{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:44:00Z","timestamp":1792637040692,"version":"4.5.0"},"reference-count":204,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.03060","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T23:26:25Z","timestamp":1579735585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":197,"title":["Xenotransplantation: Current Status in Preclinical Research"],"prefix":"10.3389","volume":"10","author":[{"given":"Tianyu","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bochao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e12492","DOI":"10.1111\/xen.12492","article-title":"Progress in multiple genetically modified minipigs for xenotransplantation in China","volume":"26","author":"Pan","year":"2019","journal-title":"Xenotransplantation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cireng.2017.03.007","article-title":"Clinical xenotransplantation, a closer reality: literature review","volume":"95","author":"Aristizabal","year":"2017","journal-title":"Cir Esp"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1034\/j.1399-3089.2003.01082.x","article-title":"Experimental xenotransplantation: a personal history","volume":"10","author":"Najarian","year":"2003","journal-title":"Xenotransplantation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1399-3089.2004.00199.x","article-title":"History of xenotransplantation","volume":"12","author":"Deschamps","year":"2005","journal-title":"Xenotransplantation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ijsu.2015.06.060","article-title":"A brief history of clinical xenotransplantation","volume":"23","author":"Cooper","year":"2015","journal-title":"Int J Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/bmb\/ldx043","article-title":"Xenotransplantation-the current status and prospects","volume":"125","author":"Cooper","year":"2018","journal-title":"Br Med Bull"},{"key":"B7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev.med.53.082901.103900","article-title":"Will the pig solve the transplantation backlog?","volume":"53","author":"Cooper","year":"2002","journal-title":"Annu Rev Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.5435\/00124635-200801000-00002","article-title":"Xenotransplantation in orthopaedic surgery","volume":"16","author":"Laurencin","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/ajt.13096","article-title":"Lamellar keratoplasty treatment of fungal corneal ulcers with acellular porcine corneal stroma","volume":"15","author":"Zhang","year":"2015","journal-title":"Am J Transplant"},{"key":"B10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/35100578","article-title":"Xenotransplantation and other means of organ replacement","volume":"1","author":"Cascalho","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"B11","first-page":"238","article-title":"Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon","volume":"7","author":"Cooper","year":"1988","journal-title":"J Heart Transplant"},{"key":"B12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri2099","article-title":"Xenotransplantation: current status and a perspective on the future","volume":"7","author":"Yang","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/00007890-199108000-00006","article-title":"Immunopathology of hyperacute xenograft rejection in a swine-to-primate model","volume":"52","author":"Platt","year":"1991","journal-title":"Transplantation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1034\/j.1399-3089.2003.02092.x","article-title":"Pathology of xenograft rejection: a commentary","volume":"10","author":"Schuurman","year":"2003","journal-title":"Xenotransplantation"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1097\/00007890-199711150-00005","article-title":"Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy","volume":"64","author":"Kobayashi","year":"1997","journal-title":"Transplantation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1097\/01.TP.0000131167.21930.B8","article-title":"Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity","volume":"77","author":"Gollackner","year":"2004","journal-title":"Transplantation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1586\/eci.09.81","article-title":"Overcoming the barriers to xenotransplantation: prospects for the future","volume":"6","author":"Ekser","year":"2010","journal-title":"Expert Rev Clin Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/nm1330","article-title":"Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys","volume":"11","author":"Chen","year":"2005","journal-title":"Nat Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ijsu.2015.06.068","article-title":"Immunobiological barriers to xenotransplantation","volume":"23","author":"Cooper","year":"2015","journal-title":"Int J Surg."},{"key":"B20","first-page":"559","article-title":"Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans","volume":"24","author":"Good","year":"1992","journal-title":"Transplant Proc"},{"key":"B21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/978-1-4615-4771-6_10","article-title":"Anti-Gal, alpha-Gal epitopes, and xenotransplantation","volume":"32","author":"Kobayashi","year":"1999","journal-title":"Subcell Biochem"},{"key":"B22","doi-asserted-by":"crossref","first-page":"17755","DOI":"10.1016\/S0021-9258(19)77900-9","article-title":"Man, apes, and old world monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells","volume":"263","author":"Galili","year":"1988","journal-title":"J Biol Chem"},{"key":"B23","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/0167-5699(93)90261-I","article-title":"Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans","volume":"14","author":"Galili","year":"1993","journal-title":"Immunol Today"},{"key":"B24","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/j.1440-1711.2005.01366.x","article-title":"The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy","volume":"83","author":"Galili","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1128\/IAI.56.7.1730-1737.1988","article-title":"Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora","volume":"56","author":"Galili","year":"1988","journal-title":"Infect Immun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1097\/00007890-200012270-00002","article-title":"The role of anti-Galalpha1\u20133Gal antibodies in acute vascular rejection and accommodation of