{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:55:01Z","timestamp":1793148901053,"version":"4.5.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 1023"],"award-info":[{"award-number":["EXC 1023"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HU 2144\/1-1"],"award-info":[{"award-number":["HU 2144\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["GA 276704"],"award-info":[{"award-number":["GA 276704"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02555","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T04:40:04Z","timestamp":1572324004000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":118,"title":["Adiponectin Limits IFN-\u03b3 and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis"],"prefix":"10.3389","volume":"10","author":[{"given":"Jayagopi","family":"Surendar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J.","family":"Frohberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indulekha","family":"Karunakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Stamminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lena","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mam.2012.10.002","article-title":"Innate immune activation in obesity","volume":"34","author":"Lumeng","year":"2013","journal-title":"Mol Aspects Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1161\/ATVBAHA.108.165100","article-title":"T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance","volume":"28","author":"Kintscher","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.4049\/jimmunol.1000021","article-title":"Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance","volume":"185","author":"Yang","year":"2010","journal-title":"J Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nm.2001","article-title":"Normalization of obesity-associated insulin resistance through immunotherapy","volume":"15","author":"Winer","year":"2009","journal-title":"Nat Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.cmet.2013.02.009","article-title":"Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation","volume":"17","author":"Deng","year":"2013","journal-title":"Cell Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fimmu.2013.00332","article-title":"Role of adipokines signaling in the modulation of T cells function","volume":"4","author":"Procaccini","year":"2013","journal-title":"Front Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fimmu.2014.00483","article-title":"Fatty acids, lipid mediators, and T-cell function","volume":"5","author":"De Jong","year":"2014","journal-title":"Front Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic Instruction of Immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell."},{"key":"B13","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4049\/jimmunol.1301158","article-title":"Leptin metabolically licenses T cells for activation to link nutrition and immunity","volume":"192","author":"Saucillo","year":"2014","journal-title":"J Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1002\/eji.201545861","article-title":"Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity","volume":"46","author":"Gerriets","year":"2016","journal-title":"Eur J Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/pim.12401","article-title":"Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?","volume":"39","author":"Surendar","year":"2017","journal-title":"Parasite Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e707","DOI":"10.1371\/journal.pntd.0000707","article-title":"Decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (CURES 83)","volume":"4","author":"Aravindhan","year":"2010","journal-title":"PLoS Negl Trop Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"E283","DOI":"10.1210\/jc.2012-2517","article-title":"Association of previous schistosome infection with diabetes and metabolic syndrome: a cross-sectional study in rural China","volume":"98","author":"Chen","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1096\/fj.14-266239","article-title":"Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice","volume":"29","author":"Hussaarts","year":"2015","journal-title":"FASEB J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1159\/000448401","article-title":"Filarial infection or antigen administration improves glucose tolerance in diet-induced obese mice","volume":"8","author":"Berbudi","year":"2016","journal-title":"J Innate Immun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1002\/dmrr.2673","article-title":"Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes","volume":"32","author":"Berbudi","year":"2016","journal-title":"Diabetes Metab Res Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/j.1365-2567.2008.02958.x","article-title":"Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells","volume":"127","author":"H\u00fcbner","year":"2009","journal-title":"Immunology."},{"key":"B22","doi-asserted-by":"publisher","first-page":"36896","DOI":"10.1074\/jbc.M112.409516","article-title":"Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells","volume":"287","author":"Cheng","year":"2012","journal-title":"J Biol Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.immuni.2007.01.011","article-title":"A key role of leptin in the control of regulatory T cell proliferation","volume":"26","author":"De Rosa","year":"2007","journal-title":"Immunity."},{"key":"B24","doi-asserted-by":"publisher","first-page":"40657","DOI":"10.1038\/srep40657","article-title":"Adipocyte fatty acid binding protein potentiates toxic lipids-induced endoplasmic reticulum stress in macrophages via inhibition of Janus Kinase 2-dependent autophagy","volume":"7","author":"Hoo","year":"2017","journal-title":"Sci Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"13683","DOI":"10.1038\/ncomms13683","article-title":"Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARgamma directs early activation of T cells","volume":"7","author":"Angela","year":"2016","journal-title":"Nat Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1136\/ard.2010.140046","article-title":"The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype","volume":"70","author":"Klein-Wieringa","year":"2011","journal-title":"Ann Rheum Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1002\/eji.201243096","article-title":"Adipocyte-derived lipids modulate CD4+ T-cell function","volume":"43","author":"Ioan-Facsinay","year":"2013","journal-title":"Eur J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e24358","DOI":"10.1371\/journal.pone.0024358","article-title":"Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice","volume":"6","author":"Feng","year":"2011","journal-title":"PLoS ONE."