{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:21:50Z","timestamp":1790781710148,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02733","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T05:24:34Z","timestamp":1574745874000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study"],"prefix":"10.3389","volume":"10","author":[{"given":"Abdulla","family":"Watad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Luigi","family":"Bragazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Comaneshter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Amital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/BOR.0000000000000315","article-title":"Familial Mediterranean fever","volume":"28","author":"Padeh","year":"2016","journal-title":"Curr Opin Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/00005792-197409000-00002","article-title":"Associations between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, the intestinal arthropathies, and Behcet's syndrome","volume":"53","author":"Moll","year":"1974","journal-title":"Medicine."},{"key":"B3","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/annrheumdis-2015-eular.6315","article-title":"THU0562 A comparison between ankylosing spondilitis patients and familial Mediterranean fever with ankylosing spondilitis patients","volume":"74","author":"Yazici","year":"2015","journal-title":"Ann Rheum Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.3389\/fimmu.2018.02668","article-title":"The early phases of ankylosing spondylitis: emerging insights from clinical and basic science","volume":"9","author":"Watad","year":"2018","journal-title":"Front Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","article-title":"A proposed classification of the immunological diseases","volume":"3","author":"McGonagle","year":"2006","journal-title":"PLoS Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/ng.3176","article-title":"High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis","volume":"47","author":"Goyette","year":"2015","journal-title":"Nat Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/BF02030357","article-title":"Ankylosing spondylitis. An unusual manifestation of familial Mediterranean fever Report of a case complicated by amyloidosis and polyneuropathy","volume":"8","author":"Knockaert","year":"1989","journal-title":"Clin Rheumatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00296-008-0616-6","article-title":"Coexistence of familial Mediterranean fever and psoriasis in a patient with seronegative spondyloarthropathy","volume":"29","author":"Bodur","year":"2008","journal-title":"Rheumatol Int."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1111\/1756-185X.12354","article-title":"Two elderly cases of familial Mediterranean fever with rheumatoid arthritis","volume":"21","author":"Matsuoka","year":"2018","journal-title":"Int J Rheum Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00296-005-0074-3","article-title":"Familial Mediterranean fever","volume":"26","author":"Onen","year":"2006","journal-title":"Rheumatol Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.autrev.2016.07.027","article-title":"Does inflammatory bowel disease coexist with systemic lupus erythematosus?","volume":"15","author":"Shor","year":"2016","journal-title":"Autoimmun Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s12026-016-8884-9","article-title":"Association between ischemic heart disease and systemic lupus erythematosus-a large case-control study","volume":"65","author":"Watad","year":"2017","journal-title":"Immunol Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jad.2017.02.007","article-title":"Anxiety disorder among rheumatoid arthritis patients: insights from real-life data","volume":"213","author":"Watad","year":"2017","journal-title":"J Affect Disord."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.autrev.2018.06.003","article-title":"Giant cell arteritis and inflammatory bowel disease - Is there a connection? Results from a population-based study","volume":"17","author":"Yavne","year":"2018","journal-title":"Autoimmun Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e000550","DOI":"10.1136\/rmdopen-2017-000550","article-title":"Autoimmune-autoinflammatory rheumatoid arthritis overlaps: a rare but potentially important subgroup of diseases","volume":"3","author":"Savic","year":"2017","journal-title":"RMD Open."