{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:14:25Z","timestamp":1777886065919,"version":"3.51.4"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02285","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:39:23Z","timestamp":1569285563000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Targeting T Cell Metabolism in Inflammatory Skin Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Leonhard","family":"von Meyenn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Leonie","family":"Bertschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schlapbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1002\/eji.200939722","article-title":"Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity","volume":"39","author":"Sallusto","year":"2009","journal-title":"Euro J Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1002\/eji.201343751","article-title":"The who's who of T-cell differentiation: human memory T-cell subsets","volume":"43","author":"Mahnke","year":"2013","journal-title":"Eur J Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nm.3883","article-title":"The emerging role of resident memory T cells in protective immunity and inflammatory disease","volume":"21","author":"Park","year":"2015","journal-title":"Nat Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"269rv261","DOI":"10.1126\/scitranslmed.3010641","article-title":"Resident memory T cells in human health and disease","volume":"7","author":"Clark","year":"2015","journal-title":"Sci Transl Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.cmet.2014.05.004","article-title":"The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function","volume":"20","author":"Macintyre","year":"2014","journal-title":"Cell Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1084\/jem.20151159","article-title":"T cell metabolism drives immunity","volume":"212","author":"Buck","year":"2015","journal-title":"J Exp Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science."},{"key":"B10","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.smim.2016.10.009","article-title":"Metabolic pathways in T cell activation and lineage differentiation","volume":"28","author":"Almeida","year":"2016","journal-title":"Sem. Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Ann Rev Cell Dev Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.4049\/jimmunol.180.7.4476","article-title":"Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways","volume":"180","author":"Jacobs","year":"2008","journal-title":"J Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"B14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/imm.12655","article-title":"T-cell metabolism governing activation, proliferation and differentiation; a modular view","volume":"150","author":"Dimeloe","year":"2017","journal-title":"Immunology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/ni.2687","article-title":"Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch","volume":"14","author":"Gubser","year":"2013","journal-title":"Nat Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.immuni.2011.09.021","article-title":"The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"B17","doi-asserted-by":"publisher","first-page":"18348","DOI":"10.1073\/pnas.1108856108","article-title":"Estrogen-related receptor-alpha is a metabolic regulator of effector T-cell activation and differentiation","volume":"108","author":"Michalek","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ni.2714","article-title":"Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen","volume":"14","author":"Doedens","year":"2013","journal-title":"Nat Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.celrep.2015.09.036","article-title":"Preventing allograft rejection by targeting immune metabolism","volume":"13","author":"Lee","year":"2015","journal-title":"Cell Rep"},{"key":"B21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","first-page":"274ra218","DOI":"10.1126\/scitranslmed.aaa0835","article-title":"Normalization of CD4+ T cell metabolism reverses lupus","volume":"7","author":"Yin","year":"2015","journal-title":"Sci Trans Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1084\/jem.20130252","article-title":"Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells","volume":"210","author":"Yang","year":"2013","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/ni.3269","article-title":"Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants","volume":"16","author":"De Rosa","year":"2015","journal-title":"Nat Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.immuni.2016.02.022","article-title":"The proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements","volume":"44","author":"Procaccini","year":"2016","journal-title":"Immunity"},{"key":"B27","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nrneph.2017.59","article-title":"Metabolic reprogramming in clear cell renal cell carcinoma","volume":"13","author":"Wettersten","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/nm.3704","article-title":"De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells","volume":"20","author":"Berod","year":"2014","journal-title":"Nat Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nature21379","article-title":"Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism","volume":"543","author":"Pan","year":"2017","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.4049\/jimmunol.0903586","article-title":"Glutamine uptake and metabolism are coordinately regulated by ERK\/MAPK during T lymphocyte activation","volume":"185","author":"Carr","year":"2010","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ni.2556","article-title":"Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation","volume":"14","author":"Sinclair","year":"2013","journal-title":"Nat Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.immuni.2014.12.030","article-title":"The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo","volume":"42","author":"Blagih","year":"2015","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1182\/blood-2013-04-495515","article-title":"Effector T cells require fatty acid metabolism during murine graft-versus-host disease","volume":"122","author":"Byersdorfer","year":"2013","journal-title":"Blood"},{"key":"B34","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4049\/jimmunol.1501537","article-title":"Glucose oxidation is critical for CD4+ T cell activation in a mouse model of systemic lupus erythematosus","volume":"196","author":"Yin","year":"2016","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1146\/annurev-immunol-042617-053019","article-title":"Unraveling