xenografts","volume":"70","author":"Lin","year":"2000","journal-title":"Transplantation"},{"key":"B27","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1399-3089.2008.00480.x","article-title":"Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation","volume":"15","author":"Byrne","year":"2008","journal-title":"Xenotransplantation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20090835","article-title":"Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation","volume":"427","author":"Song","year":"2010","journal-title":"Biochem J"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e12394","DOI":"10.1111\/xen.12394","article-title":"B4GALNT2 and xenotransplantation: a newly appreciated xenogeneic antigen","volume":"25","author":"Byrne","year":"2018","journal-title":"Xenotransplantation"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e12424","DOI":"10.1111\/xen.12424","article-title":"Evolution of sialic acids: implications in xenotransplant biology","volume":"25","author":"Paul","year":"2018","journal-title":"Xenotransplantation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/ajpa.10018","article-title":"Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution","volume":"33","author":"Varki","year":"2001","journal-title":"Am J Phys Anthropol Suppl"},{"key":"B32","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/BF01053190","article-title":"Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal alpha 1\u20133Gal), blood group H determinant and N-glycolylneuraminic acid","volume":"13","author":"Bouhours","year":"1996","journal-title":"Glycoconj J"},{"key":"B33","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/j.1399-3089.2010.00610.x","article-title":"Deficiency of N-glycolylneuraminic acid and Gal\u03b11\u20133Gal\u03b21\u20134GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies","volume":"17","author":"Basnet","year":"2010","journal-title":"Xenotransplantation"},{"key":"B34","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/xen.12161","article-title":"Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1\/CMAH\/\u03b24GalNT2 genes","volume":"22","author":"Estrada","year":"2015","journal-title":"Xenotransplantation"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.4049\/jimmunol.1301195","article-title":"Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts","volume":"191","author":"Scobie","year":"2013","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/TP.0b013e318203c27d","article-title":"Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation","volume":"91","author":"Byrne","year":"2011","journal-title":"Transplantation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1016\/j.transproceed.2008.08.125","article-title":"The role of macrophages in xenograft rejection","volume":"40","author":"Cadili","year":"2008","journal-title":"Transplant Proc"},{"key":"B38","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4049\/jimmunol.149.4.1416","article-title":"Early recognition of a discordant xenogeneic organ by human circulating lymphocytes","volume":"149","author":"Inverardi","year":"1992","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1067\/msy.2000.107063","article-title":"Development of an ex vivo model of pig kidney perfused with human lymphocytes","volume":"128","author":"Khalfoun","year":"2000","journal-title":"Anal Xenogeneic Cell Reactions Surg"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/S0022-5223(98)70218-1","article-title":"Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model","volume":"115","author":"Xu","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B41","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/S0041-1345(00)01046-0","article-title":"Identification, detection, and in vitro characterization of cynomolgus monkey natural killer cells in delayed xenograft rejection of hDAF transgenic porcine renal xenografts","volume":"32","author":"Quan","year":"2000","journal-title":"Transplant Proc"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4627384","DOI":"10.1155\/2017\/4627384","article-title":"The role of NK cells in pig-to-human xenotransplantation","volume":"2017","author":"Puga Yung","year":"2017","journal-title":"J Immunol Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1046\/j.1365-3083.2001.00966.x","article-title":"Adhesive interactions between human NK cells and porcine endothelial cells","volume":"54","author":"Schneider","year":"2001","journal-title":"Scand J Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1034\/j.1399-3089.2002.01074.x","article-title":"Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin\/granzyme B dependent and not inhibited by Bcl-2 overexpression","volume":"9","author":"Matter-Reissmann","year":"2002","journal-title":"Xenotransplantation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/B978-0-12-800147-9.00005-4","article-title":"How to trigger a killer: modulation of natural killer cell reactivity on many levels","volume":"124","author":"Watzl","year":"2014","journal-title":"Adv Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.4049\/jimmunol.177.4.2146","article-title":"Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D","volume":"177","author":"Lilienfeld","year":"2006","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.4049\/jimmunol.175.8.5463","article-title":"Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D","volume":"175","author":"Forte","year":"2005","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.4049\/jimmunol.159.5.2318","article-title":"Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes","volume":"159","author":"Sullivan","year":"1997","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1097\/TP.0000000000000757","article-title":"The role of natural killer cells in humoral rejection","volume":"99","author":"Resch","year":"2015","journal-title":"Transplantation"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e86","DOI":"10.1097\/TP.0000000000001646","article-title":"Humoral reactivity of renal transplant-waitlisted patients to cells from GGTA1\/CMAH\/B4GalNT2, and SLA class I knockout pigs","volume":"101","author":"Martens","year":"2017","journal-title":"Transplantation"},{"key":"B52","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.4049\/jimmunol.172.10.6460","article-title":"Lack of galactose-alpha-1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity","volume":"172","author":"Baumann","year":"2004","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1097\/00007890-199612270-00042","article-title":"T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection","volume":"62","author":"Candinas","year":"1996","journal-title":"Transplantation"},{"key":"B54","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1681\/ASN.2011040429","article-title":"Pathologic