{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:42:24Z","timestamp":1790808144770,"version":"4.1.0"},"reference-count":118,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007903","name":"Bloodwise","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02193","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T04:59:51Z","timestamp":1568782791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":101,"title":["The T-cell Response to Epstein-Barr Virus\u2013New Tricks From an Old Dog"],"prefix":"10.3389","volume":"10","author":[{"given":"Heather M.","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Meckiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/s0140-6736(64)91524-7","article-title":"Virus particles in cultured lymphoblasts from Burkitt's lymphoma","volume":"1","author":"Epstein","year":"1964","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1038\/cti.2015.1","article-title":"Infectious mononucleosis","volume":"4","author":"Balfour","year":"2015","journal-title":"Clin Transl Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/infdis\/jis646","article-title":"Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students","volume":"207","author":"Balfour","year":"2013","journal-title":"J Infect Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1086\/505400","article-title":"A cohort study among university students: identification of risk factors for Epstein-Barr virus seroconversion and infectious mononucleosis","volume":"43","author":"Crawford","year":"2006","journal-title":"Clin Infect Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1056\/NEJMoa023141","article-title":"Characteristics of Hodgkin's lymphoma after infectious mononucleosis","volume":"349","author":"Hjalgrim","year":"2003","journal-title":"New Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/978-3-319-22822-8_15","article-title":"EBV and autoimmunity","volume":"390","author":"Ascherio","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B7","first-page":"p. 1898","article-title":"Epstein-Barr virus","volume-title":"Fields Virology","author":"Longnecker","year":"2013"},{"key":"B8","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1146\/annurev-immunol-032414-112326","article-title":"The immunology of Epstein-Barr virus-induced disease","volume":"33","author":"Taylor","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.coviro.2013.04.005","article-title":"The pathogenesis of Epstein-Barr virus persistent infection","volume":"3","author":"Thorley-Lawson","year":"2013","journal-title":"Curr Opin Virol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1000341","DOI":"10.1371\/journal.ppat.1000341","article-title":"An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp\/BHRF1 link","volume":"5","author":"Kelly","year":"2009","journal-title":"PLoS Pathog"},{"key":"B11","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S1074-7613(00)00049-2","article-title":"The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell","volume":"13","author":"Babcock","year":"2000","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00279094","article-title":"A routine method for the establishment of permanent growing lymphoblastoid cell lines","volume":"73","author":"Neitzel","year":"1986","journal-title":"Hum Genet"},{"key":"B13","first-page":"75","article-title":"Lymphoblastoid cell lines: a continuous in vitro source of cells to study carcinogen sensitivity and DNA repair","volume":"1","author":"Hussain","year":"2012","journal-title":"Int J Mol Cell Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int J Cancer"},{"key":"B15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1074-7613(00)80622-6","article-title":"EBV persistence in memory B cells in vivo","volume":"9","author":"Babcock","year":"1998","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.archoralbio.2010.06.009","article-title":"Shedding dynamics of Epstein-Barr virus: a type 1 carcinogen","volume":"55","author":"Perera","year":"2010","journal-title":"Arch Oral Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.1038\/cti.2016.28","article-title":"Epstein\u2013Barr virus dynamics in asymptomatic immunocompetent adults: an intensive 6-month study","volume":"5","author":"Johnson","year":"2016","journal-title":"Clin Trans Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fonc.2019.00109","article-title":"Epstein Barr virus associated B-cell lymphomas and iatrogenic lymphoproliferative disorders","volume":"9","author":"Crombie","year":"2019","journal-title":"Front Oncol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1005286","DOI":"10.1371\/journal.ppat.1005286","article-title":"The incubation period of primary Epstein-Barr virus infection: viral dynamics and immunologic events","volume":"11","author":"Dunmire","year":"2015","journal-title":"PLoS Pathog"},{"key":"B20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12288-012-0207-2","article-title":"Epstein-Barr virus infection masquerading as acute leukemia: a report of two cases and review of literature","volume":"30","author":"Chhabra","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1086\/491741","article-title":"Differential targeting and shifts in the immunodominance of Epstein-Barr virus\u2013specific CD8 and CD4 T cell responses during acute and persistent infection","volume":"192","author":"Woodberry","year":"2005","journal-title":"J Infect Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5398","DOI":"10.4049\/jimmunol.1301629","article-title":"CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response","volume":"191","author":"Abbott","year":"2013","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1172\/JCI24810","article-title":"Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance","volume":"115","author":"Hislop","year":"2005","journal-title":"J Clin Invest"},{"key":"B24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1084\/jem.20041542","article-title":"CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells","volume":"201","author":"Pudney","year":"2005","journal-title":"J