Rheum Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nrrheum.2013.161","article-title":"Immune mechanisms in medium and large-vessel vasculitis","volume":"9","author":"Weyand","year":"2013","journal-title":"Nat Rev Rheumatol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1002\/art.39037","article-title":"Th1 and Th17 cytokines drive inflammation in Takayasu arteritis","volume":"67","author":"Saadoun","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1002\/art.34647","article-title":"Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis","volume":"64","author":"Samson","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B76","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1136\/annrheumdis-2012-202883","article-title":"Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis","volume":"73","author":"Corbera-Bellalta","year":"2014","journal-title":"Ann Rheum Dis."},{"key":"B77","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.autrev.2017.05.014","article-title":"Recent advances in our understanding of giant cell arteritis pathogenesis","volume":"16","author":"Samson","year":"2017","journal-title":"Autoimmun Rev."},{"key":"B78","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/nrdp.2018.2","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers."},{"key":"B79","doi-asserted-by":"publisher","first-page":"e000471","DOI":"10.1136\/rmdopen-2017-000471","article-title":"Synovial fibroblasts in 2017","volume":"3","author":"Ospelt","year":"2017","journal-title":"RMD Open."},{"key":"B80","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1749-6632.2002.tb04199.x","article-title":"Fifty years of experience with cortisone therapy in the study and treatment of rheumatoid arthritis","volume":"966","author":"Neeck","year":"2002","journal-title":"Ann N Y Acad Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/BOR.0b013e3280d6471a","article-title":"Glucocorticoids: action and new therapeutic insights in rheumatoid arthritis","volume":"19","author":"Kirwan","year":"2007","journal-title":"Curr Opin Rheumatol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/13543784.2017.1276562","article-title":"Glucocorticoid-targeted therapies for the treatment of rheumatoid arthritis","volume":"26","author":"Strehl","year":"2017","journal-title":"Expert Opin Invest Drugs."},{"key":"B83","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1136\/ard.2003.014050","article-title":"Lack of radiological and clinical benefit over two years of low dose prednisolone for rheumatoid arthritis: results of a randomised controlled trial","volume":"63","author":"Capell","year":"2004","journal-title":"Ann Rheum Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1002\/art.21421","article-title":"Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial","volume":"52","author":"Wassenberg","year":"2005","journal-title":"Arthritis Rheum."},{"key":"B85","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1002\/art.11269","article-title":"Prognostic factors in a large cohort of patients with early undifferentiated inflammatory arthritis after application of a structured management protocol","volume":"48","author":"Quinn","year":"2003","journal-title":"Arthritis Rheum."},{"key":"B86","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1136\/ard.2009.122473","article-title":"The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis","volume":"69","author":"Machold","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1136\/ard.2009.119149","article-title":"Beneficial effects of a 3-week course of intramuscular glucocorticoid injections in patients with very early inflammatory polyarthritis: results of the STIVEA trial","volume":"69","author":"Verstappen","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1749-6632.2009.05133.x","article-title":"Th1 and Th17 cells: adversaries and collaborators","volume":"1183","author":"Damsker","year":"2010","journal-title":"Ann N Y Acad Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1002\/art.1780351209","article-title":"Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation","volume":"35","author":"Thomas","year":"1992","journal-title":"Arthritis Rheum."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1136\/annrheumdis-2011-200612","article-title":"Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease","volume":"71","author":"Klarenbeek","year":"2012","journal-title":"Ann Rheum Dis."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1056\/NEJMoa035075","article-title":"Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig","volume":"349","author":"Kremer","year":"2003","journal-title":"N Engl J Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheum."},{"key":"B93","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/art.1780391204","article-title":"Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis","volume":"39","author":"Dolhain","year":"1996","journal-title":"Arthritis Rheum."},{"key":"B94","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/j.1365-3083.1992.tb03260.x","article-title":"T cells cloned from human rheumatoid synovial membrane functionally represent the Th1 subset","volume":"35","author":"Miltenburg","year":"1992","journal-title":"Scand J Immunol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1006\/clim.2000.4957","article-title":"CXCR3 and CCR5 ligands in rheumatoid arthritis synovium","volume":"98","author":"Patel","year":"2001","journal-title":"Clin Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1084\/jem.187.6.875","article-title":"Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes","volume":"187","author":"Sallusto","year":"1998","journal-title":"J Exp Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1172\/JCI1422","article-title":"The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions","volume":"101","author":"Qin","year":"1998","journal-title":"J Clin Invest."},{"key":"B98","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1084\/jem.184.3.963","article-title":"Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes","volume":"184","author":"Loetscher","year":"1996","journal-title":"J Exp Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"581","DOI":"10.14670\/HH-22.581","article-title":"Macrophages in rheumatoid arthritis","volume":"22","author":"Maruotti","year":"2007","journal-title":"Histol Histopathol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1172\/JCI7317","article-title":"A proinflammatory role for IL-18 in rheumatoid arthritis","volume":"104","author":"Gracie","year":"1999","journal-title":"J Clin Invest."