characteristics of transplanted kidney xenografts","volume":"23","author":"Shimizu","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/TP.0b013e318199c34f","article-title":"The innate immune response and activation of coagulation in \u03b11,3-galactosyltransferase gene-knockout xenograft recipients","volume":"87","author":"Ezzelarab","year":"2009","journal-title":"Transplantation"},{"key":"B56","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/tan.12669","article-title":"The immunological barriers to xenotransplantation","volume":"86","author":"Vadori","year":"2015","journal-title":"Tissue Antigens"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1097\/00007890-200110150-00017","article-title":"Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons","volume":"72","author":"Basker","year":"2001","journal-title":"Transplantation"},{"key":"B58","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s001090050315","article-title":"Cytokine mRNA expression in peripheral blood cells of immunosuppressed human islet transplant recipients","volume":"77","author":"El-Ouaghlidi","year":"1999","journal-title":"J Mol Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.4049\/jimmunol.174.4.2004","article-title":"Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system","volume":"174","author":"Okazawa","year":"2005","journal-title":"J Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nri1859","article-title":"The SIRP family of receptors and immune regulation","volume":"6","author":"Barclay","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1182\/blood-2006-04-019794","article-title":"Attenuation of phagocytosis of xenogeneic cells by manipulating CD47","volume":"109","author":"Wang","year":"2007","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","first-page":"5062","DOI":"10.1073\/pnas.0609661104","article-title":"Role for CD47-SIRP\u03b1 signaling in xenograft rejection by macrophages","volume":"104","author":"Ide","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1126\/science.290.5497.1768","article-title":"Down-regulation of the macrophage lineage through interaction with OX2. (CD200)","volume":"290","author":"Hoek","year":"2000","journal-title":"Science"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1084\/jem.185.10.1743","article-title":"A novel inhibitory receptor. (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing","volume":"185","author":"Cella","year":"1997","journal-title":"J Exp Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/ni1074","article-title":"Exacerbated graft-versus-host disease in Pirb\u2212\u2212\/\u2212\u2212 mice","volume":"5","author":"Nakamura","year":"2004","journal-title":"Nat Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1399-3089.2011.00687.x","article-title":"T-cell-mediated immunological barriers to xenotransplantation","volume":"19","author":"Scalea","year":"2012","journal-title":"Xenotransplantation"},{"key":"B67","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/imr.12152","article-title":"Xenotransplantation: immunological hurdles and progress toward tolerance","volume":"258","author":"Griesemer","year":"2014","journal-title":"Immunol Rev"},{"key":"B68","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.trim.2009.05.001","article-title":"Pig-to-nonhuman primate islet xenotransplantation","volume":"21","author":"Hering","year":"2009","journal-title":"Transpl Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/xen.12219","article-title":"The pathobiology of pig-to-primate xenotransplantation: a historical review","volume":"23","author":"Cooper","year":"2016","journal-title":"Xenotransplantation"},{"key":"B70","doi-asserted-by":"publisher","first-page":"8415205","DOI":"10.1155\/2017\/8415205","article-title":"The role of costimulation blockade in solid organ and islet xenotransplantation","volume":"2017","author":"Samy","year":"2017","journal-title":"J Immunol Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1097\/00007890-200006150-00013","article-title":"High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response","volume":"69","author":"Buhler","year":"2000","journal-title":"Transplantation"},{"key":"B72","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/xen.12166","article-title":"Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model","volume":"22","author":"Higginbotham","year":"2015","journal-title":"Xenotransplantation."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e12283","DOI":"10.1111\/xen.12283","article-title":"Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys","volume":"24","author":"Bottino","year":"2017","journal-title":"Xenotransplantation."},{"key":"B74","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/xen.12066","article-title":"Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model","volume":"21","author":"Mohiuddin","year":"2014","journal-title":"Xenotransplantation."},{"key":"B75","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/ajt.12562","article-title":"One-year heterotopic cardiac xenograft survival in a pig to baboon model","volume":"14","author":"Mohiuddin","year":"2014","journal-title":"Am J Transplant"},{"key":"B76","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/xen.12167","article-title":"Pig-to-baboon heterotopic heart transplantation\u2013exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens","volume":"22","author":"Iwase","year":"2015","journal-title":"Xenotransplantation"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1097\/00007890-200011150-00010","article-title":"Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates","volume":"70","author":"Buhler","year":"2000","journal-title":"Transplantation"},{"key":"B78","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/nm1171","article-title":"Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience","volume":"11","author":"Kuwaki","year":"2005","journal-title":"Nat Med"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1586\/1744666X.2015.1083861","article-title":"Recent advances in understanding xenotransplantation: implications for the clinic","volume":"11","author":"Cooper","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/jth.13235","article-title":"Contact system revisited: an interface between