{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:28:25Z","timestamp":1784903305976,"version":"3.55.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872378"],"award-info":[{"award-number":["31872378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012172","name":"Double First Class University Plan","doi-asserted-by":"publisher","award":["SYL201802009"],"award-info":[{"award-number":["SYL201802009"]}],"id":[{"id":"10.13039\/501100012172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02800","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T04:33:15Z","timestamp":1576038795000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Honokiol Ameliorates High-Fat-Diet-Induced Obesity of Different Sexes of Mice by Modulating the Composition of the Gut Microbiota"],"prefix":"10.3389","volume":"10","author":[{"given":"Yanan","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehe","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults","volume":"390","author":"Abarca-G\u00f3mez","year":"2017","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2014.11.010","article-title":"Diet dominates host genotype in shaping the murine gut microbiota","volume":"17","author":"Carmody","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B3","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ismej.2009.112","article-title":"Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice","volume":"4","author":"Zhang","year":"2010","journal-title":"ISME J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mam.2012.11.001","article-title":"The gut microbiota, obesity and insulin resistance","volume":"34","author":"Shen","year":"2013","journal-title":"Mol Aspects Med"},{"key":"B7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Emmanuelle","year":"2013","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-Induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B9","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"B\u00e4ckhed","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B10","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Na-Ri","year":"2014","journal-title":"Gut"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Amandine","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","article-title":"Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia","volume":"50","author":"Cani","year":"2007","journal-title":"Diabetologia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1161\/CIRCRESAHA.116.309006","article-title":"Hypertension-linked pathophysiological alterations in the gut","volume":"120","author":"Santisteban","year":"2016","journal-title":"Circ Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db07-1181","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"B16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"31208","DOI":"10.1038\/srep31208","article-title":"Non-absorbable apple procyanidins prevent obesity associated with gut microbial and metabolomic changes","volume":"6","author":"Masumoto","year":"2016","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-019-0332-1","article-title":"Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice","author":"Wang","year":"2019","journal-title":"Int J Obes"},{"key":"B19","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fneur.2013.00130","article-title":"Neuro-modulating effects of honokiol: a review","volume":"4","author":"Woodbury","year":"2013","journal-title":"Front Neurol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1745-4514.2010.00393.x","article-title":"Antimicrobial activity of Magnolia officinalis extracts in vitro and its effects on the preservation of chilled mutton","volume":"35","author":"Yongjin","year":"2011","journal-title":"J Food Biochem"},{"key":"B21","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1021\/np50075a010","article-title":"Studies on inhibitors of skin tumor promotion, IX. Neolignans from Magnolia officinalis","volume":"54","author":"Konoshima","year":"1991","journal-title":"J Nat Prod"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.biochi.2011.06.012","article-title":"Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA","volume":"93","author":"Zhao","year":"2011","journal-title":"Biochimie"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1002\/mnfr.201300113","article-title":"Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice","volume":"57","author":"Kim","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s11101-016-9459-z","article-title":"The chemistry of gut microbial metabolism of polyphenols","volume":"15","author":"Stevens","year":"2016","journal-title":"Phyochem Rev"},{"key":"B25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.yhbeh.2008.07.010","article-title":"Sex-associated differences in the leptin and ghrelin systems related with the induction of hyperphagia under high-fat diet exposure in rats","volume":"55","author":"Priego","year":"2009","journal-title":"Hormones Behav"},{"key":"B26","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/ijo.2011.87","article-title":"Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control","volume":"36","author":"Medrikova","year":"2012","journal-title":"Int J Obes"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3748\/wjg.v20.i5.1192","article-title":"Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?","volume":"20","author":"Hold","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2011","journal-title":"Gastroenterology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3389\/fmicb.2014.00508","article-title":"Application of high-throughput sequencing in understanding human oral microbiome related with health and disease","volume":"5","author":"Chen","year":"2014","journal-title":"Front Microbiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1128\/AEM.01996-06","article-title":"Quantitative