the complex interplay between T cell metabolism and function","volume":"36","author":"Geltink","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.2174\/1381612820666140306095106","article-title":"Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches","volume":"20","author":"Sanchis-Gomar","year":"2014","journal-title":"Curr Pharm Design"},{"key":"B37","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"van der Windt","year":"2012","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4049\/jimmunol.1501766","article-title":"The immune-metabolic basis of effector memory CD4+ T cell function under hypoxic conditions","volume":"196","author":"Dimeloe","year":"2016","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem J"},{"key":"B40","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature08097","article-title":"Enhancing CD8 T-cell memory by modulating fatty acid metabolism","volume":"460","author":"Pearce","year":"2009","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.immuni.2014.06.005","article-title":"Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development","volume":"41","author":"O'Sullivan","year":"2014","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial dynamics controls T cell fate through metabolic programming","volume":"166","author":"Buck","year":"2016","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.immuni.2016.02.018","article-title":"Fine-tuning of CD8(+) T cell mitochondrial metabolism by the respiratory chain repressor MCJ dictates protection to influenza virus","volume":"44","author":"Champagne","year":"2016","journal-title":"Immunity"},{"key":"B44","doi-asserted-by":"publisher","first-page":"67ra68","DOI":"10.1126\/scitranslmed.3001975","article-title":"Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease","volume":"3","author":"Gatza","year":"2011","journal-title":"Sci Trans Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.coi.2017.04.006","article-title":"Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease","volume":"46","author":"Patel","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.immuni.2014.04.007","article-title":"Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation","volume":"40","author":"Nakaya","year":"2014","journal-title":"Immunity"},{"key":"B48","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.immuni.2013.09.015","article-title":"T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming","volume":"39","author":"Yang","year":"2013","journal-title":"Immunity"},{"key":"B50","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/ni.2570","article-title":"Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity","volume":"14","author":"Kidani","year":"2013","journal-title":"Nat Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cell.2008.04.052","article-title":"LXR signaling couples sterol metabolism to proliferation in the acquired immune response","volume":"134","author":"Bensinger","year":"2008","journal-title":"Cell"},{"key":"B52","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nature01158","article-title":"The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease","volume":"420","author":"Youssef","year":"2002","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.4049\/jimmunol.1302985","article-title":"Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity","volume":"192","author":"Lee","year":"2014","journal-title":"J Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3389\/fimmu.2018.01347","article-title":"Metabolic reprogramming and longevity of tissue-resident memory T cells","volume":"9","author":"Pan","year":"2018","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1002\/eji.201646745","article-title":"Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation","volume":"48","author":"Veldhoen","year":"2018","journal-title":"Euro J Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cell.2016.02.035","article-title":"The CASTOR proteins are arginine sensors for the mTORC1 pathway","volume":"165","author":"Chantranupong","year":"2016","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/labinvest.2010.36","article-title":"Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells","volume":"90","author":"Chen","year":"2010","journal-title":"Lab Invest"},{"key":"B58","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.4049\/jimmunol.1103143","article-title":"Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells","volume":"188","author":"Waickman","year":"2012","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.it.2014.11.005","article-title":"Regulation of T cells by mTOR: the known knowns and the known unknowns","volume":"36","author":"Pollizzi","year":"2015","journal-title":"Trends Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41573-019-0019-2","article-title":"AMP-activated protein kinase: the current landscape for drug development","volume":"18","author":"Steinberg","year":"2019","journal-title":"Nat Rev Drug Disc."},{"key":"B62","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol Cell"},{"key":"B63","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.intimp.2013.03.020","article-title":"Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis","volume":"16","author":"Kang","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1124\/jpet.109.164954","article-title":"Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis","volume":"333","author":"Bai","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e0135858","DOI":"10.1371\/journal.pone.0135858","article-title":"Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17\/treg balance","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS ONE."