inflammation, coagulation, and innate immunity","volume":"14","author":"Long","year":"2016","journal-title":"J Thromb Haemost"},{"key":"B81","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1056\/NEJMra0801082","article-title":"Mechanisms of thrombus formation","volume":"359","author":"Furie","year":"2008","journal-title":"N Engl J Med"},{"key":"B82","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/MOT.0b013e3283373ccc","article-title":"Coagulation, platelet activation and thrombosis in xenotransplantation","volume":"15","author":"Schmelzle","year":"2010","journal-title":"Curr Opin Organ Transplant"},{"key":"B83","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1055\/s-0037-1615883","article-title":"Structure and function of von Willebrand factor","volume":"82","author":"Ruggeri","year":"1999","journal-title":"Thromb Haemost"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1538-7836.2009.03660.x","article-title":"The discovery of the endothelial cell protein C receptor","volume":"8","author":"Esmon","year":"2010","journal-title":"J Thromb Haemost"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1111\/jth.14246","article-title":"Tissue factor at the crossroad of coagulation and cell signaling","volume":"16","author":"Zelaya","year":"2018","journal-title":"J Thromb Haemost"},{"key":"B86","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2141.1992.tb04597.x","article-title":"Interaction of porcine von Willebrand factor with the platelet glycoproteins Ib and IIb\/IIIa complex","volume":"82","author":"Pareti","year":"1992","journal-title":"Br J Haematol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1399-3089.2009.00534.x","article-title":"Current status of xenotransplantation and prospects for clinical application","volume":"16","author":"Pierson","year":"2009","journal-title":"Xenotransplantation"},{"key":"B88","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/TP.0b013e31818410a3","article-title":"Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells","volume":"86","author":"Lin","year":"2008","journal-title":"Transplantation"},{"key":"B89","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/icb.2008.107","article-title":"Complement activation and coagulation in xenotransplantation","volume":"87","author":"Cowan","year":"2009","journal-title":"Immunol Cell Biol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/j.1600-6143.2008.02210.x","article-title":"Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI","volume":"8","author":"Roussel","year":"2008","journal-title":"Am J Transplant"},{"key":"B91","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cardiores.2003.11.036","article-title":"Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium","volume":"61","author":"Gawaz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.3389\/fimmu.2018.01711","article-title":"Clustered regularly interspaced short palindromic repeats\/Cas9 gene editing technique in xenotransplantation","volume":"9","author":"Naeimi Kararoudi","year":"2018","journal-title":"Front Immunol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1126\/science.1078942","article-title":"Production of alpha 1,3-galactosyltransferase-deficient pigs","volume":"299","author":"Phelps","year":"2003","journal-title":"Science"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1038\/srep01981","article-title":"Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs","volume":"3","author":"Kwon","year":"2013","journal-title":"Sci Rep"},{"key":"B95","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1097\/00007890-200101150-00021","article-title":"A human CD46 transgenic pig model system for the study of discordant xenotransplantation","volume":"71","author":"Diamond","year":"2001","journal-title":"Transplantation"},{"key":"B96","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/nm0995-964","article-title":"The generation of transgenic pigs as potential organ donors for humans","volume":"1","author":"Cozzi","year":"1995","journal-title":"Nat Med"},{"key":"B97","doi-asserted-by":"publisher","first-page":"11153","DOI":"10.1073\/pnas.91.23.11153","article-title":"Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection","volume":"91","author":"Fodor","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"B98","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1111\/j.1399-3089.2009.00537.x","article-title":"Pigs transgenic for human thrombomodulin have elevated production of activated protein C","volume":"16","author":"Petersen","year":"2009","journal-title":"Xenotransplantation"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1111\/j.1538-7836.2010.03950.x","article-title":"Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells","volume":"8","author":"Lin","year":"2010","journal-title":"J Thromb Haemost"},{"key":"B100","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.yjmcc.2012.01.002","article-title":"Transgenic swine: expression of human CD39 protects against myocardial injury","volume":"52","author":"Wheeler","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/j.1399-3089.2009.00556.x","article-title":"Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli","volume":"16","author":"Oropeza","year":"2009","journal-title":"Xenotransplantation"},{"key":"B102","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1111\/ajt.12918","article-title":"Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation","volume":"14","author":"Tena","year":"2014","journal-title":"Am J Transplant"},{"key":"B103","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s11248-004-7268-4","article-title":"Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation","volume":"14","author":"Martin","year":"2005","journal-title":"Transgenic Res"},{"key":"B104","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11248-014-9833-9","article-title":"Transgenic expression of human cytoxic T-lymphocyte associated antigen4-immunoglobulin. (hCTLA4Ig) by porcine skin for xenogeneic skin grafting","volume":"24","author":"Wang","year":"2015","journal-title":"Transgenic