{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:33:37Z","timestamp":1790728417344,"version":"4.1.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01833","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:25:45Z","timestamp":1565137545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals"],"prefix":"10.3389","volume":"10","author":[{"given":"Claudia","family":"Baumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias M.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Holecska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Pinschewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"L\u00f6hning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.272.5258.54","article-title":"Immunological memory and protective immunity: understanding their relation","volume":"272","author":"Ahmed","year":"1996","journal-title":"Science."},{"key":"B2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/80868","article-title":"Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo","volume":"1","author":"Schluns","year":"2000","journal-title":"Nat Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1084\/jem.20020369","article-title":"Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells","volume":"195","author":"Becker","year":"2002","journal-title":"J Exp Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat Rev Immunol."},{"key":"B5","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.4049\/jimmunol.163.8.4125","article-title":"Induction and visualization of mucosal memory CD8 T cells following systemic virus infection","volume":"163","author":"Kim","year":"1999","journal-title":"J Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1126\/science.1254803","article-title":"T cell memory. Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert","volume":"346","author":"Ariotti","year":"2014","journal-title":"Science."},{"key":"B7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1254536","article-title":"T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"346","author":"Schenkel","year":"2014","journal-title":"Science."},{"key":"B8","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/nature04790","article-title":"Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells","volume":"441","author":"Williams","year":"2006","journal-title":"Nature."},{"key":"B9","doi-asserted-by":"publisher","first-page":"11013","DOI":"10.1073\/pnas.1510119112","article-title":"Transforming growth factor-beta signaling is constantly shaping memory T-cell population","volume":"112","author":"Ma","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e3331","DOI":"10.1371\/journal.pone.0003331","article-title":"The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel \u2018alarmin'?","volume":"3","author":"Moussion","year":"2008","journal-title":"PLoS ONE."},{"key":"B12","doi-asserted-by":"publisher","first-page":"15327","DOI":"10.1038\/ncomms15327","article-title":"Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy","volume":"8","author":"Kallert","year":"2017","journal-title":"Nat Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nrrheum.2011.53","article-title":"Interleukin-33 biology with potential insights into human diseases","volume":"7","author":"Palmer","year":"2011","journal-title":"Nat Rev Rheumatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in health and disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.it.2016.03.007","article-title":"IL-33 in T cell differentiation, function, and immune homeostasis","volume":"37","author":"Peine","year":"2016","journal-title":"Trends Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1126\/science.1215418","article-title":"The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses","volume":"335","author":"Bonilla","year":"2012","journal-title":"Science."},{"key":"B17","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/382174a0","article-title":"Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice","volume":"382","author":"Kaplan","year":"1996","journal-title":"Nature."},{"key":"B18","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1126\/science.1065543","article-title":"Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells","volume":"295","author":"Szabo","year":"2002","journal-title":"Science."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"Muller","year":"1994","journal-title":"Science."},{"key":"B20","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S1074-7613(00)80413-6","article-title":"IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses","volume":"4","author":"Magram","year":"1996","journal-title":"Immunity."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-gamma receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1084\/jem.191.6.1069","article-title":"T1\/ST2-deficient mice demonstrate the importance of T1\/ST2 in developing primary T helper cell type 2 responses","volume":"191","author":"Townsend","year":"2000","journal-title":"J Exp Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0092-8674(00)81289-1","article-title":"Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease","volume":"84","author":"Durbin","year":"1996","journal-title":"Cell."},{"key":"B24","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/342559a0","article-title":"Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen","volume":"342","author":"Pircher","year":"1989","journal-title":"Nature."},{"key":"B25","doi-asserted-by":"publisher","first-page":"18581","DOI":"10.1073\/pnas.1003059107","article-title":"IL-33 is a crucial amplifier of innate rather than acquired immunity","volume":"107","author":"Oboki","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0166-0934(91)90018-U","article-title":"Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates","volume":"33","author":"Battegay","year":"1991","journal-title":"J Virol Methods."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1002\/eji.201141629","article-title":"IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells","volume":"41","author":"Yang","year":"2011","journal-title":"Eur J Immunol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.163.10.5374","article-title":"Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence","volume":"163","author":"Holz","year":"1999","journal-title":"J Immunol."