Exp Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.4049\/jimmunol.167.8.4450","article-title":"Differential evolution and stability of epitope-specific CD8(+) T cell responses in EBV infection","volume":"167","author":"Catalina","year":"2001","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1084\/jem.20011692","article-title":"Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection","volume":"195","author":"Hislop","year":"2002","journal-title":"J Exp Med"},{"key":"B27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1074-7613(00)80397-0","article-title":"Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing","volume":"7","author":"Blake","year":"1997","journal-title":"Immunity"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1084\/jem.187.9.1395","article-title":"Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo","volume":"187","author":"Callan","year":"1998","journal-title":"J Exp Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.4049\/jimmunol.168.8.4184","article-title":"Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cells","volume":"168","author":"Catalina","year":"2002","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1172\/JCI10590","article-title":"CD8(+) T-cell selection, function, and death in the primary immune response in vivo","volume":"106","author":"Callan","year":"2000","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1182\/blood-2003-06-1791","article-title":"Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection","volume":"103","author":"Soares","year":"2004","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.4049\/jimmunol.170.5.2590","article-title":"Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection","volume":"170","author":"Precopio","year":"2003","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1084\/jem.20022058","article-title":"Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection","volume":"198","author":"Amyes","year":"2003","journal-title":"J Exp Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1084\/jem.20121437","article-title":"MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response","volume":"210","author":"Long","year":"2013","journal-title":"J Exp Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1365-2249.2008.03699.x","article-title":"Detailed analysis of EpsteinBarr virus-specific CD4+ and CD8+ T cell responses during infectious mononucleosis","volume":"153","author":"Scherrenburg","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1073\/pnas.84.2.570","article-title":"Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection","volume":"84","author":"Henle","year":"1987","journal-title":"Proc Natl Acad Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/jmv.1890390311","article-title":"Expression of Epstein-Barr virus nuclear antigen 1,2A and 2B in the baculovirus expression system: serological evaluation of human antibodies to these proteins","volume":"39","author":"Hille","year":"1993","journal-title":"J Med Virol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4896","DOI":"10.1128\/JVI.79.8.4896-4907.2005","article-title":"CD4+ T-cell responses to Epstein-Barr Virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines","volume":"79","author":"Long","year":"2005","journal-title":"J Virol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4049\/jimmunol.1100590","article-title":"Cytotoxic CD4+ T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition","volume":"187","author":"Long","year":"2011","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e583","DOI":"10.1371\/journal.pone.0000583","article-title":"Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy","volume":"2","author":"Adhikary","year":"2007","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3389\/fmicb.2018.00416","article-title":"Emergence of CD4+ and CD8+ Polyfunctional T cell responses against immunodominant lytic and latent EBV antigens in children with primary EBV infection","volume":"9","author":"Lam","year":"2018","journal-title":"Front Microbiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.4049\/jimmunol.1900377","article-title":"Primary EBV infection induces an acute wave of activated antigen-specific cytotoxic CD4+ T cells","volume":"203","author":"Meckiff","year":"2019","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"5954","DOI":"10.4049\/jimmunol.168.11.5954","article-title":"Characterization of CD4(+) CTLs ex vivo","volume":"168","author":"Appay","year":"2002","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1086\/428097","article-title":"Long-term shedding of infectious Epstein-Barr virus after infectious mononucleosis","volume":"191","author":"Fafi-Kremer","year":"2005","journal-title":"J Infect Dis"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1086\/491740","article-title":"A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis","volume":"192","author":"Balfour","year":"2005","journal-title":"J Infect Dis"},{"key":"B46","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1182\/blood-2002-01-0160","article-title":"Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential","volume":"100","author":"Dunne","year":"2002","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/ijc.2910220305","article-title":"Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations during seroconversion","volume":"22","author":"Biggar","year":"1978","journal-title":"Int J Cancer"},{"key":"B48","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/infdis\/139.5.553","article-title":"Primary infection with Epstein-Barr virus in infants in the United States: clinical and serologic observations","volume":"139","author":"Fleisher","year":"1979","journal-title":"J Infect Dis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1004746","DOI":"10.1371\/journal.ppat.1004746","article-title":"Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children","volume":"11","author":"Jayasooriya","year":"2015","journal-title":"PLoS