Res"},{"key":"B105","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/imm.12107","article-title":"Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status","volume":"140","author":"Hara","year":"2013","journal-title":"Immunology"},{"key":"B106","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1399-3089.2011.00674.x","article-title":"Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys","volume":"18","author":"Petersen","year":"2011","journal-title":"Xenotransplantation"},{"key":"B107","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/xen.12164","article-title":"Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein","volume":"22","author":"Paris","year":"2015","journal-title":"Xenotransplantation"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1126\/science.aan4187","article-title":"Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9","volume":"357","author":"Niu","year":"2017","journal-title":"Science"},{"key":"B109","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/00007890-199402150-00009","article-title":"The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts","volume":"57","author":"Pruitt","year":"1994","journal-title":"Transplantation"},{"key":"B110","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/00007890-199109000-00029","article-title":"Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection","volume":"52","author":"Dalmasso","year":"1991","journal-title":"Transplantation"},{"key":"B111","doi-asserted-by":"publisher","first-page":"S648","DOI":"10.1111\/tri.1992.5.s1.648","article-title":"Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement","volume":"5","author":"White","year":"1992","journal-title":"Transpl Int"},{"key":"B112","doi-asserted-by":"publisher","first-page":"e12517","DOI":"10.1111\/xen.12517","article-title":"The complex functioning of the complement system in xenotransplantation","volume":"26","author":"Zhou","year":"2019","journal-title":"Xenotransplantation."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1111\/ajt.12673","article-title":"Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury","volume":"14","author":"Burdorf","year":"2014","journal-title":"Am J Transplant"},{"key":"B114","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1007\/s12033-018-0091-6","article-title":"Generation of GTKO diannan miniature pig expressing human complementary regulator proteins hCD55 and hCD59 via T2A peptide-based bicistronic vectors and SCNT","volume":"60","author":"Liu","year":"2018","journal-title":"Mol Biotechnol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1574-695X.2001.tb00521.x","article-title":"Protection of xenogeneic cells from human complement-mediated lysis by the expression of human DAF, CD59 and MCP","volume":"31","author":"Huang","year":"2001","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1399-3089.2005.00209.x","article-title":"Transgenic pigs expressing human CD59, in combination with human membrane cofactor protein and human decay-accelerating factor","volume":"12","author":"Zhou","year":"2005","journal-title":"Xenotransplantation"},{"key":"B117","first-page":"259","article-title":"[The cortical column, a new processing unit for cortex-like networks]","volume":"309","author":"Alexandre","year":"1989","journal-title":"C R Acad Sci III"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1097\/00007890-199611270-00001","article-title":"In vivo immunoadsorption of antipig antibodies in baboons using a specific Gal(alpha)1\u20133Gal column","volume":"62","author":"Taniguchi","year":"1996","journal-title":"Transplantation"},{"key":"B119","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nbt0302-251","article-title":"Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs","volume":"20","author":"Dai","year":"2002","journal-title":"Nat Biotechnol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1126\/science.1068228","article-title":"Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning","volume":"295","author":"Lai","year":"2002","journal-title":"Science"},{"key":"B121","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.1073\/pnas.0307819101","article-title":"Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations","volume":"101","author":"Kolber-Simonds","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B122","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nm1172","article-title":"Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue","volume":"11","author":"Yamada","year":"2005","journal-title":"Nat Med"},{"key":"B123","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/xen.12019","article-title":"Double knockout pigs deficient in N-glycolylneuraminic acid and galactose \u03b1-1,3-galactose reduce the humoral barrier to xenotransplantation","volume":"20","author":"Lutz","year":"2013","journal-title":"Xenotransplantation"},{"key":"B124","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1097\/SLA.0000000000002977","article-title":"Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival","volume":"268","author":"Adams","year":"2018","journal-title":"Ann Surg"},{"key":"B125","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/xen.12131","article-title":"Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection","volume":"22","author":"Li","year":"2015","journal-title":"Xenotransplantation"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1111\/ajt.12744","article-title":"Reduced binding of human antibodies to cells from GGTA1\/CMAH KO pigs","volume":"14","author":"Burlak","year":"2014","journal-title":"Am J Transplant"},{"key":"B127","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/TP.0000000000001071","article-title":"Silencing porcine CMAH and GGTA1 genes significantly reduces xenogeneic consumption of human platelets by porcine livers","volume":"100","author":"Butler","year":"2016","journal-title":"Transplantation"},{"key":"B128","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.actbio.2018.03.055","article-title":"Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1\/\u03b24GalNT2\/CMAH","volume":"72","author":"Zhang","year":"2018","journal-title":"Acta Biomater"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1399-3089.2011.00622.x","article-title":"Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk","volume":"18","author":"Padler-Karavani","year":"2011","journal-title":"Xenotransplantation"},{"key":"B130","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00251-014-0795-0","article-title":"Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc","volume":"66","author":"Springer","year":"2014","journal-title":"Immunogenetics"},{"key":"B131","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1097\/TP.0b013e3182472850","article-title":"Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts","volume":"93","author":"McGregor","year":"2012","journal-title":"Transplantation"},{"key":"B132","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/xen.12176","article-title":"Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein","volume":"22","author":"Azimzadeh","year":"2015","journal-title":"Xenotransplantation"},{"key":"B133","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/TP.0000000000001966","article-title":"Role