},{"key":"B101","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/1529-0131(199802)41:2<306::AID-ART15>3.0.CO;2-4","article-title":"Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis","volume":"41","author":"Morita","year":"1998","journal-title":"Arthritis Rheum."},{"key":"B102","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/art.1780330602","article-title":"How important are T cells in chronic rheumatoid synovitis?","volume":"33","author":"Firestein","year":"1990","journal-title":"Arthritis Rheum."},{"key":"B103","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1002\/art.1780300804","article-title":"Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor","volume":"30","author":"Firestein","year":"1987","journal-title":"Arthritis Rheum."},{"key":"B104","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1038\/emi.2013.58","article-title":"IL-17 cytokines in immunity and inflammation","volume":"2","author":"Jin","year":"2013","journal-title":"Emerg Microbes Infect."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12399","article-title":"Human Th1 dichotomy: origin, phenotype and biologic activities","author":"Annunziato","year":"2014","journal-title":"Immunology."},{"key":"B106","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000363502","article-title":"Th17 and non-classic Th1 cells in chronic inflammatory disorders: two sides of the same coin","volume":"164","author":"Cosmi","year":"2014","journal-title":"Int Arch Allergy Immunol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1002\/eji.201242648","article-title":"Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells","volume":"42","author":"Maggi","year":"2012","journal-title":"Eur J Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1002\/art.30332","article-title":"Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis","volume":"63","author":"Cosmi","year":"2011","journal-title":"Arthritis Rheum."},{"key":"B109","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1002\/eji.201646618","article-title":"Reverse plasticity: TGF-beta and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut","volume":"46","author":"Geginat","year":"2016","journal-title":"Eur J Immunol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e1004324","DOI":"10.1371\/journal.pcbi.1004324","article-title":"A minimal regulatory network of extrinsic and intrinsic factors recovers observed patterns of CD4+ T cell differentiation and plasticity","volume":"11","author":"Martinez-Sanchez","year":"2015","journal-title":"PLoS Comput Biol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/eji.201444726","article-title":"TGF-beta converts Th1 cells into Th17 cells through stimulation of Runx1 expression","volume":"45","author":"Liu","year":"2015","journal-title":"Eur J Immunol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.jaci.2013.03.015","article-title":"Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease","volume":"131","author":"Hirahara","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"4186027","DOI":"10.1155\/2016\/4186027","article-title":"Elevated ratio of Th17 cell-derived Th1 cells (CD161(+)Th1 cells) to CD161(+)Th17 cells in peripheral blood of early-onset rheumatoid arthritis patients","volume":"2016","author":"Kotake","year":"2016","journal-title":"Biomed Res Int."},{"key":"B114","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/all.12840","article-title":"BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis","volume":"71","author":"Banuelos","year":"2016","journal-title":"Allergy."},{"key":"B115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4049\/jimmunol.149.1.107","article-title":"IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis","volume":"149","author":"Zubiaga","year":"1992","journal-title":"J Immunol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1136\/ard.58.1.49","article-title":"The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon gamma and interleukin 4 production","volume":"58","author":"Verhoef","year":"1999","journal-title":"Ann Rheum Dis."},{"key":"B117","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.133.1.273","article-title":"Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA","volume":"133","author":"Arya","year":"1984","journal-title":"J Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1096\/fj.06-7452com","article-title":"The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction","volume":"21","author":"Liberman","year":"2007","journal-title":"FASEB J."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.4049\/jimmunol.164.4.1768","article-title":"Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes","volume":"164","author":"Franchimont","year":"2000","journal-title":"J Immunol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/j.jaci.2018.07.019","article-title":"Glucocorticoids promote intrinsic human TH17 differentiation","volume":"142","author":"de Castro Kroner","year":"2018","journal-title":"J Allergy Clin Immunol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"Kotake","year":"1999","journal-title":"J Clin Invest."},{"key":"B122","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/ar4325","article-title":"Role of neutrophils in systemic autoimmune diseases","volume":"15","author":"Kaplan","year":"2013","journal-title":"Arthritis Res Ther."},{"key":"B123","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","article-title":"The multifactorial role of neutrophils in rheumatoid arthritis","volume":"10","author":"Wright","year":"2014","journal-title":"Nat Rev Rheumatol."},{"key":"B124","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1182\/blood.V86.8.3181.3181","article-title":"Glucocorticoids inhibit apoptosis of human neutrophils","volume":"86","author":"Liles","year":"1995","journal-title":"Blood."},{"key":"B125","unstructured":"One year in review 2017: systemic lupus erythematosus55161 La PagliaGMC LeoneMC LepriG VagelliR ValentiniE AlunnoA 28721860Clin Exp Rheumatol.352017"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1056\/NEJM199805073381906","article-title":"Antibodies to DNA","volume":"338","author":"Hahn","year":"1998","journal-title":"N Engl J Med."