{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:31:24Z","timestamp":1792182684030,"version":"4.4.0"},"reference-count":176,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG04802"],"award-info":[{"award-number":["AG04802"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG059877"],"award-info":[{"award-number":["AG059877"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL130541"],"award-info":[{"award-number":["HL130541"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL142804"],"award-info":[{"award-number":["HL142804"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02204","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T08:30:11Z","timestamp":1568363411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":208,"title":["The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"Li","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Rondina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1378\/chest.15-0287","article-title":"VTE incidence and risk factors in patients with severe sepsis and septic shock","volume":"148","author":"Kaplan","year":"2015","journal-title":"Chest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/jth.13911","article-title":"Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis","volume":"16","author":"Iba","year":"2018","journal-title":"J Thromb Haemost"},{"key":"B3","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1055\/s-0033-1343894","article-title":"Sepsis and thrombosis","volume":"39","author":"Levi","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"B4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fped.2018.00142","article-title":"The role of inflammation in venous thromboembolism","volume":"6","author":"Branchford","year":"2018","journal-title":"Front Pediatr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3389\/fimmu.2019.01348","article-title":"Fibrinolysis and inflammation in venous thrombus resolution","volume":"10","author":"Mukhopadhyay","year":"2019","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.molmed.2014.01.007","article-title":"Why have clinical trials in sepsis failed?","volume":"20","author":"Marshall","year":"2014","journal-title":"Trends Mol Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1161\/CIRCRESAHA.108.185785","article-title":"Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase","volume":"104","author":"Blair","year":"2009","journal-title":"Circ Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1136\/annrheumdis-2013-203430","article-title":"Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease","volume":"73","author":"Kambas","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1111\/jth.12977","article-title":"Extracellular DNA and histones: double-edged swords in immunothrombosis","volume":"13","author":"Gould","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B11","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.smim.2016.10.010","article-title":"Blood coagulation in immunothrombosis-At the frontline of intravascular immunity","volume":"28","author":"Gaertner","year":"2016","journal-title":"Semin Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3389\/fimmu.2014.00653","article-title":"Emerging evidence for platelets as immune and inflammatory effector cells","volume":"5","author":"Rondina","year":"2014","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-813456-6.00029-1","article-title":"The role of platelets in antimicrobial host defense","volume-title":"Platelets","author":"Yeaman","year":"2019"},{"key":"B14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fimmu.2015.00082","article-title":"Platelets and infections - complex interactions with bacteria","volume":"6","author":"Hamzeh-Cognasse","year":"2015","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fimmu.2015.00083","article-title":"The inflammatory role of platelets via their TLRs and siglec receptors","volume":"6","author":"Cognasse","year":"2015","journal-title":"Front Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fmed.2018.00121","article-title":"Platelets in immune response to virus and immunopathology of viral infections","volume":"5","author":"Hottz","year":"2018","journal-title":"Front Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1182\/blood-2017-01-764621","article-title":"Platelets: killers of parasites or patients?","volume":"129","author":"Morrell","year":"2017","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1182\/blood-2015-11-636464","article-title":"Emerging roles for hemostatic dysfunction in malaria pathogenesis","volume":"127","author":"O'Sullivan","year":"2016","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fcvm.2019.00085","article-title":"Platelet-neutrophil interplay: insights into neutrophil extracellular trap (NET)-driven coagulation in infection","volume":"6","author":"Zucoloto","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"B20","unstructured":"MichelsonAD AmsterdamElsevierPlatelets2013"},{"key":"B21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors","volume":"544","author":"Lefrancais","year":"2017","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1182\/blood-2015-07-607945","article-title":"Hematopoietic stem\/progenitor cell commitment