{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:55:19Z","timestamp":1791244519135,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02366","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:31:46Z","timestamp":1570667506000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Prognostic Implications of the Complement Protein C1q in Gliomas"],"prefix":"10.3389","volume":"10","author":[{"given":"Alessandro","family":"Mangogna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Belmonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agostinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Gerardo","family":"Iacopino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Martorana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Rodolico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Bonazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Zanconati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3389\/fimmu.2017.00592","article-title":"C1 complex: an adaptable proteolytic module for complement and non-complement functions","volume":"8","author":"Lu","year":"2017","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0162-3109(00)80301-X","article-title":"C1q: structure, function, and receptors","volume":"49","author":"Kishore","year":"2000","journal-title":"Immunopharmacology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/BF00185116","article-title":"Localization of the gene cluster encoding the A, B, and C chains of human C1q to 1p34.1-1p36.3","volume":"35","author":"Sellar","year":"1992","journal-title":"Immunogenetics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1042\/bj1550019","article-title":"Subunit composition and structure of subcomponent C1q of the first component of human complement","volume":"155","author":"Reid","year":"1976","journal-title":"Biochem J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.it.2004.08.006","article-title":"C1q and tumor necrosis factor superfamily: modularity and versatility","volume":"25","author":"Kishore","year":"2004","journal-title":"Trends Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.4049\/jimmunol.0903215","article-title":"An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development","volume":"185","author":"Agostinis","year":"2010","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1073\/pnas.1311968111","article-title":"C1q as a unique player in angiogenesis with therapeutic implication in wound healing","volume":"111","author":"Bossi","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12026-015-8705-6","article-title":"Fundamental role of C1q in autoimmunity and inflammation","volume":"63","author":"Son","year":"2015","journal-title":"Immunol Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fimmu.2012.00052","article-title":"The C1q family of proteins: insights into the emerging non-traditional functions","volume":"3","author":"Ghebrehiwet","year":"2012","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"10346","DOI":"10.1038\/ncomms10346","article-title":"C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation","volume":"7","author":"Bulla","year":"2016","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.3389\/fimmu.2017.01559","article-title":"Complement protein C1q binds to hyaluronic acid in the malignant pleural mesothelioma microenvironment and promotes tumor growth","volume":"8","author":"Agostinis","year":"2017","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e5755","DOI":"10.1371\/journal.pone.0005755","article-title":"Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells","volume":"4","author":"Hong","year":"2009","journal-title":"PLoS ONE"},{"key":"B13","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3389\/fimmu.2016.00599","article-title":"Human C1q induces apoptosis in an ovarian cancer cell line via tumor necrosis factor pathway","volume":"7","author":"Kaur","year":"2016","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1253653","DOI":"10.1080\/2162402X.2016.1253653","article-title":"The non-inflammatory role of C1q during Her2\/neu-driven mammary carcinogenesis","volume":"5","author":"Bandini","year":"2016","journal-title":"Oncoimmunology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"865","DOI":"10.3389\/fimmu.2019.00865","article-title":"Is the complement protein C1q a pro- or anti-tumorigenic factor? bioinformatics analysis involving human carcinomas","volume":"10","author":"Mangogna","year":"2019","journal-title":"Front Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/j.1471-4159.2007.05012.x","article-title":"Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms","volume":"104","author":"Pisalyaput","year":"2008","journal-title":"J Neurochem"},{"key":"B18","doi-asserted-by":"publisher","first-page":"652","DOI":"10.14336\/AD.2019.0118","article-title":"Emerging roles of complement protein C1q in neurodegeneration","volume":"10","author":"Cho","year":"2019","journal-title":"Aging Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s40478-018-0591-4","article-title":"The complement system in glioblastoma multiforme","volume":"6","author":"Bouwens van der Vlis","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"B20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"B21","first-page":"408","volume-title":"WHO Classification of Tumours of the Central Nervous