{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:15:43Z","timestamp":1787026543523,"version":"build-2736575974"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008771","name":"Animal and Plant Quarantine Agency","doi-asserted-by":"publisher","award":["B-1543386-2017-18-01"],"award-info":[{"award-number":["B-1543386-2017-18-01"]}],"id":[{"id":"10.13039\/501100008771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008771","name":"Animal and Plant Quarantine Agency","doi-asserted-by":"publisher","award":["B-1543386-2019-21-0301"],"award-info":[{"award-number":["B-1543386-2019-21-0301"]}],"id":[{"id":"10.13039\/501100008771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02509","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:45:51Z","timestamp":1572309951000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Mincle and STING-Stimulating Adjuvants Elicit Robust Cellular Immunity and Drive Long-Lasting Memory Responses in a Foot-and-Mouth Disease Vaccine"],"prefix":"10.3389","volume":"10","author":[{"given":"Min Ja","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyundong","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Mi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byounghan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang Sub","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hyeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1128\/CMR.17.2.465-493.2004","article-title":"Foot-and-mouth disease","volume":"17","author":"Grubman","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1865-1682.2011.01236.x","article-title":"The pathogenesis of foot-and-mouth disease II: viral pathways in swine, small ruminants, and wildlife; myotropism, chronic syndromes, and molecular virus-host interactions","volume":"58","author":"Arzt","year":"2011","journal-title":"Transbound Emerg Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.vaccine.2018.12.064","article-title":"Considerations for design and implementation of vaccine field trials for novel foot-and-mouth disease vaccines","volume":"37","author":"Lyons","year":"2019","journal-title":"Vaccine"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s00705-019-04216-x","article-title":"Foot-and-mouth disease vaccines: recent updates and fufure perspectives","volume":"164","author":"Kamel","year":"2019","journal-title":"Arch Virol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.1016\/j.vaccine.2005.07.043","article-title":"Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: use in emergency outbreak response","volume":"23","author":"Golde","year":"2005","journal-title":"Vaccine"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0378-1135(89)90045-X","article-title":"Simultaneous vaccination of piglets against foot-and-mouth disease and classical swine fever","volume":"20","author":"De Clercq","year":"1989","journal-title":"Vet Microbiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1746-6148-10-2","article-title":"Resiquimod and polyinosinic-polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine","volume":"10","author":"Zhou","year":"2014","journal-title":"BMC Vet Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"7929","DOI":"10.1016\/j.vaccine.2018.11.012","article-title":"The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs","volume":"36","author":"Chen","year":"2018","journal-title":"Vaccine"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1128\/CVI.00127-14","article-title":"Rapeseed oil and ginseng saponins work synergistically to enhance Th1 and Th2 immune responses induced by the foot-and-mouth disease vaccine","volume":"21","author":"Zhang","year":"2014","journal-title":"Clin Vaccine Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.tips.2017.06.002","article-title":"An overview of novel adjuvants designed for improving vaccine efficacy","volume":"38","author":"Bonam","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/vaccines3020320","article-title":"Vaccine adjuvants: from 1920 to 2015 and beyond","volume":"3","author":"Di Pasquale","year":"2015","journal-title":"Vaccines"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.3389\/fimmu.2018.02874","article-title":"Adjuvants enhancing cross-presentation by dendritic cells: the key to more effective vaccines?","volume":"9","author":"Ho","year":"2018","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1172\/JCI81083","article-title":"Beyond antigens and adjuvants: formulating future vaccines","volume":"126","author":"Moyer","year":"2016","journal-title":"J Clin Invest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e00155","DOI":"10.1128\/JVI.00155-17","article-title":"Rapid engineering of foot-and-mouth disease vaccine and challenge viruses","volume":"91","author":"Lee","year":"2017","journal-title":"J Virol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/BF01315592","article-title":"Binary ethylenimmine as an inactivated for foot-and-mouth disease virus and its application for vaccine production","volume":"47","author":"Bahnemann","year":"1975","journal-title":"Arch Virol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1016\/j.vaccine.2014.01.067","article-title":"Protection to homologous and heterologous challenge in pigs immunized with vaccine against foot-and-mouth disease type O caused an epidemic in East Asia during 2010\/2011","volume":"32","author":"Park","year":"2014","journal-title":"Vaccine"},{"key":"B18","volume-title":"Terrestrial Animal Health Code","year":"2012"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.1016\/j.vaccine.2010.02.074","article-title":"Marker vaccine potential of a foot-and-mouth disease virus with a partial VP1 G-H loop deletion","volume":"28","author":"Fowler","year":"2010","journal-title":"Vaccine"},{"key":"B20","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1177\/1040638715584156","article-title":"Comparative performance of fetal goat tongue cell line ZZ-R 127 and fetal porcine kidney cell line LFBK-alphavbeta6 for foot-and-mouth disease virus isolation","volume":"27","author":"Fukai","year":"2015","journal-title":"J Vet Diagn Invest"},{"key":"B21","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.immuni.2018.12.020","article-title":"Microbiota sensing by mincle-syk axis in dendritic cells regulates interleukin-17 and\u221222 production and promotes intestinal barrier integrity","volume":"50","author":"Martinez-Lopez","year":"2019","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e1006333","DOI":"10.1371\/journal.ppat.1006333","article-title":"Signaling C-type lectin receptors in antimycobacterial immunity","volume":"13","author":"Marakalala","year":"2017","journal-title":"PLoS Pathog"},{"key":"B24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fimmu.2018.00225","article-title":"Dectin-1-Syk-CARD9 signaling pathway in TB immunity","volume":"9","author":"Wagener","year":"2018","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3389\/fimmu.2018.01297","article-title":"The cgas-sting signaling pathway is required for the innate immune response against ectromelia virus","volume":"9","author":"Cheng","year":"2018","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1002\/eji.201546113","article-title":"Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway","volume":"46","author":"Bode","year":"2016","journal-title":"Eur J Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1038\/s41467-018-03782-z","article-title":"STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection","volume":"9","author":"Ding","year":"2018","journal-title":"Nat Commun"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coi.2017.06.006","article-title":"Non-human primates as a model for understanding the mechanism of action of toll-like receptor-based vaccine adjuvants","volume":"47","author":"Thompson","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.virol.2018.07.014","article-title":"Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin","volume":"522","author":"Vanwalscappel","year":"2018","journal-title":"Virology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1073\/pnas.98.3.1212","article-title":"Prolonging the half-life of human interferon-alpha 2 in circulation: design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2","volume":"98","author":"Shechter","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"B31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2165\/00003088-199019050-00003","article-title":"Clinical pharmacokinetics of interferons","volume":"19","author":"Wills","year":"1990","journal-title":"Clin Pharmacokinet"},{"key":"B32","doi-asserted-by":"publisher","first-page":"7088","DOI":"10.1016\/j.vaccine.2017.10.094","article-title":"Long-term humoral immunity induced by CVC1302-adjuvanted serotype O foot-and-mouth disease inactivated vaccine correlates with promoted T follicular helper cells and thus germinal center responses in mice","volume":"35","author":"Du","year":"2017","journal-title":"Vaccine"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02509\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:45:52Z","timestamp":1572309952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02509\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":32,"alternative-id":["10.3389\/fimmu.2019.02509"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02509","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"article-number":"2509"}}