to the megakaryocyte lineage","volume":"127","author":"Woolthuis","year":"2016","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature25168","article-title":"Clonal analysis of lineage fate in native haematopoiesis","volume":"553","author":"Rodriguez-Fraticelli","year":"2018","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1182\/blood-2018-11-835371","article-title":"Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation","volume":"133","author":"Psaila","year":"2019","journal-title":"Blood"},{"key":"B25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/09537104.2018.1445842","article-title":"Platelet toll-like receptors are crucial sensors of infectious danger moieties","volume":"29","author":"Hamzeh-Cognasse","year":"2018","journal-title":"Platelets"},{"key":"B26","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/jth.13262","article-title":"How can non-nucleated platelets be so smart?","volume":"14","author":"Cognasse","year":"2016","journal-title":"J Thromb Haemost"},{"key":"B27","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"Wong","year":"2013","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.3389\/fimmu.2018.02712","article-title":"Role of platelets in leukocyte recruitment and resolution of inflammation","volume":"9","author":"Rossaint","year":"2018","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1111\/jth.12965","article-title":"Regulation of the genetic code in megakaryocytes and platelets","volume":"13","author":"Rondina","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B30","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/MOH.0b013e328357010e","article-title":"Platelet mRNA: the meaning behind the message","volume":"19","author":"Rowley","year":"2012","journal-title":"Curr Opin Hematol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1182\/blood-2011-03-339705","article-title":"Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes","volume":"118","author":"Rowley","year":"2011","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1126\/science.342.6157.415","article-title":"Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts","volume":"342","author":"Normile","year":"2013","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mjafi.2014.09.011","article-title":"Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control","volume":"71","author":"Mustafa","year":"2015","journal-title":"Med J Armed Forces India"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1016\/S1473-3099(16)30545-X","article-title":"Disease and economic burdens of dengue","volume":"17","author":"Castro","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"B35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12250-016-3855-9","article-title":"Progress towards understanding the pathogenesis of dengue hemorrhagic fever","volume":"32","author":"Pang","year":"2017","journal-title":"Virol Sin"},{"key":"B36","first-page":"253","article-title":"Detection of dengue virus in platelets isolated from dengue patients","volume":"40","author":"Noisakran","year":"2009","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"B37","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/jth.12178","article-title":"Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases","volume":"11","author":"Hottz","year":"2013","journal-title":"J Thromb Haemost"},{"key":"B38","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1182\/blood-2014-09-598029","article-title":"Dengue virus binding and replication by platelets","volume":"126","author":"Simon","year":"2015","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e0206346","DOI":"10.1371\/journal.pone.0206346","article-title":"Dynamic modulation of DC-SIGN and FcUpsilonR2A receptors expression on platelets in dengue","volume":"13","author":"Tomo","year":"2018","journal-title":"PLoS ONE"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e1007625","DOI":"10.1371\/journal.ppat.1007625","article-title":"Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage","volume":"15","author":"Chao","year":"2019","journal-title":"PLoS Pathog"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1038\/s41467-019-10360-4","article-title":"Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A\/TLR2","volume":"10","author":"Sung","year":"2019","journal-title":"Nat Commun"},{"key":"B42","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1126\/science.aai8128","article-title":"IgG antibodies to dengue enhanced for FcgammaRIIIA binding determine disease severity","volume":"355","author":"Wang","year":"2017","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/imr.12370","article-title":"The platelet Fc receptor, FcgammaRIIa","volume":"268","author":"Qiao","year":"2015","journal-title":"Immunol Rev"},{"key":"B45","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3109\/09537104.2016.1148129","article-title":"Human platelet activation by Escherichia coli: roles for FcgammaRIIA and integrin