of human CD200 overexpression in Pig-to-human xenogeneic immune response compared with human CD47 overexpression","volume":"102","author":"Yan","year":"2018","journal-title":"Transplantation"},{"key":"B134","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/TP.0000000000001267","article-title":"Prolonged survival of pig skin on baboons after administration of pig cells expressing human CD47","volume":"101","author":"Tena","year":"2017","journal-title":"Transplantation"},{"key":"B135","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1365-2567.2011.03496.x","article-title":"Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules","volume":"134","author":"Koshika","year":"2011","journal-title":"Immunology"},{"key":"B136","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.4049\/jimmunol.159.11.5187","article-title":"Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation","volume":"159","author":"Levisetti","year":"1997","journal-title":"J Immunol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1111\/ajt.13704","article-title":"Cell therapy for parkinson's disease: a translational approach to assess the role of local and systemic immunosuppression","volume":"16","author":"Aron Badin","year":"2016","journal-title":"Am J Transplant"},{"key":"B138","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1399-3089.2009.00533.x","article-title":"Production and characterization of transgenic pigs expressing porcine CTLA4-Ig","volume":"16","author":"Phelps","year":"2009","journal-title":"Xenotransplantation"},{"key":"B139","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.4049\/jimmunol.1402059","article-title":"Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease","volume":"193","author":"Reyes","year":"2014","journal-title":"J Immunol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1399-3089.2011.00691.x","article-title":"The effect of Gal expression on pig cells on the human T-cell xenoresponse","volume":"19","author":"Wilhite","year":"2012","journal-title":"Xenotransplantation"},{"key":"B141","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/xen.12209","article-title":"Transgenic expression of human CD46: does it reduce the primate T-cell response to pig endothelial cells?","volume":"22","author":"Ezzelarab","year":"2015","journal-title":"Xenotransplantation"},{"key":"B142","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/xen.12024","article-title":"Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney xenotransplantation","volume":"20","author":"Spiezia","year":"2013","journal-title":"Xenotransplantation"},{"key":"B143","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1399-3089.2009.00555.x","article-title":"Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation","volume":"17","author":"Miwa","year":"2010","journal-title":"Xenotransplantation"},{"key":"B144","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/xen.12073","article-title":"Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition","volume":"21","author":"Iwase","year":"2014","journal-title":"Xenotransplantation"},{"key":"B145","doi-asserted-by":"publisher","first-page":"11138","DOI":"10.1038\/ncomms11138","article-title":"Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft","volume":"7","author":"Mohiuddin","year":"2016","journal-title":"Nat Commun."},{"key":"B146","doi-asserted-by":"publisher","first-page":"e12465","DOI":"10.1111\/xen.12465","article-title":"Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs","volume":"26","author":"Singh","year":"2019","journal-title":"Xenotransplantation"},{"key":"B147","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1073\/pnas.0611493104","article-title":"Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells","volume":"104","author":"Bae","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1034\/j.1600-6143.2003.00190.x","article-title":"The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation","volume":"3","author":"Lau","year":"2003","journal-title":"Am J Transplant"},{"key":"B149","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1600-6143.2006.01603.x","article-title":"Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts","volume":"7","author":"Cantu","year":"2007","journal-title":"Am J Transplant"},{"key":"B150","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/MOT.0000000000000459","article-title":"Liver xenotransplantation","volume":"22","author":"Patel","year":"2017","journal-title":"Curr Opin Organ Transplant"},{"key":"B151","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0002-9440(10)64004-7","article-title":"Immune complex formation after xenotransplantation: evidence of type III as well as type II immune reactions provide clues to pathophysiology","volume":"158","author":"Holzknecht","year":"2001","journal-title":"Am J Pathol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/j.1600-6143.2009.02602.x","article-title":"Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation","volume":"9","author":"Knosalla","year":"2009","journal-title":"Am J Transplant"},{"key":"B153","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/xen.12149","article-title":"Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood","volume":"22","author":"Harris","year":"2015","journal-title":"Xenotransplantation"},{"key":"B154","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ijsu.2015.07.643","article-title":"Systemic inflammation in xenograft recipients. (SIXR): a new paradigm in pig-to-primate xenotransplantation?","volume":"23","author":"Ezzelarab","year":"2015","journal-title":"Int J Surg."