{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T04:54:20Z","timestamp":1759812860706,"version":"3.41.2"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02562","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T23:53:37Z","timestamp":1573689217000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Live Attenuated Salmonella enterica Expressing and Releasing Cell-Permeable Bax BH3 Peptide Through the MisL Autotransporter System Elicits Antitumor Activity in a Murine Xenograft Model of Human B Non-hodgkin's Lymphoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Armando Alfredo","family":"Mateos-Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Mu\u00f1oz-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elayne Irene","family":"Becerra-B\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Fernando","family":"Flores-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Prada-Gracia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana Marisol","family":"Moreno-Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermina Juliana","family":"Baay-Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uriel","family":"Ju\u00e1rez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana","family":"Ch\u00e1vez-Mungu\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Cabrera-Mu\u00f1\u00f3z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosendo","family":"Luria-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin."},{"key":"B2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10552-019-01155-5","article-title":"Global patterns and trends in the incidence of non-Hodgkin lymphoma","volume":"30","author":"Miranda-Filho","year":"2019","journal-title":"Cancer Causes Control."},{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues.","year":"2017","author":"Swerdlow","key":"B3"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s00277-018-3571-7","article-title":"Stage I non-Hodgkin lymphoma: no plateau in disease-specific survival ?","volume":"98","author":"Chihara","year":"2019","journal-title":"Ann Hematol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0140-6736(16)32407-2","article-title":"Non-Hodgkin lymphoma","volume":"390","author":"Armitage","year":"2017","journal-title":"Lancet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/bjh.15783","article-title":"Novel targeted therapeutic agents for the treatment of childhood, adolescent and young adult non-Hodgkin lymphoma","volume":"182","author":"Barth","year":"2019","journal-title":"Br J Haematol."},{"key":"B8","first-page":"95","article-title":"Cellular mechanisms of multidrug resistance of tumor cells","volume":"65","author":"Stavrovskaya","year":"2000","journal-title":"Biochemistry Biokhimiia."},{"key":"B9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","article-title":"Apoptosis: a link between cancer genetics and chemotherapy","volume":"108","author":"Johnstone","year":"2002","journal-title":"Cell."},{"key":"B10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1182\/blood.V81.1.151.151","article-title":"Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line","volume":"81","author":"Miyashita","year":"1993","journal-title":"Blood."},{"key":"B11","first-page":"2331","article-title":"bcl-2 but not p53 expression is associated with resistance to chemotherapy in advanced breast cancer","volume":"4","author":"Bonetti","year":"1998","journal-title":"Clin Cancer Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1002\/ijc.22977","article-title":"Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer","volume":"121","author":"Wesarg","year":"2007","journal-title":"Int J Cancer J Int Cancer."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1167\/iovs.05-1312","article-title":"Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma","volume":"47","author":"Wallace","year":"2006","journal-title":"Invest Ophthal Visual Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1365-2559.2006.02501.x","article-title":"BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma","volume":"49","author":"Goodlad","year":"2006","journal-title":"Histopathology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1038\/sj.onc.1209979","article-title":"Distinct promoters mediate constitutive and inducible Bcl-XL expression in malignant lymphocytes","volume":"26","author":"Habens","year":"2007","journal-title":"Oncogene."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.3109\/10428194.2012.733874","article-title":"Hypoxia inducible factor-1alpha induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-(xL)","volume":"54","author":"Hernandez-Luna","year":"2012","journal-title":"Leuk Lymph."},{"key":"B17","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.bbamcr.2010.12.019","article-title":"Molecular biology of Bax and Bak activation and action","volume":"1813","author":"Westphal","year":"2011","journal-title":"Biochim Biophys Acta."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.biochi.2011.05.013","article-title":"Bax: addressed to kill","volume":"93","author":"Renault","year":"2011","journal-title":"Biochimie."},{"key":"B19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0167-4889(03)00175-7","article-title":"Structural biology of the Bcl-2 family of proteins","volume":"1644","author":"Petros","year":"2004","journal-title":"Biochim Biophys Acta."