alphaIIbbeta3","volume":"27","author":"Watson","year":"2016","journal-title":"Platelets"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1182\/blood-2013-12-544692","article-title":"Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics","volume":"123","author":"Simon","year":"2014","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"publisher","first-page":"E1550","DOI":"10.1073\/pnas.1720553115","article-title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","volume":"115","author":"Cloutier","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0004607","DOI":"10.1371\/journal.pntd.0004607","article-title":"Serum metabolomics reveals serotonin as a predictor of severe dengue in the early phase of dengue fever","volume":"10","author":"Cui","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1111\/j.1538-7836.2006.02065.x","article-title":"Blood platelets activate the classical pathway of human complement","volume":"4","author":"Peerschke","year":"2006","journal-title":"J Thromb Haemost"},{"key":"B50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470015902.a0000512.pub3","article-title":"Complement receptors","volume-title":"eLS","author":"Verschoor","year":"2017"},{"key":"B51","doi-asserted-by":"publisher","first-page":"41697","DOI":"10.1038\/srep41697","article-title":"Platelet activation determines the severity of thrombocytopenia in dengue infection","volume":"7","author":"Ojha","year":"2017","journal-title":"Sci Rep"},{"key":"B52","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1006\/viro.1995.1567","article-title":"Antibody-enhanced binding of dengue-2 virus to human platelets","volume":"213","author":"Wang","year":"1995","journal-title":"Virology"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-869156","article-title":"John AL. Peripheral serotonin causes dengue-induced thrombocytopenia through 5HT2 receptors","author":"Masri","year":"2019","journal-title":"Blood"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1084\/jem.187.11.1779","article-title":"Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor","volume":"187","author":"Ishii","year":"1998","journal-title":"J Exp Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"14138","DOI":"10.1073\/pnas.0906467106","article-title":"Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection","volume":"106","author":"Souza","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1182\/blood-2018-09-873984","article-title":"Human megakaryocytes possess intrinsic anti-viral immunity through regulated induction of IFITM3","volume":"133","author":"Campbell","year":"2019","journal-title":"Blood"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1006385","DOI":"10.1371\/journal.ppat.1006385","article-title":"Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue","volume":"13","author":"Trugilho","year":"2017","journal-title":"PLoS Pathog"},{"key":"B58","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000501015","article-title":"Altered platelet fatty acids in dengue cases by gas chromatography-mass spectrometry analysis","volume":"62","author":"Samadanam","year":"2019","journal-title":"Intervirology."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e0005498","DOI":"10.1371\/journal.pntd.0005498","article-title":"The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue","volume":"11","author":"Lam","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2187390","DOI":"10.1155\/2017\/2187390","article-title":"Mathematical modelling of immune parameters in the evolution of severe dengue","volume":"2017","author":"Premaratne","year":"2017","journal-title":"Comput Math Methods Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1152\/physiol.00020.2016","article-title":"New concepts and mechanisms of platelet activation signaling","volume":"32","author":"Estevez","year":"2017","journal-title":"Physiology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"E357","DOI":"10.3390\/v10070357","article-title":"Dengue virus induces the release of sCD40L and changes in levels of membranal CD42b and CD40L molecules in human platelets","volume":"10","author":"Nunez-Avellaneda","year":"2018","journal-title":"Viruses"},{"key":"B63","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/jmicro\/dfn007","article-title":"Imaging the interaction between dengue 2 virus and human blood platelets using atomic force and electron microscopy","volume":"57","author":"Ghosh","year":"2008","journal-title":"J Electron Microsc"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.4049\/jimmunol.1400091","article-title":"Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue","volume":"193","author":"Hottz","year":"2014","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1160\/TH14-01-0056","article-title":"Platelet function alterations in dengue are associated with plasma leakage","volume":"112","author":"Michels","year":"2014","journal-title":"Thromb Haemost"},{"key":"B66","doi-asserted-by":"publisher","first-page":"435","DOI":"10.4269\/ajtmh.2002.66.435","article-title":"Platelet adhesion to dengue-2 virus-infected endothelial cells","volume":"66","author":"Krishnamurti","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"B67","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1182\/blood-2013-05-504449","article-title":"Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation","volume":"122","author":"Hottz","year":"2013","journal-title":"Blood"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-1-4831-9940-5.50008-9","article-title":"The