{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:31:12Z","timestamp":1793039472208,"version":"4.5.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.03020","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T09:16:49Z","timestamp":1579857409000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus"],"prefix":"10.3389","volume":"10","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Haidar","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Min","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrrheum.2017.2","article-title":"Systemic lupus erythematosus: new pathway blocks disease in lupus-prone mice","volume":"13","author":"Collison","year":"2017","journal-title":"Nat Rev Rheumatol."},{"key":"B2","first-page":"303","volume-title":"Systemic Lupus Erythematosus. Primer on the Rheumatic Diseases","author":"Buyon","year":"2008"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.4049\/jimmunol.1300041","article-title":"Cutting edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice","volume":"190","author":"Li","year":"2013","journal-title":"J Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12382","article-title":"Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity","volume":"269","author":"McGaha","year":"2016","journal-title":"Immunol Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3389\/fimmu.2015.00526","article-title":"Predominant role of plasmacytoid dendritic cells in stimulating systemic autoimmunity","volume":"6","author":"Huang","year":"2015","journal-title":"Front Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3389\/fimmu.2015.00480","article-title":"Splenic macrophage subsets and their function during blood-borne infections","volume":"6","author":"Borges da Silva","year":"2015","journal-title":"Front Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.3389\/fimmu.2018.02393","article-title":"The Mst1 kinase is required for follicular B cell homing and B-1 B cell development","volume":"9","author":"Alsufyani","year":"2018","journal-title":"Front Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.jaci.2019.02.010","article-title":"B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans","volume":"143","author":"Moran","year":"2019","journal-title":"J Allergy Clin Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3389\/fimmu.2018.00427","article-title":"Plasma cell differentiation pathways in systemic lupus erythematosus","volume":"9","author":"Malkiel","year":"2018","journal-title":"Front Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1191\/0961203305lu2237xx","article-title":"Slow development of massive splenomegaly, portal and pulmonary hypertension in systematic lupus erythematosus: can nodular regenerative hyperplasia of the liver explain all these findings?","volume":"14","author":"Colmegna","year":"2005","journal-title":"Lupus."},{"key":"B13","first-page":"698","article-title":"Massive splenomegaly: a manifestation of active systemic lupus erythematosus","volume":"11","author":"Zuckerman","year":"1993","journal-title":"Clin Exp Rheumatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"688","DOI":"10.12998\/wjcc.v6.i13.688","article-title":"Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: a case report and review of literature","volume":"6","author":"Yang","year":"2018","journal-title":"World J Clin Cases."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1084\/jem.20170479","article-title":"Bim suppresses the development of SLE by limiting myeloid inflammatory responses","volume":"214","author":"Tsai","year":"2017","journal-title":"J Exp Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1016\/j.forsciint.2019.01.042","article-title":"The forensic spleen: morphological, radiological, and toxicological investigations","volume":"214","author":"Palmiere","year":"2019","journal-title":"Foren Sci Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/ndt\/gfy267","article-title":"B-cell therapy in lupus nephritis: an overview","volume":"34","author":"Almaani","year":"2019","journal-title":"Nephrol Dial Transplant."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7154","DOI":"10.4049\/jimmunol.0902514","article-title":"Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway","volume":"184","author":"Deng","year":"2010","journal-title":"J Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.clim.2017.03.015","article-title":"Skin inflammation induced by lupus serum was inhibited in IL-1R deficient mice","volume":"180","author":"Li","year":"2017","journal-title":"Clin Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3389\/fimmu.2018.01457","article-title":"Role of hepatic deposited immunoglobulin G in the pathogenesis of liver damage in systemic lupus erythematosus","volume":"9","author":"Fang","year":"2018","journal-title":"Front. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.autrev.2016.02.006","article-title":"Targeting FcgammaRs to treat antibody-dependent autoimmunity","volume":"15","author":"Yu","year":"2016","journal-title":"Autoimmun Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1038\/nm.3709","article-title":"Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes","volume":"20","author":"Clatworthy","year":"2014","journal-title":"Nat Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1084\/jem.20111644","article-title":"Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation","volume":"209","author":"Joo","year":"2012","journal-title":"J Exp Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.4049\/jimmunol.178.5.3272","article-title":"Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus","volume":"178","author":"Su","year":"2007","journal-title":"J Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1097\/SHK.0000000000000796","article-title":"Fc gamma receptor IIB deficient mice: a lupus model with increased endotoxin tolerance-related sepsis susceptibility","volume":"47","author":"Ondee","year":"2017","journal-title":"Shock."