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1111\/j.1468-1331.2011.03356.x","article-title":"Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohorts","volume":"18","author":"Yahalom","year":"2011","journal-title":"Eur J Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3109\/14397595.2013.852843","article-title":"Coexistence of familial Mediterranean fever and rheumatoid arthritis","volume":"24","author":"Migita","year":"2014","journal-title":"Mod Rheumatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/annrheumdis-2013-203643","article-title":"Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells","volume":"73","author":"Jacques","year":"2014","journal-title":"Ann Rheum Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/BOR.0000000000000003","article-title":"Genetics of Beh\u00e7et's disease: lessons learned from genomewide association studies","volume":"26","author":"G\u00fcl","year":"2014","journal-title":"Curr Opin Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nrrheum.2015.147","article-title":"'MHC-I-opathy'-unified concept for spondyloarthritis and Behcet disease","volume":"11","author":"McGonagle","year":"2015","journal-title":"Nat Rev Rheumatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ejim.2016.10.011","article-title":"Behcet's disease and familial Mediterranean fever: two sides of the same coin or just an association? A cross-sectional study","volume":"39","author":"Watad","year":"2017","journal-title":"Eur J Intern Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e0182967","DOI":"10.1371\/journal.pone.0182967","article-title":"MEFV M694V mutation has a role in susceptibility to ankylosing spondylitis: a meta-analysis","volume":"12","author":"Zhong","year":"2017","journal-title":"PLoS ONE."},{"key":"B23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.2174\/1871530317666171003155517","article-title":"Ankylosing spondylitis among familial Mediterranean fever patients","volume":"18","author":"Merashli","year":"2018","journal-title":"Endocr Metab Immune Disord Drug Targets."},{"key":"B24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/qjmed\/90.1.37","article-title":"The clinical patterns of arthritis in children with familial Mediterranean fever","volume":"90","author":"Majeed","year":"1997","journal-title":"QJM Int J Med."},{"key":"B25","first-page":"475","article-title":"[Subacute and chronic joint involvement occurring during the course of familial Mediterranean fever (author's transl)]","volume":"132","author":"Brodsky","year":"1981","journal-title":"Ann Med Interne."},{"key":"B26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/03009734.2017.1423425","article-title":"Increased psoriasis frequency in patients with familial Mediterranean fever","volume":"123","author":"Erden","year":"2018","journal-title":"Ups J Med Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/00005792-200211000-00001","article-title":"Crohn disease in patients with familial Mediterranean fever","volume":"81","author":"Fidder","year":"2002","journal-title":"Medicine."},{"key":"B28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1089\/gtmb.2008.0094","article-title":"Detection of MEFV gene mutations in patients with inflammatory bowel disease","volume":"13","author":"Yurtcu","year":"2009","journal-title":"Genet Test Mol Biomarkers."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1097\/MCG.0b013e3182597992","article-title":"Association of the MEFV gene variations with inflammatory bowel disease in Turkey","volume":"47","author":"Akyuz","year":"2013","journal-title":"J Clin Gastroenterol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s00702-013-1080-3","article-title":"Multiple sclerosis is primarily a neurodegenerative disease","volume":"120","author":"Chaudhuri","year":"2013","journal-title":"J Neural Transm."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0132704","DOI":"10.1371\/journal.pone.0132704","article-title":"Association between MEFV mutations M694V and M680I and Beh\u00e7et's disease: a meta-analysis","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS ONE."},{"key":"B32","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/1346-8138.13068","article-title":"Psoriasis-like lesions in a patient with familial Mediterranean fever","volume":"43","author":"Ashida","year":"2016","journal-title":"J Dermatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1136\/ard.2004.023176","article-title":"Open label trial of anakinra in active ankylosing spondylitis over 24 weeks","volume":"64","author":"Haibel","year":"2005","journal-title":"Ann Rheum Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","author":"Cortes","year":"2013","journal-title":"Nat Genet"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1136\/ard.2004.020800","article-title":"Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study","volume":"63","author":"Tan","year":"2004","journal-title":"Ann Rheum Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.autrev.2018.06.001","article-title":"Mechanistic immunological based classification of rheumatoid arthritis","volume":"17","author":"McGonagle","year":"2018","journal-title":"Autoimmun Rev."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02733\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T05:24:35Z","timestamp":1574745875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02733\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":36,"alternative-id":["10.3389\/fimmu.2019.02733"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02733","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"article-number":"2733"}}