{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:53:51Z","timestamp":1753890831753,"version":"3.41.2"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02789","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T04:41:37Z","timestamp":1575002497000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection"],"prefix":"10.3389","volume":"10","author":[{"given":"Michelle L.","family":"D'Antoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalpana J.","family":"Kallianpur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Premeaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Corley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth I.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Ogata-Arakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic C.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedbar S.","family":"Khadka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia M.","family":"Shikuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishomwa C.","family":"Ndhlovu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/QAI.0b013e3181af83d6","article-title":"Changes in cognition during antiretroviral therapy: comparison of 2 different ranking systems to measure antiretroviral drug efficacy on HIV-associated neurocognitive disorders","volume":"52","author":"Tozzi","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1017\/S1355617704102130","article-title":"The impact of HIV-associated neuropsychological impairment on everyday functioning","volume":"10","author":"Heaton","year":"2004","journal-title":"J Int Neuropsychol Soc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1001\/archneur.1997.00550160054016","article-title":"Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV neurobehavioral research center group","volume":"54","author":"Ellis","year":"1997","journal-title":"Arch Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1001\/jama.285.11.1466","article-title":"Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study","volume":"285","author":"Ickovics","year":"2001","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/QAD.0b013e328340fd42","article-title":"Editorial neuroAIDS review","volume":"25","author":"Shapshak","year":"2011","journal-title":"Aids"},{"key":"B7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1176\/appi.neuropsych.11050109","article-title":"Cognitive performance related to HIV-1-infected monocytes","volume":"24","author":"Kusao","year":"2012","journal-title":"J Neuropsych Clin Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nri1527","article-title":"The neuropathogenesis of AIDS","volume":"5","author":"Gonzalez-Scarano","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1212\/01.WNL.0000145763.68284.15","article-title":"Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia","volume":"63","author":"Sevigny","year":"2004","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s11481-013-9512-2","article-title":"Applications and limitations of inflammatory biomarkers for studies on neurocognitive impairment in HIV infection","volume":"8","author":"Cassol","year":"2013","journal-title":"J Neuroimmune Pharmacol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1097\/QAD.0000000000000706","article-title":"The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients","volume":"29","author":"Thames","year":"2015","journal-title":"AIDS"},{"key":"B12","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1126\/science.287.5453.602","article-title":"HIV infection and dementia","volume":"287","author":"Gartner","year":"2000","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/jnen\/64.6.529","article-title":"Influence of HAART on HIV-related CNS disease and neuroinflammation","volume":"64","author":"Anthony","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1000842","DOI":"10.1371\/journal.ppat.1000842","article-title":"Increased monocyte turnover from bone marrow correlates with severity of SIV encephalitis and CD163 levels in plasma","volume":"6","author":"Burdo","year":"2010","journal-title":"PLoS Pathog"},{"key":"B15","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.immuni.2017.06.007","article-title":"Myeloid cells in the central nervous system","volume":"46","author":"Herz","year":"2017","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nn.4475","article-title":"The role of peripheral immune cells in the CNS in steady state and disease","volume":"20","author":"Prinz","year":"2017","journal-title":"Nat Neurosci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/ni.3423","article-title":"Origin, fate and dynamics of macrophages at central nervous system interfaces","volume":"17","author":"Goldmann","year":"2016","journal-title":"Nat Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/ana.21800","article-title":"Multiple sclerosis: distribution of inflammatory cells in newly forming lesions","volume":"66","author":"Henderson","year":"2009","journal-title":"Ann Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.neuron.2015.01.013","article-title":"The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury","volume":"85","author":"Gadani","year":"2015","journal-title":"Neuron"},{"key":"B20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","article-title":"Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus","volume":"38","author":"Shechter","year":"2013","journal-title":"Immunity"},{"key":"B21","doi-asserted-by":"publisher","first-page":"33310","DOI":"10.1038\/srep33310","article-title":"Comparative DNA methylation profiling reveals an immunoepigenetic signature of HIV-related cognitive impairment","volume":"6","author":"Corley","year":"2016","journal-title":"Sci Rep"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.1182\/blood.V94.11.3764.423k03_3764_3771","article-title":"Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein","volume":"94","author":"Scheller","year":"1999","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1089\/107999002753452755","article-title":"ICSBP\/IRF-8: its regulatory roles in the development of myeloid