{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:38:54Z","timestamp":1773387534703,"version":"3.50.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015M3A9C6030280"],"award-info":[{"award-number":["NRF-2015M3A9C6030280"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1A5A2009656"],"award-info":[{"award-number":["NRF-2015R1A5A2009656"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017M3A9B4051542"],"award-info":[{"award-number":["NRF-2017M3A9B4051542"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1D1A3B06029459"],"award-info":[{"award-number":["NRF-2017R1D1A3B06029459"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02095","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T12:45:11Z","timestamp":1567601111000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Formyl Peptide Receptor 2 Activation Ameliorates Dermal Fibrosis and Inflammation in Bleomycin-Induced Scleroderma"],"prefix":"10.3389","volume":"10","author":[{"given":"Gyu Tae","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Woo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Wook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Gyu","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Chang","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J Clin Invest."},{"key":"B2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrrheum.2011.149","article-title":"Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities","volume":"8","author":"Bhattacharyya","year":"2011","journal-title":"Nat Rev Rheumatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2147\/ITT.S82037","article-title":"Current perspectives on the immunopathogenesis of systemic sclerosis","volume":"5","author":"Fuschiotti","year":"2016","journal-title":"Immunotargets Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/cei.13238","article-title":"The immunopathogenesis of fibrosis in systemic sclerosis","volume":"195","author":"Brown","year":"2019","journal-title":"Clin Exp Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/j.1600-0625.2008.00828.x","article-title":"Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma","volume":"18","author":"Higashi-Kuwata","year":"2009","journal-title":"Exp Dermatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jid.2015.10.058","article-title":"Tamibarotene ameliorates bleomycin-induced dermal fibrosis by modulating phenotypes of fibroblasts, endothelial cells, and immune cells","volume":"136","author":"Toyama","year":"2016","journal-title":"J Invest Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40169-015-0047-4","article-title":"The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases","volume":"4","author":"Wermuth","year":"2015","journal-title":"Clin Transl Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S1471-4906(02)02316-5","article-title":"Formyl-peptide receptors revisited","volume":"23","author":"Le","year":"2002","journal-title":"Trends Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.4049\/jimmunol.171.4.2050","article-title":"Expression and function of formyl peptide receptors on human fibroblast cells","volume":"171","author":"VanCompernolle","year":"2003","journal-title":"J Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1124\/pr.109.001578","article-title":"International union of basic and clinical pharmacology. LXXIII. nomenclature for the formyl peptide receptor (FPR) family","volume":"61","author":"Ye","year":"2009","journal-title":"Pharmacol Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"18736","DOI":"10.18632\/oncotarget.4915","article-title":"FPRs: linking innate immune system and fibrosis","volume":"6","author":"Rossi","year":"2015","journal-title":"Oncotarget."},{"key":"B14","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.4049\/jimmunol.1402819","article-title":"Upregulation of the N-formyl peptide receptors in scleroderma fibroblasts fosters the switch to myofibroblasts","volume":"194","author":"Rossi","year":"2015","journal-title":"J Immunol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2340\/0001555564534537","article-title":"Collagen metabolites in urine in localized scleroderma (morphoea)","volume":"64","author":"Ammitzboll","year":"1984","journal-title":"Acta Derm Venereol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","article-title":"Recent developments in myofibroblast biology: paradigms for connective tissue remodeling","volume":"180","author":"Hinz","year":"2012","journal-title":"Am J Pathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.yjmcc.2015.10.005","article-title":"Has the search for a marker of activated fibroblasts finally come to an end?","volume":"88","author":"Matthijs Blankesteijn","year":"2015","journal-title":"J Mol Cell Cardiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3109\/08977194.2011.595714","article-title":"TGF-beta signaling in fibrosis","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors."},{"key":"B19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1346-8138.2009.00738.x","article-title":"Mechanisms of skin fibrosis in systemic sclerosis","volume":"37","author":"Jinnin","year":"2010","journal-title":"J Dermatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/nrrheum.2014.137","article-title":"Transforming growth factor beta\u2013at the centre of systemic sclerosis","volume":"10","author":"Lafyatis","year":"2014","journal-title":"Nat Rev Rheumatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.3390\/ijms14047193","article-title":"Distinct signaling cascades elicited by different formyl peptide receptor 2 (FPR2) agonists","volume":"14","author":"Cattaneo","year":"2013","journal-title":"Int J Mol Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/ncprheum0375","article-title":"Mechanisms of disease: leukotrienes and lipoxins in scleroderma lung disease\u2013insights and potential therapeutic implications","volume":"3","author":"Kowal-Bielecka","year":"2007","journal-title":"Nat Clin Pract Rheumatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e12628","DOI":"10.14814\/phy2.12628","article-title":"17(R)-resolvin D1 ameliorates bleomycin-induced pulmonary fibrosis in mice","volume":"3","author":"Yatomi","year":"2015","journal-title":"Physiol Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1084\/jem.189.12.1923","article-title":"Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis","volume":"189","author":"Hachicha","year":"1999","journal-title":"J Exp Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1096\/fj.10-159913","article-title":"FPR2\/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis","volume":"24","author":"Maderna","year":"2010","journal-title":"FASEB J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"174ra26","DOI":"10.1126\/scitranslmed.3004812","article-title":"Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma","volume":"5","author":"Barnig","year":"2013","journal-title":"Sci Transl Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.2205","article-title":"The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques","volume":"13","author":"van Gils","year":"2012","journal-title":"Nat Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jacbts.2018.08.005","article-title":"Resolution of inflammation through the lipoxin and ALX\/FPR2 receptor pathway protects against abdominal aortic aneurysms","volume":"3","author":"Petri","year":"2018","journal-title":"JACC Basic Transl Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"14530","DOI":"10.1073\/pnas.1410851111","article-title":"Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway","volume":"111","author":"Fredman","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B30","doi-asserted-by":"publisher","first-page":"S379","DOI":"10.1038\/sj.bjp.0707604","article-title":"Agonist-selective mechanisms of GPCR desensitization","volume":"153","author":"Kelly","year":"2008","journal-title":"Br J Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1002\/cmdc.201700429","article-title":"Functional N-formyl peptide receptor 2 (FPR2) antagonists based on the ureidopropanamide scaffold have potential to protect against inflammation-associated oxidative stress","volume":"12","author":"Stama","year":"2017","journal-title":"ChemMedChem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1365-2567.2010.03367.x","article-title":"Inhibition of neutrophil migration in mice by mouse formyl peptide receptors 1 and 2 dual agonist: indication of cross-desensitization in vivo","volume":"132","author":"Sogawa","year":"2011","journal-title":"Immunology."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood.V94.4.1165","article-title":"A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1\/LXA4R","volume":"94","author":"Deng","year":"1999","journal-title":"Blood."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1182\/blood.V97.10.2941","article-title":"The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1","volume":"97","author":"Li","year":"2001","journal-title":"Blood."},{"key":"B35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/14779072.2019.1612745","article-title":"Pro-inflammatory and pro-resolving mechanisms in the immunopathology of arteriovenous fistula maturation","volume":"17","author":"Satish","year":"2019","journal-title":"Expert Rev Cardiovasc Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1038\/emm.2013.77","article-title":"The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis","volume":"45","author":"Kim","year":"2013","journal-title":"Exp Mol Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.4049\/jimmunol.1102481","article-title":"Airway activation of formyl peptide receptors inhibits Th1 and Th17 cell responses via inhibition of mediator release from immune and inflammatory cells and maturation of dendritic cells","volume":"188","author":"Tae","year":"2012","journal-title":"J Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"6815","DOI":"10.1038\/s41598-019-43321-4","article-title":"WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia-induced lung injuries in newborn mice","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.4049\/jimmunol.1500936","article-title":"Lipoxin A4 Attenuates Constitutive and TGF-beta1-dependent profibrotic activity in human lung myofibroblasts","volume":"195","author":"Roach","year":"2015","journal-title":"J Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1165\/rcmb.2005-0184OC","article-title":"Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor","volume":"34","author":"Wu","year":"2006","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jdermsci.2016.04.006","article-title":"Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis","volume":"83","author":"Stenstrom","year":"2016","journal-title":"J Dermatol Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.jid.2016.08.037","article-title":"Glycyrrhizin ameliorates fibrosis, vasculopathy, and inflammation in animal models of systemic sclerosis","volume":"137","author":"Yamashita","year":"2017","journal-title":"J Invest Dermatol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02095\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T21:03:18Z","timestamp":1695157398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02095\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2019.02095"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02095","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"article-number":"2095"}}