},{"key":"B66","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1002\/eji.200738045","article-title":"AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function","volume":"38","author":"Mayer","year":"2008","journal-title":"Euro J Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nri.2017.99","article-title":"The spectrum of T cell metabolism in health and disease","volume":"18","author":"Bantug","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cmet.2018.07.009","article-title":"Translating in vitro T cell metabolic findings to in vivo tumor models of nutrient competition","volume":"28","author":"Ecker","year":"2018","journal-title":"Cell Metab"},{"key":"B69","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cmet.2016.08.011","article-title":"LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell-derived lactic acid on human T cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"B71","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"B72","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.4049\/jimmunol.0903002","article-title":"Metabolic shifts in immunity and inflammation","volume":"184","author":"Kominsky","year":"2010","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.immuni.2015.04.016","article-title":"Epidermal fatty acid binding protein promotes skin inflammation induced by high-fat diet","volume":"42","author":"Zhang","year":"2015","journal-title":"Immunity"},{"key":"B74","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4161\/derm.3.2.14816","article-title":"Role of fatty acid transporters in epidermis: Implications for health and disease","volume":"3","author":"Khnykin","year":"2011","journal-title":"Dermato Endocrinol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"eaan2543","DOI":"10.1126\/sciimmunol.aan2543","article-title":"Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes","volume":"3","author":"Konjar","year":"2018","journal-title":"Sci Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.4049\/jimmunol.169.9.4717","article-title":"Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells","volume":"169","author":"Wang","year":"2002","journal-title":"J Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/JLB.3MR0118-034R","article-title":"PPAR-gamma in innate and adaptive lung immunity","volume":"104","author":"Nobs","year":"2018","journal-title":"J Leukoc Biol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"eaam9171","DOI":"10.1126\/scitranslmed.aam9171","article-title":"A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders","volume":"9","author":"Wambre","year":"2017","journal-title":"Sci Trans Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"aal5196","DOI":"10.1126\/sciimmunol.aal5196","article-title":"PPAR-gamma promotes type 2 immune responses in allergy and nematode infection","volume":"2","author":"Chen","year":"2017","journal-title":"Sci Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1084\/jem.20162069","article-title":"PPARgamma in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation","volume":"214","author":"Nobs","year":"2017","journal-title":"J Exp Med"},{"key":"B81","doi-asserted-by":"publisher","first-page":"219ra218","DOI":"10.1126\/scitranslmed.3007828","article-title":"Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity","volume":"6","author":"Schlapbach","year":"2014","journal-title":"Sci Trans Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00281-016-0607-8","article-title":"TH9 cells in skin disorders","volume":"39","author":"Clark","year":"2017","journal-title":"Sem Immunopathol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"aat5943","DOI":"10.1126\/sciimmunol.aat5943","article-title":"Human \u201cTH9\u201d cells are a subpopulation of PPAR-gamma(+) TH2 cells","volume":"4","author":"Micoss\u00e9","year":"2019","journal-title":"Sci Immunol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nm.3860","article-title":"Common clonal origin of central and resident memory T cells following skin immunization","volume":"21","author":"Gaide","year":"2015","journal-title":"Nat Med"},{"key":"B85","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPARgamma signaling and metabolism: the good, the bad and the future","volume":"19","author":"Ahmadian","year":"2013","journal-title":"Nat Med"},{"key":"B86","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1172\/JCI84431","article-title":"HIF1alpha and metabolic reprogramming in inflammation","volume":"126","author":"Corcoran","year":"2016","journal-title":"J Clin Invest"},{"key":"B87","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrrheum.2016.69","article-title":"Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis","volume":"12","author":"Fearon","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"53562","DOI":"10.1074\/jbc.M406096200","article-title":"6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia","volume":"279","author":"Obach","year":"2004","journal-title":"J Biol Chem"},{"key":"B89","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bbrc.2014.02.062","article-title":"Dimethyl fumarate inhibits the expression and function of hypoxia-inducible factor-1alpha (HIF-1alpha)","volume":"448","author":"Zhao","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"B91","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41577-019-0124-9","article-title":"Immunometabolism at the interface between macrophages and pathogens","volume":"19","author":"Russell","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.3389\/fimmu.2018.03026","article-title":"Inhibiting glycolysis and ATP production attenuates IL-33-mediated mast cell function and peritonitis","volume":"9","author":"Caslin","year":"2018","journal-title":"Front Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/s41591-018-0003-0","article-title":"Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat Med"},{"key":"B94","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1152\/physiol.00031.2016","article-title":"Central role of metabolism in endothelial cell function and vascular disease","volume":"32","author":"Bierhansl","year":"2017","journal-title":"Physiology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.3389\/fimmu.2017.01750","article-title":"How endothelial cells adapt their metabolism to form vessels in tumors","volume":"8","author":"Zecchin","year":"2017","journal-title":"Front Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s42255-018-0008-5","article-title":"Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis","volume":"1","author":"Zhao","year":"2019","journal-title":"Nat Metab"},{"key":"B97","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1128\/MCB.01288-12","article-title":"WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function","volume":"33","author":"Piotrowski","year":"2013","journal-title":"Mol Cell Biol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/jdv.14673","article-title":"Immune response patterns in non-communicable inflammatory skin diseases","volume":"32","author":"Eyerich","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.immuni.2015.05.024","article-title":"Complement regulates nutrient influx and metabolic reprogramming during Th1 cell responses","volume":"42","author":"Kolev","year":"2015","journal-title":"Immunity"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1126\/science.1172638","article-title":"Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response","volume":"324","author":"Sundrud","year":"2009","journal-title":"Science"},{"key":"B102","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nchembio.790","article-title":"Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase","volume":"8","author":"Keller","year":"2012","journal-title":"Nat