{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:38:13Z","timestamp":1784547493396,"version":"3.55.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P29881-B30"],"award-info":[{"award-number":["P29881-B30"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00016","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T23:29:21Z","timestamp":1579735761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection"],"prefix":"10.3389","volume":"11","author":[{"given":"Maximilian","family":"Koblischke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia S.","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Florian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan W.","family":"Aberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Malafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Fae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cassaniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Jungbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Laferl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Baldanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Stiasny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz X.","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith H.","family":"Aberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"E823","DOI":"10.3390\/v11090823","article-title":"Twenty years of progress toward west nile virus vaccine development","volume":"11","author":"Kaiser","year":"2019","journal-title":"Viruses"},{"key":"B2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2807\/1560-7917.ES.2018.23.43.1800545","article-title":"Increase in human West Nile and Usutu virus infections, Austria, 2018","volume":"23","author":"Aberle","year":"2018","journal-title":"Eurosurveillance"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jtm\/tay096","article-title":"West Nile in Europe: an increasing public health problem","volume":"25","author":"Barrett","year":"2018","journal-title":"J Travel Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1172\/JCI21623","article-title":"West Nile virus: a growing concern?","volume":"113","author":"Gould","year":"2004","journal-title":"J Clin Invest"},{"key":"B5","unstructured":"West Nile Virus-Symptoms Diagnosis and Treatment"},{"key":"B6","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1600-065X.2008.00676.x","article-title":"The structural immunology of antibody protection against West Nile virus","volume":"225","author":"Diamond","year":"2008","journal-title":"Immunol Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-3-540-72146-8_5","article-title":"The molecular basis of antibody protection against West Nile Virus","volume":"317","author":"Mehlhop","year":"2008","journal-title":"Hum Antibody Therapeut Viral Disease"},{"key":"B8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.chom.2008.08.004","article-title":"Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: implications for vaccine development","volume":"4","author":"Pierson","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B9","doi-asserted-by":"publisher","first-page":"8568","DOI":"10.4049\/jimmunol.181.12.8568","article-title":"West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection","volume":"181","author":"Brien","year":"2008","journal-title":"J Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"12060","DOI":"10.1128\/JVI.01650-06","article-title":"CD4(+) T-cell responses are required for clearance of West Nile virus from the central nervous system","volume":"80","author":"Sitati","year":"2006","journal-title":"J Virol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"8475","DOI":"10.1128\/JVI.71.11.8475-8481.1997","article-title":"Proteolytic activation of tick-borne encephalitis virus by furin","volume":"71","author":"Stadler","year":"1997","journal-title":"J Virol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.virol.2015.03.043","article-title":"Viral membrane fusion","author":"Harrison","year":"2015","journal-title":"Virology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00726-009-0370-4","article-title":"Molecular mechanisms of flavivirus membrane fusion","volume":"41","author":"Stiasny","year":"2011","journal-title":"Amino Acids"},{"key":"B14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.coi.2014.12.005","article-title":"Determinants of immunodominance for CD4 T cells","volume":"34","author":"Kim","year":"2015","journal-title":"Curr Opin Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"41913","DOI":"10.1074\/jbc.M106018200","article-title":"Allocation of helper T-cell epitope immunodominance according to three-dimensional structure in the human immunodeficiency virus type I envelope glycoprotein gp120","volume":"276","author":"Dai","year":"2001","journal-title":"J Biol Chem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1089\/vim.2017.0008","article-title":"Structural basis for CD4+ T cell epitope dominance in arbo-flavivirus envelope proteins: a meta-analysis","volume":"30","author":"Landry","year":"2017","journal-title":"Viral Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1128\/JVI.02026-07","article-title":"Three-dimensional structure determines the pattern of CD4(+) T-cell epitope dominance in influenza virus hemagglutinin","volume":"82","author":"Landry","year":"2008","journal-title":"J Virol"},{"key":"B18","first-page":"1231","article-title":"Antigen structure influences helper T-cell epitope dominance in the human immune response to HIV envelope glycoprotein gp120","volume-title":"J Immunol","author":"Mirano-Bascos","year":"2008"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.molimm.2006.06.014","article-title":"Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes","volume":"44","author":"Carmicle","year":"2007","journal-title":"Mol Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s12026-011-8257-3","article-title":"Beyond the classical: influenza virus and the elucidation of alternative MHC class II-restricted antigen processing pathways","volume":"51","author":"Eisenlohr","year":"2011","journal-title":"Immunol Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jcv.2018.09.020","article-title":"CD4 T cell responses to flaviviruses","volume":"108","author":"Aberle","year":"2018","journal-title":"J Clin Virol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"8907","DOI":"10.1038\/s41598-017-09331-w","article-title":"Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination","volume":"7","author":"Koblischke","year":"2017","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.3389\/fimmu.2018.02083","article-title":"Structural influence on the dominance of virus-specific CD4 T cell epitopes in Zika virus infection","volume":"9","author":"Koblischke","year":"2018","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"7828","DOI":"10.1128\/JVI.00196-14","article-title":"Specificities