{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:56:02Z","timestamp":1778237762556,"version":"3.51.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008393","name":"Teknologi og Produktion, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008393","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02646","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:27:42Z","timestamp":1573817262000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation in L. acidophilus and S. aureus Stimulated Dendritic Cells"],"prefix":"10.3389","volume":"10","author":[{"given":"Ronja","family":"Mathiesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene M. S.","family":"Eld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fuglsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisbeth Drozd","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Taverniti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Fr\u00f8ki\u00e6r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.it.2004.12.001","article-title":"The mannose receptor: linking homeostasis and immunity through sugar recognition","volume":"26","author":"Taylor","year":"2005","journal-title":"Trends Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/eji.200838872","article-title":"Synergistic regulation of Pseudomonas aeruginosa-induced cytokine production in human monocytes by mannose receptor and TLR2","volume":"39","author":"Xaplanteri","year":"2009","journal-title":"Eur J Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nri2587","article-title":"A cell biological view of Toll-like receptor function: regulation through compartmentalization","volume":"9","author":"Kagan","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/imm.12650","article-title":"Plasma membrane TLR activation increases bacterial uptake but abrogates endosomal Lactobacillus acidophilus induction of interferon-\u03b2","volume":"149","author":"Boye","year":"2016","journal-title":"Immunology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e149092","DOI":"10.1371\/journal.pone.0149092","article-title":"D-alanylation of teichoic acid and loss of poly-N-acetyl glucosamine in Staphylococcus aureus during exponential phase enhance IL-12 production in murine dendritic cells","volume":"11","author":"Lund","year":"2016","journal-title":"PLos ONE"},{"key":"B6","doi-asserted-by":"publisher","first-page":"6090","DOI":"10.4049\/jimmunol.1401605","article-title":"TRAM is required for TLR2 endosomal signalling to type I interferon induction","volume":"193","author":"Stack","year":"2014","journal-title":"J Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1365-2567.2010.03301.x","article-title":"Lactobacillus acidophilus induces expression of virus defense genes in murine dendritic cells by a TLR2 dependent mechanism","volume":"131","author":"Weiss","year":"2010","journal-title":"Immunology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/ni1569","article-title":"TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-b","volume":"9","author":"Kagan","year":"2008","journal-title":"Nat Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1365-2567.2007.02800.x","article-title":"TLR2 and NOD2 play divergent roles in the recognition of gut-derived lactobacillus and bifidobacteria in human and murine dendritic cells","volume":"124","author":"Zeuthen","year":"2008","journal-title":"Immunology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"11794","DOI":"10.1086\/523647","article-title":"The contribution of dendritic cells to host defenses against Streptococcus pyogenes","volume":"196","author":"Loof","year":"2007","journal-title":"J Infect Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri2569","article-title":"Signalling through C-type lectin receptors: shaping immune responses","volume":"9","author":"Geijtenbeek","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4038","DOI":"10.1182\/blood-2004-03-1140","article-title":"Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages","volume":"104","author":"Herre","year":"2004","journal-title":"Blood."},{"key":"B13","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.imbio.2008.11.004","article-title":"Influence of the mannose receptor in host immune responses","volume":"214","author":"Gazi","year":"2009","journal-title":"Immunobiology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1371\/journal.ppat.0040017","article-title":"The mannose receptor mediates dengue virus infection of macrophages","volume":"4","author":"Miller","year":"2008","journal-title":"PLOS Pathogens."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/j.jaci.2015.10.033","article-title":"The mannose receptor negatively modulates the Toll-like receptor 4\u2013aryl hydrocarbon receptor\u2013indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization","volume":"137","author":"Salazar","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.cyto.2011.07.024","article-title":"Lactobacilli and bifidobacteria induce differential interferon-beta profile in dendritic cells","volume":"56","author":"Weiss","year":"2011","journal-title":"Cytokine."},{"key":"B17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1128\/CVI.13.3.365-375.2006","article-title":"Lactic acid bacteria inducing a weak interleukin-12 and tumor necrosis factor alpha response in human dendritic cells inhibit strongly stimulating lactic acid bacteria but act synergistically with Gram-negative bacteria","volume":"13","author":"Zeuthen","year":"2006","journal-title":"Clin Vaccine Immun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.cell.2011.09.051","article-title":"CD14 controls the LPS induced endocytosis of Toll-like receptor 4","volume":"147","author":"Zanoni","year":"2011","journal-title":"Cell."