{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:09:42Z","timestamp":1767848982397,"version":"3.49.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI120714-01A1"],"award-info":[{"award-number":["R01AI120714-01A1"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["R21HD083344"],"award-info":[{"award-number":["R21HD083344"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02307","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T12:30:04Z","timestamp":1569933004000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Bacille Calmette-Gu\u00e9rin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants"],"prefix":"10.3389","volume":"10","author":[{"given":"Agano","family":"Kiravu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Osawe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Ursula","family":"Happel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trishana","family":"Nundalall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Wendoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Beer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobomi","family":"Dontsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olatogni Berenice","family":"Alinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sikiratu","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Datong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. William","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alash'le","family":"Abimiku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather B.","family":"Jaspan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive M.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1086\/499825","article-title":"The effect of bacille Calmette-Gu\u00e9rin vaccine strain and route of administration on induced immune responses in vaccinated infants","volume":"193","author":"Davids","year":"2006","journal-title":"J Infect Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1002174","DOI":"10.1371\/journal.ppat.1002174","article-title":"Association of human TLR1 and TLR6 deficiency with altered immune responses to bcg vaccination in south african infants","volume":"7","author":"Randhawa","year":"2011","journal-title":"PLoS Pathog."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1016\/j.vaccine.2016.07.022","article-title":"Different effects of BCG strains \u2013 a natural experiment evaluating the impact of the Danish and the Russian BCG strains on morbidity and scar formation in Guinea-Bissau","volume":"34","author":"Frankel","year":"2016","journal-title":"Vaccine."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1097\/QAD.0000000000000292","article-title":"In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants","volume":"28","author":"Kidzeru","year":"2014","journal-title":"AIDS."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.micpath.2012.12.002","article-title":"Vaccination against tuberculosis: how can we better BCG?","volume":"58","author":"Pitt","year":"2013","journal-title":"Microb Pathog."},{"key":"B6","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1016\/S0264-410X(03)00484-5","article-title":"The in vitro evolution of BCG vaccines","volume":"21","author":"Mostowy","year":"2003","journal-title":"Vaccine."},{"key":"B7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1164\/rccm.201104-0714OC","article-title":"The influence of bacille Calmette-Gu\u00e9rin vaccine strain on the immune response against tuberculosis: a randomized trial","volume":"185","author":"Ritz","year":"2012","journal-title":"Am J Respir Crit Care Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/j.1574-6976.2008.00118.x","article-title":"Influence of BCG vaccine strain on the immune response and protection against tuberculosis","volume":"32","author":"Ritz","year":"2008","journal-title":"FEMS Microbiol Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1164\/rccm.201003-0334OC","article-title":"Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Gu\u00e9rin vaccination of newborns","volume":"182","author":"Kagina","year":"2010","journal-title":"Am J Respir Crit Care Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated Tuberculosis in Interferon 7 Gene-disrupted Mice","volume":"178","author":"Cooper","year":"1993","journal-title":"J Exp Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"2004","journal-title":"J Exp Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/597304","article-title":"Infant HIV-1 infection severely impairs the bacille Calmette-Gu\u00e9rin vaccine-induced immune response","volume":"199","author":"Mansoor","year":"2010","journal-title":"J Infect Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/infdis\/jiu434","article-title":"Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants","volume":"211","author":"Tchakoute","year":"2015","journal-title":"J Infect Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0143043","article-title":"Altered memory T-cell responses to Bacillus Calmette-Guerin and Tetanus Toxoid vaccination and altered cytokine responses to polyclonal stimulation in HIV-exposed uninfected Kenyan infants","volume":"10","author":"Garcia-Knight","year":"2015","journal-title":"PLoS ONE."},{"key":"B15","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.eururo.2014.02.061","article-title":"Bacillus calmette-gu\u00e9rin strain differences have an impact on clinical outcome in bladder cancer immunotherapy","volume":"66","author":"Rentsch","year":"2014","journal-title":"Eur Urol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1016\/j.vaccine.2012.01.053","article-title":"The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda","volume":"30","author":"Anderson","year":"2012","journal-title":"Vaccine."},{"key":"B18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000355628","article-title":"Long-lasting effects of BCG vaccination on both heterologous Th1\/Th17 responses and innate trained immunity","volume":"6","author":"Kleinnijenhuis","year":"2014","journal-title":"J Innate Immun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1093\/infdis\/jiu508","article-title":"Heterologous immunological effects of early BCG vaccination in low-birth-weight infants in guinea-bissau: a randomized-controlled trial","volume":"211","author":"Jensen","year":"2015","journal-title":"J Infect Dis."