System, Revised","author":"Louis","year":"2016"},{"key":"B22","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/nox158","article-title":"CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014","volume":"19","author":"Ostrom","year":"2017","journal-title":"Neuro Oncol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jneuroim.2014.11.016","article-title":"Complement activation in Glioblastoma multiforme pathophysiology: evidence from serum levels and presence of complement activation products in tumor tissue","volume":"278","author":"Bouwens","year":"2015","journal-title":"J Neuroimmunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1593\/neo.07112","article-title":"Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles","volume":"9","author":"Rhodes","year":"2007","journal-title":"Neoplasia"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1476-5586(04)80047-2","article-title":"ONCOMINE: a cancer microarray database and integrated data-mining platform","volume":"6","author":"Rhodes","year":"2004","journal-title":"Neoplasia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1093\/neuonc\/nos263","article-title":"Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group","volume":"14","author":"Yan","year":"2012","journal-title":"Neuro Oncol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.3389\/fimmu.2018.01748","article-title":"Pathological significance and prognostic value of surfactant protein D in cancer","volume":"9","author":"Mangogna","year":"2018","journal-title":"Front Immunol"},{"key":"B29","first-page":"309","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis","year":"2007"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1002\/cam4.2192","article-title":"Immune microenvironments differ in immune characteristics and outcome of glioblastoma multiforme","volume":"8","author":"Zhang","year":"2019","journal-title":"Cancer Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1001\/jamaoncol.2018.1789","article-title":"Adult glioma incidence and survival by race or ethnicity in the United States from 2000 to 2014","volume":"4","author":"Ostrom","year":"2018","journal-title":"JAMA Oncol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.2353\/ajpath.2007.070011","article-title":"Genetic pathways to primary and secondary glioblastoma","volume":"170","author":"Ohgaki","year":"2007","journal-title":"Am J Pathol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nri.2017.97","article-title":"Complement in cancer: untangling an intricate relationship","volume":"18","author":"Reis","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1158\/2326-6066.CIR-18-0891","article-title":"Tumor cells hijack macrophage-produced complement C1q to promote tumor growth","volume":"7","author":"Roumenina","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1093\/jnci\/djt205","article-title":"Investigation of complement activation product c4d as a diagnostic and prognostic biomarker for lung cancer","volume":"105","author":"Ajona","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.molimm.2011.04.003","article-title":"Complement in the brain","volume":"48","author":"Veerhuis","year":"2011","journal-title":"Mol Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"6409","DOI":"10.2147\/CMAR.S183293","article-title":"Specific clinical and immune features of CD68 in glioma via 1,024 samples","volume":"10","author":"Wang","year":"2018","journal-title":"Cancer Manag Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/jcp.24260","article-title":"Tumor associated macrophages and neutrophils in tumor progression","volume":"228","author":"Galdiero","year":"2013","journal-title":"J Cell Physiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nn.4185","article-title":"The role of microglia and macrophages in glioma maintenance and progression","volume":"19","author":"Hambardzumyan","year":"2016","journal-title":"Nat Neurosci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.molimm.2014.06.011","article-title":"cC1qR\/CR and gC1qR\/p33: observations in cancer","volume":"61","author":"Peerschke","year":"2014","journal-title":"Mol Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3109\/14653249.2011.651532","article-title":"Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q","volume":"14","author":"Qiu","year":"2012","journal-title":"Cytotherapy"},{"key":"B42","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.stem.2011.04.013","article-title":"Deadly teamwork: neural cancer stem cells and the tumor microenvironment","volume":"8","author":"Lathia","year":"2011","journal-title":"Cell Stem Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"16970","DOI":"10.1073\/pnas.0808616105","article-title":"Wnt-mediated self-renewal of neural stem\/progenitor cells","volume":"105","author":"Kalani","year":"2008","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02366\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:31:49Z","timestamp":1570667509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02366\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,10]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2019.02366"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02366","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736814294.793589888","asserted-by":"object"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,10]]},"article-number":"2366"}}