},{"key":"B29","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1182\/blood-2015-06-655126","article-title":"CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia","volume":"127","author":"Guo","year":"2016","journal-title":"Blood."},{"key":"B30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.immuni.2019.05.004","article-title":"The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells","volume":"51","author":"Omenetti","year":"2019","journal-title":"Immunity."},{"key":"B31","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.immuni.2009.05.012","article-title":"Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose","volume":"31","author":"Saraiva","year":"2009","journal-title":"Immunity."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e52739","DOI":"10.3791\/52739","article-title":"Mouse naive CD4+ T cell isolation and in vitro differentiation into T cell subsets","author":"Flaherty","year":"2015","journal-title":"J Vis Exp."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e93072","DOI":"10.1371\/journal.pone.0093072","article-title":"ST2 Deficiency does not impair Type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance","volume":"9","author":"Ajendra","year":"2014","journal-title":"PLoS ONE."},{"key":"B34","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jnutbio.2016.04.004","article-title":"Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b(+) macrophages","volume":"34","author":"De Boer","year":"2016","journal-title":"J Nutr Biochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia."},{"key":"B36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1515\/hmbci-2013-0053","article-title":"The role of leptin\/adiponectin ratio in metabolic syndrome and diabetes","volume":"18","author":"Lopez-Jaramillo","year":"2014","journal-title":"Horm Mol Biol Clin Investig."},{"key":"B37","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J Clin Invest."},{"key":"B39","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","article-title":"Inflammation and insulin resistance","volume":"582","author":"De Luca","year":"2008","journal-title":"FEBS Lett."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1002\/eji.200838893","article-title":"Obesity predisposes to Th17 bias","volume":"39","author":"Winer","year":"2009","journal-title":"Eur J Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1161\/ATVBAHA.114.304636","article-title":"T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans","volume":"34","author":"Mclaughlin","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2337\/db11-1065","article-title":"Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype","volume":"61","author":"Van Der Weerd","year":"2012","journal-title":"Diabetes."},{"key":"B43","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/nm.2353","article-title":"B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies","volume":"17","author":"Winer","year":"2011","journal-title":"Nat Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.celrep.2014.09.004","article-title":"An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation","volume":"9","author":"Cho","year":"2014","journal-title":"Cell Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/ni.3120","article-title":"NK cells link obesity-induced adipose stress to inflammation and insulin resistance","volume":"16","author":"Wensveen","year":"2015","journal-title":"Nat Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e17154","DOI":"10.1371\/journal.pone.0017154","article-title":"Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages","volume":"6","author":"Meijer","year":"2011","journal-title":"PLoS ONE."},{"key":"B48","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/ijo.2015.145","article-title":"Large adipocytes function as antigen-presenting cells to activate CD4(+) T cells via upregulating MHCII in obesity","volume":"40","author":"Xiao","year":"2016","journal-title":"Int J Obes (Lond)."},{"key":"B49","doi-asserted-by":"publisher","first-page":"7474","DOI":"10.4049\/jimmunol.1001674","article-title":"Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient\/energy-sensing mammalian target of rapamycin signaling pathway","volume":"185","author":"Galgani","year":"2010","journal-title":"J Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1161\/CIRCRESAHA.107.164988","article-title":"Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis","volume":"102","author":"Okamoto","year":"2008","journal-title":"Circ Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'neill","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"4607","DOI":"10.1038\/s41598-018-22920-7","article-title":"Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages","volume":"8","author":"Su","year":"2018","journal-title":"Sci Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.1038\/nutd.2017.37","article-title":"Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio: a randomized-controlled trial","volume":"7","author":"Tahapary","year":"2017","journal-title":"Nutr Diabetes."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02555\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T04:40:09Z","timestamp":1572324009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02555\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":53,"alternative-id":["10.3389\/fimmu.2019.02555"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02555","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"article-number":"2555"}}