Chem Biol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"aap9520","DOI":"10.1126\/sciimmunol.aap9520","article-title":"Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8(+) T cells","volume":"4","author":"Gemta","year":"2019","journal-title":"Sci Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/j.cell.2018.10.001","article-title":"Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism","volume":"175","author":"Johnson","year":"2018","journal-title":"Cell"},{"key":"B105","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","article-title":"Serine is an essential metabolite for effector T cell expansion","volume":"25","author":"Ma","year":"2017","journal-title":"Cell Metab"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.chembiol.2017.08.028","article-title":"Targeting metabolism for cancer therapy","volume":"24","author":"Luengo","year":"2017","journal-title":"Cell Chem Biol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.ircmb.2018.05.009","article-title":"Impact of immunosuppressive drugs on the metabolism of T cells","volume":"341","author":"Pallet","year":"2018","journal-title":"Int Rev Cell Mol Biol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4062\/biomolther.2017.178","article-title":"Targeting glutamine metabolism for cancer treatment","volume":"26","author":"Choi","year":"2018","journal-title":"Biomol Therap"},{"key":"B109","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-019-0162-3","article-title":"T cells and the skin: from protective immunity to inflammatory skin disorders","author":"Ho","year":"2019","journal-title":"Nat Rev Immunol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1172\/JCI93396","article-title":"Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing alphabeta T cell clones","volume":"127","author":"Matos","year":"2017","journal-title":"J Clin Invest"},{"key":"B111","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1111\/all.13223","article-title":"Nonlesional atopic dermatitis skin shares similar T-cell clones with lesional tissues","volume":"72","author":"Brunner","year":"2017","journal-title":"Allergy"},{"key":"B112","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/exd.13879","article-title":"Vitiligo as a skin memory disease: the need for early intervention with immunomodulating agents and a maintenance therapy to target resident memory T cells","volume":"28","author":"Boniface","year":"2019","journal-title":"Exp Dermatol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00281-015-0540-2","article-title":"Adverse cutaneous drug eruptions: current understanding","volume":"38","author":"Hoetzenecker","year":"2016","journal-title":"Semin Immunopathol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1111\/jdv.15642","article-title":"Atopic dermatitis and the metabolic syndrome: a cross-sectional study of 116 816 patients","volume":"33","author":"Shalom","year":"2019","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.3389\/fimmu.2018.01961","article-title":"Regulation, communication, and functional roles of adipose tissue-resident CD4(+) T cells in the control of metabolic homeostasis","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Immunol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.it.2017.07.001","article-title":"Do Type I interferons link systemic autoimmunities and metabolic syndrome in a pathogenetic continuum?","volume":"39","author":"Ganguly","year":"2018","journal-title":"Trends Immunol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00403-013-1374-1","article-title":"Rational for statin use in psoriatic patients","volume":"305","author":"Mosiewicz","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"B119","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.4049\/jimmunol.1100580","article-title":"Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis","volume":"187","author":"Zhang","year":"2011","journal-title":"J Immunol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cmet.2015.08.002","article-title":"Statin-induced myopathy is associated with mitochondrial complex III inhibition","volume":"22","author":"Schirris","year":"2015","journal-title":"Cell Metab"},{"key":"B121","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"key":"B122","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.immuni.2015.09.007","article-title":"Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine","volume":"43","author":"Haghikia","year":"2015","journal-title":"Immunity"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1016\/j.jid.2018.03.1522","article-title":"High-fat diet exacerbates early psoriatic skin inflammation independent of obesity: saturated fatty acids as key players","volume":"138","author":"Herbert","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/exd.13484","article-title":"High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice","volume":"27","author":"Higashi","year":"2018","journal-title":"Exp. Dermatol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17741","article-title":"Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis? A critically appraised topic","author":"Mahil","year":"2019","journal-title":"Br J Dermatol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.4049\/jimmunol.1700739","article-title":"Arginase1 deficiency in monocytes\/macrophages upregulates inducible nitric oxide synthase to promote cutaneous contact hypersensitivity","volume":"199","author":"Suwanpradid","year":"2017","journal-title":"J Immunol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/j.jid.2016.02.816","article-title":"Myeloid-derived suppressor cells in psoriasis are an expanded population exhibiting diverse T-cell-suppressor mechanisms","volume":"136","author":"Cao","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/0148607192016005429","article-title":"Arginine enhances T-cell responses in athymic nude mice","volume":"16","author":"Kirk","year":"1992","journal-title":"JPEN."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02285\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:39:26Z","timestamp":1569285566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02285\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,24]]},"references-count":128,"alternative-id":["10.3389\/fimmu.2019.02285"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02285","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,24]]},"article-number":"2285"}}