{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:42:15Z","timestamp":1785307335163,"version":"3.55.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02151","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T02:59:56Z","timestamp":1568170796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef\u2013AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells"],"prefix":"10.3389","volume":"10","author":[{"given":"Bingfeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliang","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baijin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiancai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.med.53.082901.104011","article-title":"Immunologic control of HIV-1","volume":"53","author":"Gandhi","year":"2002","journal-title":"Ann Rev Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/nm0703-853","article-title":"HIV-1 pathogenesis","volume":"9","author":"Stevenson","year":"2003","journal-title":"Nat Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev.immunol.21.120601.141053","article-title":"T cell dynamics in HIV-1 infection","volume":"21","author":"Douek","year":"2003","journal-title":"Ann Rev Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nri998","article-title":"Hide, shield and strike back: how HIV-infected cells avoid immune eradication","volume":"3","author":"Peterlin","year":"2003","journal-title":"Nat Rev Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S1074-7613(02)00307-2","article-title":"Live and let die: Nef functions beyond HIV replication","volume":"16","author":"Fackler","year":"2002","journal-title":"Immunity."},{"key":"B6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cub.2005.02.058","article-title":"The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4","volume":"15","author":"Michel","year":"2005","journal-title":"Curr Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature15400","article-title":"SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef","volume":"526","author":"Usami","year":"2015","journal-title":"Nature."},{"key":"B8","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature15399","article-title":"HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation","volume":"526","author":"Rosa","year":"2015","journal-title":"Nature."},{"key":"B9","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1128\/JVI.79.1.632-636.2005","article-title":"Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2","volume":"79","author":"Williams","year":"2005","journal-title":"J Virol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nsmb.2328","article-title":"Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef","volume":"19","author":"Jia","year":"2012","journal-title":"Nat Struct Mol Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1128\/JVI.77.5.3041-3049.2003","article-title":"Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells","volume":"77","author":"Kasper","year":"2003","journal-title":"J Virol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1091\/mbc.e11-11-0928","article-title":"An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I","volume":"23","author":"Dikeakos","year":"2012","journal-title":"Mol Biol Cell."},{"key":"B13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/34929","article-title":"HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes","volume":"391","author":"Collins","year":"1998","journal-title":"Nature."},{"key":"B14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/0092-8674(94)90360-3","article-title":"Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain","volume":"76","author":"Aiken","year":"1994","journal-title":"Cell."},{"key":"B15","doi-asserted-by":"publisher","first-page":"11229","DOI":"10.1073\/pnas.95.19.11229","article-title":"Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity","volume":"95","author":"Craig","year":"1998","journal-title":"Proc Natl Acad Sci USA."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1128\/JVI.75.8.3960-3964.2001","article-title":"Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain","volume":"75","author":"Preusser","year":"2001","journal-title":"J Virol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1742-4690-5-84","article-title":"HIV-1 Nef: at the crossroads","volume":"5","author":"Foster","year":"2008","journal-title":"Retrovirology."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e01822","DOI":"10.1128\/JVI.01822-17","article-title":"Maintenance of AP-2-dependent functional activities of Nef restricts pathways of immune escape from CD8 T lymphocyte responses","volume":"92","author":"Schouest","year":"2018","journal-title":"J Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e01754","DOI":"10.7554\/eLife.01754","article-title":"How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4","volume":"3","author":"Ren","year":"2014","journal-title":"eLife."