{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:21:59Z","timestamp":1790403719408,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02071","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T04:20:46Z","timestamp":1568089246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["CXCR5+PD1+ICOS+ Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation"],"prefix":"10.3389","volume":"10","author":[{"given":"Richard","family":"Danger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Chesneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Delbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Le Bot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Kerleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Chenouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Degauque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Conchon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cesbron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Giral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1681\/ASN.2014111120","article-title":"IgG donor-specific anti-human HLA antibody subclasses and kidney allograft antibody-mediated injury","volume":"27","author":"Lefaucheur","year":"2016","journal-title":"J Am Soc Nephrol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1681\/ASN.2016030368","article-title":"Value of donor-specific anti-HLA antibody monitoring and characterization for risk stratification of kidney allograft loss","volume":"28","author":"Viglietti","year":"2017","journal-title":"J Am Soc Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nrneph.2012.81","article-title":"The impact of donor-specific anti-HLA antibodies on late kidney allograft failure","volume":"8","author":"Loupy","year":"2012","journal-title":"Nat Rev Nephrol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1600-6143.2012.04013.x","article-title":"Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant","volume":"12","author":"Wiebe","year":"2012","journal-title":"Am J Transplant."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1111\/j.1600-6143.2009.02799.x","article-title":"Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure","volume":"9","author":"Einecke","year":"2009","journal-title":"Am J Transplant."},{"key":"B6","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/TP.0b013e31827d62e3","article-title":"Incidence and impact of de novo donor-specific alloantibody in primary renal allografts","volume":"95","author":"Everly","year":"2013","journal-title":"Transplantation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/ajt.14584","article-title":"Antibody-mediated rejection: new approaches in prevention and management","volume":"18","author":"Montgomery","year":"2018","journal-title":"Am J Transplant."},{"key":"B8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/ajt.12589","article-title":"Diagnosis and management of antibody-mediated rejection: current status and novel approaches","volume":"14","author":"Djamali","year":"2014","journal-title":"Am J Transplant."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.4049\/jimmunol.1102830","article-title":"Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells","volume":"188","author":"Conlon","year":"2012","journal-title":"J Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/cei.12576","article-title":"Follicular T helper cells and humoral reactivity in kidney transplant patients","volume":"180","author":"de Graav","year":"2015","journal-title":"Clin Exp Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity."},{"key":"B12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1146\/annurev.immunol.26.021607.090344","article-title":"T follicular helper (TFH) cells in normal and dysregulated immune responses","volume":"26","author":"King","year":"2008","journal-title":"Annu Rev Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.immuni.2010.12.012","article-title":"Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion","volume":"34","author":"Morita","year":"2011","journal-title":"Immunity."},{"key":"B14","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity."},{"key":"B15","doi-asserted-by":"publisher","first-page":"230ra46","DOI":"10.1126\/scitranslmed.3008146","article-title":"Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue","volume":"6","author":"Liarski","year":"2014","journal-title":"Sci Transl Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1097\/TP.0000000000001217","article-title":"T follicular helper cells in transplantation","volume":"100","author":"Walters","year":"2016","journal-title":"Transplantation."},{"key":"B17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature12058","article-title":"Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility","volume":"496","author":"Xu","year":"2013","journal-title":"Nature."},{"key":"B18","doi-asserted-by":"publisher","first-page":"26494","DOI":"10.1038\/srep26494","article-title":"ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination","volume":"6","author":"Bentebibel","year":"2016","journal-title":"Sci Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ajt.12526","article-title":"Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection","volume":"14","author":"Kim","year":"2014","journal-title":"Am J Transplant."