{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:05:51Z","timestamp":1792447551050,"version":"4.5.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02050","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T12:33:17Z","timestamp":1567600397000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity"],"prefix":"10.3389","volume":"10","author":[{"given":"Heng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.4049\/jimmunol.1600847","article-title":"T cell fates zipped up: how the Bach2 basic leucine zipper transcriptional repressor directs T cell differentiation and function","volume":"197","author":"Richer","year":"2016","journal-title":"J Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/S0140-6736(11)60874-X","article-title":"Identification of IL6R and chromosome 11q13.5 as risk loci for asthma","volume":"378","author":"Ferreira","year":"2011","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ng.2272","article-title":"Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo","volume":"44","author":"Jin","year":"2012","journal-title":"Nat Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ng.249","article-title":"Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci","volume":"40","author":"Cooper","year":"2008","journal-title":"Nat Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/ng.3603","article-title":"Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus","volume":"48","author":"Morris","year":"2016","journal-title":"Nat Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12199","article-title":"BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis","volume":"498","author":"Roychoudhuri","year":"2013","journal-title":"Nature."},{"key":"B8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature02596","article-title":"The transcriptional programme of antibody class switching involves the repressor Bach2","volume":"429","author":"Muto","year":"2004","journal-title":"Nature."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1182\/blood-2013-07-518605","article-title":"Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation","volume":"123","author":"Huang","year":"2014","journal-title":"Blood."},{"key":"B10","doi-asserted-by":"publisher","first-page":"10735","DOI":"10.1073\/pnas.1306691110","article-title":"Bach2 maintains T cells in a naive state by suppressing effector memory-related genes","volume":"110","author":"Tsukumo","year":"2013","journal-title":"Proc Nat Acad Sci USA."},{"key":"B11","doi-asserted-by":"publisher","first-page":"985","DOI":"10.4049\/jimmunol.1302378","article-title":"Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice","volume":"192","author":"Kim","year":"2014","journal-title":"J Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1038\/s41467-018-05676-6","article-title":"SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation","volume":"9","author":"Yu","year":"2018","journal-title":"Nat Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"12596","DOI":"10.1038\/ncomms12596","article-title":"Bach2\u2013Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop","volume":"7","author":"Kuwahara","year":"2016","journal-title":"Nat Commun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1038\/ncomms4555","article-title":"The Menin\u2013Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis","volume":"5","author":"Kuwahara","year":"2014","journal-title":"Nat Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Ann Rev Immun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Ann Rev Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/ni.3054","article-title":"Pathophysiology of T follicular helper cells in humans and mice","volume":"16","author":"Ueno","year":"2015","journal-title":"Nat Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nri2637","article-title":"Dysregulation of germinal centres in autoimmune disease","volume":"9","author":"Vinuesa","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrrheum.2012.58","article-title":"Follicular helper T cells in immunity and systemic autoimmunity","volume":"8","author":"Craft","year":"2012","journal-title":"Nat Rev Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1084\/jem.20081886","article-title":"Follicular helper T cells are required for systemic autoimmunity","volume":"206","author":"Linterman","year":"2009","journal-title":"J Exp Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nature03555","article-title":"A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity","volume":"435","author":"Vinuesa","year":"2005","journal-title":"Nature."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.immuni.2016.04.013","article-title":"Store-operated Ca(2+) entry in follicular T cells controls humoral immune responses and autoimmunity","volume":"44","author":"Vaeth","year":"2016","journal-title":"Immunity."},{"key":"B23","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1177\/0961203314567750","article-title":"Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production","volume":"24","author":"Zhang","year":"2015","journal-title":"Lupus."},{"key":"B24","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1002\/art.39020","article-title":"Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity","volume":"67","author":"Choi","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J Exp Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity."},{"key":"B27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/imr.12040","article-title":"Transcriptional regulation of follicular T-helper (Tfh) cells","volume":"252","author":"Liu","year":"2013","journal-title":"Immunol Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3389\/fimmu.2016.00520","article-title":"Regulators of Tfh cell differentiation","volume":"7","author":"Jogdand","year":"2016","journal-title":"Front Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","article-title":"The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment","volume":"31","author":"Yu","year":"2009","journal-title":"Immunity."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science."},{"key":"B32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/ni.1690","article-title":"The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells","volume":"10","author":"Bauquet","year":"2009","journal-title":"Nat Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.4049\/jimmunol.1103246","article-title":"Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation","volume":"188","author":"Kroenke","year":"2012","journal-title":"J Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3389\/fimmu.2017.00480","article-title":"The transcription factor c-Maf promotes the differentiation of follicular helper T cells","volume":"8","author":"Andris","year":"2017","journal-title":"Front Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.immuni.2018.10.012","article-title":"The transcription factor Ets1 suppresses T follicular helper type 2 cell differentiation to halt the onset of systemic lupus erythematosus","volume":"49","author":"Kim","year":"2018","journal-title":"Immunity."},{"key":"B36","doi-asserted-by":"publisher","first-page":"704","DOI":"10.4049\/jimmunol.1800876","article-title":"BCL6-mediated silencing of PD-1 ligands in germinal center B cells maintains follicular T cell population","volume":"202","author":"Peng","year":"2019","journal-title":"J Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1084\/jem.20141380","article-title":"BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms","volume":"212","author":"Hatzi","year":"2015","journal-title":"J Exp Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4049\/jimmunol.0903505","article-title":"Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)","volume":"185","author":"Yusuf","year":"2010","journal-title":"J Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.4049\/jimmunol.1801626","article-title":"Bach2 negatively regulates T follicular helper cell differentiation and is critical for CD4(+) T cell memory","volume":"202","author":"Geng","year":"2019","journal-title":"J Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.4049\/jimmunol.1801400","article-title":"Bach2 controls T follicular helper cells by direct repression of Bcl-6","volume":"202","author":"Lahmann","year":"2019","journal-title":"J Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/ni.3554","article-title":"TFH cells progressively differentiate to regulate the germinal center response","volume":"17","author":"Weinstein","year":"2016","journal-title":"Nat Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.20090303","article-title":"T follicular helper cells differentiate from Th2 cells in response to helminth antigens","volume":"206","author":"Glatman Zaretsky","year":"2009","journal-title":"J Exp Med."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02050\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T12:33:18Z","timestamp":1567600398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02050\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":42,"alternative-id":["10.3389\/fimmu.2019.02050"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02050","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"article-number":"2050"}}