},{"key":"B127","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.immuni.2006.08.010","article-title":"Type I interferon in systemic lupus erythematosus and other autoimmune diseases","volume":"25","author":"Banchereau","year":"2006","journal-title":"Immunity."},{"key":"B128","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/nature09102","article-title":"TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus","volume":"465","author":"Guiducci","year":"2010","journal-title":"Nature."},{"key":"B129","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.immunol.23.021704.115843","article-title":"Type I interferons (alpha\/beta) in immunity and autoimmunity","volume":"23","author":"Theofilopoulos","year":"2005","journal-title":"Annu Rev Immunol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/0961203308090020","article-title":"The innate immune system in SLE: type I interferons and dendritic cells","volume":"17","author":"Ronnblom","year":"2008","journal-title":"Lupus."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1084\/jem.180.4.1295","article-title":"The role of B cells in lpr\/lpr-induced autoimmunity","volume":"180","author":"Shlomchik","year":"1994","journal-title":"J Exp Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1084\/jem.189.10.1639","article-title":"A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus","volume":"189","author":"Chan","year":"1999","journal-title":"J Exp Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"e44362","DOI":"10.1371\/journal.pone.0044362","article-title":"Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus","volume":"7","author":"Lugar","year":"2012","journal-title":"PLoS ONE."},{"key":"B134","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.molimm.2013.05.241","article-title":"Up-regulation of transcription factor Blimp1 in systemic lupus erythematosus","volume":"56","author":"Luo","year":"2013","journal-title":"Mol Immunol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1196\/annals.1313.004","article-title":"BAFF overexpression is associated with autoantibody production in autoimmune diseases","volume":"1050","author":"Pers","year":"2005","journal-title":"Ann N Y Acad Sci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.berh.2017.10.003","article-title":"Role of interferons in SLE","volume":"31","author":"Bengtsson","year":"2017","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/art.27233","article-title":"Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II\/III systemic lupus erythematosus evaluation of rituximab trial","volume":"62","author":"Merrill","year":"2010","journal-title":"Arthritis Rheum."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1136\/annrheumdis-2018-214833","article-title":"Rituximab in moderate to severe non-renal systemic lupus erythematosus: a reanalysis of the EXPLORER study","volume":"78","author":"Scherlinger","year":"2019","journal-title":"Ann Rheum Dis."},{"key":"B139","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/art.27189","article-title":"Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study","volume":"62","author":"Jacobi","year":"2010","journal-title":"Arthritis Rheum."},{"key":"B140","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nrrheum.2016.158","article-title":"Beyond pan-B-cell-directed therapy - new avenues and insights into the pathogenesis of SLE","volume":"12","author":"Dorner","year":"2016","journal-title":"Nat Rev Rheumatol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/aps.2015.76","article-title":"Prednisone treatment inhibits the differentiation of B lymphocytes into plasma cells in MRL\/MpSlac-lpr mice","volume":"36","author":"Yan","year":"2015","journal-title":"Acta Pharmacol Sin."},{"key":"B142","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/01.TP.0000441826.70687.f6","article-title":"Comparative analysis of drug action on B-cell proliferation and differentiation for mycophenolic acid, everolimus, and prednisolone","volume":"97","author":"Haneda","year":"2014","journal-title":"Transplantation."},{"key":"B143","doi-asserted-by":"publisher","first-page":"5970","DOI":"10.4049\/jimmunol.165.10.5970","article-title":"Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus","volume":"165","author":"Odendahl","year":"2000","journal-title":"J Immunol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1191\/096120301675075008","article-title":"Treatment of lupus with corticosteroids","volume":"10","author":"Chatham","year":"2001","journal-title":"Lupus."},{"key":"B145","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0009-8981(01)00661-1","article-title":"The phase-shift mutation in the glucocorticoid receptor gene: potential etiologic significance of neuroendocrine mechanisms in lupus nephritis","volume":"313","author":"Jiang","year":"2001","journal-title":"Clin Chim Acta."},{"key":"B146","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1203\/00006450-200101000-00025","article-title":"Effect of glucocorticoid therapy on glucocorticoid receptors in children with autoimmune diseases","volume":"49","author":"Andreae","year":"2001","journal-title":"Pediatr Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1749-6632.2002.tb04252.x","article-title":"Involvement of the glucocorticoid receptor in the pathogenesis of rheumatoid arthritis","volume":"966","author":"Neeck","year":"2002","journal-title":"Ann N Y Acad Sci."},{"key":"B148","first-page":"681","article-title":"Glucocorticoid receptors in systemic lupus erythematosus","volume":"18","author":"Gladman","year":"1991","journal-title":"J Rheumatol."},{"key":"B149","unstructured":"Down regulation of glucocorticoid receptors in early-diagnosed rheumatoid arthritis4638 van EverdingenAA HuismanAM WentingMJ van ReesemaS JacobsJW BijlsmaJW 12175100Clin Exp Rheumatol.202002"},{"key":"B150","first-page":"878","article-title":"Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy","volume":"19","author":"Tanaka","year":"1992","journal-title":"J Rheumatol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3899\/jrheum.090191","article-title":"Negative relationship between expression of glucocorticoid receptor alpha and disease activity: glucocorticoid treatment of patients with systemic lupus erythematosus","volume":"37","author":"Li","year":"2010","journal-title":"J Rheumatol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1136\/ard.2008.096495","article-title":"HLA-DRhigh\/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus","volume":"69","author":"Jacobi","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B153","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1136\/annrheumdis-2015-207744","article-title":"Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus","volume":"75","author":"Jones","year":"2016","journal-title":"Ann Rheum Dis."