{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:10:41Z","timestamp":1794265841985,"version":"4.9.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470877"],"award-info":[{"award-number":["31470877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570635"],"award-info":[{"award-number":["81570635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012167","name":"National Science and Technology Infrastructure Program","doi-asserted-by":"publisher","award":["2017ZX10302301-002"],"award-info":[{"award-number":["2017ZX10302301-002"]}],"id":[{"id":"10.13039\/501100012167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012167","name":"National Science and Technology Infrastructure Program","doi-asserted-by":"publisher","award":["2016YFC1200105"],"award-info":[{"award-number":["2016YFC1200105"]}],"id":[{"id":"10.13039\/501100012167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["201704020226"],"award-info":[{"award-number":["201704020226"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["201604020006"],"award-info":[{"award-number":["201604020006"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030311009"],"award-info":[{"award-number":["2015A030311009"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01925","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T04:38:42Z","timestamp":1565757522000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2"],"prefix":"10.3389","volume":"10","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lantian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3201\/eid1509.090442","article-title":"Zika virus outside Africa","volume":"15","author":"Hayes","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","volume":"387","author":"Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.micinf.2015.12.010","article-title":"Zika and microcephaly: causation, correlation, or coincidence?","volume":"18","author":"Tetro","year":"2016","journal-title":"Microbes Infect"},{"key":"B4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.chom.2017.01.004","article-title":"Zika virus pathogenesis and tissue tropism","volume":"21","author":"Miner","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.meegid.2019.01.018","article-title":"ZIKA virus entry mechanisms in human cells","volume":"69","author":"Agrelli","year":"2019","journal-title":"Infect Genet Evol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"35296","DOI":"10.1038\/srep35296","article-title":"ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy","volume":"6","author":"El Costa","year":"2016","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3201\/eid2101.140894","article-title":"Detection of Zika virus in urine","volume":"21","author":"Gourinat","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1590\/1806-9282.64.01.11","article-title":"Microcephaly caused by congenital Zika virus infection and viral detection in maternal urine during pregnancy","volume":"64","author":"Regadas","year":"2018","journal-title":"Rev Assoc Med Bras."},{"key":"B9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/infdis\/jix171","article-title":"Zika virus infection of the human glomerular cells: implications for viral reservoirs and renal pathogenesis","volume":"216","author":"Alcendor","year":"2017","journal-title":"J Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1038\/emi.2017.67","article-title":"Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects","volume":"6","author":"Chen","year":"2017","journal-title":"Emerg Microbes Infect"},{"key":"B11","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00467-017-3588-5","article-title":"Does Zika virus infection induce prolonged remissions in children with idiopathic nephrotic syndrome?","volume":"32","author":"Peralta-Aros","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0006416","DOI":"10.1371\/journal.pntd.0006416","article-title":"Zika virus infection in the Veterans Health Administration (VHA), 2015-2016","volume":"12","author":"Schirmer","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1093\/ckj\/sfs117","article-title":"Acute kidney injury in dengue virus infection","volume":"5","author":"Khalil","year":"2012","journal-title":"Clin Kidney J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e0210360","DOI":"10.1371\/journal.pone.0210360","article-title":"Characteristics and associated factors of acute kidney injury among adult dengue patients: a retrospective single-center study","volume":"14","author":"Diptyanusa","year":"2019","journal-title":"PLoS ONE"},{"key":"B15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s40520-018-1001-2","article-title":"Acute kidney injury is linked to higher mortality in elderly hospitalized patients with non-valvular atrial fibrillation","volume":"31","author":"Novo-Veleiro","year":"2018","journal-title":"Aging Clin Exp Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.3389\/fimmu.2018.02563","article-title":"Inflammasome-independent role of NLRP3 mediates mitochondrial regulation in renal injury","volume":"9","author":"Kim","year":"2018","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000480340","article-title":"Involvement of S100A8\/A9-TLR4-NLRP3 inflammasome pathway in contrast-induced acute kidney injury","volume":"43","author":"Tan","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B18","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/nrneph.2014.91","article-title":"Pattern recognition receptors and the inflammasome in kidney disease","volume":"10","author":"Leemans","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/nyas.12458","article-title":"Mechanism of NLRP3 inflammasome activation","volume":"1319","author":"Sutterwala","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.3389\/fimmu.2018.01900","article-title":"Inflammasomes in tissue damages and immune disorders after trauma","volume":"9","author":"Bortolotti","year":"2018","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"F910","DOI":"10.1152\/ajprenal.00649.2014","article-title":"Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome","volume":"308","author":"Wang","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00430-015-0445-7","article-title":"Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase","volume":"205","author":"Tappe","year":"2016","journal-title":"Med Microbiol Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.immuni.2012.08.027","article-title":"NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells","volume":"37","author":"Masters","year":"2012","journal-title":"Immunity"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1073\/pnas.0809414106","article-title":"Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization","volume":"106","author":"Faustin","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cell.2007.01.045","article-title":"Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1","volume":"129","author":"Bruey","year":"2007","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nature20556","article-title":"Zika virus infection damages the testes in