},{"key":"B19","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0304-4157(86)90002-x","article-title":"How do the polyene macrolide antibiotics affect the cellular membrane properties?","volume":"864","author":"Bolard","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"B20","first-page":"77","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4049\/jimmunol.168.1.171","article-title":"Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cell","volume":"168","author":"Christensen","year":"2002","journal-title":"JImmunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-delta delta CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B23","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 is a major beta-glucan receptor on macrophages","volume":"196","author":"Brown","year":"2002","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1084\/jem.182.2.389","article-title":"Dendritic cells use macropinocytosips and the mannose receptor to concentrate macromolecules in the major histocompability complex class II compartment: downregulation by cytokines and bacterial prducts","volume":"182","author":"Sallustro","year":"1995","journal-title":"J Exp Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1073\/pnas.79.7.2291","article-title":"Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin","volume":"79","author":"Schlegel","year":"1982","journal-title":"Proc Natl Acad Sci USA."},{"key":"B26","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00109-004-0539-y","article-title":"Ceramide, membrane rafts and infections","volume":"2","author":"Gulbins","year":"2004","journal-title":"J Mol Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"9997","DOI":"10.1074\/jbc.M309992200","article-title":"Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function","volume":"279","author":"Megha","year":"2004","journal-title":"J Biol Chem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/mt.2009.281","article-title":"The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls","volume":"18","author":"Vercauteren","year":"2010","journal-title":"Mol Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fimmu.2016.00004","article-title":"Responses to microbial challenges by SLAMF receptors","volume":"7","author":"van Driel","year":"2016","journal-title":"Front Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"21001290","DOI":"10.1371\/journal.ppat.1001290","article-title":"DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells","volume":"7","author":"Avota","year":"2011","journal-title":"PLoS Pathog."},{"key":"B31","first-page":"357","article-title":"Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures","volume":"38","author":"Albouz","year":"1981","journal-title":"Biomedicine."},{"key":"B32","doi-asserted-by":"publisher","first-page":"29694","DOI":"10.1074\/jbc.M000571200","article-title":"A di-aroomatic motif in the cytosolic tail of the mannose receptor mediates endosomal sorting","volume":"275","author":"Schweizer","year":"2000","journal-title":"J Biol Chhem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e1000218","DOI":"10.1371\/journal.ppat.1000218","article-title":"Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis","volume":"4","author":"Heinsbroek","year":"2008","journal-title":"PLoS Pathog"},{"key":"B34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1365-2249.2010.04244.x","article-title":"The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling","volume":"162","author":"Li","year":"2010","journal-title":"Clin Eur Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1111\/j.1462-5822.2011.01646.x","article-title":"Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice","volume":"13","author":"Lippmann","year":"2011","journal-title":"Cell Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.4049\/jimmunol.1103491","article-title":"MyD88 drives the IFN-\u03b2 response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7","volume":"189","author":"Weiss","year":"2012","journal-title":"JImmunol"},{"key":"B37","first-page":"1","article-title":"Enhancement of ceramide formation increases endocytosis of Lactobacillus acidophilus and leads to increased IFN-\u03b2 and IL-12 production in dendritic cells","volume":"1","author":"Fuglsang","year":"2017","journal-title":"J.Clin. Immunol. Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1053\/j.gastro.2007.08.004","article-title":"Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease","volume":"133","author":"Mpofu","year":"2007","journal-title":"Gastroenterology."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1083\/jcb.201707027","article-title":"SLAMF1 is required for TLR4-mediated TRAM-TRIF\u2013dependent signaling in human macrophages","volume":"217","author":"Yurchenko","year":"2018","journal-title":"J Cell Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/ni.1931","article-title":"SLAM is a microbial sensor that regulates bacterial phagosome e functions in macrophages","volume":"11","author":"Berger","year":"2010","journal-title":"Nat Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1128\/iai.71.1.437-445.2003","article-title":"Normal host defense during systemic candidiasis in mannose receptor-deficient mice","volume":"71","author":"Lee","year":"2003","journal-title":"Infect Immun"},{"key":"B42","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.celrep.2017.09.034","article-title":"M. tuberculosis-initiated human mannose receptor signaling temporally regulates macrophage recognition and vesicle trafficking by FcR\u03b3-chain, Grb2 and SHP-1","volume":"21","author":"Rajaran","year":"2017","journal-title":"Cell Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1189\/jlb.0512231","article-title":"The mannose receptor","volume":"92","author":"Martinez-Pomares","year":"2012","journal-title":"J leukoc Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02646\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:27:47Z","timestamp":1573817267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02646\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2019.02646"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02646","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"article-number":"2646"}}