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1681\/ASN.2015070774","article-title":"Anti-CD28 antibody and belatacept exert differential effects on mechanisms of renal allograft rejection","volume":"27","author":"Ville","year":"2016","journal-title":"J Am Soc Nephrol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/cmi.2015.101","article-title":"T follicular helper expansion and humoral-mediated rejection are independent of the HVEM\/BTLA pathway","volume":"14","author":"Rodriguez-Barbosa","year":"2017","journal-title":"Cell Mol Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/ajt.14400","article-title":"Selective CD28 blockade results in superior inhibition of donor-specific T follicular helper cell and antibody responses relative to CTLA4-Ig","volume":"18","author":"Badell","year":"2018","journal-title":"Am J Transplant."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15517","article-title":"Circulating T Follicular helper cells are a biomarker of humoral alloreactivity and predict donor-specific antibody formation after transplantation","author":"La Muraglia","year":"2019","journal-title":"Am J Transplant."},{"key":"B24","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12882-015-0172-8","article-title":"Increased circulating follicular helper T cells with decreased programmed death-1 in chronic renal allograft rejection","volume":"16","author":"Shi","year":"2015","journal-title":"BMC Nephrol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1111\/ajt.14142","article-title":"Renal operational tolerance is associated with a defect of blood Tfh cells that Exhibit impaired B cell help","volume":"17","author":"Chenouard","year":"2017","journal-title":"Am J Transplant."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1681\/ASN.2017060679","article-title":"Control of humoral response in renal transplantation by belatacept depends on a direct effect on B cells and impaired T follicular helper-B cell crosstalk","volume":"29","author":"Leibler","year":"2018","journal-title":"J Am Soc Nephrol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/ajt.14987","article-title":"Longitudinal profile of circulating T follicular helper lymphocytes parallels anti-HLA sensitization in renal transplant recipients","volume":"19","author":"Cano-Romero","year":"2019","journal-title":"Am J Transplant."},{"key":"B28","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3389\/fimmu.2018.00275","article-title":"CD4+ T cell help is mandatory for naive and memory donor-specific antibody responses: impact of therapeutic immunosuppression","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1038\/s41598-018-22391-w","article-title":"Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype","volume":"8","author":"Desy","year":"2018","journal-title":"Sci Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.it.2014.06.002","article-title":"Phenotype and functions of memory Tfh cells in human blood","volume":"35","author":"Schmitt","year":"2014","journal-title":"Trends Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/oxfordjournals.aje.a115101","article-title":"The impact of confounder selection criteria on effect estimation","volume":"129","author":"Mickey","year":"1989","journal-title":"Am J Epidemiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.4049\/jimmunol.177.7.4927","article-title":"ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells","volume":"177","author":"Bossaller","year":"2006","journal-title":"J Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1084\/jem.192.11.1553","article-title":"CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function","volume":"192","author":"Schaerli","year":"2000","journal-title":"J Exp Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","article-title":"Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production","volume":"192","author":"Breitfeld","year":"2000","journal-title":"J Exp Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","article-title":"Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer","volume":"39","author":"Bindea","year":"2013","journal-title":"Immunity."},{"key":"B36","doi-asserted-by":"publisher","first-page":"E2551","DOI":"10.1073\/pnas.1205894109","article-title":"Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors","volume":"109","author":"Strutt","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/j.1600-6143.2007.01756.x","article-title":"Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection","volume":"7","author":"Nasr","year":"2007","journal-title":"Am J Transplant."},{"key":"B38","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1097\/TP.0b013e3182a203e4","article-title":"Kinetics of homeostatic proliferation and thymopoiesis after rATG induction therapy in kidney transplant patients","volume":"96","author":"Bouvy","year":"2013","journal-title":"Transplantation."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.3389\/fimmu.2018.01184","article-title":"The calcineurin inhibitor tacrolimus specifically suppresses human T follicular helper cells","volume":"9","author":"Wallin","year":"2018","journal-title":"Front Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trim.2017.09.005","article-title":"Impact of immunosuppressive drugs on circulating Tfh cells in kidney transplant recipients: a pilot study","volume":"46","author":"Li","year":"2018","journal-title":"Transpl Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1111\/j.1600-6143.2010.03210.x","article-title":"Immune reconstitution following rabbit antithymocyte globulin","volume":"10","author":"Gurkan","year":"2010","journal-title":"Am J Transplant."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02071\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T04:20:48Z","timestamp":1568089248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02071\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":41,"alternative-id":["10.3389\/fimmu.2019.02071"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02071","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]},"article-number":"2071"}}