Pathog"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1182\/blood.v98.13.3739","article-title":"Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load","volume":"98","author":"Silins","year":"2001","journal-title":"Blood"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e00382","DOI":"10.1128\/JVI.00382-17","article-title":"Asymptomatic primary infection with Epstein-Barr virus: observations on young adult cases","volume":"91","author":"Abbott","year":"2017","journal-title":"J Virol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.4049\/jimmunol.167.4.2019","article-title":"EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function","volume":"167","author":"Hislop","year":"2001","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e1003076","DOI":"10.1371\/journal.ppat.1003076","article-title":"The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age","volume":"8","author":"Lelic","year":"2012","journal-title":"PLoS Pathog"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e1002889","DOI":"10.1371\/journal.ppat.1002889","article-title":"Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years","volume":"8","author":"Klarenbeek","year":"2012","journal-title":"PLoS Pathog"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.4049\/jimmunol.180.3.1643","article-title":"EBV latent membrane proteins. (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines","volume":"180","author":"Haigh","year":"2008","journal-title":"J Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"8649","DOI":"10.1128\/jvi.75.18.8649-8659.2001","article-title":"Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responses","volume":"75","author":"Leen","year":"2001","journal-title":"J Virol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1365-2567.2011.03476.x","article-title":"Long-term carriers generate Epstein-Barr virus (EBV)-specific CD4(+) and CD8(+) polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins","volume":"134","author":"Ning","year":"2011","journal-title":"Immunology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nri.2015.3","article-title":"Tissue-resident memory T cells: local specialists in immune defence","volume":"16","author":"Mueller","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","article-title":"Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets","volume":"38","author":"Sathaliyawala","year":"2013","journal-title":"Immunity"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","article-title":"Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites","volume":"20","author":"Kumar","year":"2017","journal-title":"Cell Rep"},{"key":"B61","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/S0531-5131(03)00964-6","article-title":"Immunology of tonsils and adenoids: everything the ENT surgeon needs to know","volume":"67","author":"Brandtzaeg","year":"2003","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1128\/JVI.02003-14","article-title":"Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function","volume":"89","author":"Remmerswaal","year":"2015","journal-title":"J Virol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1182\/blood-2008-02-138040","article-title":"Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow","volume":"112","author":"Palendira","year":"2008","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e1005799","DOI":"10.1371\/journal.ppat.1005799","article-title":"Compartmentalization of total and virus-specific tissue-resident memory CD8+ T cells in human lymphoid organs","volume":"12","author":"Woon","year":"2016","journal-title":"PLoS Pathog"},{"key":"B65","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nature04606","article-title":"CD69 acts downstream of interferon-alpha\/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs","volume":"440","author":"Shiow","year":"2006","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/eji.201646837","article-title":"CD69: from activation marker to metabolic gatekeeper","volume":"47","author":"Cibri\u00e1n","year":"2017","journal-title":"Eur J Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.4049\/jimmunol.175.7.4355","article-title":"Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population","volume":"175","author":"Woodberry","year":"2005","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/modpathol.3800369","article-title":"Distribution and phenotype of Epstein-Barr virus-infected cells in human pharyngeal tonsils","volume":"18","author":"Hudnall","year":"2005","journal-title":"Mod Pathol"},{"key":"B70","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1074-7613(00)00048-0","article-title":"EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency","volume":"13","author":"Kurth","year":"2000","journal-title":"Immunity"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.3389\/fimmu.2018.01501","article-title":"Development and selection of the human V\u03b39V\u03b42+ T-cell repertoire","volume":"9","author":"Willcox","year":"2018","journal-title":"Front Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.it.2018.03.003","article-title":"Recasting human V\u03b41 lymphocytes in an adaptive role","volume":"39","author":"Davey","year":"2018","journal-title":"Trends Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e1004702","DOI":"10.1371\/journal.ppat.1004702","article-title":"\u03b3\u03b4 T cells confer protection against murine cytomegalovirus (MCMV)","volume":"11","author":"Khairallah","year":"2015","journal-title":"PLoS Pathog"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1004481","DOI":"10.1371\/journal.ppat.1004481","article-title":"Control of murine cytomegalovirus infection by \u03b3\u03b4 T cells","volume":"11","author":"Sell","year":"2015","journal-title":"PLOS Pathogens"},{"key":"B75","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1126\/science.1063916","article-title":"Regulation of cutaneous malignancy by gamma delta T