{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:03:11Z","timestamp":1789916591831,"version":"4.0.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02499","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:36:15Z","timestamp":1571704575000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity"],"prefix":"10.3389","volume":"10","author":[{"given":"Mar\u00eda F.","family":"Ferrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00edda O.","family":"L\u00f3pez Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E.","family":"Errasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Charo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Romanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gorgojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio A.","family":"Carrera Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo M.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.micinf.2010.12.006","article-title":"Junin virus. A XXI century update","volume":"13","author":"Gomez","year":"2011","journal-title":"Microbes Infect"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s00705-015-2418-y","article-title":"Past, present, and future of arenavirus taxonomy","volume":"160","author":"Radoshitzky","year":"2015","journal-title":"Arch Virol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.vetmic.2009.08.027","article-title":"Zoonotic aspects of arenavirus infections","volume":"140","author":"Charrel","year":"2010","journal-title":"Vet Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jcv.2014.12.004","article-title":"Research efforts to control highly pathogenic arenaviruses: a summary of the progress and gaps","volume":"64","author":"Kerber","year":"2015","journal-title":"J Clin Virol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e02063","DOI":"10.1128\/mBio.02063-14","article-title":"Arenavirus stable signal peptide is the keystone subunit for glycoprotein complex organization","volume":"5","author":"Bederka","year":"2014","journal-title":"MBio"},{"key":"B6","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/ni.3324","article-title":"New insights into the multidimensional concept of macrophage ontogeny, activation and function","volume":"17","author":"Ginhoux","year":"2016","journal-title":"Nat Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B9","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1165\/rcmb.2015-0012OC","article-title":"Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages","volume":"53","author":"Tarique","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.yjmcc.2015.05.010","article-title":"Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis","volume":"85","author":"De Giusti","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.celrep.2019.06.062","article-title":"Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice","volume":"28","author":"Carestia","year":"2019","journal-title":"Cell Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"ra75","DOI":"10.1126\/scisignal.2005196","article-title":"Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFalpha in glioblastoma","volume":"7","author":"Kusne","year":"2014","journal-title":"Sci Signal"},{"key":"B13","doi-asserted-by":"publisher","first-page":"7409","DOI":"10.1128\/JVI.01014-15","article-title":"Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic junin virus strains","volume":"89","author":"Negrotto","year":"2015","journal-title":"J Virol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature05539","article-title":"Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses","volume":"446","author":"Radoshitzky","year":"2007","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1000847","DOI":"10.1371\/journal.ppat.1000847","article-title":"Junin virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling","volume":"6","author":"Pozner","year":"2010","journal-title":"PLoS Pathog"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S1357-2725(99)00070-9","article-title":"The transferrin receptor: role in health and disease","volume":"31","author":"Ponka","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"12.11","DOI":"10.1146\/annurev-immunol-032414-112103","article-title":"TAM receptor signaling in immune homeostasis","volume":"33","author":"Rothlin","year":"2015","journal-title":"Ann Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1126\/science.aai8132","article-title":"Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells","volume":"356","author":"Bosurgi","year":"2017","journal-title":"Science"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1038\/nm.3974","article-title":"The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity","volume":"21","author":"Miner","year":"2015","journal-title":"Nat Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e12414","DOI":"10.7554\/eLife.12414","article-title":"AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity","volume":"5","author":"Schmid","year":"2016","journal-title":"Elife."},{"key":"B21","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/ni.2986","article-title":"Diversification of TAM receptor tyrosine kinase function","volume":"15","author":"Zagorska","year":"2014","journal-title":"Nat Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.humimm.2014.09.015","article-title":"The regulation role of interferon regulatory factor-1 gene and clinical relevance","volume":"75","author":"Dou","year":"2014","journal-title":"Hum Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/infdis\/154.3.478","article-title":"Macrophage maturity and modulation of response to Junin virus in infected rats","volume":"154","author":"Blejer","year":"1986","journal-title":"J Infect Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"10516","DOI":"10.1128\/JVI.78.19.10516-10524.2004","article-title":"Human macrophages, but not dendritic cells, are activated and produce alpha\/beta interferons in response to Mopeia virus infection","volume":"78","author":"Pannetier","year":"2004","journal-title":"J Virol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.4049\/jimmunol.172.5.2861","article-title":"Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells","volume":"172","author":"Baize","year":"2004","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"12093","DOI":"10.1128\/JVI.00429-11","article-title":"Lassa virus nucleoprotein mutants generated by reverse genetics induce a robust type I interferon response in human dendritic cells and