},{"key":"B20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1128\/JVI.00196-18","article-title":"HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome\/lysosome system","volume":"92","author":"Shi","year":"2018","journal-title":"J Virol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"10915","DOI":"10.1128\/JVI.01246-16","article-title":"The antagonism of HIV-1 Nef to SERINC5 particle infectivity restriction involves the counteraction of virion-associated pools of the restriction factor","volume":"90","author":"Trautz","year":"2016","journal-title":"J Virol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"28539","DOI":"10.1074\/jbc.M114.600031","article-title":"Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment","volume":"289","author":"Alvarado","year":"2014","journal-title":"J Biol Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1002\/j.1460-2075.1995.tb07024.x","article-title":"Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4","volume":"14","author":"Saksela","year":"1995","journal-title":"EMBO J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/nm1101-1217","article-title":"HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals","volume":"7","author":"Wolf","year":"2001","journal-title":"Nat Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"12732","DOI":"10.1128\/JVI.79.20.12732-12741.2005","article-title":"Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef\/p21-activated kinase 2 complex","volume":"79","author":"Raney","year":"2005","journal-title":"J Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"93684","DOI":"10.1172\/jci.insight.93684","article-title":"Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro","volume":"2","author":"Mujib","year":"2017","journal-title":"JCI Insight."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.bmcl.2016.01.043","article-title":"Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists","volume":"26","author":"Emert-Sedlak","year":"2016","journal-title":"Bioorg Med Chem Lett."},{"key":"B28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.chembiol.2012.11.005","article-title":"Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity","volume":"20","author":"Emert-Sedlak","year":"2013","journal-title":"Chem Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1742-4690-10-135","article-title":"Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen","volume":"10","author":"Trible","year":"2013","journal-title":"Retrovirology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1091\/mbc.e10-05-0470","article-title":"Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action","volume":"21","author":"Dikeakos","year":"2010","journal-title":"Mol Biol Cell."},{"key":"B31","doi-asserted-by":"publisher","first-page":"19256","DOI":"10.1073\/pnas.0707130104","article-title":"Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: application to the HIV-1 Nef protein","volume":"104","author":"Betzi","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B32","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1021\/cb900195c","article-title":"Chemical library screens targeting an HIV-1 accessory factor\/host cell kinase complex identify novel antiretroviral compounds","volume":"4","author":"Emert-Sedlak","year":"2009","journal-title":"ACS Chem Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e20033","DOI":"10.1371\/journal.pone.0020033","article-title":"Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef","volume":"6","author":"Breuer","year":"2011","journal-title":"PLoS ONE."},{"key":"B34","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12916-015-0517-y","article-title":"HIV-1 functional cure: will the dream come true?","volume":"13","author":"Liu","year":"2015","journal-title":"BMC Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e174","DOI":"10.1093\/nar\/gnh172","article-title":"Site-directed, Ligase-Independent Mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h","volume":"32","author":"Chiu","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e1003398","DOI":"10.1371\/journal.ppat.1003398","article-title":"Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay","volume":"9","author":"Laird","year":"2013","journal-title":"PLoS Pathog."},{"key":"B37","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nature14053","article-title":"Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations","volume":"517","author":"Deng","year":"2015","journal-title":"Nature."},{"key":"B38","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1074\/jbc.M004895200","article-title":"The multimerization of human immunodeficiency virus type I Vif protein: a requirement for Vif function in the viral life cycle","volume":"276","author":"Yang","year":"2001","journal-title":"J Biol Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.clinbiochem.2007.03.016","article-title":"Mevalonate pathway: a review of clinical and therapeutical implications","volume":"40","author":"Buhaescu","year":"2007","journal-title":"Clin Biochem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S0092-8674(02)01162-5","article-title":"HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway","volume":"111","author":"Blagoveshchenskaya","year":"2002","journal-title":"Cell."},{"key":"B41","doi-asserted-by":"publisher","first-page":"7535","DOI":"10.1128\/JVI.76.15.7535-7543.2002","article-title":"Different effects of Nef-mediated HLA class I down-regulation on human immunodeficiency virus type 1-specific CD8+ T-cell cytolytic activity and cytokine production","volume":"76","author":"Tomiyama","year":"2002","journal-title":"J Virol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1128\/JVI.76.4.1626-1631.2002","article-title":"Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes","volume":"76","author":"Yang","year":"2002","journal-title":"J Virol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1091\/mbc.e07-03-0218","article-title":"HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2","volume":"18","author":"Lubben","year":"2007","journal-title":"Mol Biol Cell."