of human CD4(+) T Cell Responses to an Inactivated Flavivirus Vaccine and Infection: correlation with Structure and Epitope Prediction","volume":"88","author":"Schwaiger","year":"2014","journal-title":"J Virol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"11000","DOI":"10.1128\/JVI.01735-06","article-title":"Crystal structure of West Nile virus envelope glycoprotein reveals viral surface epitopes","volume":"80","author":"Kanai","year":"2006","journal-title":"J Virol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature19780","article-title":"Structural basis of potent Zika-dengue virus antibody cross-neutralization","volume":"539","author":"Barba-Spaeth","year":"2016","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"6986","DOI":"10.1073\/pnas.0832193100","article-title":"A ligand-binding pocket in the dengue virus envelope glycoprotein","volume":"100","author":"Modis","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B28","volume-title":"Crystal Structure of the Precursor Membrane Protein-Envelope Protein Heterodimer From the Yellow Fever Virus.","author":"Rey","year":"2017"},{"key":"B29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12985-018-1092-6","article-title":"Crystal structure of Usutu virus envelope protein in the pre-fusion state","volume":"15","author":"Chen","year":"2018","journal-title":"Virol J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/375291a0","article-title":"The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution","volume":"375","author":"Rey","year":"1995","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2807\/1560-7917.ES2013.18.43.20614","article-title":"Retrospective identification of human cases of West Nile virus infection in Austria (2009 to 2010) by serological differentiation from Usutu and other flavivirus infections","volume":"18","author":"Stiasny","year":"2013","journal-title":"Eurosurveillance"},{"key":"B32","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jcv.2006.02.008","article-title":"Highly sensitive TaqMan RT-PCR assay for detection and quantification of both lineages of West Nile virus RNA","volume":"36","author":"Tang","year":"2006","journal-title":"J Clin Virol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nature03956","article-title":"Structural basis of West Nile virus neutralization by a therapeutic antibody","volume":"437","author":"Nybakken","year":"2005","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.1016\/j.vaccine.2009.09.069","article-title":"Characteristics of antibody responses in tick-borne encephalitis vaccination breakthroughs","volume":"27","author":"Stiasny","year":"2009","journal-title":"Vaccine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41541-019-0133-5","article-title":"Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination","volume":"4","author":"Bradt","year":"2019","journal-title":"NPJ Vaccines."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.str.2004.04.024","article-title":"West Nile virus core protein; tetramer structure and ribbon formation","volume":"12","author":"Dokland","year":"2004","journal-title":"Structure"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1128\/JVI.06072-11","article-title":"Crystal structure of the Japanese encephalitis virus envelope protein","volume":"86","author":"Luca","year":"2012","journal-title":"J Virol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41467-017-00024-6","article-title":"Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"B39","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1128\/JVI.01950-12","article-title":"Structure of the St. Louis Encephalitis virus postfusion envelope trimer","volume":"87","author":"Luca","year":"2013","journal-title":"J Virol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1128\/JVI.02675-12","article-title":"Differential targeting of viral components by CD4(+) versus CD8(+) T lymphocytes in dengue virus infection","volume":"87","author":"Rivino","year":"2013","journal-title":"J Virol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1128\/JVI.79.9.5665-5675.2005","article-title":"Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections","volume":"79","author":"Simmons","year":"2005","journal-title":"J Virol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.1073\/pnas.0305892101","article-title":"Solution structure of dengue virus capsid protein reveals another fold","volume":"101","author":"Ma","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B43","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol Syst Biol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8 angstrom resolution cryo-EM structure of Zika virus","volume":"352","author":"Sirohi","year":"2016","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e02147","DOI":"10.1128\/JVI.02147-16","article-title":"Human CD4(+) T cell responses to an attenuated tetravalent dengue vaccine parallel those induced by natural infection in magnitude, HLA restriction, and antigen specificity","volume":"91","author":"Angelo","year":"2017","journal-title":"J Virol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/infdis\/jiw309","article-title":"HLA-DRB1 alleles are associated with different magnitudes of dengue virus-specific CD4(+) T-cell responses","volume":"214","author":"Weiskopf","year":"2016","journal-title":"J Infect Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1084\/jem.20151517","article-title":"Human T cell responses to Japanese encephalitis virus in health and disease","volume":"213","author":"Turtle","year":"2016","journal-title":"J Exp Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1110\/ps.690101","article-title":"A normalized root-mean-square distance for comparing protein three-dimensional structures","volume":"10","author":"Carugo","year":"2001","journal-title":"Prot Sci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-1-61779-588-6_10","article-title":"Methods of protein structure comparison","volume":"857","author":"Kufareva","year":"2012","journal-title":"Methods Mol Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/tan.13439","article-title":"HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype","volume":"93","author":"Fae","year":"2019","journal-title":"Hla"},{"key":"B51","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1034\/j.1399-0039.2003.00103.x","article-title":"New HLA haplotype frequency reference standards: High-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans","volume":"62","author":"Klitz","year":"2003","journal-title":"Tissue