{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:39:05Z","timestamp":1793108345741,"version":"4.5.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02384","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T08:46:38Z","timestamp":1571388398000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry"],"prefix":"10.3389","volume":"10","author":[{"given":"Adrien","family":"Leite Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Bitoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Paoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetane","family":"Nocturne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Marcos Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cosma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Le Grand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Tchitchek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3238\/arztebl.2013.0477","article-title":"Rheumatoide arthritis - Fr\u00fchdiagnose und krankheitskontrolle","volume":"110","author":"Schneider","year":"2013","journal-title":"Dtsch Arztebl Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.hcl.2010.09.002","article-title":"Advances in the medical treatment of rheumatoid arthritis","volume":"27","author":"Kahlenberg","year":"2011","journal-title":"Hand Clin."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/art.33418","article-title":"The CD14brightCD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population","volume":"64","author":"Rossol","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1136\/annrheumdis-2015-208356","article-title":"Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs","volume":"75","author":"Corsiero","year":"2016","journal-title":"Ann Rheum Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/art.40323","article-title":"A randomized phase IIb study of mavrilimumab and golimumab in rheumatoid arthritis","volume":"70","author":"Weinblatt","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/cyto.a.23107","article-title":"In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry","volume":"91","author":"Elhmouzi-Younes","year":"2017","journal-title":"Cytom Part A J Int Soc Anal Cytol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nbt.1991","article-title":"Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE","volume":"29","author":"Qiu","year":"2011","journal-title":"Nat Biotechnol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"817038","DOI":"10.1155\/2015\/817038","article-title":"Regulation of neutrophil degranulation and cytokine secretion: a novel model approach based on linear fitting","volume":"2015","author":"Naegelen","year":"2015","journal-title":"J Immunol Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1046\/j.1365-3083.1999.00602.x","article-title":"Enhanced Expression of Integrins and CD66b on Peripheral Blood Neutrophils and Eosinophils in Patients with Rheumatoid Arthritis, and the Effect of Glucocorticoids","volume":"50","author":"Torsteinsd\u00f3ttir","year":"1999","journal-title":"Scand. J. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1182\/blood-2018-07-864538","article-title":"Human neutrophils express low levels of Fc g RIIIA, which plays a role in PMN activation","volume":"133","author":"Golay","year":"2019","journal-title":"Blood."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.1182\/blood-2004-03-0859","article-title":"Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells","volume":"104","author":"Grossman","year":"2004","journal-title":"Blood."},{"key":"B14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12865-014-0036-1","article-title":"Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells","volume":"15","author":"Lin","year":"2014","journal-title":"BMC Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1128\/IAI.00749-12","article-title":"CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes","volume":"81","author":"Bose","year":"2013","journal-title":"Infect Immun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s10875-012-9674-3","article-title":"Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis","volume":"32","author":"Cho","year":"2012","journal-title":"J Clin Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cyto.2018.08.018","article-title":"A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7\/8 engagements in HIV-1 infected humans","volume":"111","author":"Leite Pereira","year":"2018","journal-title":"Cytokine."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.3389\/fimmu.2019.01777","article-title":"Characterization of leukocytes from HIV-ART patients using combined cytometric profiles of 72 cell markers","volume":"10","author":"Leite Pereira","year":"2019","journal-title":"Front Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/cyto.a.22271","article-title":"Normalization of mass cytometry data with bead standards","volume":"83","author":"Finck","year":"2013","journal-title":"Cytom Part A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/bioinformatics\/btw708","article-title":"SPADEVizR: an R package for visualization, analysis and integration of SPADE results","volume":"33","author":"Gautreau","year":"2016","journal-title":"Bioinformatics."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v049.i08","article-title":"Deducer: a data analysis GUI for R","volume":"49","author":"Ian Fellows","year":"2012","journal-title":"J. Stat. Softw."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02384\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T08:46:40Z","timestamp":1571388400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02384\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,18]]},"references-count":22,"alternative-id":["10.3389\/fimmu.2019.02384"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02384","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,18]]},"article-number":"2384"}}