cells","volume":"294","author":"Girardi","year":"2001","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/nm.3909","article-title":"The prognostic landscape of genes and infiltrating immune cells across human cancers","volume":"21","author":"Gentles","year":"2015","journal-title":"Nat Med"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/infdis\/161.5.1013","article-title":"Gamma delta T cell receptor-bearing lymphocytes during Epstein-Barr virus infection","volume":"161","author":"De Paoli","year":"1990","journal-title":"J Infect Dis"},{"key":"B78","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1365-2141.1991.tb07990.x","article-title":"Elevated T cell receptor gamma delta + T cells in patients with infectious mononucleosis","volume":"77","author":"Hassan","year":"1991","journal-title":"Br J Haematol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"17775","DOI":"10.1038\/s41598-017-18195-z","article-title":"Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection","volume":"7","author":"Zhong","year":"2017","journal-title":"Sci Rep"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1038\/bmt.2013.75","article-title":"Clinical evidence implicating gamma-delta T cells in EBV control following cord blood transplantation","volume":"48","author":"Farnault","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"B81","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1365-2249.2007.03388.x","article-title":"Skewed T cell receptor repertoire of Vdelta1(+) gammadelta T lymphocytes after human allogeneic haematopoietic stem cell transplantation and the potential role for Epstein-Barr virus-infected B cells in clonal restriction","volume":"149","author":"Fujishima","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/ijc.10326","article-title":"Peripheral gamma delta T-cell deficit in nasopharyngeal carcinoma","volume":"99","author":"Zheng","year":"2002","journal-title":"Int J Cancer"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s00262-008-0629-8","article-title":"Phenotypic and functional alterations of Vgamma2Vdelta2 T cell subsets in patients with active nasopharyngeal carcinoma","volume":"58","author":"Puan","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"B84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1475-2875-6-69","article-title":"Selective activation of TCR-\u03b3\u03b4+ cells in endemic Burkitt's lymphoma","volume":"6","author":"Futagbi","year":"2007","journal-title":"Malar J"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1002\/ijc.23374","article-title":"Authentication of nasopharyngeal carcinoma tumor lines","volume":"122","author":"Chan","year":"2008","journal-title":"Int J Cancer"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1038\/s41467-018-04076-0","article-title":"The human V\u03b42+ T-cell compartment comprises distinct innate-like V\u03b39+ and adaptive V\u03b39- subsets","volume":"9","author":"Davey","year":"2018","journal-title":"Nat Commun"},{"key":"B87","doi-asserted-by":"publisher","first-page":"14760","DOI":"10.1038\/ncomms14760","article-title":"Clonal selection in the human V\u03b41 T cell repertoire indicates \u03b3\u03b4 TCR-dependent adaptive immune surveillance","volume":"8","author":"Davey","year":"2017","journal-title":"Nat Commun"},{"key":"B88","first-page":"1300","article-title":"Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines","volume":"28","author":"Klein","year":"1968","journal-title":"Cancer Res"},{"key":"B89","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00262-006-0235-6","article-title":"Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens","volume":"56","author":"Hebbeler","year":"2007","journal-title":"Cancer Immunol Immunother"},{"key":"B90","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.4049\/jimmunol.148.8.2315","article-title":"MHC-unrestricted cytotoxic and proliferative responses of two distinct human gamma\/delta T cell subsets to Daudi cells","volume":"148","author":"Fisch","year":"1992","journal-title":"J Immunol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1126\/science.1978758","article-title":"Recognition by human V gamma 9\/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells","volume":"250","author":"Fisch","year":"1990","journal-title":"Science"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1084\/jem.171.5.1567","article-title":"Gamma\/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis","volume":"171","author":"Fisch","year":"1990","journal-title":"J Exp Med"},{"key":"B93","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.4049\/jimmunol.151.3.1214","article-title":"Close correlation between Daudi and mycobacterial antigen recognition by human gamma delta T cells and expression of V9JPC1 gamma\/V2DJC delta-encoded T cell receptors","volume":"151","author":"Davodeau","year":"1993","journal-title":"J Immunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1006\/cimm.1994.1152","article-title":"Human peripheral gamma delta T cells are stimulated by Daudi Burkitt's lymphoma and not by any other Burkitt's lymphoma tested","volume":"156","author":"Kaur","year":"1994","journal-title":"Cell Immunol"},{"key":"B95","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.4049\/jimmunol.150.5.2046","article-title":"Human peripheral gamma delta T cells recognize hsp60 molecules on Daudi Burkitt's lymphoma cells","volume":"150","author":"Kaur","year":"1993","journal-title":"J Immunol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1084\/jem.20021500","article-title":"Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells","volume":"197","author":"Gober","year":"2003","journal-title":"J Exp Med"},{"key":"B97","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1046\/j.1365-2567.1999.00761.x","article-title":"The expansion of human gammadelta T cells in response to Daudi cells requires the participation of CD4+ T cells","volume":"97","author":"Fayen","year":"1999","journal-title":"Immunology"},{"key":"B98","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.4049\/jimmunol.145.10.3202","article-title":"Human