{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:48:46Z","timestamp":1790477326616,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02564","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T04:30:18Z","timestamp":1573187418000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["VP1 of Enterovirus 71 Protects Mice Against Enterovirus 71 and Coxsackievirus B3 in Lethal Challenge Experiment"],"prefix":"10.3389","volume":"10","author":[{"given":"Fang-Hong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Li","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian-Zhi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.2217\/fmb-2018-0336","article-title":"Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)","volume":"14","author":"Andr\u00e9s","year":"2019","journal-title":"Fut Microbiol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_576_17","article-title":"Hand, foot and mouth disease caused by Coxsackie viruses A6 and A16 in Assam, Northeast India: a need for surveillance","author":"Borkakoty","year":"2019","journal-title":"Indian J Dermatol Venereol Leprol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/jmv.24658","article-title":"Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain","volume":"89","author":"Cabrerizo","year":"2017","journal-title":"J Med Virol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ram.2018.05.003","article-title":"Atypical hand, foot, and mouth disease caused by Coxsackievirus A6 in Argentina in 2015","volume":"51","author":"Cisterna","year":"2019","journal-title":"Rev Argent Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijid.2018.12.004","article-title":"Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013\u20132015: inpatients and outpatients","volume":"80","author":"Hoang","year":"2019","journal-title":"Int J Infect Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.5604\/01.3001.0010.4889","article-title":"Genetic Characterization of human enteroviruses associated with hand, foot and mouth diseases in Poland, 2013\u20132016","volume":"66","author":"Wieczorek","year":"2017","journal-title":"Polish J Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/jmv.25250","article-title":"Molecular epidemiology of coxsackievirus A6 derived from hand, foot, and mouth disease in Fukuoka between 2013 and 2017","volume":"90","author":"Yoshitomi","year":"2018","journal-title":"J Med Virol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12879-019-3878-6","article-title":"Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China","volume":"19","author":"Cai","year":"2019","journal-title":"BMC Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1017\/S0950268815001107","article-title":"Epidemiological characteristics and influential factors of hand, foot and mouth disease (HFMD) reinfection in children in Anhui province","volume":"144","author":"Chen","year":"2016","journal-title":"Epidemiol Infect."},{"key":"B10","doi-asserted-by":"publisher","first-page":"8904","DOI":"10.1038\/srep08904","article-title":"Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013","volume":"5","author":"Huang","year":"2015","journal-title":"Sci Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/rmv.1827","article-title":"Comparative epidemiology and virology of fatal and nonfatal cases of hand, foot and mouth disease in mainland China from 2008 to 2014","volume":"25","author":"Liu","year":"2015","journal-title":"Rev Med Virol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41426-017-0011-z","article-title":"Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016 article","volume":"7","author":"Wang","year":"2018","journal-title":"Emerg Microbes Infect."},{"key":"B13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41426-018-0134-x","article-title":"The emergence and spread of one Coxsackievirus A16 Genogroup D novel recombinant strain that caused a clustering HFMD outbreak in Shanghai, China, 2016","volume":"7","author":"Wang","year":"2018","journal-title":"Emerg Microbes Infect."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e11610","DOI":"10.1097\/MD.0000000000011610","article-title":"Molecular characteristics of hand, foot, and mouth disease for hospitalized pediatric patients in Yunnan, China","volume":"97","author":"Zhao","year":"2018","journal-title":"Medicine."},{"key":"B15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.vaccine.2012.10.032","article-title":"Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity","volume":"31","author":"Chen","year":"2013","journal-title":"Vaccine."