},{"key":"B20","first-page":"1","volume-title":"National Consolidated Guidelines","year":"2015"},{"key":"B21","unstructured":"National AIDS and STI's Control Programme, Federal Ministry of Health: National Guidelines for HIV Prevention Treatment and Care (2016)2016"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1097\/QAD.0000000000001974","article-title":"Breastfeeding mitigates the effects of maternal HIV on infant infectious morbidity in the Option B+ era","volume":"32","author":"Tchakoute","year":"2018","journal-title":"AIDS."},{"key":"B23","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jim.2004.06.010","article-title":"Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies","volume":"291","author":"Hanekom","year":"2004","journal-title":"J Immunol Methods."},{"key":"B24","unstructured":"30628467ViennaR Foundation for Statistical ComputingR: A Language and Environment for Statistical Computing2014"},{"key":"B25","first-page":"65","article-title":"Board of the Foundation of the Scandinavian Journal of Statistics. A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Source Scand J Stat."},{"key":"B26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","author":"Roederer","year":"2011","journal-title":"Cytom Part A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/nbt.3187","article-title":"COMPASS identifies T-cell subsets correlated with clinical outcomes","volume":"33","author":"Lin","year":"2015","journal-title":"Nat Biotechnol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5349","DOI":"10.1128\/JCM.41.11.5349.2003","article-title":"genetic composition of Mycobacterium bovis BCG substrain sofia [2]","volume":"41","author":"Stefanova","year":"2003","journal-title":"J Clin Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1592","article-title":"Multifunctional T H 1 cells define a correlate of vaccine- mediated protection against Leishmania major","volume":"13","author":"Darrah","year":"2007","journal-title":"Nat Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"12071","DOI":"10.1128\/JVI.01261-07","article-title":"Human immunodeficiency virus Type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines","volume":"81","author":"Kannanganat","year":"2007","journal-title":"J Virol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1128\/CVI.00721-14","article-title":"Quest for correlates of protection against tuberculosis","volume":"22","author":"Bhatt","year":"2015","journal-title":"Clin Vaccine Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/trstmh\/tru168","article-title":"Trained immunity: consequences for the heterologous effects of BCG vaccination","volume":"109","author":"Kleinnijenhuis","year":"2014","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/QAD.0000000000000536","article-title":"The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Gu\u00e9rin vaccination","volume":"29","author":"Jones","year":"2015","journal-title":"AIDS."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.4049\/jimmunol.180.5.3569","article-title":"Bacillus calmette-guerin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles","volume":"180","author":"Soares","year":"2014","journal-title":"J Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1097\/INF.0000000000001946","article-title":"High incidence of tuberculosis infection in HIV-exposed children exiting an isoniazid preventive therapy trial","volume":"37","author":"Cranmer","year":"2018","journal-title":"Pediatr Infect Dis J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1126\/science.284.5419.1520","article-title":"Comparative genomics of BCG vaccines by whole-genome DNA microarray","volume":"284","author":"Behr","year":"1999","journal-title":"Science."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0071243","article-title":"Genome sequencing and analysis of BCG vaccine strains","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS ONE."},{"key":"B39","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/mt.2015.216","article-title":"Variable virulence and efficacy of BCG vaccine strains in mice and correlation with genome polymorphisms","volume":"24","author":"Zhang","year":"2016","journal-title":"Mol Ther."},{"key":"B40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/IAI.64.1.1-9.1996","article-title":"Comparison of immune responses of mice immunized with five different Mycobacterium bovis BCG vaccine strains","volume":"64","author":"Lagranderie","year":"1996","journal-title":"Infect Immun."},{"key":"B41","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1086\/515614","article-title":"Cellular immune responses to four doses of percutaneous Bacille Calmette-Guerin in healthy adults","volume":"178","author":"Lowry","year":"2012","journal-title":"J Infect Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1128\/CVI.00309-06","article-title":"Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates","volume":"14","author":"Davids","year":"2007","journal-title":"Clin Vaccine Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1086\/597069","article-title":"Population differences in immune responses to Bacille Calmette-Gu\u00e9rin vaccination in infancy","volume":"199","author":"Lalor","year":"2009","journal-title":"J Infect Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.jaci.2009.03.040","article-title":"Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations","volume":"124","author":"van den Biggelaar","year":"2009","journal-title":"J Allergy Clin Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1016\/j.vaccine.2008.04.083","article-title":"Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-\u03b2 production","volume":"26","author":"Elias","year":"2008","journal-title":"Vaccine."},{"key":"B46","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.vaccine.2010.10.047","article-title":"Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation","volume":"29","author":"Elliott","year":"2010","journal-title":"Vaccine."},{"key":"B47","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.vaccine.2017.12.010","article-title":"Bacillus Calmette-Gu\u00e9rin (BCG) vaccine: a global assessment of demand and supply balance","volume":"36","author":"Cernuschi","year":"2018","journal-title":"Vaccine."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02307\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T22:36:03Z","timestamp":1611441363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02307\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":47,"alternative-id":["10.3389\/fimmu.2019.02307"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02307","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,1]]},"article-number":"2307"}}