},{"key":"B155","doi-asserted-by":"publisher","first-page":"29081","DOI":"10.1038\/srep29081","article-title":"Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing","volume":"6","author":"Fischer","year":"2016","journal-title":"Sci Rep"},{"key":"B156","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1517\/13543784.9.9.2051","article-title":"Animal models in xenotransplantation","volume":"9","author":"Zhang","year":"2000","journal-title":"Exp Opin Investig Drugs"},{"key":"B157","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-1-61779-845-0_9","article-title":"Small animal models of xenotransplantation","volume":"885","author":"Wang","year":"2012","journal-title":"Methods Mol Biol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1126\/science.365.6452.426","article-title":"The CRISPR animal kingdom","volume":"365","author":"Cohen","year":"2019","journal-title":"Science"},{"key":"B159","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1097\/00007890-199809150-00001","article-title":"Discordant organ xenotransplantation in primates: world experience and current status","volume":"66","author":"Lambrigts","year":"1998","journal-title":"Transplantation"},{"key":"B160","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/xen.12127","article-title":"Progress in pig-to-non-human primate transplantation models. (1998\u20132013): a comprehensive review of the literature","volume":"21","author":"Cooper","year":"2014","journal-title":"Xenotransplantation"},{"key":"B161","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41586-018-0765-z","article-title":"Consistent success in life-supporting porcine cardiac xenotransplantation","volume":"564","author":"Langin","year":"2018","journal-title":"Nature"},{"key":"B162","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1111\/ajt.15329","article-title":"Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion","volume":"19","author":"Kim","year":"2019","journal-title":"Am J Transplant"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12552","article-title":"Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival","author":"Watanabe","year":"2019","journal-title":"Xenotransplantation."},{"key":"B164","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1111\/ajt.14341","article-title":"Prolonged survival following pig-to-primate liver xenotransplantation utilizing exogenous coagulation factors and costimulation blockade","volume":"17","author":"Shah","year":"2017","journal-title":"Am J Transplant"},{"key":"B165","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/00007890-199802150-00009","article-title":"Intravenous infusion of Galalpha1\u20133Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts","volume":"65","author":"Simon","year":"1998","journal-title":"Transplantation"},{"key":"B166","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/j.1600-6143.2011.03846.x","article-title":"B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months","volume":"12","author":"Mohiuddin","year":"2012","journal-title":"Am J Transplant."},{"key":"B167","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1399-3089.2010.00620.x","article-title":"Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation","volume":"18","author":"Byrne","year":"2011","journal-title":"Xenotransplantation"},{"key":"B168","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/xen.12174","article-title":"Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date","volume":"22","author":"Iwase","year":"2015","journal-title":"Xenotransplantation"},{"key":"B169","doi-asserted-by":"publisher","first-page":"e12293","DOI":"10.1111\/xen.12293","article-title":"Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts","volume":"24","author":"Iwase","year":"2017","journal-title":"Xenotransplantation."},{"key":"B170","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1111\/j.1432-2277.2012.01506.x","article-title":"Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation","volume":"25","author":"Ekser","year":"2012","journal-title":"Transpl Int"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/S0140-6736(68)91869-2","article-title":"Pig-to-baboon liver xenografts","volume":"1","author":"Calne","year":"1968","journal-title":"Lancet"},{"key":"B172","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/TP.0b013e3181e98d51","article-title":"Hepatic function after genetically engineered pig liver transplantation in baboons","volume":"90","author":"Ekser","year":"2010","journal-title":"Transplantation"},{"key":"B173","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1600-6143.2009.02945.x","article-title":"Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance","volume":"10","author":"Ekser","year":"2010","journal-title":"Am J Transplant"},{"key":"B174","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1399-3089.2012.00717.x","article-title":"Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons","volume":"19","author":"Kim","year":"2012","journal-title":"Xenotransplantation"},{"key":"B175","doi-asserted-by":"publisher","first-page":"e12473","DOI":"10.1111\/xen.12473","article-title":"Amino acid and lipid profiles following pig-to-primate liver xenotransplantation","volume":"26","author":"Shah","year":"2019","journal-title":"Xenotransplantation"},{"key":"B176","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/S0140-6736(11)61091-X","article-title":"Clinical xenotransplantation: the next medical revolution?","volume":"379","author":"Ekser","year":"2012","journal-title":"Lancet"},{"key":"B177","doi-asserted-by":"publisher","first-page":"e12294","DOI":"10.1111\/xen.12294","article-title":"Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury","volume":"24","author":"Laird","year":"2017","journal-title":"Xenotransplantation."},{"key":"B178","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/MOT.0000000000000465","article-title":"Lung xenotransplantation","volume":"22","author":"Sahara","year":"2017","journal-title":"Curr Opin Organ Transplant"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.jtcvs.2006.11.043","article-title":"Life-supporting function of genetically modified swine lungs in baboons","volume":"133","author":"Nguyen","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B180","doi-asserted-by":"publisher","first-page":"e12391","DOI":"10.1111\/xen.12391","article-title":"GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels","volume":"25","author":"Watanabe","year":"2018","journal-title":"Xenotransplantation"},{"key":"B181","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12033-017-0024-9","article-title":"Genetically modified pigs as organ donors for xenotransplantation","volume":"59","author":"Hryhorowicz","year":"2017","journal-title":"Mol Biotechnol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12977-018-0411-8","article-title":"Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?","volume":"15","author":"Denner","year":"2018","journal-title":"Retrovirology"},{"key":"B183","doi-asserted-by":"publisher","first-page":"12363","DOI":"10.1128\/JVI.77.22.12363-12368.2003","article-title":"Relative