{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:40Z","timestamp":1787161600883,"version":"build-2736575974"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.02852","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T01:02:18Z","timestamp":1575334938000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":225,"title":["Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"Daphne","family":"van der Heide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Weiskirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ni.2691","article-title":"Immune surveillance by the liver","volume":"14","author":"Jenne","year":"2013","journal-title":"Nat Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver-from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/hep.27793","article-title":"Liver inflammation abrogates immunological tolerance induced by Kupffer cells","volume":"62","author":"Heymann","year":"2015","journal-title":"Hepatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/hep.23043","article-title":"Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver","volume":"50","author":"Breous","year":"2009","journal-title":"Hepatology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1055\/s-2001-17550","article-title":"History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells","volume":"21","author":"Geerts","year":"2001","journal-title":"Semin Liver Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00424-012-1209-5","article-title":"Hepatic stellate cells\u2013the pericytes in the liver","volume":"465","author":"Hellerbrand","year":"2013","journal-title":"Pflugers Arch."},{"key":"B8","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.14841.1","article-title":"Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts","volume":"7","author":"Weiskirchen","year":"2018","journal-title":"F1000Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1111\/j.1872-034X.2012.01111.x","article-title":"Activated hepatic stellate cells mediate the differentiation of macrophages","volume":"43","author":"Chang","year":"2007","journal-title":"Hepatol Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J Hepatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/hep4.1356","article-title":"Liver macrophages: old dogmas and new insights","volume":"3","author":"Guillot","year":"2019","journal-title":"Hepatol Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/cmi.2015.104","article-title":"Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies","volume":"13","author":"Ju","year":"2016","journal-title":"Cell Mol Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2016.03.009","article-title":"A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair","volume":"165","author":"Wang","year":"2016","journal-title":"Cell."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1002\/hep.26754","article-title":"Macrophage plasticity and polarization in liver homeostasis and pathology","volume":"59","author":"Sica","year":"2014","journal-title":"Hepatology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00424-017-1954-6","article-title":"Liver macrophages in healthy and diseased liver","volume":"469","author":"Abdullah","year":"2017","journal-title":"Pflugers Arch."},{"key":"B16","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1242\/dev.126.22.5073","article-title":"Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse","volume":"126","author":"Palis","year":"1999","journal-title":"Development."},{"key":"B17","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/intimm\/dxy044","article-title":"Delineating the origins, developmental programs and homeostatic functions of tissue-resident macrophages","volume":"30","author":"Mass","year":"2018","journal-title":"Int Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature."},{"key":"B19","doi-asserted-by":"publisher","first-page":"eaaf4238","DOI":"10.1126\/science.aaf4238","article-title":"Specification of tissue-resident macrophages during organogenesis","volume":"353","author":"Mass","year":"2016","journal-title":"Science."},{"key":"B20","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.immuni.2015.03.011","article-title":"C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages","volume":"42","author":"Hoeffel","year":"2015","journal-title":"Immunity."},{"key":"B21","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1146\/annurev.immunol.25.022106.141538","article-title":"Ontogeny of the hematopoietic system","volume":"25","author":"Cumano","year":"2007","journal-title":"Annu Rev Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1182\/blood-2005-02-0461","article-title":"Three pathways to mature macrophages in the early mouse yolk sac","volume":"106","author":"Bertrand","year":"2005","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.jhep.2016.05.037","article-title":"Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions","volume":"65","author":"Beattie","year":"2016","journal-title":"J Hepatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.jhep.2017.11.029","article-title":"Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis","volume":"68","author":"Borst","year":"2018","journal-title":"J Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.immuni.2014.12.020","article-title":"Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection","volume":"42","author":"Bl\u00e9riot","year":"2015","journal-title":"Immunity."