mice","volume":"540","author":"Govero","year":"2016","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1128\/JCM.00279-16","article-title":"Zika virus: diagnostics for an emerging pandemic threat","volume":"54","author":"Waggoner","year":"2016","journal-title":"J Clin Microbiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"9825","DOI":"10.1021\/acsnano.7b03150","article-title":"In situ imaging of tissue remodeling with collagen hybridizing peptides","volume":"11","author":"Hwang","year":"2017","journal-title":"ACS Nano"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1038\/s41467-018-06522-5","article-title":"Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases","volume":"9","author":"Xu","year":"2018","journal-title":"Nat Commun"},{"key":"B30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijdevneu.2015.10.004","article-title":"Inhibition of BCL-2 leads to increased apoptosis and delayed neuronal differentiation in human ReNcell VM cells in vitro","volume":"48","author":"Frohlich","year":"2016","journal-title":"Int J Dev Neurosci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bpa.2017.10.003","article-title":"Biomarkers in acute kidney injury (AKI)","volume":"31","author":"Teo","year":"2017","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"740","DOI":"10.4103\/ijccm.IJCCM_315_17","article-title":"Role of urinary neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury in patients with circulatory shock","volume":"21","author":"Shyam","year":"2017","journal-title":"Indian J Crit Care Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0140-6736(05)74811-X","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery","volume":"365","author":"Mishra","year":"2005","journal-title":"Lancet"},{"key":"B34","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1074\/jbc.273.7.4135","article-title":"Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury","volume":"273","author":"Ichimura","year":"1998","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"F552","DOI":"10.1152\/ajprenal.00285.2002","article-title":"Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury","volume":"286","author":"Ichimura","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1172\/JCI34487","article-title":"Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells","volume":"118","author":"Ichimura","year":"2008","journal-title":"J Clin Invest"},{"key":"B37","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/414872a","article-title":"Structural basis of water-specific transport through the AQP1 water channel","volume":"414","author":"Sui","year":"2001","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1113\/jphysiol.2012.250852","article-title":"Genetic ablation of aquaporin-2 in the mouse connecting tubules results in defective renal water handling","volume":"591","author":"Kortenoeven","year":"2013","journal-title":"J Physiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5049\/EBP.2010.8.1.1","article-title":"Importance of residual water permeability on the excretion of water during water diuresis in rats","volume":"8","author":"Cheema-Dhadli","year":"2010","journal-title":"Electrolyte Blood Press"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.1172\/JCI58662","article-title":"PGC-1alpha promotes recovery after acute kidney injury during systemic inflammation in mice","volume":"121","author":"Tran","year":"2011","journal-title":"J Clin Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"F1239","DOI":"10.1152\/ajprenal.90521.2008","article-title":"Renal tubulointerstitial fibrosis: common but never simple","volume":"296","author":"Hewitson","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol Rev"},{"key":"B43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/nrrheum.2016.166","article-title":"Interleukin-1 function and role in rheumatic disease","volume":"12","author":"Schett","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e1007593","DOI":"10.1371\/journal.ppat.1007593","article-title":"Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation","volume":"15","author":"Negash","year":"2019","journal-title":"PLoS Pathog"},{"key":"B45","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jneuroim.2008.01.009","article-title":"Japanese Encephalitis virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death","volume":"195","author":"Das","year":"2008","journal-title":"J Neuroimmunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.molimm.2017.01.023","article-title":"Regulation and functions of NLRP3 inflammasome during influenza virus infection","volume":"86","author":"Kuriakose","year":"2017","journal-title":"Mol Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/imm.13046","article-title":"Differential role of the NLRP3 inflammasome in infection and tumorigenesis","volume":"156","author":"Tartey","year":"2019","journal-title":"Immunology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1523\/JNEUROSCI.3045-16.2017","article-title":"HIV-1 Tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation","volume":"37","author":"Chivero","year":"2017","journal-title":"J Neurosci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1093\/infdis\/jiy129","article-title":"NLRP3 Inflammasome activation mediates Zika virus-associated inflammation","volume":"217","author":"He","year":"2018","journal-title":"J Infect Dis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41467-017-02645-3","article-title":"Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1beta secretion","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018121218","article-title":"Mitochondria permeability transition versus necroptosis in oxalate-induced AKI","author":"Mulay","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1038\/s41467-019-09753-2","article-title":"Caspase-1 initiates apoptosis in the absence of gasdermin D","volume":"10","author":"Tsuchiya","year":"2019","journal-title":"Nat Commun"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation","volume":"10","author":"Rogers","year":"2019","journal-title":"Nat Commun"},{"key":"B54","doi-asserted-by":"publisher","first-page":"34682","DOI":"10.1038\/srep34682","article-title":"NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis","volume":"6","author":"Shen","year":"2016","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7257","DOI":"10.1523\/JNEUROSCI.0196-06.2006","article-title":"BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death","volume":"26","author":"Akhtar","year":"2006","journal-title":"J Neurosci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01925\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T04:40:50Z","timestamp":1569300050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01925\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":56,"alternative-id":["10.3389\/fimmu.2019.01925"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01925","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fimmu.2019.01925.s001","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fimmu.2019.01925.s002","asserted-by":"subject"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,14]]},"article-number":"1925"}}