{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:55:02Z","timestamp":1790762102988,"version":"4.1.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02185","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T11:58:17Z","timestamp":1568375897000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia"],"prefix":"10.3389","volume":"10","author":[{"given":"Mehwish","family":"Younas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Psomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Reynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Cezar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Kundura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Portales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Merle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Atoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Le Moing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Barbuat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Moranne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Sotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Fabbro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dunyach-Remy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Reynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Lavigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Corbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.imlet.2014.01.008","article-title":"Persistent inflammation in HIV infection: established concepts, new perspectives","volume":"161","author":"Nasi","year":"2014","journal-title":"Immunol Lett."},{"key":"B2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11904-012-0118-8","article-title":"HIV and inflammation: mechanisms and consequences","volume":"9","author":"Hunt","year":"2012","journal-title":"Curr HIV\/AIDS Rep."},{"key":"B3","first-page":"1387","article-title":"Antiretroviral Therapy Cohort C. Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies","volume-title":"Clin Infect Dis.","year":"2010"},{"key":"B4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ebiom.2016.05.008","article-title":"One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: the ACTIVIH study","volume":"8","author":"Psomas","year":"2016","journal-title":"EBioMed."},{"key":"B5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/hiv.12310","article-title":"Immune activation in the course of HIV-1 infection: causes, phenotypes and persistence under therapy","volume":"17","author":"Younas","year":"2016","journal-title":"HIV Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1086\/597476","article-title":"Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection","volume":"199","author":"Jiang","year":"2009","journal-title":"J Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12","author":"Brenchley","year":"2006","journal-title":"Nat Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1000852","DOI":"10.1371\/journal.ppat.1000852","article-title":"Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation","volume":"6","author":"Nazli","year":"2010","journal-title":"PLoS Pathog."},{"key":"B9","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1086\/381396","article-title":"Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy","volume":"189","author":"Li","year":"2004","journal-title":"J Infect Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1004543","DOI":"10.1371\/journal.ppat.1004543","article-title":"Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation","volume":"10","author":"Schuetz","year":"2014","journal-title":"PLoS Pathog."},{"key":"B11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/QAD.0000000000000511","article-title":"Gut epithelial barrier and systemic inflammation during chronic HIV infection","volume":"29","author":"Somsouk","year":"2015","journal-title":"AIDS."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1093\/gerona\/gls178","article-title":"Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults","volume":"67","author":"Stehle","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1093\/infdis\/jiu238","article-title":"Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection","volume":"210","author":"Hunt","year":"2014","journal-title":"J Infect Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/mi.2013.116","article-title":"An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia","volume":"7","author":"Dillon","year":"2014","journal-title":"Mucosal Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.chom.2013.08.006","article-title":"Alterations in the gut microbiota associated with HIV-1 infection","volume":"14","author":"Lozupone","year":"2013","journal-title":"Cell Host Microbe."},{"key":"B16","doi-asserted-by":"publisher","first-page":"193ra191","DOI":"10.1126\/scitranslmed.3006438","article-title":"Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism","volume":"5","author":"Vujkovic-Cvijin","year":"2013","journal-title":"Sci Transl Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ebiom.2016.01.032","article-title":"Gut microbiota linked to sexual preference and HIV infection","volume":"5","author":"Noguera-Julian","year":"2016","journal-title":"EBio Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1182\/blood-2013-06-507012","article-title":"Maraviroc-induced decrease in circulating bacterial products is not linked to an increase in immune activation in HIV-infected individuals","volume":"122","author":"Psomas","year":"2013","journal-title":"Blood."},{"key":"B19","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1056\/NEJM200108093450603","article-title":"Dysfunction of endothelial protein C activation in severe meningococcal sepsis","volume":"345","author":"Faust","year":"2001","journal-title":"N Engl J Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"507","DOI":"10.4161\/viru.24530","article-title":"Biomarkers of endothelial activation\/dysfunction in infectious diseases","volume":"4","author":"Page","year":"2013","journal-title":"Virulence."},{"key":"B21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0008-6363(02)00512-6","article-title":"TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS","volume":"56","author":"Zeuke","year":"2002","journal-title":"Cardiovasc Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1002\/1529-0131(200112)44:12<2870::AID-ART475>3.0.CO;2-Y","article-title":"Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype","volume":"44","author":"Meroni","year":"2001","journal-title":"Arthritis Rheum"},{"key":"B23","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/QAI.0000000000000339","article-title":"Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART","volume":"67","author":"Pedersen","year":"2014","journal-title":"J Acquir Immune Defic Syndr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/1471-2334-14-521","article-title":"A 12 week longitudinal study of microbial translocation and systemic inflammation in undernourished HIV-infected Zambians initiating antiretroviral therapy","volume":"14","author":"Canipe","year":"2014","journal-title":"BMC Infect Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/QAI.0b013e31829f919d","article-title":"Microbial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction","volume":"64","author":"Pedersen","year":"2013","journal-title":"J Acquir Immune Defic Syndr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/hiv.12015","article-title":"Markers of microbial translocation predict hypertension in HIV-infected individuals","volume":"14","author":"Manner","year":"2013","journal-title":"HIV Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e97171","DOI":"10.1371\/journal.pone.0097171","article-title":"Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature","volume":"9","author":"Steele","year":"2014","journal-title":"PLoS ONE."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E64","DOI":"10.3390\/microorganisms5040064","article-title":"Markers of microbial translocation and immune activation predict cognitive processing speed in heavy-drinking men living with HIV","volume":"5","author":"Monnig","year":"2017","journal-title":"Microorganisms."},{"key":"B29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jpsychires.2017.11.009","article-title":"Increased systemic microbial translocation is associated with depression during early pregnancy","volume":"97","author":"Zhou","year":"2018","journal-title":"J Psychiatr Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1093\/infdis\/jit225","article-title":"Microbial translocation and liver disease progression in women coinfected with HIV and hepatitis C virus","volume":"208","author":"French","year":"2013","journal-title":"J Infect Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1097\/QAD.0000000000001771","article-title":"A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma","volume":"32","author":"Epeldegui","year":"2018","journal-title":"AIDS."},{"key":"B32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/COH.0000000000000429","article-title":"Altered gut microbiome composition in HIV infection: causes, effects and potential intervention","volume":"13","author":"Bandera","year":"2018","journal-title":"Curr Opin HIV AIDS."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02185\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T11:58:18Z","timestamp":1568375898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02185\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,13]]},"references-count":32,"alternative-id":["10.3389\/fimmu.2019.02185"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02185","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,13]]},"article-number":"2185"}}