},{"key":"B16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10096-018-3206-x","article-title":"Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention","volume":"37","author":"Esposito","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B17","first-page":"53","article-title":"Group B Coxsackie disease in children","volume-title":"The Coxsackie B Viruses. Current Topics in Microbiology and Immunology","author":"Modlin","year":"2011"},{"key":"B18","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1128\/JVI.72.2.1688-1690.1998","article-title":"Protective immune response to foot-and-mouth disease virus with VP1 expressed in transgenic plants","volume":"72","author":"Carrillo","year":"1998","journal-title":"J Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1016\/j.vaccine.2005.12.047","article-title":"Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71","volume":"24","author":"Chen","year":"2006","journal-title":"Vaccine."},{"key":"B20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF01317504","article-title":"Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria","volume":"60","author":"Chumakov","year":"1979","journal-title":"Arch Virol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0166-3542(00)00132-7","article-title":"DNA vaccine-mediated immune responses in Coxsackie virus B3-infected mice","volume":"49","author":"Henke","year":"2001","journal-title":"Antiviral Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/(SICI)1096-9071(200006)61:2<228::AID-JMV9>3.0.CO;2-R","article-title":"Expression of caspid protein VP1 for use as antigen for the diagnosis of enterovirus 71 infection","volume":"61","author":"Shih","year":"2000","journal-title":"J Med Virol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0264-410X(01)00385-1","article-title":"Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus","volume":"20","author":"Wu","year":"2001","journal-title":"Vaccine."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1099\/vir.0.81264-0","article-title":"Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions","volume":"86","author":"Lukashev","year":"2005","journal-title":"J Gen Virol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1099\/vir.0.79789-0","article-title":"Complete genome sequences of all members of the species Human enterovirus A","volume":"85","author":"Oberste","year":"2004","journal-title":"J Gen Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"10310","DOI":"10.1128\/JVI.00372-07","article-title":"Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice","volume":"81","author":"Wu","year":"2007","journal-title":"J Virol."},{"key":"B27","volume-title":"Hsiung's diagnostic virology: As ilustrated by light and electron microscopy","author":"Zuckerman","year":"1994"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1002829","DOI":"10.1371\/journal.pcbi.1002829","article-title":"Reliable B cell epitope predictions: impacts of method development and improved benchmarking","volume":"8","author":"Kringelum","year":"2012","journal-title":"PLoS Comput Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/1471-2105-11-381","article-title":"EPSVR and EPMeta: prediction of antigenic epitopes using support vector regression and multiple server results","volume":"11","author":"Liang","year":"2010","journal-title":"BMC Bioinformatics."},{"key":"B30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.virusres.2006.12.005","article-title":"Identification of neutralizing linear epitopes from the VP1 capsid protein of Enterovirus 71 using synthetic peptides","volume":"125","author":"Foo","year":"2007","journal-title":"Virus Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1469-0691.2007.01904.x","article-title":"Identification of immunodominant VP1 linear epitope of enterovirus71 (EV71) using synthetic peptides for detecting human anti-EV71 IgG antibodies in western blots","volume":"14","author":"Foo","year":"2008","journal-title":"Clin Microbiol Infect."},{"key":"B32","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/1471-2180-11-246","article-title":"Comparing enterovirus 71 with coxsackievirus A16 by analyzing nucleotide sequences and antigenicity of recombinant proteins of VP1s and VP4s","volume":"11","author":"Li","year":"2011","journal-title":"BMC Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/15321819.2011.559297","article-title":"Cross-reactivity of anti-Ev71 IgM and neutralizing antibody in series sera of patients infected with enterovirus 71 and Coxsackievirus A 16","volume":"32","author":"Lin","year":"2011","journal-title":"J Immunoass Immunochem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jmii.2011.09.025","article-title":"Seroprevalence of enterovirus 71 and no evidence of crossprotection of enterovirus 71 antibody against the other enteroviruses in kindergarten children in Taipei city","volume":"45","author":"Huang","year":"2012","journal-title":"J Microbiol Immunol Infect."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02564\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T03:55:32Z","timestamp":1611806132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02564\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":34,"alternative-id":["10.3389\/fimmu.2019.02564"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02564","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]},"article-number":"2564"}}