},{"key":"B26","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.jhep.2019.03.016","article-title":"Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers","volume":"71","author":"Lefere","year":"2019","journal-title":"J Hepatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"347","DOI":"10.2337\/db09-0016","article-title":"Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance","volume":"59","author":"Huang","year":"2010","journal-title":"Diabetes."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0159524","DOI":"10.1371\/journal.pone.0159524","article-title":"Kupffer cells undergo fundamental changes during the development of experimental NASH and are critical in initiating liver damage and inflammation","volume":"11","author":"Reid","year":"2016","journal-title":"PLoS ONE."},{"key":"B29","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.immuni.2017.10.006","article-title":"Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells","volume":"47","author":"Roberts","year":"2017","journal-title":"Immunity."},{"key":"B30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.cell.2019.02.028","article-title":"Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage","volume":"177","author":"Uderhardt","year":"2019","journal-title":"Cell."},{"key":"B31","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.1117729","article-title":"A clonogenic bone marrow progenitor specific for macrophages and dendritic cells","volume":"311","author":"Fogg","year":"2006","journal-title":"Science"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e42180","DOI":"10.1371\/journal.pone.0042180","article-title":"An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene","volume":"7","author":"Miura","year":"2012","journal-title":"PLoS ONE."},{"key":"B33","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1136\/gutjnl-2011-300304","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","volume":"61","author":"Baeck","year":"2012","journal-title":"Gut."},{"key":"B34","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"Karlmark","year":"2009","journal-title":"Hepatology."},{"key":"B35","doi-asserted-by":"publisher","first-page":"G1310","DOI":"10.1152\/ajpgi.00365.2011","article-title":"Hepatic recruitment of macrophages promotes non-alcoholic steatohepatitis through CCR2","volume":"302","author":"Miura","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1042\/CS20110515","article-title":"Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis","volume":"123","author":"Galastri","year":"2012","journal-title":"Clin Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.24764","article-title":"Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice","volume":"55","author":"Heymann","year":"2012","journal-title":"Hepatology."},{"key":"B38","doi-asserted-by":"publisher","first-page":"344","DOI":"10.4049\/jimmunol.1400574","article-title":"Infiltrating monocyte-derived macrophages and resident Kupffer cells display different ontogeny and functions in acute liver injury","volume":"193","author":"Zigmond","year":"2014","journal-title":"J Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B40","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1186\/1755-1536-5-S1-S27","article-title":"Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo","volume":"5","author":"Tacke","year":"2012","journal-title":"Fibrogenesis Tissue Repair."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1172\/jci37444","article-title":"CCR1 and CCR5 promote hepatic fibrosis in mice","volume":"119","author":"Seki","year":"2009","journal-title":"J Clin Invest"},{"key":"B42","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fimmu.2015.00225","article-title":"Revisiting mouse peritoneal macrophages: heterogeneity, development, and function","volume":"6","author":"Cassado Ados","year":"2015","journal-title":"Front Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/hep.28883","volume":"65","year":"2017","journal-title":"Hepatology."},{"key":"B44","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science."},{"key":"B45","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1159\/000495276","article-title":"The spleen promotes the secretion of CCL2 and supports an M1 dominant phenotype in hepatic macrophages during liver fibrosis","volume":"51","author":"Li","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/labinvest.2017.44","article-title":"Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice","volume":"97","author":"Aoyama","year":"2017","journal-title":"Lab Invest."},{"key":"B47","doi-asserted-by":"publisher","first-page":"816460","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"Roszer","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B48","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/JLB.3RU1018-378RR","article-title":"M2b macrophage polarization and its roles in diseases","volume":"106","author":"Wang","year":"2019","journal-title":"J Leukoc Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat Commun."