V gamma 9-V delta 2 T cell receptor-gamma delta lymphocytes show specificity to Daudi Burkitt's lymphoma cells","volume":"145","author":"Sturm","year":"1990","journal-title":"J Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1084\/jem.20161017","article-title":"Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and \u03b3\u03b4 T cells","volume":"214","author":"Djaoud","year":"2017","journal-title":"J Exp Med"},{"key":"B100","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-065X.2006.00479.x","article-title":"Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens","volume":"215","author":"Morita","year":"2007","journal-title":"Immunol Rev"},{"key":"B101","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.immuni.2014.03.003","article-title":"The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V\u03b39V\u03b42 T cells","volume":"40","author":"Sandstrom","year":"2014","journal-title":"Immunity"},{"key":"B102","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1182\/blood-2008-12-196287","article-title":"The NKG2D ligand ULBP4 binds to TCRgamma9\/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D","volume":"114","author":"Kong","year":"2009","journal-title":"Blood"},{"key":"B103","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/ijc.1198","article-title":"Anti-tumor effects of human peripheral \u03b3\u03b4 T cells in a mouse tumor model","volume":"92","author":"Zheng","year":"2001","journal-title":"Int J Cancer"},{"key":"B104","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.coviro.2017.07.026","article-title":"Humanized mouse models for Epstein Barr virus infection","volume":"25","author":"M\u00fcnz","year":"2017","journal-title":"Curr Opin Virol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1365-2249.1994.tb06246.x","article-title":"Human T cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumour immunity","volume":"96","author":"Malkovska","year":"1994","journal-title":"Clini Exp Immunol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.ccr.2014.07.026","article-title":"Targeted activation of human V\u03b39V\u03b42-T cells controls Epstein-Barr virus-induced B cell lymphoproliferative disease","volume":"26","author":"Xiang","year":"2014","journal-title":"Cancer Cell"},{"key":"B107","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3389\/fimmu.2018.00800","article-title":"Improving the efficiency of V\u03b39V\u03b42 T-cell immunotherapy in cancer","volume":"9","author":"Hoeres","year":"2018","journal-title":"Front Immunol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e93179","DOI":"10.1172\/jci.insight.93179","article-title":"Adoptively transferred V\u03b39V\u03b42 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model","volume":"2","author":"Zumwalde","year":"2017","journal-title":"JCI Insight"},{"key":"B109","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4049\/jimmunol.149.12.3984","article-title":"V delta 1+ subset of human gamma delta T cells responds to ligands expressed by EBV-infected Burkitt lymphoma cells and transformed B lymphocytes","volume":"149","author":"H\u00e4cker","year":"1992","journal-title":"J Immunol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1365-3083.1993.tb01735.x","article-title":"A subset of V\u03b41+ T cells proliferates in response to Epstein-Barr virus-transformed B cell lines in vitro","volume":"38","author":"Orsini","year":"1993","journal-title":"Scand J Immunol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1002\/eji.1830241243","article-title":"Functional and molecular characterization of B cell-responsive V delta 1+ gamma delta T cells","volume":"24","author":"Orsini","year":"1994","journal-title":"Eur J Immunol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3389\/fimmu.2018.00384","article-title":"Novel approaches to exploiting invariant NKT cells in cancer immunotherapy","volume":"9","author":"Wolf","year":"2018","journal-title":"Front. Immunol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1365-2141.2005.05452.x","article-title":"The immune response to primary EBV infection: a role for natural killer cells","volume":"129","author":"Williams","year":"2005","journal-title":"Br J Haematol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"7935","DOI":"10.1158\/0008-5472.CAN-09-0828","article-title":"EBV-induced human CD8+ NKT cells suppress tumorigenesis by EBV-associated malignancies","volume":"69","author":"Yuling","year":"2009","journal-title":"Cancer Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1084\/jem.20161846","article-title":"Human immunity against EBV\u2014lessons from the clinic","volume":"214","author":"Tangye","year":"2017","journal-title":"J Exp Med"},{"key":"B116","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1182\/blood-2013-01-480665","article-title":"Innate immune control of EBV-infected B cells by invariant natural killer T cells","volume":"122","author":"Chung","year":"2013","journal-title":"Blood"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1172\/JCI24041","article-title":"Regulation of CD1d expression and function by a herpesvirus infection","volume":"115","author":"Sanchez","year":"2005","journal-title":"J Clin Invest"},{"key":"B118","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/ni1364","article-title":"Herpes simplex virus evades natural killer T cell recognition by suppressing CD1d recycling","volume":"7","author":"Yuan","year":"2006","journal-title":"Nat Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02193\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T12:27:18Z","timestamp":1695212838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02193\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":118,"alternative-id":["10.3389\/fimmu.2019.02193"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02193","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"article-number":"2193"}}