role of lipids in blood coagulation","volume":"4","author":"Marcus","year":"1966","journal-title":"Adv Lipid Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1172\/JCI103776","article-title":"Platelet phosphatides: their separation, identification, and clotting activity","volume":"37","author":"Marcus","year":"1958","journal-title":"J Clin Invest"},{"key":"B70","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0163-7827(03)00025-0","article-title":"Exposure of platelet membrane phosphatidylserine regulates blood coagulation","volume":"42","author":"Lentz","year":"2003","journal-title":"Prog Lipid Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"943","DOI":"10.4269\/ajtmh.2012.12-0020","article-title":"Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability","volume":"87","author":"Michels","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.3324\/haematol.2018.191700","article-title":"NLRP3 regulates platelet integrin alphaIIbbeta3 outside-in signaling, hemostasis and arterial thrombosis","volume":"103","author":"Qiao","year":"2018","journal-title":"Haematologica"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1160\/TH14-07-0637","article-title":"Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcgammaRIII","volume":"113","author":"Lien","year":"2015","journal-title":"Thromb Haemost"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e0214245","DOI":"10.1371\/journal.pone.0214245","article-title":"Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations","volume":"14","author":"Marin-Palma","year":"2019","journal-title":"PLoS ONE"},{"key":"B75","doi-asserted-by":"publisher","first-page":"916","DOI":"10.4049\/jimmunol.1200580","article-title":"Platelets present antigen in the context of MHC class I","volume":"189","author":"Chapman","year":"2012","journal-title":"J Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"L258","DOI":"10.1152\/ajplung.00311.2002","article-title":"Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products","volume":"285","author":"Schaphorst","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ebiom.2018.11.049","article-title":"Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses","volume":"39","author":"Ojha","year":"2019","journal-title":"EBioMedicine"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e113394","DOI":"10.1371\/journal.pone.0113394","article-title":"Sphingosine 1-phosphate in acute dengue infection","volume":"9","author":"Gomes","year":"2014","journal-title":"PLoS ONE"},{"key":"B79","year":"2018","journal-title":"World Malaria Report 2018"},{"key":"B80","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1086\/519844","article-title":"Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria","volume":"196","author":"de Mast","year":"2007","journal-title":"J Infect Dis"},{"key":"B81","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1111\/bjh.14582","article-title":"Platelets and infections in the resource-limited countries with a focus on malaria and viral haemorrhagic fevers","volume":"177","author":"Thachil","year":"2017","journal-title":"Br J Haematol"},{"key":"B82","first-page":"239","article-title":"Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics?","volume":"58","author":"Lathia","year":"2004","journal-title":"Indian J Med Sci"},{"key":"B83","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1080\/20477724.2019.1600855","article-title":"Characterization of platelet count and platelet indices and their potential role to predict severity in malaria","volume":"113","author":"Gupta","year":"","journal-title":"Pathog Glob Health"},{"key":"B84","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.redox.2018.04.011","article-title":"Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling","volume":"17","author":"Gardinassi","year":"2018","journal-title":"Redox Biol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1172\/JCI33314","article-title":"A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI","volume":"118","author":"von Zur Muhlen","year":"2008","journal-title":"J Clin Invest"},{"key":"B86","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1086\/367960","article-title":"Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria","volume":"187","author":"Grau","year":"2003","journal-title":"J Infect Dis"},{"key":"B87","first-page":"415","article-title":"TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1\/ICAM-1 interaction","volume":"4","author":"Grau","year":"1993","journal-title":"Eur Cytokine Netw"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e10413","DOI":"10.1371\/journal.pone.0010413","article-title":"Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria","volume":"5","author":"Srivastava","year":"2010","journal-title":"PLoS ONE"},{"key":"B89","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.chom.2008.07.003","article-title":"Platelet factor 4 mediates inflammation in experimental cerebral malaria","volume":"4","author":"Srivastava","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B90","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11011-015-9787-5","article-title":"Cerebral malaria\u2013clinical manifestations and pathogenesis","volume":"31","author":"Hora","year":"2016","journal-title":"Metab