},{"key":"B50","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jhep.2008.08.009","article-title":"The importance of immune dysfunction in determining outcome in acute liver failure","volume":"49","author":"Antoniades","year":"2008","journal-title":"J Hepatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1111\/j.1478-3231.2010.02262.x","article-title":"Acute liver failure: mechanisms of immune-mediated liver injury","volume":"30","author":"Wu","year":"2010","journal-title":"Liver Int."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1021\/tx0255976","article-title":"Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice","volume":"15","author":"Ju","year":"2002","journal-title":"Chem Res Toxicol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol Aspects Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0036-1597816","article-title":"Regression of Liver Fibrosis","volume":"37","author":"Campana","year":"2017","journal-title":"Semin Liver Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3390\/cells8080845","article-title":"Current status in testing for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)","volume":"8","author":"Drescher","year":"2019","journal-title":"Cells."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut."},{"key":"B59","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s00125-016-3904-9","article-title":"Adipose tissue macrophages: going off track during obesity","volume":"59","author":"Boutens","year":"2016","journal-title":"Diabetologia."},{"key":"B60","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1055\/s-0037-1604480","article-title":"Macrophages in non-alcoholic fatty liver disease: a role model of pathogenic immunometabolism","volume":"37","author":"Krenkel","year":"2017","journal-title":"Semin Liver Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/hep.23337","article-title":"Kupffer cells promote hepatic steatosis via interleukin-1\u03b2-dependent suppression of peroxisome proliferator-activated receptor \u03b1 activity","volume":"51","author":"Stienstra","year":"2010","journal-title":"Hepatology."},{"key":"B63","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/hep.26081","article-title":"Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of non-alcoholic steatohepatitis through inflammasome activation in mice","volume":"57","author":"Miura","year":"2013","journal-title":"Hepatology."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e107265","DOI":"10.1371\/journal.pone.0107265","article-title":"IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis","volume":"9","author":"Negrin","year":"2014","journal-title":"PLoS ONE."},{"key":"B65","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/hep.22404","article-title":"Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes","volume":"48","author":"Cl\u00e9ment","year":"2008","journal-title":"Hepatology."},{"key":"B66","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1172\/JCI83885","article-title":"Hepatocyte mitochondrial DNA drives non-alcoholic steatohepatitis by activation of TLR9","volume":"126","author":"Garcia-Martinez","year":"2016","journal-title":"J Clin Invest."},{"key":"B67","doi-asserted-by":"publisher","first-page":"7381","DOI":"10.3748\/wjg.v20.i23.7381","article-title":"Role of gut microbiota and Toll-like receptors in non-alcoholic fatty liver disease","volume":"20","author":"Miura","year":"2014","journal-title":"World J Gastroenterol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318382","article-title":"Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis","author":"Krenkel","year":"2019","journal-title":"Gut."},{"key":"B69","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.molcel.2019.07.028","article-title":"Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis","volume":"75","author":"Xiong","year":"2019","journal-title":"Mol Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/hep.23258","article-title":"Alcoholic liver disease","volume":"51","author":"O'Shea","year":"2010","journal-title":"Hepatology."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1136\/jim-2016-000210","article-title":"Role of hepatic macrophages in alcoholic liver disease","volume":"64","author":"Ju","year":"2016","journal-title":"J Investig Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e96864","DOI":"10.1371\/journal.pone.0096864","article-title":"Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals","volume":"9","author":"Bala","year":"2014","journal-title":"PLoS ONE."},{"key":"B73","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/hep.27489","article-title":"Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice","volume":"61","author":"Chen","year":"2015","journal-title":"Hepatology."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology."},{"key":"B75","doi-asserted-by":"publisher","first-page":"G516","DOI":"10.1152\/ajpgi.00537.2010","article-title":"Innate immunity in alcoholic liver disease","volume":"300","author":"Gao","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/hep.28680","article-title":"Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease","volume":"64","author":"Bukong","year":"2016","journal-title":"Hepatology."