macrophages","volume":"85","author":"Carnec","year":"2011","journal-title":"J Virol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2637","DOI":"10.1371\/journal.pntd.0002637","article-title":"Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever","volume":"8","author":"Pannetier","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1137","DOI":"10.1371\/journal.pntd.0001137","article-title":"Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages","volume":"5","author":"Groseth","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"12513","DOI":"10.1128\/JVI.01674-15","article-title":"Differential inhibition of macrophage activation by lymphocytic choriomeningitis virus and pichinde virus is mediated by the Z protein N-terminal domain","volume":"89","author":"Xing","year":"2015","journal-title":"J Virol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1128\/JVI.03349-14","article-title":"The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production","volume":"89","author":"Xing","year":"2015","journal-title":"J Virol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3389\/fimmu.2019.00372","article-title":"Hemorrhagic fever-causing arenaviruses: lethal pathogens and potent immune suppressors","volume":"10","author":"Brisse","year":"2019","journal-title":"Front Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/v5010340","article-title":"Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers","volume":"5","author":"Schattner","year":"2013","journal-title":"Viruses"},{"key":"B33","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nat Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4172\/2155-9899.1000311","article-title":"Macrophage polarization in virus-host interactions","volume":"6","author":"Sang","year":"","journal-title":"J Clin Cell Immunol"},{"key":"B35","first-page":"138","article-title":"Macrophage-virus interactions","volume-title":"The Macrophage.","author":"Zink","year":"2002"},{"key":"B36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/82_2010_96","article-title":"The role of IL-10 in regulating immunity to persistent viral infections","volume":"350","author":"Wilson","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1003735","DOI":"10.1371\/journal.ppat.1003735","article-title":"Macrophage and T cell produced IL-10 promotes viral chronicity","volume":"9","author":"Richter","year":"2013","journal-title":"PLoS Pathog"},{"key":"B38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/rmv.1817","article-title":"The role of macrophage IL-10\/innate IFN interplay during virus-induced asthma","volume":"25","author":"Zdrenghea","year":"2015","journal-title":"Rev Med Virol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1099\/vir.0.058966-0","article-title":"IL-10 encoded by viruses: a remarkable example of independent acquisition of a cellular gene by viruses and its subsequent evolution in the viral genome","volume":"95","author":"Ouyang","year":"2014","journal-title":"J Gen Virol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1126\/science.1074883","article-title":"Viral IL-6-induced cell proliferation and immune evasion of interferon activity","volume":"298","author":"Chatterjee","year":"2002","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"B42","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.bbadis.2017.01.006","article-title":"IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection","volume":"1863","author":"Sanmarco","year":"2017","journal-title":"Biochim Biophys Acta"},{"key":"B44","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fimmu.2018.00152","article-title":"Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice","volume":"9","author":"Hanazawa","year":"2018","journal-title":"Front Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fimmu.2015.00212","article-title":"Anatomy of a discovery: m1 and m2 macrophages","volume":"6","author":"Mills","year":"2015","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12920-018-0335-0","article-title":"Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection","volume":"11","author":"Zhang","year":"2018","journal-title":"BMC Med Genomics"},{"key":"B47","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S0092-8674(88)91307-4","article-title":"Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements","volume":"54","author":"Miyamoto","year":"1988","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1002230","DOI":"10.1371\/journal.ppat.1002230","article-title":"Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection","volume":"7","author":"Brien","year":"2011","journal-title":"PLoS Pathog"},{"key":"B49","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1096\/fj.201600356R","article-title":"IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes","volume":"30","author":"Xu","year":"2016","journal-title":"FASEB J"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12867-017-0084-1","article-title":"Properties of STAT1 and IRF1 enhancers and the influence of SNPs","volume":"18","author":"Abou El Hassan","year":"2017","journal-title":"BMC Mol Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0092-8674(90)90163-9","article-title":"Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated","volume":"63","author":"Harada","year":"1990","journal-title":"Cell"},{"key":"B52","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1074-7613(00)00064-9","article-title":"CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha\/beta signaling","volume":"13","author":"Hida","year":"2000","journal-title":"Immunity"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1084\/jem.20010753","article-title":"Modulation of human immunodeficiency virus 1 replication by interferon regulatory factors","volume":"195","author":"Sgarbanti","year":"2002","journal-title":"J Exp Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1182\/blood-2010-07-297721","article-title":"HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production","volume":"118","author":"Harman","year":"2011","journal-title":"Blood"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02499\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:36:19Z","timestamp":1571704579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02499\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":54,"alternative-id":["10.3389\/fimmu.2019.02499"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02499","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]},"article-number":"2499"}}