},{"key":"B154","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.lfs.2018.08.038","article-title":"Molecular mechanisms of glucocorticoid resistance in systemic lupus erythematosus: a review","volume":"209","author":"Gao","year":"2018","journal-title":"Life Sci."},{"key":"B155","first-page":"3010","article-title":"Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations","volume":"56","author":"Beck","year":"1996","journal-title":"Cancer Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"4965","DOI":"10.3390\/ijms15034965","article-title":"P-glycoprotein and drug resistance in systemic autoimmune diseases","volume":"15","author":"Picchianti-Diamanti","year":"2014","journal-title":"Int J Mol Sci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10238-017-0459-0","article-title":"Serum levels of P-glycoprotein and persistence of disease activity despite treatment in patients with systemic lupus erythematosus","volume":"18","author":"Perez-Guerrero","year":"2018","journal-title":"Clin Exp Med."},{"key":"B158","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10067-015-3079-7","article-title":"Persistent expression and function of P-glycoprotein on peripheral blood lymphocytes identifies corticosteroid resistance in patients with systemic lupus erythematosus","volume":"35","author":"Kansal","year":"2016","journal-title":"Clin Rheumatol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cca.2008.09.014","article-title":"Macrophage migration inhibitory factor: a key cytokine in RA, SLE and atherosclerosis","volume":"399","author":"Santos","year":"2009","journal-title":"Clin Chim Acta."},{"key":"B160","unstructured":"Macrophage migration inhibitory factor in systemic lupus erythematosus26873 FooteA BrigantiEM KipenY SantosL LeechM MorandEF 14760795J Rheumatol.312004"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00467-005-1930-9","article-title":"Association of macrophage migration inhibitory factor \u2212173C allele polymorphism with steroid resistance in children with nephrotic syndrome","volume":"20","author":"Berdeli","year":"2005","journal-title":"Pediatr Nephrol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1186\/ar3828","article-title":"New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus","volume":"14","author":"Wang","year":"2012","journal-title":"Arthritis Res Ther."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1093\/rheumatology\/keu148","article-title":"Glucocorticoids and irreversible damage in patients with systemic lupus erythematosus","volume":"53","author":"Ruiz-Arruza","year":"2014","journal-title":"Rheumatology."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1177\/0961203316636468","article-title":"A liposomal steroid nano-drug for treating systemic lupus erythematosus","volume":"25","author":"Moallem","year":"2016","journal-title":"Lupus."},{"key":"B165","doi-asserted-by":"publisher","first-page":"e25721","DOI":"10.1371\/journal.pone.0025721","article-title":"Fabrication principles and their contribution to the superior in vivo therapeutic efficacy of nano-liposomes remote loaded with glucocorticoids","volume":"6","author":"Avnir","year":"2011","journal-title":"PLoS ONE."},{"key":"B166","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/art.23230","article-title":"Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: a novel approach to treating autoimmune arthritis","volume":"58","author":"Avnir","year":"2008","journal-title":"Arthritis Rheum."},{"key":"B167","doi-asserted-by":"publisher","first-page":"e0130442","DOI":"10.1371\/journal.pone.0130442","article-title":"Nano-drugs based on nano sterically stabilized liposomes for the treatment of inflammatory neurodegenerative diseases","volume":"10","author":"Turjeman","year":"2015","journal-title":"PLoS ONE."},{"key":"B168","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jconrel.2011.12.024","article-title":"Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines","volume":"160","author":"Ulmansky","year":"2012","journal-title":"J Control Release."},{"key":"B169","doi-asserted-by":"publisher","first-page":"e72722","DOI":"10.1371\/journal.pone.0072722","article-title":"Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria","volume":"8","author":"Waknine-Grinberg","year":"2013","journal-title":"PLoS ONE."},{"key":"B170","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jconrel.2015.04.019","article-title":"[(18)]F FDG PET\/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis","volume":"209","author":"van der Geest","year":"2015","journal-title":"J Control Release."},{"key":"B171","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/0165-6147(94)90027-2","article-title":"TH2 and \u2018TH2-like' cells in allergy and asthma: pharmacological perspectives","volume":"15","author":"Anderson","year":"1994","journal-title":"Trends Pharmacol Sci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cytogfr.2016.05.002","article-title":"A gradient of glucocorticoid sensitivity among helper T cell cytokines","volume":"31","author":"Banuelos","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"B173","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat Rev Immunol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nri2992","article-title":"Diversity and dialogue in immunity to helminths","volume":"11","author":"Allen","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s001030070045","article-title":"Allergische Krankheiten in DeutschlandErgebnisse einer repr\u00e4sentativen Studie","volume":"43","author":"Hermann-Kunz","year":"2000","journal-title":"Bundesgesundheitsblatt."