{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:14:27Z","timestamp":1772622867989,"version":"3.50.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA041302"],"award-info":[{"award-number":["DA041302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA042373"],"award-info":[{"award-number":["DA042373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA045568"],"award-info":[{"award-number":["DA045568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02601","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T04:19:39Z","timestamp":1573791579000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Morphine Withdrawal Enhances HIV Infection of Macrophages"],"prefix":"10.3389","volume":"10","author":[{"given":"Xu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Zhe","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"B1","first-page":"883","article-title":"Alterations of immune functions in heroin addicts and heroin withdrawal subjects","volume":"286","author":"Govitrapong","year":"1998","journal-title":"J Pharmacol Exp Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S0165-5728(02)00103-0","article-title":"Abrupt or precipitated withdrawal from morphine induces immunosuppression","volume":"127","author":"Rahim","year":"2002","journal-title":"J Neuroimmunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0165-5728(94)90043-4","article-title":"Morphine amplifies HIV-1 expression in chronically infected promonocytes cocultured with human brain cells","volume":"50","author":"Peterson","year":"1994","journal-title":"J Neuroimmunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1615\/CritRevImmunol.v16.i2.10","article-title":"Opioid and opiate immunoregulatory processes","volume":"16","author":"Stefano","year":"1996","journal-title":"Crit Rev Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/00042871-200211010-00027","article-title":"Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor","volume":"50","author":"Guo","year":"2002","journal-title":"J Invest Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1203\/01.PDR.0000074973.83826.4C","article-title":"Morphine enhances HIV infection of neonatal macrophages","volume":"54","author":"Li","year":"2003","journal-title":"Pediatr Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1086\/338011","article-title":"Methadone enhances human immunodeficiency virus infection of human immune cells","volume":"185","author":"Li","year":"2002","journal-title":"J Infect Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.3389\/fmicb.2015.01230","article-title":"Heroin inhibits HIV-restriction miRNAs and enhances HIV infection of macrophages","volume":"6","author":"Wang","year":"2015","journal-title":"Front Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fmicb.2015.00614","article-title":"HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation","volume":"6","author":"Samikkannu","year":"2015","journal-title":"Front Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.lfs.2010.10.029","article-title":"Drugs of abuse and HIV infection\/replication: implications for mother-fetus transmission","volume":"88","author":"Wang","year":"2011","journal-title":"Life Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ajpath.2010.11.042","article-title":"Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes","volume":"178","author":"Wang","year":"2011","journal-title":"Am J Pathol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/bjc.2014.384","article-title":"Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review","volume":"111","author":"Boland","year":"2014","journal-title":"Br J Cancer."},{"key":"B13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s11481-011-9290-7","article-title":"Immunosuppressive effects of opioids\u2013clinical relevance","volume":"6","author":"Brack","year":"2011","journal-title":"J Neuroimmune Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1111\/j.1476-5381.2011.01513.x","article-title":"Opioids and the immune system: what is their mechanism of action?","volume":"164","author":"Eisenstein","year":"2011","journal-title":"Br J Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.2174\/1389557515666150101095237","article-title":"Immunomodulatory effects of endogenous and synthetic peptides activating opioid receptors","volume":"14","author":"Pomorska","year":"2014","journal-title":"Mini Rev Med Chem."},{"key":"B16","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1189\/jlb.71.5.782","article-title":"The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor","volume":"71","author":"Wang","year":"2002","journal-title":"J Leukoc Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1126\/science.3313729","article-title":"Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line","volume":"238","author":"Folks","year":"1987","journal-title":"Science."},{"key":"B18","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.4049\/jimmunol.140.4.1117","article-title":"Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate","volume":"140","author":"Folks","year":"1988","journal-title":"J Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/jcb.240450410","article-title":"Extrachromosomal human immunodeficiency virus type-1 DNA can initiate a spreading infection of HL-60 cells","volume":"45","author":"Butera","year":"1991","journal-title":"J Cell Biochem."},{"key":"B20","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1128\/JVI.68.4.2726-2730.1994","article-title":"Human immunodeficiency virus type 1 RNA expression by four chronically infected cell lines indicates multiple mechanisms of latency","volume":"68","author":"Butera","year":"1994","journal-title":"J Virol."