{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:33:58Z","timestamp":1785227638370,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02009","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T14:09:22Z","timestamp":1567174162000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["A Computational Pipeline for the Diagnosis of CVID Patients"],"prefix":"10.3389","volume":"10","author":[{"given":"Annelies","family":"Emmaneel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delfien J.","family":"Bogaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Van Gassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Tavernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Dullaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomeen","family":"Haerynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Saeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International consensus document (ICON): common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J Aller Clin Immunol Pract."},{"key":"B2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3466","article-title":"Primary antibody deficiencies","volume":"13","author":"Durandy","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2,212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J Aller Clin Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1136\/jmedgenet-2015-103690","article-title":"Genes associated with common variable immunodeficiency: one diagnosis to rule them all?","volume":"53","author":"Bogaert","year":"2016","journal-title":"J Med Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.jaip.2016.09.006","article-title":"Common variable immunodeficiency disorders (CVID) \u2014 diagnoses of exclusion, especially combined immune defects","volume":"4","author":"Chapel","year":"2016","journal-title":"J Aller Clin Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"39710","DOI":"10.1038\/srep39710","article-title":"Common variable immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia","volume":"7","author":"Stuchl\u00fd","year":"2017","journal-title":"Sci Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/cyto.b.20432","article-title":"Flowcytometric phenotyping of common variable immunodeficiency","volume":"74","author":"Warnatz","year":"2008","journal-title":"Cytometr B Clin Cytometr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3324\/haematol.2016.149112","article-title":"The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives","volume":"102","author":"Bogaert","year":"2017","journal-title":"Haematologica."},{"key":"B10","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.immuni.2015.04.006","article-title":"Thinking outside the gate: single-cell assessments in multiple dimensions","volume":"42","author":"Kvistborg","year":"2015","journal-title":"Immunity."},{"key":"B11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nri.2016.56","article-title":"Computational flow cytometry: helping to make sense of high-dimensional immunology data","volume":"16","author":"Saeys","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1093\/bioinformatics\/btw191","article-title":"flowAI: automatic and interactive anomaly discerning tools for flow cytometry data","volume":"32","author":"Monaco","year":"2016","journal-title":"Bioinformatics."},{"key":"B13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/cyto.a.22837","article-title":"flowClean: Automated identification and removal of fluorescence anomalies in flow cytometry data","volume":"89","author":"Fletez-Brant","year":"2016","journal-title":"Cytomet A J Int Soc Analyt Cytol."},{"key":"B14","first-page":"2579","article-title":"Visualizing data using t-SNE","volume-title":"J Mach Learn Res JMLR.","author":"Van der Maaten","year":"2008"},{"key":"B15","doi-asserted-by":"publisher","first-page":"861","DOI":"10.21105\/joss.00861","article-title":"UMAP: uniform manifold approximation and projection","volume":"3","author":"McInnes","year":"2018","journal-title":"J Open Source Softw."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/cyto.a.23030","article-title":"Comparison of clustering methods for high-dimensional single-cell flow and mass cytometry data","volume":"89","author":"Weber","year":"2016","journal-title":"Cytometry Part A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: using self-organizing maps for visualization and interpretation of cytometry data","volume":"87","author":"Van Gassen","year":"2015","journal-title":"Cytomet A J Int Soc Analyt Cytol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.cell.2015.05.047","article-title":"Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis","volume":"162","author":"Levine","year":"2015","journal-title":"Cell."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.3109\/09513590.2013.852531","article-title":"The immune system and aging: a review","author":"Castelo-Branco","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/cyto.a.22734","article-title":"FloReMi: flow density survival regression using minimal feature redundancy","volume":"89","author":"Van Gassen","year":"2016","journal-title":"Cytometr A J Int Soc Analyt Cytol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02009\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T14:09:26Z","timestamp":1567174166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02009\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":20,"alternative-id":["10.3389\/fimmu.2019.02009"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02009","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,30]]},"article-number":"2009"}}