},{"key":"B176","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/j.1399-3038.2012.01342.x","article-title":"Prevalence and risk factors of atopic diseases in German children and adolescents","volume":"23","author":"Schmitz","year":"2012","journal-title":"Pediatr Allergy Immunol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jaci.2017.02.025","article-title":"Pathogenic CD4(+) T cells in patients with asthma","volume":"140","author":"Muehling","year":"2017","journal-title":"J Allergy Clin Immunol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","article-title":"Interleukin-13 in asthma pathogenesis","volume":"202","author":"Wills-Karp","year":"2004","journal-title":"Immunol Rev."},{"key":"B179","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1146\/annurev.immunol.22.012703.104716","article-title":"Asthma: mechanisms of disease persistence and progression","volume":"22","author":"Cohn","year":"2004","journal-title":"Annu Rev Immunol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.0105-2896.2006.00413.x","article-title":"The regulation of allergy and asthma","volume":"212","author":"Umetsu","year":"2006","journal-title":"Immunol Rev."},{"key":"B181","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00106-012-2483-4","article-title":"[Mechanism of action of nasal glucocorticosteroids in the treatment of allergic rhinitis. Part 1: Pathophysiology, molecular basis]","volume":"60","author":"Klimek","year":"2012","journal-title":"Hno."},{"key":"B182","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/rr39","article-title":"Th2 cytokines and asthma: an introduction","volume":"2","author":"Barnes","year":"2001","journal-title":"Respir Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/rr7","article-title":"The gene encoding interleukin-13: a susceptibility locus for asthma and related traits","volume":"1","author":"Wills-Karp","year":"2000","journal-title":"Respir Res."},{"key":"B184","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V73.6.1504.1504","article-title":"Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF","volume":"73","author":"Clutterbuck","year":"1989","journal-title":"Blood."},{"key":"B185","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1046\/j.1365-2249.1997.d01-884.x","article-title":"IL-5 but not interferon-gamma (IFN-gamma) inhibits eosinophil apoptosis by up-regulation of bcl-2 expression","volume":"107","author":"Ochiai","year":"1997","journal-title":"Clin Exp Immunol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1172\/JCI117408","article-title":"Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis","volume":"94","author":"Hamid","year":"1994","journal-title":"J Clin Invest."},{"key":"B187","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1067\/mai.2000.108111","article-title":"Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils","volume":"106","author":"Benson","year":"2000","journal-title":"J Allergy Clin Immunol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1172\/JCI115166","article-title":"Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma","volume":"87","author":"Hamid","year":"1991","journal-title":"J Clin Invest"},{"key":"B189","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1056\/NEJM199201303260504","article-title":"Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma","volume":"326","author":"Robinson","year":"1992","journal-title":"N Engl J Med."},{"key":"B190","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1165\/ajrcmb.12.5.7742012","article-title":"Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects","volume":"12","author":"Ying","year":"1995","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1164\/ajrccm\/146.1.109","article-title":"Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage","volume":"146","author":"Walker","year":"1992","journal-title":"Am Rev Respir Dis."},{"key":"B192","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1007\/s00106-012-2484-3","article-title":"[Mechanism of action of nasal glucocorticosteroids in the treatment of allergic rhinitis. Part 2: practical aspects of application]","volume":"60","author":"von Bernus","year":"2012","journal-title":"Hno."},{"key":"B193","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1164\/ajrccm.153.2.8564096","article-title":"Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa","volume":"153","author":"Bentley","year":"1996","journal-title":"Am J Respir Crit Care Med."},{"key":"B194","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1111\/j.1365-2222.1994.tb02724.x","article-title":"Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge","volume":"24","author":"Rak","year":"1994","journal-title":"Clin Exp Allergy."},{"key":"B195","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1002\/eji.1830191221","article-title":"Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4","volume":"19","author":"Daynes","year":"1989","journal-title":"Eur J Immunol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1084\/jem.171.4.979","article-title":"Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function","volume":"171","author":"Daynes","year":"1990","journal-title":"J Exp Med."},{"key":"B197","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0165-5728(94)90230-5","article-title":"Alterations in interleukin-4 and antibody production following pheromone exposure: role of glucocorticoids","volume":"54","author":"Moynihan","year":"1994","journal-title":"J Neuroimmunol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.4049\/jimmunol.168.3.1087","article-title":"Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids","volume":"168","author":"Miyaura","year":"2002","journal-title":"J Immunol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0167-0115(97)01063-X","article-title":"Effects of dexamethasone on the profile of cytokine secretion in human whole blood cell cultures","volume":"73","author":"Franchimont","year":"1998","journal-title":"Regul Pept."},{"key":"B200","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1089\/jir.1998.18.1059","article-title":"Glucocorticoid-induced type 1\/type 2 cytokine alterations in humans: a model for stress-related immune dysfunction","volume":"18","author":"Agarwal","year":"1998","journal-title":"J Interferon Cytokine Res."