Brain Dis"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1182\/blood-2015-07-654921","article-title":"A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria","volume":"127","author":"O'Regan","year":"2016","journal-title":"Blood"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e1000349","DOI":"10.1371\/journal.ppat.1000349","article-title":"Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition","volume":"5","author":"Larkin","year":"2009","journal-title":"PLoS Pathog"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e1600187","DOI":"10.1002\/prca.201600187","article-title":"Identification of host-response in cerebral malaria patients using quantitative proteomic analysis","volume":"12","author":"Kumar","year":"2018","journal-title":"Proteomics Clin Appl"},{"key":"B94","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/B978-0-12-813456-6.00028-X","article-title":"Chapter 28. The role of platelets in inflammation","volume-title":"Platelets","author":"Rondina","year":"2019"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1073\/pnas.98.4.1805","article-title":"Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria","volume":"98","author":"Pain","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"B96","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1096\/fj.09-135822","article-title":"Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium","volume":"23","author":"Faille","year":"2009","journal-title":"FASEB J"},{"key":"B97","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1017\/S0031182000059011","article-title":"Plasmodium falciparum growth inhibition by human platelets in vitro","volume":"99","author":"Peyron","year":"1989","journal-title":"Parasitology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1126\/science.1166296","article-title":"Platelets kill intraerythrocytic malarial parasites and mediate survival to infection","volume":"323","author":"McMorran","year":"2009","journal-title":"Science"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1182\/blood-2018-05-849307","article-title":"Platelets kill circulating parasites of all major Plasmodium species in human malaria","volume":"132","author":"Kho","year":"2018","journal-title":"Blood"},{"key":"B100","first-page":"615","article-title":"Thrombocytopenia in malaria\u2013correlation with type and severity of malaria","volume":"52","author":"Jadhav","year":"2004","journal-title":"J Assoc Physicians India"},{"key":"B101","doi-asserted-by":"publisher","first-page":"686","DOI":"10.4269\/ajtmh.2002.66.686","article-title":"Prognostic value of thrombocytopenia in African children with falciparum malaria","volume":"66","author":"Gerardin","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1182\/blood-2016-08-733519","article-title":"Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response","volume":"129","author":"Gramaglia","year":"2017","journal-title":"Blood"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1126\/science.1228892","article-title":"Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum","volume":"338","author":"McMorran","year":"2012","journal-title":"Science"},{"key":"B104","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.chom.2012.10.017","article-title":"Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials","volume":"12","author":"Love","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.chembiol.2018.06.009","article-title":"Defense peptides engineered from human platelet factor 4 kill plasmodium by selective membrane disruption","volume":"25","author":"Lawrence","year":"2018","journal-title":"Cell Chem Biol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.1074\/jbc.RA118.006321","article-title":"ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp","volume":"294","author":"Wang","year":"2019","journal-title":"J Biol Chem."},{"key":"B107","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.4049\/jimmunol.1202672","article-title":"Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria","volume":"190","author":"Aggrey","year":"2013","journal-title":"J Immunol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/j.1365-2141.2006.06067.x","article-title":"von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation","volume":"133","author":"Hollestelle","year":"2006","journal-title":"Br J Haematol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"492","DOI":"10.4269\/ajtmh.2009.80.492","article-title":"ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria","volume":"80","author":"de Mast","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"B110","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/j.1365-2141.2010.08399.x","article-title":"Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy","volume":"151","author":"de Mast","year":"2010","journal-title":"Br J Haematol"},{"key":"B111","first-page":"287","article-title":"Blood platelet: a review of its characteristics and function in acute malaria infection","volume":"43","author":"Essien","year":"2014","journal-title":"Afr J Med Med Sci"},{"key":"B112","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"B113","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1182\/blood-2005-03-0916","article-title":"Platelets