Antigens"},{"key":"B52","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.4049\/jimmunol.1103640","article-title":"The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection","volume":"188","author":"Chaves","year":"2012","journal-title":"J Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00251-013-0720-y","article-title":"NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ","volume":"65","author":"Karosiene","year":"2013","journal-title":"Immunogenetics"},{"key":"B54","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/1471-2105-12-241","article-title":"PeptX: Using Genetic Algorithms to optimize peptides for MHC binding","volume":"12","author":"Knapp","year":"2011","journal-title":"BMC Bioinform"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6164","DOI":"10.4049\/jimmunol.1403074","article-title":"A population response analysis approach to assign class II HLA-epitope restrictions","volume":"194","author":"Paul","year":"2015","journal-title":"J Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12865-017-0204-1","article-title":"Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes","volume":"18","author":"Paul","year":"2017","journal-title":"BMC Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jim.2016.02.013","article-title":"CD4+T-cell epitope prediction using antigen processing constraints","volume":"432","author":"Mettu","year":"2016","journal-title":"J Immunol Methods"},{"key":"B58","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1006\/jtbi.1999.1056","article-title":"Helper T-cell epitope immunodominance associated with structurally stable segments of hen egg lysozyme and HIV gp120","volume":"203","author":"Landry","year":"2000","journal-title":"J Theor Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/j.1460-2075.1986.tb04288.x","article-title":"The relation between the divergence of sequence and structure in proteins","volume":"5","author":"Chothia","year":"1986","journal-title":"Embo J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e1005375","DOI":"10.1371\/journal.ppat.1005375","article-title":"Neuroinvasive West Nile infection elicits elevated and atypically polarized t cell responses that promote a pathogenic outcome","volume":"12","author":"James","year":"2016","journal-title":"PLoS Pathogens"},{"key":"B61","doi-asserted-by":"publisher","first-page":"7890","DOI":"10.4049\/jimmunol.178.12.7890","article-title":"A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection","volume":"178","author":"Assarsson","year":"2007","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13073-015-0245-0","article-title":"Immunoinformatics and epitope prediction in the age of genomic medicine","volume":"7","author":"Backert","year":"2015","journal-title":"Genome Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"943","DOI":"10.4049\/jimmunol.1000405","article-title":"Molecular determinants of T cell epitope recognition to the common timothy grass allergen","volume":"185","author":"Oseroff","year":"2010","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1002\/eji.1830191209","article-title":"Universally immunogenic T-cell epitopes - promiscuous binding to human mhc class-ii and promiscuous recognition by T-cells","volume":"19","author":"Paninabordignon","year":"1989","journal-title":"Eur J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e140545","DOI":"10.1371\/journal.pone.0140545","article-title":"Human CD4(+) T helper cell responses after tick-borne encephalitis vaccination and infection","volume":"10","author":"Aberle","year":"2015","journal-title":"PLoS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nm1240","article-title":"Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus","volume":"11","author":"Oliphant","year":"2005","journal-title":"Nat Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"18950","DOI":"10.1073\/pnas.1011036107","article-title":"Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354","volume":"107","author":"Kaufmann","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4587","DOI":"10.1073\/pnas.071063898","article-title":"Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing","volume":"98","author":"Surman","year":"2001","journal-title":"Proc Natl Acad Sci USA."},{"key":"B69","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.4049\/jimmunol.171.8.4140","article-title":"Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity","volume":"171","author":"Brown","year":"2003","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nri1149","article-title":"Mhc-guided processing: binding of large antigen fragments","volume":"3","author":"Sercarz","year":"2003","journal-title":"Nat Rev Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1128\/JVI.69.2.695-700.1995","article-title":"Oligomeric rearrangement of tick-borne encephalitis-virus envelope proteins induced by an acidic Ph","volume":"69","author":"Allison","year":"1995","journal-title":"J Virol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/nm.3958","article-title":"Endogenous antigen processing drives the primary CD4(+) T cell response to influenza","volume":"21","author":"Miller","year":"2015","journal-title":"Nat Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1086\/648731","article-title":"Persistent Infection with West Nile Virus Years after Initial Infection","volume":"201","author":"Murray","year":"2010","journal-title":"J Infect Diseases"},{"key":"B74","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1172\/JCI39387","article-title":"Tregs control the development of symptomatic West Nile virus infection in humans and mice","volume":"119","author":"Lanteri","year":"2009","journal-title":"J Clin Invest"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e22948","DOI":"10.1371\/journal.pone.0022948","article-title":"Association between HLA class I and class II alleles and the outcome of west nile virus infection: an exploratory study","volume":"6","author":"Lanteri","year":"2011","journal-title":"PLoS ONE."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e165952","DOI":"10.1371\/journal.pone.0165952","article-title":"Genetic contribution of MHC Class II genes in susceptibility to West Nile virus infection","volume":"11","author":"Sarri","year":"2016","journal-title":"PLoS ONE"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e205557","DOI":"10.1371\/journal.pone.0205557","article-title":"Amino acid signatures in the HLA class II peptide-binding region associated with protection\/susceptibility to the severe West Nile Virus disease","volume":"13","author":"Sarri","year":"2018","journal-title":"PLoS ONE"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00016\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T23:29:26Z","timestamp":1579735766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00016\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2020.00016"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00016","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]},"article-number":"16"}}