},{"key":"B20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.abb.2006.12.022","article-title":"BH3-only proteins trigger cytochrome c release, but how?","volume":"462","author":"Hacker","year":"2007","journal-title":"Arch Biochem Biophys."},{"key":"B21","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3389\/fonc.2018.00636","article-title":"Targeting the Bcl-2 family in B cell lymphoma","volume":"8","author":"Adams","year":"2018","journal-title":"Front Oncol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"13298","DOI":"10.1074\/jbc.274.19.13298","article-title":"Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases","volume":"274","author":"Holinger","year":"1999","journal-title":"J Biol Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"19426","DOI":"10.1074\/jbc.M209472200","article-title":"Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins","volume":"278","author":"Moreau","year":"2003","journal-title":"J Biol Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"6217","DOI":"10.1073\/pnas.0701297104","article-title":"Structural insights into the degradation of Mcl-1 induced by BH3 domains","volume":"104","author":"Czabotar","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1593\/neo.07394","article-title":"Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells","volume":"9","author":"Li","year":"2007","journal-title":"Neoplasia."},{"key":"B26","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nm.3048","article-title":"ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets","volume":"19","author":"Souers","year":"2013","journal-title":"Nat Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.ccell.2018.11.004","article-title":"BH3-mimetic drugs: blazing the trail for new cancer medicines","volume":"34","author":"Merino","year":"2018","journal-title":"Cancer Cell."},{"key":"B28","first-page":"4537","article-title":"Tumor-targeted Salmonella as a novel anticancer vector","volume":"57","author":"Pawelek","year":"1997","journal-title":"Cancer research."},{"key":"B29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bmhimx.2015.02.005","article-title":"Salmonella enterica: un aliado en la terapia contra el c\u00e1ncer","volume":"72","author":"Ch\u00e1vez-Navarro","year":"2015","journal-title":"Bol Med Hosp Infant Mex."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2984247","DOI":"10.1155\/2018\/2984247","article-title":"Cancer immunotherapy: priming the host immune response with live attenuated Salmonella enterica","volume":"2018","author":"Hernandez-Luna","year":"2018","journal-title":"J Immunol Res."},{"key":"B31","first-page":"65","article-title":"[Therapeutic intervention alternatives in cancer, using attenuated live bacterial vectors: Salmonella enterica as a carrier of heterologous molecules]","volume":"65","author":"Hernandez-Luna","year":"2013","journal-title":"Rev Invest Clin."},{"key":"B32","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/nrc2934","article-title":"Engineering the perfect (bacterial) cancer therapy","volume":"10","author":"Forbes","year":"2010","journal-title":"Nat Rev Cancer."},{"key":"B33","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bmhimx.2016.10.002","article-title":"Bactofection of sequences encoding a Bax protein peptide chemosensitizes prostate cancer tumor cells","volume":"73","author":"Hernandez-Luna","year":"2016","journal-title":"Bol Med Hosp Infant Mex."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1016\/j.vaccine.2007.03.047","article-title":"A fusogenic peptide expressed on the surface of Salmonella enterica elicits CTL responses to a dengue virus epitope","volume":"25","author":"Luria-Perez","year":"2007","journal-title":"Vaccine."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1128\/IAI.70.7.3611-3620.2002","article-title":"Expression of the Plasmodium falciparum immunodominant epitope (NANP)(4) on the surface of Salmonella enterica using the autotransporter MisL.","volume":"70","author":"Ruiz-Perez","year":"2002","journal-title":"Infect Immun."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/82377","article-title":"Enhanced major histocompatibility complex class I-dependent presentation of antigens modified with cationic and fusogenic peptides","volume":"18","author":"Laus","year":"2000","journal-title":"Nat Biotechnol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"D313","DOI":"10.1093\/nar\/gkw1132","article-title":"The SWISS-MODEL Repository-new features and functionality","volume":"45","author":"Bienert","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J Mol Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5.6.1","DOI":"10.1002\/0471250953.bi0506s15","article-title":"Comparative protein structure modeling using Modeller","volume":"15","author":"Eswar","year":"2006","journal-title":"Curr Protoc Bioinformatics."},{"key":"B41","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/cr.2010.149","article-title":"Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX.","volume":"21","author":"Ku","year":"2011","journal-title":"Cell Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.cell.2012.12.031","article-title":"Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis","volume":"152","author":"Czabotar","year":"2013","journal-title":"Cell."