},{"key":"B77","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/j.1365-2036.2004.01906.x","article-title":"Review article: hepatitis vaccination in patients with chronic liver disease","volume":"19","author":"Reiss","year":"2004","journal-title":"Aliment Pharmacol Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jhep.2014.04.026","article-title":"The role of Kupffer cells in hepatitis B and hepatitis C virus infections","volume":"61","author":"Boltjes","year":"2014","journal-title":"J Hepatol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20072195","article-title":"TLR-dependent cross talk between human Kupffer cells and NK cells","volume":"205","author":"Tu","year":"2008","journal-title":"J Exp Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1093\/infdis\/jiu599","article-title":"Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function","volume":"211","author":"Boltjes","year":"2015","journal-title":"J Infect Dis."},{"key":"B81","doi-asserted-by":"publisher","first-page":"12284","DOI":"10.1128\/JVI.01962-13","article-title":"Hepatitis C virus induces interleukin-1\u03b2 (IL-1\u03b2)\/IL-18 in circulatory and resident liver macrophages","volume":"87","author":"Shrivastava","year":"2013","journal-title":"J Virol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1189\/jlb.0207128","article-title":"Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins","volume":"82","author":"Chang","year":"2007","journal-title":"J Leukoc Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.semcancer.2010.10.007","article-title":"The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets","volume":"21","author":"Yang","year":"2011","journal-title":"Semin Cancer Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1535-6108(04)00058-3","article-title":"Focus on hepatocellular carcinoma","volume":"5","author":"Bruix","year":"2004","journal-title":"Cancer Cell."},{"key":"B85","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1749-6632.2009.03704.x","article-title":"Inflammation and liver cancer: new molecular links","volume":"1155","author":"Berasain","year":"2009","journal-title":"Ann N Y Acad Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"187204","DOI":"10.1155\/2013\/187204","article-title":"The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages","volume":"2013","author":"Capece","year":"2013","journal-title":"Biomed Res Int."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1189\/jlb.0609385","article-title":"Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation","volume":"86","author":"Solinas","year":"2009","journal-title":"J Leukoc Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.imbio.2009.06.014","article-title":"Cellular and molecular pathways linking inflammation and cancer","volume":"214","author":"Porta","year":"2009","journal-title":"Immunobiology."},{"key":"B89","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.3389\/fimmu.2018.02948","article-title":"The role of monocytes and macrophages in acute and acute-on-chronic liver failure","volume":"9","author":"Triantafyllou","year":"2018","journal-title":"Front Immunol."},{"key":"B91","unstructured":"Bethesda, MD: National Institute of Diabetes and Digestive and Kidney DiseasesClinical and Research Information on Drug-Induced Liver Injury2012"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1053\/j.gastro.2015.08.053","article-title":"CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure","volume":"149","author":"Stutchfield","year":"2015","journal-title":"Gastroenterology."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1002\/hep.26933","article-title":"Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure","volume":"59","author":"Antoniades","year":"2014","journal-title":"Hepatology."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1016\/j.biomaterials.2013.01.033","article-title":"Multifunctional polymeric nanoparticles for oral delivery of TNF-\u03b1 siRNA to macrophages","volume":"34","author":"He","year":"2013","journal-title":"Biomaterials."},{"key":"B95","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.biomaterials.2014.10.030","article-title":"Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases","volume":"37","author":"Bartneck","year":"2015","journal-title":"Biomaterials."},{"key":"B96","unstructured":"FreundB HeerenJ NielsenP CarambiaA HerkelJ BrunsO Nanoparticle Compositions for Generation of Regulatory T Cells and Treatment of Autoimmune Diseases and Other Chronic Inflammatory Conditions. United States Patent Application 201803258212018"},{"key":"B97","doi-asserted-by":"publisher","first-page":"e83481","DOI":"10.1371\/journal.pone.0083481","article-title":"Therapy of experimental NASH and fibrosis with galectin inhibitors","volume":"8","author":"Traber","year":"2013","journal-title":"PLoS ONE."},{"key":"B98","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jconrel.2018.09.004","article-title":"Therapeutic inhibition of spleen tyrosine kinase in inflammatory macrophages using PLGA nanoparticles for the treatment of non-alcoholic steatohepatitis","volume":"288","author":"Kurniawan","year":"2018","journal-title":"J Control Release."