},{"key":"B201","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1155\/1998\/73401","article-title":"Glucocorticoids induce a Th2 response in vitro","volume":"6","author":"Ramirez","year":"1998","journal-title":"Dev Immunol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/S0091-6749(98)70335-5","article-title":"Glucocorticoids inhibit IL-4 and mitogen-induced IL-4R alpha chain expression by different posttranscriptional mechanisms","volume":"102","author":"Mozo","year":"1998","journal-title":"J Allergy Clin Immunol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1002\/eji.1830211053","article-title":"Glucocorticoids suppress the production of interleukin 4 by human lymphocytes","volume":"21","author":"Wu","year":"1991","journal-title":"Eur J Immunol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/S0091-6749(97)70255-0","article-title":"Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses","volume":"100","author":"Braun","year":"1997","journal-title":"J Allergy Clin Immunol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"e0123068","DOI":"10.1371\/journal.pone.0123068","article-title":"Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue","volume":"10","author":"Beck","year":"2015","journal-title":"PLoS ONE"},{"key":"B206","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0165-5728(00)00298-8","article-title":"Molecular mechanisms and Th1\/Th2 pathways in corticosteroid regulation of cytokine production","volume":"109","author":"Kovalovsky","year":"2000","journal-title":"J Neuroimmunol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1749-6632.2003.tb03150.x","article-title":"Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells","volume":"992","author":"Refojo","year":"2003","journal-title":"Ann N Y Acad Sci."},{"key":"B208","unstructured":"Cytokine signaling\/transcription factor cross-talk in T cell activation and Th1-Th2 differentiation35165 LibermanAC RefojoD ArztE 14692657Arch Immunol Ther Exp.512003"},{"key":"B209","doi-asserted-by":"publisher","first-page":"23243","DOI":"10.1074\/jbc.M503659200","article-title":"Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment","volume":"280","author":"Jee","year":"2005","journal-title":"J Biol Chem."},{"key":"B210","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nri1128","article-title":"Regulation of IL4 gene expression by T cells and therapeutic perspectives","volume":"3","author":"Li-Weber","year":"2003","journal-title":"Nat Rev Immunol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"e1000076","DOI":"10.1371\/journal.pmed.1000076","article-title":"Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease","volume":"6","author":"Maneechotesuwan","year":"2009","journal-title":"PLoS Med."},{"key":"B212","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000485890","article-title":"Glucocorticoids modulate Th1 and Th2 responses in asthmatic mouse models by inhibition of Notch1 signaling","volume":"175","author":"Hu","year":"2018","journal-title":"Int Arch Allergy Immunol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1067\/mai.2002.124776","article-title":"Maternal stress and T-cell differentiation of the developing immune system: possible implications for the development of asthma and atopy","volume":"109","author":"von Hertzen","year":"2002","journal-title":"J Allergy Clin Immunol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.alit.2017.04.013","article-title":"The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma","volume":"67","author":"Miyasaka","year":"2018","journal-title":"Allergol Int."},{"key":"B215","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.2147\/IJN.S71543","article-title":"Downregulation of immunological mediators in 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions by hydrocortisone-loaded chitosan nanoparticles","volume":"9","author":"Hussain","year":"2014","journal-title":"Int J Nanomed"},{"key":"B216","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1111\/j.1365-2222.2005.02381.x","article-title":"Topical corticosteroid inhibits interleukin-4,\u22125 and\u221213 in nasal secretions following allergen challenge","volume":"35","author":"Erin","year":"2005","journal-title":"Clin Exp Allergy."},{"key":"B217","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1164\/ajrccm.151.6.7767538","article-title":"Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid","volume":"151","author":"Bradding","year":"1995","journal-title":"Am J Respir Crit Care Med."},{"key":"B218","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.jaci.2012.01.079","article-title":"Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy","volume":"129","author":"Wen","year":"2012","journal-title":"J Allergy Clin Immunol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1164\/ajrccm.155.3.9117015","article-title":"Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy","volume":"155","author":"Naseer","year":"1997","journal-title":"Am J Respir Crit Care Med."},{"key":"B220","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1542\/peds.99.5.695","article-title":"Inhaled glucocorticoid therapy of childhood asthma is associated with reduced peripheral blood T cell activation and \u2018Th2-type' cytokine mRNA expression","volume":"99","author":"Gemou-Engesaeth","year":"1997","journal-title":"Pediatrics."},{"key":"B221","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1164\/ajrccm\/148.2.401","article-title":"Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression","volume":"148","author":"Robinson","year":"1993","journal-title":"Am Rev Respir Dis."},{"key":"B222","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1046\/j.1365-2745.2002.01418.x","article-title":"Dexamethasone inhibits maturation, cytokine production and Fc epsilon RI expression of human cord blood-derived mast cells","volume":"32","author":"Smith","year":"2002","journal-title":"Clin Exp Allergy."},{"key":"B223","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S1081-1206(10)63238-3","article-title":"Glucocorticosteroids inhibit leukotriene production","volume":"78","author":"Crocker","year":"1997","journal-title":"Ann Allergy Asthma Immunol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0090-6980(84)90084-4","article-title":"Hydrocortisone selectively inhibits IgE-dependent arachidonic acid release from rat peritoneal mast cells","volume":"27","author":"Heiman","year":"1984","journal-title":"Prostaglandins."},{"key":"B225","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.4049\/jimmunol.157.6.2374","article-title":"Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells","volume":"157","author":"Rider","year":"1996","journal-title":"J Immunol."