},{"key":"B44","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","article-title":"Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annual review of biochemistry","volume":"72","author":"Bonifacino","year":"2003"},{"key":"B45","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jmb.2009.09.047","article-title":"HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication","volume":"394","author":"Poe","year":"2009","journal-title":"J Mol Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1074\/jbc.M707760200","article-title":"The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail","volume":"283","author":"Wonderlich","year":"2008","journal-title":"J Biol Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1093\/emboj\/17.10.2777","article-title":"The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes","volume":"17","author":"Greenberg","year":"1998","journal-title":"EMBO J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1083\/jcb.200407031","article-title":"HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail","volume":"167","author":"Roeth","year":"2004","journal-title":"J Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.immuni.2018.04.030","article-title":"Targeting the latent reservoir for HIV-1","volume":"48","author":"Sengupta","year":"2018","journal-title":"Immunity."},{"key":"B50","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1084\/jem.20040061","article-title":"Statins inhibit HIV-1 infection by down-regulating Rho activity","volume":"200","author":"del Real","year":"2004","journal-title":"J Exp Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1097\/QAD.0000000000000475","article-title":"Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients","volume":"28","author":"Overton","year":"2014","journal-title":"AIDS."},{"key":"B52","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/QAD.0000000000000917","article-title":"Atorvastatin restricts HIV replication in CD4+ T cells by upregulation of p21","volume":"30","author":"Elahi","year":"2016","journal-title":"AIDS."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/S0969-2126(97)00286-4","article-title":"The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling","volume":"5","author":"Arold","year":"1997","journal-title":"Structure."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1002\/pro.5560060613","article-title":"Refined solution structure and backbone dynamics of HIV-1 Nef","volume":"6","author":"Grzesiek","year":"1997","journal-title":"Protein Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S0092-8674(00)81276-3","article-title":"Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain","volume":"85","author":"Lee","year":"1996","journal-title":"Cell."},{"key":"B56","doi-asserted-by":"publisher","first-page":"8725","DOI":"10.1074\/jbc.M210115200","article-title":"HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes","volume":"278","author":"Janvier","year":"2003","journal-title":"J Biol Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1083\/jcb.200307157","article-title":"Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes","volume":"163","author":"Janvier","year":"2003","journal-title":"J Cell Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1126\/science.1075327","article-title":"Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network","volume":"297","author":"Doray","year":"2002","journal-title":"Science."},{"key":"B59","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1042\/bst0230557","article-title":"The role of myristoylation in the interactions between human immunodeficiency virus type I Nef and cellular proteins","volume":"23","author":"Harris","year":"1995","journal-title":"Biochem Soc Transac."},{"key":"B60","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.virol.2006.07.003","article-title":"Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef","volume":"355","author":"Giese","year":"2006","journal-title":"Virology."},{"key":"B61","doi-asserted-by":"publisher","first-page":"201700014","DOI":"10.1002\/bies.201700014","article-title":"Prenylation of viral proteins by enzymes of the host: virus-driven rationale for therapy with statins and FT\/GGT1 inhibitors","volume":"39","author":"Marakasova","year":"2017","journal-title":"Bioessays."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1128\/JVI.78.4.1685-1696.2004","article-title":"Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity","volume":"78","author":"Alexander","year":"2004","journal-title":"J Virol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"5391","DOI":"10.1182\/blood-2010-11-320226","article-title":"HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo","volume":"117","author":"Chapuis","year":"2011","journal-title":"Blood."},{"key":"B64","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1172\/JCI80566","article-title":"HIV-specific CD8+ T cells and HIV eradication","volume":"126","author":"Jones","year":"2016","journal-title":"J Clin Invest."},{"key":"B65","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.coviro.2019.04.004","article-title":"Development of CAR-T cells for long-term eradication and surveillance of HIV-1 reservoir","volume":"38","author":"Liu","year":"2019","journal-title":"Curr Opin Virol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"77732","DOI":"10.18632\/oncotarget.12792","article-title":"Efficient generation of antigen-specific CTLs by the BAFF-activated human B Lymphocytes as APCs: a novel approach for immunotherapy","volume":"7","author":"Yiwen","year":"2016","journal-title":"Oncotarget."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02151\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T07:38:12Z","timestamp":1569137892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02151\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":66,"alternative-id":["10.3389\/fimmu.2019.02151"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02151","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]},"article-number":"2151"}}