express functional Toll-like receptor-4","volume":"106","author":"Andonegui","year":"2005","journal-title":"Blood"},{"key":"B114","doi-asserted-by":"publisher","first-page":"13464","DOI":"10.1038\/ncomms13464","article-title":"Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response","volume":"7","author":"Rossaint","year":"2016","journal-title":"Nat Commun"},{"key":"B115","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.chom.2012.06.011","article-title":"Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis","volume":"12","author":"McDonald","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B116","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1038\/s41467-017-02402-6","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","volume":"8","author":"Rayes","year":"2017","journal-title":"Nat Commun"},{"key":"B117","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/j.1538-7836.2011.04208.x","article-title":"The septic milieu triggers expression of spliced tissue factor mRNA in human platelets","volume":"9","author":"Rondina","year":"2011","journal-title":"J Thromb Haemost"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/j.cell.2017.11.001","article-title":"Migrating platelets are mechano-scavengers that collect and bundle bacteria","volume":"171","author":"Gaertner","year":"2017","journal-title":"Cell"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1161\/ATVBAHA.114.304954","article-title":"Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors","volume":"35","author":"Koupenova","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1053\/j.seminhematol.2016.04.002","article-title":"The nonhemostatic immune functions of platelets","volume":"53","author":"Kapur","year":"2016","journal-title":"Semin Hematol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1440-1711.2005.01314.x","article-title":"Evidence of Toll-like receptor molecules on human platelets","volume":"83","author":"Cognasse","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1161\/01.RES.86.10.1031","article-title":"Immunoneutralization of glycoprotein Ibalpha attenuates endotoxin-induced interactions of platelets and leukocytes with rat venular endothelium in vivo","volume":"86","author":"Katayama","year":"2000","journal-title":"Circ Res"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"B124","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S1074-7613(00)80086-2","article-title":"Unresponsiveness of MyD88-deficient mice to endotoxin","volume":"11","author":"Kawai","year":"1999","journal-title":"Immunity"},{"key":"B125","doi-asserted-by":"publisher","first-page":"7997","DOI":"10.4049\/jimmunol.0802884","article-title":"Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4\/MyD88 and the cGMP-dependent protein kinase pathway","volume":"182","author":"Zhang","year":"2009","journal-title":"J Immunol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","article-title":"Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo","volume":"107","author":"Aslam","year":"2006","journal-title":"Blood"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1161\/CIRCRESAHA.113.300512","article-title":"Platelets as cellular effectors of inflammation in vascular diseases","volume":"112","author":"Rondina","year":"2013","journal-title":"Circ Res"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e0185431","DOI":"10.1371\/journal.pone.0185431","article-title":"Human platelet interaction with E. coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4","volume":"12","author":"Matus","year":"2017","journal-title":"PLoS ONE"},{"key":"B129","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cellimm.2018.04.002","article-title":"LPS enhances platelets aggregation via TLR4, which is related to mitochondria damage caused by intracellular ROS, but not extracellular ROS","volume":"328","author":"Feng","year":"2018","journal-title":"Cell Immunol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1182\/blood-2005-08-3219","article-title":"Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome","volume":"108","author":"Stahl","year":"2006","journal-title":"Blood"},{"key":"B131","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1365-2141.2008.06999.x","article-title":"Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets","volume":"141","author":"Cognasse","year":"2008","journal-title":"Br J Haematol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"4803","DOI":"10.1182\/blood-2006-12-062695","article-title":"Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets","volume":"109","author":"Semple","year":"2007","journal-title":"Blood"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1182\/blood-2016-09-741298","article-title":"Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice","volume":"129","author":"McDonald","year":"2017","journal-title":"Blood"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1002\/hep.28003","article-title":"Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice","volume":"62","author":"Slaba","year":"2015","journal-title":"Hepatology"},{"key":"B136","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat Med"},{"key":"B138","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","author":"Massberg","year":"2010","journal-title":"Nat Med"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.21873\/invivo.11169","article-title":"Role for Neutrophil Extracellular Traps (NETs) and platelet aggregation in early sepsis-induced hepatic dysfunction","volume":"31","author":"Sakurai","year":"2017","journal-title":"In Vivo"},{"key":"B140","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00441-017-2727-4","article-title":"Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease","volume":"371","author":"Lisman","year":"2018","journal-title":"Cell Tissue Res"},{"key":"B141","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/jth.13226","article-title":"Escherichia coli induces platelet aggregation in an FcgammaRIIa-dependent manner","volume":"14","author":"Moriarty","year":"2016","journal-title":"J Thromb Haemost"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1111\/jth.13955","article-title":"Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcgammaRIIA","volume":"16","author":"Palankar","year":"2018","journal-title":"J Thromb Haemost"},{"key":"B143","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.chom.2016.05.023","article-title":"Dual-track clearance of circulating bacteria balances rapid restoration of blood sterility with induction of adaptive immunity","volume":"20","author":"Broadley","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B144","doi-asserted-by":"publisher","first-page":"295","DOI":"10.4049\/jimmunol.1700885","article-title":"Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in aging","volume":"200","author":"Campbell","year":"2018","journal-title":"J Immunol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.1182\/blood-2012-04-420661","article-title":"Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets","volume":"120","author":"Kraemer","year":"2012","journal-title":"Blood"},{"key":"B146","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/S0163-4453(09)60003-7","article-title":"Infections caused by Gram-positive bacteria: a review of the global challenge","volume":"59","author":"Woodford","year":"2009","journal-title":"J Infect"},{"key":"B147","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jinf.2017.09.013","article-title":"Review manuscript: Mechanisms of platelet activation by the pneumococcus and the role of platelets in community-acquired pneumonia","volume":"75","author":"Anderson","year":"2017","journal-title":"J Infect"},{"key":"B148","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/infdis\/114.5.488","article-title":"Action of staphylococcal toxin on human platelets","volume":"114","author":"Siegel","year":"1964","journal-title":"J Infect Dis"},{"key":"B149","first-page":"367","article-title":"Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors","volume":"65","author":"Clawson","year":"1971","journal-title":"Am J Pathol"},{"key":"B150","first-page":"449","article-title":"Platelet interaction with bacteria. 3. Ultrastructure","volume":"70","author":"Clawson","year":"1973","journal-title":"Am J Pathol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"e1002355","DOI":"10.1371\/journal.ppat.1002355","article-title":"Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation","volume":"7","author":"Kraemer","year":"2011","journal-title":"PLoS Pathog"},{"key":"B152","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1128\/IAI.60.6.2368-2374.1992","article-title":"Staphylococcus aureus susceptibility to thrombin-induced platelet microbicidal protein is independent of platelet adherence and aggregation in vitro","volume":"60","author":"Yeaman","year":"1992","journal-title":"Infect Immun"},{"key":"B153","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/infdis\/166.1.65","article-title":"Characterization of Staphylococcus aureus-platelet binding by quantitative flow cytometric analysis","volume":"166","author":"Yeaman","year":"1992","journal-title":"J Infect Dis"},{"key":"B154","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1128\/IAI.68.4.2061-2068.2000","article-title":"Staphylococcus aureus protein A recognizes platelet gC1qR\/p33: a novel mechanism for staphylococcal interactions with platelets","volume":"68","author":"Nguyen","year":"2000","journal-title":"Infect Immun"},{"key":"B155","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.chom.2015.05.011","article-title":"Synergistic action of Staphylococcus aureus alpha-toxin on platelets and myeloid lineage cells contributes to lethal sepsis","volume":"17","author":"Powers","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1111\/j.1538-7836.2009.03564.x","article-title":"Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ibalpha and alpha IIb beta 3","volume":"7","author":"de Haas","year":"2009","journal-title":"J Thromb Haemost"},{"key":"B157","doi-asserted-by":"publisher","first-page":"e19190","DOI":"10.1371\/journal.pone.0019190","article-title":"GPVI and GPIbalpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors","volume":"6","author":"Hu","year":"2011","journal-title":"PLoS ONE"},{"key":"B158","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1055\/s-0038-1637735","article-title":"Secreted immunomodulatory proteins of Staphylococcus