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J Comput Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J Comput Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1021\/acs.jctc.5b00935","article-title":"CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM\/OpenMM simulations using the CHARMM36 additive force field","volume":"12","author":"Lee","year":"2016","journal-title":"J Chem Theory Comput."},{"key":"B46","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/bioinformatics\/btk023","article-title":"OPM: orientations of proteins in membranes database","volume":"22","author":"Lomize","year":"2006","journal-title":"Bioinformatics."},{"key":"B47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by Calpha geometry: phi,psi and Cbeta deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins."},{"key":"B49","doi-asserted-by":"publisher","first-page":"33509","DOI":"10.1038\/srep33509","article-title":"ProQ3: improved model quality assessments using Rosetta energy terms","volume":"6","author":"Uziela","year":"2016","journal-title":"Sci Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1093\/bioinformatics\/btw819","article-title":"ProQ3D: improved model quality assessments using deep learning","volume":"33","author":"Uziela","year":"2017","journal-title":"Bioinformatics."},{"key":"B51","doi-asserted-by":"publisher","first-page":"W510","DOI":"10.1093\/nar\/gkp322","article-title":"QMEAN server for protein model quality estimation","volume":"37","author":"Benkert","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/291238a0","article-title":"Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines","volume":"291","author":"Hoiseth","year":"1981","journal-title":"Nature."},{"key":"B53","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/CJI.0b013e3182886d95","article-title":"Therapeutic effects of Salmonella typhi in a mouse model of T-cell lymphoma","volume":"36","author":"Vendrell","year":"2013","journal-title":"J Immunother."},{"key":"B54","first-page":"36","article-title":"Enhancing tumor implantation and growth rate of Ramos B-cell lymphoma in nude mice","volume":"52","author":"Manders","year":"2002","journal-title":"Comp Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jconrel.2012.01.016","article-title":"Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo","volume":"159","author":"Nakase","year":"2012","journal-title":"J Controlled Release."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s00404-019-05147-3","article-title":"Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model","volume":"299","author":"Miyake","year":"2019","journal-title":"Arch Gynecol Obstet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1465-9921-13-60","article-title":"HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation","volume":"13","author":"Baay-Guzman","year":"2012","journal-title":"Respir Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0147-619X(03)00047-7","article-title":"Display and release of the Plasmodium falciparum circumsporozoite protein using the autotransporter MisL of Salmonella enterica","volume":"50","author":"Ruiz-Olvera","year":"2003","journal-title":"Plasmid."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e15942","DOI":"10.5812\/jjm.15942","article-title":"Construction of a synthetically engineered nirb promoter for expression of recombinant protein in Escherichia coli","volume":"7","author":"Nasr","year":"2014","journal-title":"Jundishapur J Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1091\/mbc.01-05-0272","article-title":"Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling","volume":"13","author":"Los","year":"2002","journal-title":"Mol Biol Cell."},{"key":"B61","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bcp.2019.01.015","article-title":"A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics","volume":"162","author":"Knight","year":"2019","journal-title":"Biochem Pharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1046\/j.1365-2141.2002.03253.x","article-title":"High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin's lymphoma","volume":"116","author":"Kuramoto","year":"2002","journal-title":"Br J Haematol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nature03579","article-title":"An inhibitor of Bcl-2 family proteins induces regression of solid tumours","volume":"435","author":"Oltersdorf","year":"2005","journal-title":"Nature."},{"key":"B64","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1200\/JCO.2011.34.7898","article-title":"Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease","volume":"30","author":"Roberts","year":"2012","journal-title":"J Clin Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4038","DOI":"10.1158\/1078-0432.CCR-10-0822","article-title":"Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma","volume":"16","author":"Hwang","year":"2010","journal-title":"Clin Cancer Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41568-018-0070-z","article-title":"Tumour-targeting bacteria engineered to fight cancer","volume":"18","author":"Zhou","year":"2018","journal-title":"Nat Rev Cancer."},{"key":"B67","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/bit.20883","article-title":"Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro","volume":"94","author":"Kasinskas","year":"2006","journal-title":"Biotechnol Bioeng."