{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:49:14Z","timestamp":1793162954818,"version":"4.5.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L008564\/1"],"award-info":[{"award-number":["MR\/L008564\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01747","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T09:39:26Z","timestamp":1563961166000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":56,"title":["Comparison of CD8+ T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria"],"prefix":"10.3389","volume":"10","author":[{"given":"Valentina","family":"Barrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Haley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Strangward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Attree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kamiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl B.","family":"Seydel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie E.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Danny A.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alister G.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin N.","family":"Couper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"B1","unstructured":"29619211World Malaria Report 2018"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e20181026","DOI":"10.1542\/peds.2018-1026","article-title":"Neurodevelopmental impairments 1 year after cerebral malaria","volume":"143","author":"Langfitt","year":"2019","journal-title":"Pediatrics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.12688\/f1000research.12401.1","article-title":"Do we know enough to find an adjunctive therapy for cerebral malaria in African children?","volume":"6","author":"Riggle","year":"2017","journal-title":"F1000Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijpara.2016.08.002","article-title":"Severe malaria: what's new on the pathogenesis front?","volume":"47","author":"Wassmer","year":"2017","journal-title":"Int J Parasitol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1016\/j.ajpath.2011.01.016","article-title":"The neuropathology of fatal cerebral malaria in Malawian children","volume":"178","author":"Dorovini-Zis","year":"2011","journal-title":"Am J Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/infdis\/jit116","article-title":"Lethal malaria: Marchiafava and Bignami were right","volume":"208","author":"White","year":"2013","journal-title":"J Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fcimb.2014.00100","article-title":"Pathogenesis of cerebral malaria\u2013inflammation and cytoadherence","volume":"4","author":"Storm","year":"2014","journal-title":"Front Cell Infect Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.3389\/fimmu.2018.02016","article-title":"Cerebral malaria in mouse and man","volume":"9","author":"Ghazanfari","year":"2018","journal-title":"Front Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00281-015-0476-6","article-title":"Pathogenic CD8+ T cells in experimental cerebral malaria","volume":"37","author":"Howland","year":"2015","journal-title":"Semin Immunopathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.pt.2009.10.007","article-title":"The murine cerebral malaria phenomenon","volume":"26","author":"White","year":"2010","journal-title":"Trends Parasitol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/ni.3666","article-title":"The movers and shapers in immune privilege of the CNS","volume":"18","author":"Engelhardt","year":"2017","journal-title":"Nat Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nm986","article-title":"Differentiating the pathologies of cerebral malaria by postmortem parasite counts","volume":"10","author":"Taylor","year":"2004","journal-title":"Nat Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/1475-2875-12-191","article-title":"A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria","volume":"12","author":"Milner","year":"2013","journal-title":"Malar J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1093\/infdis\/jiu592","article-title":"Severity of retinopathy parallels the degree of parasite sequestration in the eyes and brains of Malawian children with fatal cerebral malaria","volume":"211","author":"Barrera","year":"2015","journal-title":"J Infect Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1006267","DOI":"10.1371\/journal.ppat.1006267","article-title":"A quantitative brain map of experimental cerebral malaria pathology","volume":"13","author":"Strangward","year":"2017","journal-title":"PLoS Pathog."},{"key":"B16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbi.2013.04.002","article-title":"CNS-specific T cells shape brain function via the choroid plexus","volume":"34","author":"Baruch","year":"2013","journal-title":"Brain Behav Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1006022","DOI":"10.1371\/journal.ppat.1006022","article-title":"CD8+ T cells induce fatal brainstem pathology during cerebral malaria via luminal antigen-specific engagement of brain vasculature","volume":"12","author":"Swanson","year":"2016","journal-title":"PLoS Pathog."},{"key":"B18","first-page":"1057","article-title":"An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration","volume":"145","author":"Turner","year":"1994","journal-title":"Am J Pathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1004963","DOI":"10.1371\/journal.ppat.1004963","article-title":"Activated brain endothelial cells cross-present malaria antigen","volume":"11","author":"Howland","year":"2015","journal-title":"PLoS Pathog."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e1001021","DOI":"10.1371\/journal.ppat.1001021","article-title":"Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions","volume":"6","author":"Jambou","year":"2010","journal-title":"PLoS Pathog."},{"key":"B21","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1126\/science.aag2638","article-title":"Multifaceted interactions between adaptive immunity and the central nervous system","volume":"353","author":"Kipnis","year":"2016","journal-title":"Science."},{"key":"B22","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.immuni.2016.04.005","article-title":"Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment","volume":"44","author":"Blank","year":"2016","journal-title":"Immunity."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1073\/pnas.0801544105","article-title":"Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria","volume":"105","author":"Campanella","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B24","doi-asserted-by":"publisher","first-page":"98911","DOI":"10.1172\/jci.insight.98911","article-title":"CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria","volume":"3","author":"Sorensen","year":"2018","journal-title":"JCI Insight."},{"key":"B25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fcimb.2017.00324","article-title":"Cytokines and chemokines in cerebral malaria pathogenesis","volume":"7","author":"Dunst","year":"2017","journal-title":"Front Cell Infect Microbiol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01747\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T22:40:13Z","timestamp":1569278413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01747\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,24]]},"references-count":25,"alternative-id":["10.3389\/fimmu.2019.01747"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01747","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,24]]},"article-number":"1747"}}