{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:33:33Z","timestamp":1782970413310,"version":"3.54.5"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02314","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:30:57Z","timestamp":1569904257000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation"],"prefix":"10.3389","volume":"10","author":[{"given":"S\u00e9bastien","family":"Gibot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Jolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Lemari\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Derive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Boufenzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","article-title":"Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes","volume":"164","author":"Bouchon","year":"2000","journal-title":"J Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/35074114","article-title":"TREM-1 amplifies inflammation and is a crucial mediator of septic shock","volume":"410","author":"Bouchon","year":"2001","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nri1106","article-title":"TREMs in the immune system and beyond","volume":"3","author":"Colonna","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/immu.200310033","article-title":"The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44","volume":"33","author":"Allcock","year":"2003","journal-title":"Eur J Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.imlet.2010.09.019","article-title":"New B-cell CD molecules","volume":"134","author":"Matesanz-Isabel","year":"2011","journal-title":"Immunol Lett"},{"key":"B6","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1177\/1753425911399796","article-title":"Induction of triggering receptor expressed on myeloid cells. (TREM-1) in airway epithelial cells by 1,25. (OH)2 vitamin D3","volume":"18","author":"Rigo","year":"2012","journal-title":"Innate Immun"},{"key":"B7","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/cvr\/cvy018","article-title":"Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock","volume":"114","author":"Jolly","year":"2018","journal-title":"Cardiovasc Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41423-018-0003-5","article-title":"TREM-1 multimerization is essential for its activation on monocytes and neutrophils","volume":"16","author":"Carrasco","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.4049\/jimmunol.1402303","article-title":"Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1","volume":"194","author":"Read","year":"2015","journal-title":"J Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/SHK.0b013e31827bcdfb","article-title":"Effects of a TREM-like transcript 1-derived peptide during hypodynamic septic shock in pigs","volume":"39","author":"Derive","year":"2013","journal-title":"Shock"},{"key":"B11","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1097\/ALN.0000000000000078","article-title":"Attenuation of responses to endotoxin by the triggering receptor expressed on myeloid cells-1 inhibitor LR12 in nonhuman primate","volume":"120","author":"Derive","year":"2014","journal-title":"Anesthesiology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1084\/jem.20040708","article-title":"A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis","volume":"200","author":"Gibot","year":"2004","journal-title":"J Exp Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/CIRCRESAHA.116.305628","article-title":"TREM-1 Mediates inflammatory injury and cardiac remodeling following myocardial infarction","volume":"116","author":"Boufenzer","year":"2015","journal-title":"Circ Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ehf2.12029","article-title":"Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction","volume":"2","author":"Lemari\u00e9","year":"2015","journal-title":"ESC Heart Fail"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1016\/j.jacc.2016.10.015","article-title":"Genetic and pharmacological inhibition of TREM-1 limits the development of experimental atherosclerosis","volume":"68","author":"Joffre","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"13151","DOI":"10.1038\/ncomms13151","article-title":"TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis","volume":"7","author":"Zysset","year":"2016","journal-title":"Nat Commun"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.1021\/acs.molpharmaceut.7b00711","article-title":"Novel TREM-1 inhibitors attenuate tumor growth and prolong survival in experimental pancreatic cancer","volume":"14","author":"Shen","year":"2017","journal-title":"Mol Pharm"},{"key":"B18","doi-asserted-by":"publisher","first-page":"14870","DOI":"10.1038\/s41598-017-14516-4","article-title":"TREM-1 promotes intestinal tumorigenesis","volume":"7","author":"Saurer","year":"2017","journal-title":"Sci Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40635-018-0196-z","article-title":"Safety and pharmacodynamic activity of a novel TREM-1 pathway inhibitory peptide in septic shock patients: phase IIa clinical trial results","volume":"6","author":"Fran\u00e7ois","year":"2018","journal-title":"ICM Exp"},{"key":"B20","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock. (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"B21","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1111\/jcmm.13173","article-title":"Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis","volume":"21","author":"Shen","year":"2017","journal-title":"J Cell Mol Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"16556","DOI":"10.1073\/pnas.1218219110","article-title":"NF-kB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-kB in immune-mediated diseases","volume":"110","author":"Sehnert","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B24","doi-asserted-by":"publisher","first-page":"21129","DOI":"10.1074\/jbc.270.36.21129","article-title":"Peptides which bind to E-selectin and block neutrophil adhesion","volume":"270","author":"Martens","year":"1995","journal-title":"J Biol Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1365-2958.1990.tb00620.x","article-title":"Analysis of the structure-function relationship of Pseudomonas aeruginosa exotoxin A","volume":"4","author":"Wick","year":"1990","journal-title":"Mol Microbiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.pharmthera.2017.02.043","article-title":"TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives","volume":"177","author":"Tammaro","year":"2017","journal-title":"Pharmacol Ther"},{"key":"B27","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.imbio.2008.07.008","article-title":"From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection","volume":"213","author":"Sharif","year":"2008","journal-title":"Immunobiology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.yexmp.2007.11.004","article-title":"Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia","volume":"84","author":"Chen","year":"2008","journal-title":"Exp Mol Pathol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1189\/jlb.0210113","article-title":"Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia","volume":"88","author":"Laskin","year":"2010","journal-title":"J Leukoc Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02314\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:30:58Z","timestamp":1569904258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02314\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":30,"alternative-id":["10.3389\/fimmu.2019.02314"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02314","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,1]]},"article-number":"2314"}}