},{"key":"B226","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.4049\/jimmunol.158.9.4373","article-title":"Glucocorticoids inhibit the cytokine-induced proliferation of mast cells, the high affinity IgE receptor-mediated expression of TNF-alpha, and the IL-10-induced expression of chymases","volume":"158","author":"Eklund","year":"1997","journal-title":"J Immunol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1172\/JCI119336","article-title":"Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems","volume":"99","author":"Finotto","year":"1997","journal-title":"J Clin Invest."},{"key":"B228","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0091-6749(99)70334-9","article-title":"An in vitro comparison of commonly used topical glucocorticoid preparations","volume":"104","author":"Stellato","year":"1999","journal-title":"J Allergy Clin Immunol."},{"key":"B229","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.156.11.4422","article-title":"Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes","volume":"156","author":"Meagher","year":"1996","journal-title":"J Immunol."},{"key":"B230","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1034\/j.1398-9995.2001.056002126.x","article-title":"Recruitment of CD1a+ Langerhans cells to the nasal mucosa in seasonal allergic rhinitis and effects of topical corticosteroid therapy","volume":"56","author":"Till","year":"2001","journal-title":"Allergy."},{"key":"B231","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1002\/eji.1830271123","article-title":"Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid","volume":"27","author":"Durham","year":"1997","journal-title":"Eur J Immunol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1248\/bpb.b16-00075","article-title":"Betamethasone, but not tacrolimus, suppresses the development of Th2 cells mediated by langerhans cell-like dendritic cells","volume":"39","author":"Matsui","year":"2016","journal-title":"Biol Pharm Bull."},{"key":"B233","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4049\/jimmunol.1601691","article-title":"Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma","volume":"199","author":"Klassen","year":"2017","journal-title":"J Immunol."},{"key":"B234","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/ACI.0000000000000129","article-title":"The paradigm of cytokine networks in allergic airway inflammation","volume":"15","author":"Pawankar","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol."},{"key":"B235","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nri1589","article-title":"Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma","volume":"5","author":"Hawrylowicz","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1136\/thoraxjnl-2013-203421","article-title":"Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma","volume":"69","author":"Gupta","year":"2014","journal-title":"Thorax."},{"key":"B237","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1164\/ajrccm.157.1.9703079","article-title":"Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma","volume":"157","author":"John","year":"1998","journal-title":"Am J Respir Crit Care Med."},{"key":"B238","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/S0091-6749(96)70197-5","article-title":"Interleukin-10 regulation in normal subjects and patients with asthma","volume":"97","author":"Borish","year":"1996","journal-title":"J Allergy Clin Immunol."},{"key":"B239","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0140-6736(98)85018-6","article-title":"Haplotype associated with low interleukin-10 production in patients with severe asthma","volume":"352","author":"Lim","year":"1998","journal-title":"Lancet"},{"key":"B240","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1183\/09031936.05.00011205","article-title":"Regulatory T-lymphocytes in asthma","volume":"26","author":"van Oosterhout","year":"2005","journal-title":"Eur Respir J."},{"key":"B241","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1111\/cea.12594","article-title":"T regulatory cell phenotypes in peripheral blood and bronchoalveolar lavage from non-asthmatic and asthmatic subjects","volume":"45","author":"Baatjes","year":"2015","journal-title":"Clin Exp Allergy."},{"key":"B242","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1111\/j.1365-2222.2004.02067.x","article-title":"Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season","volume":"34","author":"Grindebacke","year":"2004","journal-title":"Clin Exp Allergy."},{"key":"B243","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1172\/JCI21759","article-title":"Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients","volume":"116","author":"Xystrakis","year":"2006","journal-title":"J Clin Invest."},{"key":"B244","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jaci.2004.04.048","article-title":"Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism","volume":"114","author":"Dao Nguyen","year":"2004","journal-title":"J Allergy Clin Immunol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.jaci.2007.02.023","article-title":"Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma","volume":"119","author":"Hartl","year":"2007","journal-title":"J Allergy Clin Immunol."},{"key":"B246","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.jaci.2004.07.014","article-title":"Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma","volume":"114","author":"Karagiannidis","year":"2004","journal-title":"J Allergy Clin Immunol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.steroids.2016.02.019","article-title":"New dimension of glucocorticoids in cancer treatment","volume":"111","author":"Lin","year":"2016","journal-title":"Steroids."},{"key":"B248","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1517\/14656566.2015.980723","article-title":"Pain management of the cancer patient","volume":"16","author":"Schug","year":"2015","journal-title":"Expert Opin Pharmacother."},{"key":"B249","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11916-012-0273-z","article-title":"The role of corticosteroids in the treatment of pain in cancer patients","volume":"16","author":"Leppert","year":"2012","journal-title":"Curr Pain Headache Rep."