cells","volume":"22","author":"Tamura","year":"2002","journal-title":"J Interferon Cytokine Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1182\/blood-2011-06-364976","article-title":"IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors","volume":"119","author":"Becker","year":"2012","journal-title":"Blood"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.4049\/jimmunol.0803693","article-title":"IFN regulatory factor 8 regulates MDM2 in germinal center B cells","volume":"183","author":"Zhou","year":"2009","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s12031-017-0966-1","article-title":"IRF-8 is Involved in Amyloid-beta1\u201340. (Abeta1\u201340)-induced microglial activation: a new implication in alzheimer's disease","volume":"63","author":"Zeng","year":"2017","journal-title":"J Mol Neurosci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"4273108","DOI":"10.1155\/2019\/4273108","article-title":"The model of aging acceleration network reveals the correlation of alzheimer's disease and aging at system level","volume":"2019","author":"Zhou","year":"2019","journal-title":"Biomed Res Int"},{"key":"B28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1089\/aid.2011.0086","article-title":"Vitamin D levels and markers of arterial dysfunction in HIV","volume":"28","author":"Shikuma","year":"2012","journal-title":"AIDS Res Hum Retrovirus"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1212\/01.WNL.0000287431.88658.8b","article-title":"Updated research nosology for HIV-associated neurocognitive disorders","volume":"69","author":"Antinori","year":"2007","journal-title":"Neurology"},{"volume-title":"Wechsler Adult Intelligence Scale","year":"2008","author":"Wechsler","key":"B30"},{"key":"B31","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1076\/clin.13.1.30.1976","article-title":"Adult norms for the Rey-Osterrieth Complex Figure Test and for supplemental recognition and matching trials from the extended complex figure test","volume":"13","author":"Fastenau","year":"1999","journal-title":"Clin Neuropsychol"},{"volume-title":"Comprehensive Norms for An Expanded Halstead-Reitan Battery: Demographic Corrections, Research Findings, And Clinical Applications","year":"1991","author":"Robert","key":"B32"},{"key":"B33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"B34","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"B35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb Cortex"},{"key":"B36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1006\/nimg.1998.0396","article-title":"Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system","volume":"9","author":"Fischl","year":"1999","journal-title":"Neuroimage"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.neuroimage.2004.03.032","article-title":"A hybrid approach to the skull stripping problem in MRI","volume":"22","author":"Segonne","year":"2004","journal-title":"Neuroimage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1109\/42.668698","article-title":"A nonparametric method for automatic correction of intensity nonuniformity in MRI data","volume":"17","author":"Sled","year":"1998","journal-title":"IEEE Trans Med Imaging"},{"key":"B39","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.neuroimage.2004.06.018","article-title":"A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume","volume":"23","author":"Buckner","year":"2004","journal-title":"Neuroimage"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e90330","DOI":"10.1371\/journal.pone.0090330","article-title":"Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV","volume":"9","author":"Shikuma","year":"2014","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.immuni.2016.08.013","article-title":"IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively","volume":"45","author":"Sichien","year":"2016","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1084\/jem.20010753","article-title":"Modulation of human immunodeficiency virus 1 replication by interferon regulatory factors","volume":"195","author":"Sgarbanti","year":"2002","journal-title":"J Exp Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.4049\/jimmunol.174.5.2573","article-title":"IFN regulatory factor-4 and\u22128 govern dendritic cell subset development and their functional diversity","volume":"174","author":"Tamura","year":"2005","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1084\/jem.20021263","article-title":"ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells","volume":"196","author":"Schiavoni","year":"2002","journal-title":"J Exp Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1084\/jem.186.9.1535","article-title":"Interferon. (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression","volume":"186","author":"Giese","year":"1997","journal-title":"J Exp Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"271","DOI":"10.4049\/jimmunol.165.1.271","article-title":"An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein. (ICSBP), stimulates IL-12 p40 expression in macrophages","volume":"165","author":"Wang","year":"2000","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"6379","DOI":"10.1038\/ncomms7379","article-title":"IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes","volume":"6","author":"Gupta","year":"2015","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1056\/NEJMoa1100066","article-title":"IRF8 mutations and human dendritic-cell immunodeficiency","volume":"365","author":"Hambleton","year":"2011","journal-title":"N Engl J Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cell.2018.02.055","article-title":"IRF8 regulates transcription of naips for NLRC4 inflammasome activation","volume":"173","author":"Karki","year":"2018","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1101\/sqb.2013.78.020321","article-title":"The IRF family transcription factors at the interface of innate and adaptive immune responses","volume":"78","author":"Ikushima","year":"2013","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"6820","DOI":"10.4049\/jimmunol.172.11.6820","article-title":"Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8\/IFN