},{"key":"B27","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/exd.12986","article-title":"Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneous lupus erythematosus patients","volume":"25","author":"Braegelmann","year":"2016","journal-title":"Exp Dermatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/exd.13018","article-title":"The role of Syk in cutaneous lupus erythematosus","volume":"25","author":"Deng","year":"2016","journal-title":"Exp Dermatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1002\/art.27452","article-title":"Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice","volume":"62","author":"Deng","year":"2010","journal-title":"Arthritis Rheum."},{"key":"B30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.14670\/HH-18-019","article-title":"The novel histological evidence of the blood-spleen barrier in duck (Anas platyrhynchos)","volume":"34","author":"Sun","year":"2019","journal-title":"Histol Histopathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.tvjl.2015.01.013","article-title":"Identification and structural composition of the blood-spleen barrier in chickens","volume":"204","author":"Zhang","year":"2015","journal-title":"Vet J"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e22659","DOI":"10.1371\/journal.pone.0022659","article-title":"Amelioration of lupus nephritis by serum amyloid P component gene therapy with distinct mechanisms varied from different stage of the disease","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS ONE."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1182\/blood-2010-11-320028","article-title":"Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen","volume":"117","author":"McGaha","year":"2011","journal-title":"Blood."},{"key":"B34","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jaut.2009.03.011","article-title":"Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential","volume":"33","author":"Zhang","year":"2009","journal-title":"J Autoimmun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1177\/0961203316643172","article-title":"B-cell subsets, signaling and their roles in secretion of autoantibodies","volume":"25","author":"Iwata","year":"2016","journal-title":"Lupus."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.4049\/jimmunol.1203301","article-title":"Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2\/microRNA-155 pathway","volume":"190","author":"Wen","year":"2013","journal-title":"J Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.autrev.2005.10.010","article-title":"Role of anti-DNA antibodies in the pathogenesis of lupus nephritis","volume":"5","author":"Deshmukh","year":"2006","journal-title":"Autoimmun Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1126\/science.1073924","article-title":"Evolution of autoantibody responses via somatic hypermutation outside of germinal centers","volume":"297","author":"William","year":"2002","journal-title":"Science."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.4049\/jimmunol.1201594","article-title":"Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency","volume":"189","author":"Rosetti","year":"2012","journal-title":"J Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1172\/JCI81059","article-title":"Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus","volume":"125","author":"Li","year":"2015","journal-title":"J Clin Invest."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.4049\/jimmunol.171.3.1148","article-title":"Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses","volume":"171","author":"Aichele","year":"2003","journal-title":"J Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/ni1542","article-title":"Follicular shuttling of marginal zone B cells facilitates antigen transport","volume":"9","author":"Cinamon","year":"2008","journal-title":"Nat Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1182\/bloodadvances.2017015008","article-title":"Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-gamma receptors","volume":"2","author":"Nagelkerke","year":"2018","journal-title":"Blood Adv."},{"key":"B44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.it.2015.04.005","article-title":"FcgammaR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities","volume":"36","author":"Nimmerjahn","year":"2015","journal-title":"Trends Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.clim.2017.07.010","article-title":"B cell phenotypes, signaling and their roles in secretion of antibodies in systemic lupus erythematosus","volume":"186","author":"Tanaka","year":"2018","journal-title":"Clin Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.03020\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T08:45:35Z","timestamp":1580460335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.03020\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":45,"alternative-id":["10.3389\/fimmu.2019.03020"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.03020","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"article-number":"3020"}}