},{"key":"B250","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1177\/1049909111413256","article-title":"Adjuvant analgesics in cancer pain: a review","volume":"29","author":"Mitra","year":"2012","journal-title":"Am J Hosp Palliat Care."},{"key":"B251","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3322\/caac.21149","article-title":"Cancer treatment and survivorship statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin."},{"key":"B252","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1182\/blood-2012-08-452607","article-title":"Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling","volume":"121","author":"Burger","year":"2013","journal-title":"Blood."},{"key":"B253","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.biopha.2017.10.105","article-title":"Advances in chronic lymphocytic leukemia pharmacotherapy","volume":"97","author":"Gomes","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B254","doi-asserted-by":"publisher","first-page":"21","DOI":"10.5493\/wjem.v3.i2.21","article-title":"Steroid resistance in leukemia","volume":"3","author":"Shah","year":"2013","journal-title":"World J Exp Med."},{"key":"B255","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1126\/science.98.2547.367","article-title":"Influence of adrenal cortical secretion on blood elements","volume":"98","author":"Dougherty","year":"1943","journal-title":"Science."},{"key":"B256","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev.pa.19.040179.001143","article-title":"Mechanisms of glucocorticoid action on immune processes","volume":"19","author":"Parrillo","year":"1979","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"B257","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1002\/1097-0142(194911)2:6<943::aid-cncr2820020602>3.0.co;2-p","article-title":"Adrenocorticotropic hormone- and cortisone-induced regression of lymphoid tumors in man; a preliminary report","volume":"2","author":"Pearson","year":"1949","journal-title":"Cancer."},{"key":"B258","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1182\/blood.V17.2.182.182","article-title":"A study of prednisone therapy in chronic lymphocytic leukemia","volume":"17","author":"Shaw","year":"1961","journal-title":"Blood."},{"key":"B259","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.leukres.2016.05.003","article-title":"The ibrutinib B-cell proliferation inhibition is potentiated in vitro by dexamethasone: application to chronic lymphocytic leukemia","volume":"47","author":"Manzoni","year":"2016","journal-title":"Leuk Res."},{"key":"B260","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/S0140-6736(07)61165-9","article-title":"Chronic myeloid leukaemia","volume":"370","author":"Hehlmann","year":"2007","journal-title":"Lancet."},{"key":"B261","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.hoc.2017.04.006","article-title":"Tyrosine kinase inhibitor treatment for newly diagnosed chronic myeloid leukemia","volume":"31","author":"Radich","year":"2017","journal-title":"Hematol Oncol Clin North Am."},{"key":"B262","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00277-017-3148-x","article-title":"The progress and current status of immunotherapy in acute myeloid leukemia","volume":"96","author":"Yang","year":"2017","journal-title":"Ann Hematol."},{"key":"B263","doi-asserted-by":"publisher","first-page":"37790","DOI":"10.18632\/oncotarget.26492","article-title":"Precision medicine in the treatment stratification of AML patients: challenges and progress","volume":"9","author":"Lohse","year":"2018","journal-title":"Oncotarget."},{"key":"B264","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.leukres.2005.05.015","article-title":"The effect of steroid on myeloid leukemic cells: the potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis","volume":"30","author":"Hicsonmez","year":"2006","journal-title":"Leuk Res."},{"key":"B265","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/pbc.26011","article-title":"Glucocorticoid-induced proliferation in untreated pediatric acute myeloid leukemic blasts","volume":"63","author":"Klein","year":"2016","journal-title":"Pediatr Blood Cancer."},{"key":"B266","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/S1470-2045(10)70114-5","article-title":"Glucocorticoid use in acute lymphoblastic leukaemia","volume":"11","author":"Inaba","year":"2010","journal-title":"Lancet Oncol."},{"key":"B267","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1056\/NEJMra023001","article-title":"Acute lymphoblastic leukemia","volume":"350","author":"Pui","year":"2004","journal-title":"N Engl J Med."},{"key":"B268","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell."},{"key":"B269","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1182\/blood-2014-05-576470","article-title":"Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells","volume":"125","author":"Jing","year":"2015","journal-title":"Blood."},{"key":"B270","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1182\/blood-2017-02-766204","article-title":"Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia","volume":"129","author":"Kruth","year":"2017","journal-title":"Blood."},{"key":"B271","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1038\/onc.2012.321","article-title":"Erg and AP-1 as determinants of glucocorticoid response in acute lymphoblastic leukemia","volume":"32","author":"Chen","year":"2013","journal-title":"Oncogene."},{"key":"B272","doi-asserted-by":"publisher","first-page":"e349","DOI":"10.1038\/cddis.2012.89","article-title":"Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells","volume":"3","author":"Heidari","year":"2012","journal-title":"Cell Death Dis."},{"key":"B273","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/leu.2008.370","article-title":"Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia","volume":"23","author":"Rainer","year":"2009","journal-title":"Leukemia."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01744\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:43:36Z","timestamp":1695044616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01744\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,24]]},"references-count":273,"alternative-id":["10.3389\/fimmu.2019.01744"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01744","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,24]]},"article-number":"1744"}}