},{"key":"B21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1128\/JVI.62.1.139-147.1988","article-title":"In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity","volume":"62","author":"Willey","year":"1988","journal-title":"J Virol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1182\/blood-2008-09-175000","article-title":"Cellular microRNA expression correlates with susceptibility of monocytes\/macrophages to HIV-1 infection","volume":"113","author":"Wang","year":"2009","journal-title":"Blood."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2012.12.016","article-title":"miR-132 enhances HIV-1 replication","volume":"438","author":"Chiang","year":"2013","journal-title":"Virology."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1242\/jcs.167817","article-title":"MicroRNA-mediated regulation of p21 and TASK1 cellular restriction factors enhances HIV-1 infection","volume":"128","author":"Farberov","year":"2015","journal-title":"J Cell Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0960-5428(06)80057-4","article-title":"Neuroimmunomodulation by opiates: relationship to HIV infection and AIDS","volume":"3","author":"Donahoe","year":"1993","journal-title":"Adv Neuroimmunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.2353\/ajpath.2006.060358","article-title":"An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P","volume":"169","author":"Wang","year":"2006","journal-title":"Am J Pathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/nm1639","article-title":"Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes","volume":"13","author":"Huang","year":"2007","journal-title":"Nat Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E2676","DOI":"10.1073\/pnas.1408037111","article-title":"MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production","volume":"111","author":"Chen","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B29","doi-asserted-by":"publisher","first-page":"40884","DOI":"10.1074\/jbc.R112.415448","article-title":"MicroRNAs and HIV-1: complex interactions","volume":"287","author":"Klase","year":"2012","journal-title":"J Biol Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1097\/QAD.0b013e328352adca","article-title":"The role of microRNAs in HIV-1 pathogenesis and therapy","volume":"26","author":"Swaminathan","year":"2012","journal-title":"AIDS."},{"key":"B31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1742-4690-5-117","article-title":"Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication","volume":"5","author":"Ahluwalia","year":"2008","journal-title":"Retrovirology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.bbrc.2005.09.183","article-title":"Targets for human encoded microRNAs in HIV genes","volume":"337","author":"Hariharan","year":"2005","journal-title":"Biochem Biophys Res Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.molcel.2009.06.003","article-title":"Cellular microRNA and P bodies modulate host-HIV-1 interactions","volume":"34","author":"Nathans","year":"2009","journal-title":"Mol Cell."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1000263","DOI":"10.1371\/journal.ppat.1000263","article-title":"miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1","volume":"5","author":"Sung","year":"2009","journal-title":"PLoS Pathog."},{"key":"B35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature03493","article-title":"Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells","volume":"435","author":"Chiu","year":"2005","journal-title":"Nature."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5250","DOI":"10.1128\/JVI.02358-09","article-title":"APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms","volume":"84","author":"Mbisa","year":"2010","journal-title":"J Virol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1099\/vir.0.83530-0","article-title":"APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells","volume":"89","author":"Wang","year":"2008","journal-title":"J Gen Virol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1002425","DOI":"10.1371\/journal.ppat.1002425","article-title":"SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection","volume":"7","author":"Berger","year":"2011","journal-title":"PLoS Pathog."},{"key":"B39","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nature10195","article-title":"Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein","volume":"474","author":"Hrecka","year":"2011","journal-title":"Nature."},{"key":"B40","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12542","article-title":"Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection","volume":"502","author":"Goujon","year":"2013","journal-title":"Nature."},{"key":"B41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nature12653","article-title":"MX2 is an interferon-induced inhibitor of HIV-1 infection","volume":"502","author":"Kane","year":"2013","journal-title":"Nature."},{"key":"B42","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.chom.2013.08.015","article-title":"The interferon-inducible MxB protein inhibits HIV-1 infection","volume":"14","author":"Liu","year":"2013","journal-title":"Cell Host Microbe."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e31167","DOI":"10.1371\/journal.pone.0031167","article-title":"Morphine suppresses IFN signaling pathway and enhances AIDS virus infection","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS ONE."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02601\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T23:37:11Z","timestamp":1695425831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02601\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2019.02601"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02601","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"article-number":"2601"}}