consensus sequence binding protein in dendritic cells","volume":"172","author":"Tsujimura","year":"2004","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00262-009-0804-6","article-title":"Regulation of immunity and oncogenesis by the IRF transcription factor family","volume":"59","author":"Savitsky","year":"2010","journal-title":"Cancer Immunol Immunother"},{"key":"B53","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.immuni.2012.09.014","article-title":"Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes","volume":"37","author":"Henault","year":"2012","journal-title":"Immunity"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.immuni.2015.08.019","article-title":"Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation","volume":"43","author":"Maxwell","year":"2015","journal-title":"Immunity"},{"key":"B56","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s11481-014-9567-8","article-title":"Plasma cytokine levels are related to brain volumes in HIV-infected individuals","volume":"9","author":"Gongvatana","year":"2014","journal-title":"J Neuroimmune Pharmacol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s10753-016-0454-8","article-title":"Inhibition of IRF8 negatively regulates macrophage function and impairs cutaneous wound healing","volume":"40","author":"Guo","year":"2017","journal-title":"Inflammation"},{"key":"B58","doi-asserted-by":"publisher","first-page":"250","DOI":"10.14336\/AD.2016.0918","article-title":"Intercellular adhesion molecular-5 as marker in HIV associated neurocognitive disorder","volume":"8","author":"Yuan","year":"2017","journal-title":"Aging Dis"},{"key":"B59","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000236550","article-title":"Increased levels of serum intercellular adhesion molecule 1 in HIV infection are related to immune activation","volume":"102","author":"Diez-Ruiz","year":"1993","journal-title":"Int Arch Allergy Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"124267","DOI":"10.1172\/jci.insight.124267","article-title":"IFN regulatory factor-8 expression in macrophages governs an antimetastatic program","volume":"4","author":"Twum","year":"2019","journal-title":"JCI Insight"},{"key":"B61","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.4049\/jimmunol.1303183","article-title":"Cutting Edge: MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response","volume":"192","author":"Oriss","year":"2014","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1476-9255-7-37","article-title":"Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity","volume":"7","author":"Jensen","year":"2010","journal-title":"J Inflamm."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.3892\/or.2016.5171","article-title":"Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis","volume":"36","author":"Wang","year":"2016","journal-title":"Oncol Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1742-4690-2-73","article-title":"Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency","volume":"2","author":"Munier","year":"2005","journal-title":"Retrovirology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e70164","DOI":"10.1371\/journal.pone.0070164","article-title":"HIV DNA reservoir increases risk for cognitive disorders in cART-naive patients","volume":"8","author":"Valcour","year":"2013","journal-title":"PLoS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1016\/j.cub.2017.10.073","article-title":"The role of hippocampal replay in memory and planning","volume":"28","author":"Olafsdottir","year":"2018","journal-title":"Curr Biol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1212\/01.WNL.0000106463.66966.65","article-title":"Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study","volume":"62","author":"Mortimer","year":"2004","journal-title":"Neurology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/archneur.63.5.693","article-title":"Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps","volume":"63","author":"Apostolova","year":"2006","journal-title":"Arch Neurol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00429-012-0497-z","article-title":"Bigger is better! Hippocampal volume and declarative memory performance in healthy young men","volume":"219","author":"Pohlack","year":"2014","journal-title":"Brain Struct Funct"},{"key":"B70","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.1199139","article-title":"Neuroscience. Change in the brain's white matter","volume":"330","author":"Fields","year":"2010","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.biopsych.2006.01.011","article-title":"Regional white matter and neuropsychological functioning across the adult lifespan","volume":"60","author":"Brickman","year":"2006","journal-title":"Biol Psychiatr"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41598-017-01249-7","article-title":"Hypermethylation of interferon regulatory factor 8. (IRF8) confers risk to vogt-koyanagi-harada disease","volume":"7","author":"Qiu","year":"2017","journal-title":"Sci Rep"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e52341","DOI":"10.1371\/journal.pone.0052341","article-title":"miR-22 controls Irf8 mRNA abundance and murine dendritic cell development","volume":"7","author":"Li","year":"2012","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","first-page":"9680","DOI":"10.1093\/nar\/gkv1056","article-title":"Epigenetic program and transcription factor circuitry of dendritic cell development","volume":"43","author":"Lin","year":"2015","journal-title":"Nucleic Acids Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02789\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T04:41:44Z","timestamp":1575002504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02789\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":74,"alternative-id":["10.3389\/fimmu.2019.02789"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02789","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2019,11,29]]},"article-number":"2789"}}