},{"key":"B68","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/cgt.2008.48","article-title":"IL-18-producing Salmonella inhibit tumor growth","volume":"15","author":"Loeffler","year":"2008","journal-title":"Cancer Gene Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1007\/s11999-008-0243-2","article-title":"Attenuated Salmonella typhimurium with IL-2 gene reduces pulmonary metastases in murine osteosarcoma","volume":"466","author":"Sorenson","year":"2008","journal-title":"Clin Orthop Related Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.jpedsurg.2008.02.048","article-title":"Attenuated Salmonella typhimurium with interleukin 2 gene prevents the establishment of pulmonary metastases in a model of osteosarcoma","volume":"43","author":"Sorenson","year":"2008","journal-title":"J Pediatric Surg."},{"key":"B71","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/jgm.1023","article-title":"Live attenuated Salmonella as a vector for oral cytokine gene therapy in melanoma","volume":"9","author":"Agorio","year":"2007","journal-title":"J Gene Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s00262-008-0555-9","article-title":"Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth","volume":"58","author":"Loeffler","year":"2009","journal-title":"Cancer Immunol Immunother."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1093\/jnci\/djn205","article-title":"Inhibition of tumor growth using salmonella expressing Fas ligand","volume":"100","author":"Loeffler","year":"2008","journal-title":"J Natl Cancer Inst."},{"key":"B74","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1177\/030089161009600218","article-title":"Attenuated Salmonella typhimurium carrying TRAIL and VP3 genes inhibits the growth of gastric cancer cells in vitro and in vivo","volume":"96","author":"Cao","year":"2010","journal-title":"Tumori."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e80050","DOI":"10.1371\/journal.pone.0080050","article-title":"Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium","volume":"9","author":"Jeong","year":"2014","journal-title":"PLoS ONE."},{"key":"B76","doi-asserted-by":"publisher","first-page":"30591","DOI":"10.1038\/srep30591","article-title":"Engineering Salmonella as intracellular factory for effective killing of tumour cells","volume":"6","author":"Camacho","year":"2016","journal-title":"Sci Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/sj.cgt.7700634","article-title":"Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients","volume":"10","author":"Nemunaitis","year":"2003","journal-title":"Cancer Gene Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1182\/blood-2012-12-474098","article-title":"Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas","volume":"122","author":"Massa","year":"2013","journal-title":"Blood."},{"key":"B79","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1365-2958.2005.04666.x","article-title":"Salmonella enterica serotype Typhimurium MisL is an intestinal colonization factor that binds fibronectin","volume":"57","author":"Dorsey","year":"2005","journal-title":"Mol Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/1471-2407-10-146","article-title":"Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing","volume":"10","author":"Barak","year":"2010","journal-title":"BMC Cancer."},{"key":"B81","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/gt.2013.86","article-title":"Salmonella induce autophagy in melanoma by the downregulation of AKT\/mTOR pathway","volume":"21","author":"Lee","year":"2014","journal-title":"Gene Therapy."},{"key":"B82","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fimmu.2018.00007","article-title":"Salmonella immunotherapy improves the outcome of CHOP chemotherapy in non-Hodgkin lymphoma-bearing mice","volume":"9","author":"Bascuas","year":"2018","journal-title":"Front Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1080\/21505594.2018.1509664","article-title":"SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells","volume":"9","author":"Garcia-Gil","year":"2018","journal-title":"Virulence."},{"key":"B84","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/imm.12320","article-title":"Salmonella enterica serovar Typhimurium immunotherapy for B-cell lymphoma induces broad anti-tumour immunity with therapeutic effect","volume":"143","author":"Grille","year":"2014","journal-title":"Immunology."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1002\/eji.200738035","article-title":"Intra-tumoral Salmonella typhimurium induces a systemic anti-tumor immune response that is directed by low-dose radiation to treat distal disease","volume":"38","author":"Avogadri","year":"2008","journal-title":"Eur J Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.7150\/thno.11432","article-title":"Salmonella typhimurium suppresses tumor growth via the pro-inflammatory cytokine interleukin-1beta","volume":"5","author":"Kim","year":"2015","journal-title":"Theranostics."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02562\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T23:53:42Z","timestamp":1573689222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02562\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":86,"alternative-id":["10.3389\/fimmu.2019.02562"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02562","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2019,11,14]]},"article-number":"2562"}}