aureus activate platelets and induce platelet aggregation","volume":"118","author":"Binsker","year":"2018","journal-title":"Thromb Haemost"},{"key":"B159","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/toxins3020120","article-title":"Staphylococcus aureus alpha-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets","volume":"3","author":"Schubert","year":"2011","journal-title":"Toxins"},{"key":"B160","doi-asserted-by":"publisher","first-page":"13473","DOI":"10.1073\/pnas.1001815107","article-title":"Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury","volume":"107","author":"Wilke","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B161","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/infdis\/jit235","article-title":"Staphylococcus aureus alpha-hemolysin promotes platelet-neutrophil aggregate formation","volume":"208","author":"Parimon","year":"2013","journal-title":"J Infect Dis"},{"key":"B162","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.chom.2018.06.017","article-title":"alpha-toxin induces platelet aggregation and liver injury during Staphylococcus aureus sepsis","volume":"24","author":"Surewaard","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B163","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.4049\/jimmunol.0900729","article-title":"A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome","volume":"183","author":"Munoz-Planillo","year":"2009","journal-title":"J Immunol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"e7446","DOI":"10.1371\/journal.pone.0007446","article-title":"Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells","volume":"4","author":"Craven","year":"2009","journal-title":"PLoS ONE"},{"key":"B165","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/infdis\/jir846","article-title":"Staphylococcus aureus alpha-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome","volume":"205","author":"Kebaier","year":"2012","journal-title":"J Infect Dis"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1038\/ni.2140","article-title":"A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3","volume":"12","author":"Verschoor","year":"2011","journal-title":"Nat Immunol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.celrep.2016.08.088","article-title":"Dynamic regulation of a ribosome rescue pathway in erythroid cells and platelets","volume":"17","author":"Mills","year":"2016","journal-title":"Cell Rep"},{"key":"B168","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1182\/blood-2016-08-736108","article-title":"Slowed decay of mRNAs enhances platelet specific translation","volume":"129","author":"Mills","year":"2017","journal-title":"Blood"},{"key":"B169","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.ccell.2015.09.018","article-title":"RNA-Seq of Tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics","volume":"28","author":"Best","year":"2015","journal-title":"Cancer Cell"},{"key":"B170","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ccell.2017.07.004","article-title":"Swarm intelligence-enhanced detection of non-small-cell lung cancer using tumor-educated platelets","volume":"32","author":"Best","year":"2017","journal-title":"Cancer Cell"},{"key":"B171","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1182\/blood-2003-08-2804","article-title":"Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions","volume":"103","author":"Coppinger","year":"2004","journal-title":"Blood"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1111\/j.1538-7836.2007.02690.x","article-title":"Proteomic analysis of platelet alpha-granules using mass spectrometry","volume":"5","author":"Maynard","year":"2007","journal-title":"J Thromb Haemost"},{"key":"B173","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jprot.2014.02.008","article-title":"Characterization of the platelet granule proteome: evidence of the presence of MHC1 in alpha-granules","volume":"101","author":"Zufferey","year":"2014","journal-title":"J Proteomics"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1182\/blood-2011-01-330910","article-title":"Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet alpha-granules","volume":"118","author":"Kamykowski","year":"2011","journal-title":"Blood"},{"key":"B175","doi-asserted-by":"publisher","first-page":"C1230","DOI":"10.1152\/ajpcell.00053.2013","article-title":"Histone deacetylase 6-mediated deacetylation of alpha-tubulin coordinates cytoskeletal and signaling events during platelet activation","volume":"305","author":"Aslan","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"C519","DOI":"10.1152\/ajpcell.00418.2012","article-title":"The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation","volume":"305","author":"Aslan","year":"2013","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02204\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T15:16:05Z","timestamp":1611155765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02204\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,13]]},"references-count":176,"alternative-id":["10.3389\/fimmu.2019.02204"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02204","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,13]]},"article-number":"2204"}}