and qualitative beta diversity measures lead to different insights into factors that structure microbial communities","volume":"73","author":"Lozupone","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1574-6941.2007.00375.x","article-title":"Multivariate analyses in microbial ecology","volume":"62","author":"Alban","year":"2010","journal-title":"Fems Microbiol Ecol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/1471-2180-9-259","article-title":"Defining the healthy \u201ccore microbiome\u201d of oral microbial communities","volume":"9","author":"Zaura","year":"2009","journal-title":"BMC Microbiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jff.2016.11.002","article-title":"Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice","volume":"28","author":"Shang","year":"2017","journal-title":"J Funct Foods"},{"key":"B35","doi-asserted-by":"publisher","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4869","DOI":"10.1039\/C6FO01439A","article-title":"The modulatory effect of infusions of green tea, oolong tea, and black tea on gut microbiota in high-fat-induced obese mice","volume":"7","author":"Liu","year":"2016","journal-title":"Food Funct"},{"key":"B37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.taap.2015.02.020","article-title":"Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes","volume":"284","author":"Suk","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1177\/1535370214547123","article-title":"Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1c pathway","volume":"240","author":"Lee","year":"2015","journal-title":"Exp Biol Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1056\/NEJMc1701944","article-title":"Mechanisms, pathophysiology, and management of obesity","volume":"376","author":"Heymsfield","year":"2017","journal-title":"N Engl J Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1128\/AEM.71.7.4153-4155.2005","article-title":"Colonic microbiota signatures across five northern European countries","volume":"71","author":"Christophe","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Huttenhower","year":"2012","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4500","DOI":"10.1038\/ncomms5500","article-title":"Individual diet has sex-dependent effects on vertebrate gut microbiota","volume":"5","author":"Bolnick","year":"2015","journal-title":"Nat Commun"},{"key":"B43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/19490976.2016.1203502","article-title":"Sex differences and hormonal effects on gut microbiota composition in mice","volume":"7","author":"Org","year":"2016","journal-title":"Gut Microbes"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"Markle","year":"2013","journal-title":"Science."},{"key":"B45","doi-asserted-by":"publisher","first-page":"16643","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphilainversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"45356","DOI":"10.1038\/srep45356","article-title":"Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder","volume":"7","author":"Coretti","year":"2017","journal-title":"Sci Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnut.2018.00028","article-title":"Gut microbiome composition in non-human primates consuming a western or Mediterranean diet","volume":"5","author":"Yadav","year":"2018","journal-title":"Front Nutr"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1800446","DOI":"10.1002\/mnfr.201800446","article-title":"Sulfated polysaccharide from sea cucumber and its depolymerized derivative prevent obesity in association with modification of gut microbiota in high-fat diet-fed mice","volume":"62","author":"Zhu","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e41079","DOI":"10.1371\/journal.pone.0041079","article-title":"Bacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity","volume":"7","author":"Gauffin","year":"2012","journal-title":"PloS ONE"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e154090","DOI":"10.1371\/journal.pone.0154090","article-title":"Intestinal microbiota is influenced by gender and body mass index","volume":"11","author":"Haro","year":"2016","journal-title":"PloS ONE"},{"key":"B51","doi-asserted-by":"publisher","first-page":"37589","DOI":"10.1038\/srep37589","article-title":"Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota","volume":"6","author":"Lu","year":"2016","journal-title":"Sci Rep"},{"key":"B52","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/ismej.2012.146","article-title":"Microbiota conservation and BMI signatures in adult monozygotic twins","volume":"7","author":"Tims","year":"2013","journal-title":"ISME J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","article-title":"Human genetics shape the gut microbiome","volume":"159","author":"Goodrich","year":"2014","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e1011","DOI":"10.1128\/mBio.01011-14","article-title":"Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db\/db mice","volume":"5","author":"Amandine","year":"2014","journal-title":"Mbio"},{"key":"B55","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nbt.2845","article-title":"You are what you eat","volume":"32","author":"Br\u00fcssow","year":"2014","journal-title":"Nat Biotechnol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat Commun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02800\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T04:33:18Z","timestamp":1576038798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02800\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":57,"alternative-id":["10.3389\/fimmu.2019.02800"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02800","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]},"article-number":"2800"}}