},{"key":"B99","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/hep.29514","article-title":"The ASK1 inhibitor selonsertib in patients with non-alcoholic steatohepatitis: a randomized, phase 2 trial","volume":"67","author":"Loomba","year":"2018","journal-title":"Hepatology."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.jhep.2015.02.009","article-title":"Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9","volume":"63","author":"Liu","year":"2015","journal-title":"J Hepatol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J Hepatol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.metabol.2017.09.002","article-title":"Immunomodulatory liposomes targeting liver macrophages arrest progression of non-alcoholic steatohepatitis","volume":"78","author":"Maradana","year":"2018","journal-title":"Metab Clin Exp."},{"key":"B103","doi-asserted-by":"publisher","first-page":"e0158156","DOI":"10.1371\/journal.pone.0158156","article-title":"Antifibrotic effects of the dual CCR2\/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis","volume":"11","author":"Lefebvre","year":"2016","journal-title":"PLoS ONE."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/hep.29544","article-title":"Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis","volume":"67","author":"Krenkel","year":"2018","journal-title":"Hepatology."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/hep.29477","article-title":"A randomized, placebo-controlled trial of cenicriviroc for treatment of non-alcoholic steatohepatitis with fibrosis","volume":"67","author":"Friedman","year":"2018","journal-title":"Hepatology."},{"key":"B106","doi-asserted-by":"publisher","first-page":"e0169740","DOI":"10.1371\/journal.pone.0169740","article-title":"The CCR2 inhibitor propagermanium attenuates diet-induced insulin resistance, adipose tissue inflammation and non-alcoholic steatohepatitis","volume":"12","author":"Mulder","year":"2017","journal-title":"PLoS ONE."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/hep.26783","article-title":"Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice","volume":"59","author":"Baeck","year":"2014","journal-title":"Hepatology."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1093\/jac\/dku071","article-title":"Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD)","volume":"69","author":"P\u00e9rez-Mart\u00ednez","year":"2014","journal-title":"J Antimicrob Chemother."},{"key":"B109","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc1566","article-title":"Cancer nanotechnology: opportunities and challenges","volume":"5","author":"Ferrari","year":"2005","journal-title":"Nat Rev Cancer."},{"key":"B110","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1590\/S1516-89132013005000011","article-title":"Nanoparticle-based drug delivery systems: promising approaches against infections","volume":"57","author":"Ranghar","year":"2013","journal-title":"Brazilian Arch Biol Technol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"457","DOI":"10.4155\/tde.12.21","article-title":"Size matters: gold nanoparticles in targeted cancer drug delivery","volume":"3","author":"Dreaden","year":"2012","journal-title":"Ther Deliv."},{"key":"B112","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.1021\/la0633841","article-title":"Water-soluble nitric oxide-releasing gold nanoparticles","volume":"23","author":"Polizzi","year":"2007","journal-title":"Langmuir."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1002\/anie.200600214","article-title":"Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles","volume":"45","author":"Han","year":"2006","journal-title":"Angew Chem Int Ed Engl."},{"key":"B114","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1021\/bc100070g","article-title":"Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects","volume":"21","author":"Maeda","year":"2010","journal-title":"Bioconjug Chem."},{"key":"B115","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3978\/j.issn.2304-3881.2014.11.02","article-title":"Therapeutic targeting of liver inflammation and fibrosis by nanomedicine","volume":"3","author":"Bartneck","year":"2014","journal-title":"Hepatobiliary Surg Nutr."},{"key":"B116","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1159\/000444556","article-title":"Liver fibrosis: from pathogenesis to novel therapies","volume":"34","author":"Weiskirchen","year":"2016","journal-title":"Dig Dis."},{"key":"B117","doi-asserted-by":"publisher","first-page":"e0218971","DOI":"10.1371\/journal.pone.0218971","article-title":"Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride","volume":"14","author":"Pedroza","year":"2019","journal-title":"PLoS ONE."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02852\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T09:12:15Z","timestamp":1665133935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.02852\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,3]]},"references-count":117,"alternative-id":["10.3389\/fimmu.2019.02852"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.02852","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,3]]},"article-number":"2852"}}