},{"key":"B29","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4049\/jimmunol.162.2.965","article-title":"IL-12 is not required for induction of type 1 cytokine responses in viral infections","volume":"162","author":"Oxenius","year":"1999","journal-title":"J Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.4049\/jimmunol.177.9.5890","article-title":"T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity","volume":"177","author":"Taqueti","year":"2006","journal-title":"J Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1002\/eji.200637023","article-title":"Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections","volume":"37","author":"Bachmann","year":"2007","journal-title":"Eur J Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.immuni.2010.06.003","article-title":"Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation","volume":"32","author":"Wei","year":"2010","journal-title":"Immunity."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1182\/blood-2012-05-428672","article-title":"Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function","volume":"120","author":"Gil","year":"2012","journal-title":"Blood."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.1073\/pnas.1418549112","article-title":"T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses","volume":"112","author":"Baumann","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B36","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3389\/fimmu.2019.00522","article-title":"Pleiotropic effects of IL-33 on CD4+ T cell differentiation and effector functions","volume":"10","author":"Alvarez","year":"2019","journal-title":"Front Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1084\/jem.181.5.1755","article-title":"Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4","volume":"181","author":"Jacobson","year":"1995","journal-title":"J Exp Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.immuni.2009.12.004","article-title":"Interferons direct Th2 cell reprogramming to generate a stable GATA-3+T-bet+ cell subset with combined Th2 and Th1 cell functions","volume":"32","author":"Hegazy","year":"2010","journal-title":"Immunity."},{"key":"B39","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/ni.2623","article-title":"GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling","volume":"14","author":"Wang","year":"2013","journal-title":"Nat Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbaexp.2005.01.012","article-title":"T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3","volume":"1728","author":"Hayakawa","year":"2005","journal-title":"Biochim Biophys Acta."},{"key":"B41","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nature13577","article-title":"The alarmin IL-33 promotes regulatory T-cell function in the intestine","volume":"513","author":"Schiering","year":"2014","journal-title":"Nature."},{"key":"B42","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.immuni.2015.01.016","article-title":"The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway","volume":"42","author":"Endo","year":"2015","journal-title":"Immunity."},{"key":"B43","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.coi.2005.06.002","article-title":"Alarmins: chemotactic activators of immune responses","volume":"17","author":"Oppenheim","year":"2005","journal-title":"Curr Opin Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity."},{"key":"B45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<284::AID-IMMU284>3.0.CO;2-C","article-title":"Kinetics of the response of naive and memory CD8 T cells to antigen: similarities and differences","volume":"29","author":"Zimmermann","year":"1999","journal-title":"Eur J Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/76907","article-title":"Response of naive and memory CD8+ T cells to antigen stimulation in vivo","volume":"1","author":"Veiga-Fernandes","year":"2000","journal-title":"Nat Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.coi.2014.03.004","article-title":"Interleukin 33: a switch-hitting cytokine","volume":"28","author":"Villarreal","year":"2014","journal-title":"Curr Opin Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"943","DOI":"10.4049\/jimmunol.1701757","article-title":"IL-33 augments virus-specific memory T cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccine","volume":"202","author":"McLaren","year":"2019","journal-title":"J Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature14115","article-title":"Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity","volume":"519","author":"Brestoff","year":"2015","journal-title":"Nature."},{"key":"B50","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cell.2014.12.011","article-title":"Activated type 2 innate lymphoid cells regulate beige fat biogenesis","volume":"160","author":"Lee","year":"2015","journal-title":"Cell."},{"key":"B51","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.immuni.2015.05.019","article-title":"Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation","volume":"43","author":"Molofsky","year":"2015","journal-title":"Immunity."},{"key":"B52","doi-asserted-by":"publisher","first-page":"7922","DOI":"10.1128\/JVI.00199-15","article-title":"Cytokine-mediated activation of NK cells during viral infection","volume":"89","author":"Freeman","year":"2015","journal-title":"J Virol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2017.09.052","article-title":"ILC1 confer early host protection at initial sites of viral infection","volume":"171","author":"Weizman","year":"2017","journal-title":"Cell."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1084\/jem.174.6.1425","article-title":"Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression","volume":"174","author":"Fung-Leung","year":"1991","journal-title":"J Exp Med."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01833\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T17:57:28Z","timestamp":1695059848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01833\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,7]]},"references-count":54,"alternative-id":["10.3389\/fimmu.2019.01833"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01833","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,7]]},"article-number":"1833"}}