age of proviral porcine endogenous retrovirus sequences in Sus scrofa based on the molecular clock hypothesis","volume":"77","author":"Tonjes","year":"2003","journal-title":"J Virol"},{"key":"B184","doi-asserted-by":"publisher","first-page":"e12445","DOI":"10.1111\/xen.12445","article-title":"Porcine endogenous retroviruses: quantification of the copy number in cell lines, pig breeds, and organs","volume":"25","author":"Fiebig","year":"2018","journal-title":"Xenotransplantation"},{"key":"B185","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1128\/JVI.75.6.2765-2770.2001","article-title":"Identification of novel porcine endogenous betaretrovirus sequences in miniature swine","volume":"75","author":"Ericsson","year":"2001","journal-title":"J Virol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1034\/j.1399-3089.2002.01110.x","article-title":"Pig endogenous retroviruses and xenotransplantation","volume":"9","author":"Blusch","year":"2002","journal-title":"Xenotransplantation"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00705-008-0141-7","article-title":"Recombinant porcine endogenous retroviruses. (PERV-A\/C): a new risk for xenotransplantation?","volume":"153","author":"Denner","year":"2008","journal-title":"Arch Virol"},{"key":"B188","doi-asserted-by":"publisher","first-page":"e12513","DOI":"10.1111\/xen.12513","article-title":"Third WHO global consultation on regulatory requirements for xenotransplantation clinical trials, Changsha, Hunan, China December 12\u201314, 2018: \u201cThe 2018 Changsha Communique\u201d The 10-year anniversary of the international consultation on xenotransplantation","volume":"26","author":"Hawthorne","year":"2019","journal-title":"Xenotransplantation."},{"key":"B189","doi-asserted-by":"publisher","first-page":"e12366","DOI":"10.1111\/xen.12366","article-title":"PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation","volume":"24","author":"Guell","year":"2017","journal-title":"Xenotransplantation."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1097\/TP.0000000000002443","article-title":"Perspectives on the optimal genetically engineered pig in 2018 for initial clinical trials of kidney or heart xenotransplantation","volume":"102","author":"Cooper","year":"2018","journal-title":"Transplantation"},{"key":"B191","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0042-6822(03)00428-8","article-title":"Genetic alterations of the long terminal repeat of an ecotropic porcine endogenous retrovirus during passage in human cells","volume":"314","author":"Denner","year":"2003","journal-title":"Virology"},{"key":"B192","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/xen.12150","article-title":"Porcine endogenous retrovirus infection of human peripheral blood mononuclear cells","volume":"22","author":"Denner","year":"2015","journal-title":"Xenotransplantation"},{"key":"B193","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.virusres.2016.08.012","article-title":"No PERV transmission during a clinical trial of pig islet cell transplantation","volume":"227","author":"Morozov","year":"2017","journal-title":"Virus Res"},{"key":"B194","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1399-3089.2008.00442.x","article-title":"Knockdown of porcine endogenous retrovirus. (PERV) expression by PERV-specific shRNA in transgenic pigs","volume":"15","author":"Dieckhoff","year":"2008","journal-title":"Xenotransplantation"},{"key":"B195","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1399-3089.2009.00525.x","article-title":"Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs","volume":"16","author":"Ramsoondar","year":"2009","journal-title":"Xenotransplantation"},{"key":"B196","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1126\/science.aad1191","article-title":"Genome-wide inactivation of porcine endogenous retroviruses. (PERVs)","volume":"350","author":"Yang","year":"2015","journal-title":"Science"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12563","article-title":"Characterization of porcine endogenous retrovirus particles released by the CRISPR\/Cas9 inactivated cell line PK15 clone 15","author":"Godehardt","year":"2019","journal-title":"Xenotransplantation."},{"key":"B198","doi-asserted-by":"publisher","first-page":"10024","DOI":"10.1038\/s41598-017-10805-0","article-title":"Potential antigens involved in delayed xenograft rejection in a Ggta1\/Cmah Dko pig-to-monkey model","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"B199","doi-asserted-by":"publisher","first-page":"e12504","DOI":"10.1111\/xen.12504","article-title":"The desirable donor pig to eliminate all xenoreactive antigens","volume":"26","author":"Ladowski","year":"2019","journal-title":"Xenotransplantation."},{"key":"B200","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1097\/TP.0000000000001683","article-title":"Regulation of Clinical Xenotransplantation-Time for a Reappraisal","volume":"101","author":"Cooper","year":"2017","journal-title":"Transplantation"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/S1053-2498(00)00224-2","article-title":"Report of the xenotransplantation advisory committee of the international society for heart and lung transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases","volume":"19","author":"Cooper","year":"2000","journal-title":"J Heart Lung Transplant"},{"key":"B202","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nature20573","article-title":"Stem cells and interspecies chimaeras","volume":"540","author":"Wu","year":"2016","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.cell.2016.12.036","article-title":"Interspecies chimerism with mammalian pluripotent stem cells","volume":"168","author":"Wu","year":"2017","journal-title":"Cell."},{"key":"B204","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1126\/science.aav9051","article-title":"3D bioprinting of collagen to rebuild components of the human heart","volume":"365","author":"Lee","year":"2019","journal-title":"Science"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.03060\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T10:20:40Z","timestamp":1695637240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.03060\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":204,"alternative-id":["10.3389\/fimmu.2019.03060"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.03060","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]},"article-number":"3060"}}