{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:32:26Z","timestamp":1790695946654,"version":"4.1.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00020","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T05:08:12Z","timestamp":1581397692000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism"],"prefix":"10.3389","volume":"11","author":[{"given":"Vivian","family":"Bonezi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan H. D.","family":"Cataneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryana S. F.","family":"Branquinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysa B. B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gonzalez-Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds C. de Souza","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder I.","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Campa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pryscilla F.","family":"Wowk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L. V.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"B1","unstructured":"Fact sheet: Dengue and Severe Dengue2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6803098","DOI":"10.1155\/2016\/6803098","article-title":"Dengue fever: causes, complications, and vaccine strategies","volume":"2016","author":"Khetarpal","year":"2016","journal-title":"J Immunol Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1099\/0022-1317-69-2-445","article-title":"Production of interferon alpha by dengue virus-infected human monocytes","volume":"69","author":"Kurane","year":"1988","journal-title":"J Gen Virol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1099\/0022-1317-67-8-1653","article-title":"Induction of interferon alpha and gamma from human lymphocytes by dengue virus-infected cells","volume":"67","author":"Kurane","year":"1986","journal-title":"J Gen Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e02181-17","DOI":"10.1128\/JVI.02181-17","article-title":"Human T lymphocytes are permissive for dengue virus replication","volume":"92","author":"Silveira","year":"2018","journal-title":"J Virol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1096\/fasebj.5.11.1907934","article-title":"Relationship between interferon-\u03b3, indoleamine 2,3-dioxygenase, and tryptophan catabolism","volume":"5","author":"Taylor","year":"1991","journal-title":"FASEB J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1099\/vir.0.004416-0","article-title":"Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function","volume":"90","author":"Becerra","year":"2009","journal-title":"J Gen Virol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"12562","DOI":"10.1128\/JVI.00871-13","article-title":"High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection","volume":"87","author":"Tsai","year":"2013","journal-title":"J Virol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/ni.3058","article-title":"A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus","volume":"16","author":"Dejnirattisai","year":"2015","journal-title":"Nat Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5574","DOI":"10.1128\/JVI.03203-15","article-title":"B cell responses during secondary dengue virus infection are dominated by highly cross- reactive, memory-derived plasmablasts","volume":"90","author":"Priyamvada","year":"2016","journal-title":"J Virol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1128\/JVI.06075-11","article-title":"Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans","volume":"86","author":"Wrammert","year":"2012","journal-title":"J Virol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4049\/jimmunol.1103350","article-title":"Association between magnitude of the virus-specific plasmablast response and disease severity in dengue patients","volume":"190","author":"Garcia-Bates","year":"2013","journal-title":"J Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.1073\/pnas.1502619112","article-title":"Human Ebola virus infection results in substantial immune activation","volume":"112","author":"McElroy","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/ni.3533","article-title":"Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination","volume":"17","author":"Ellebedy","year":"2016","journal-title":"Nat Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/imm.12713","article-title":"Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome","volume":"151","author":"Garc\u00eda","year":"2017","journal-title":"Immunology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"Wrammert","year":"2008","journal-title":"Nature."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1043\/1543-2165(2003)127<1026:DFMPCL>2.0.CO;2","article-title":"Dengue fever mimicking plasma cell leukemia","volume":"127","author":"Gawoski","year":"2003","journal-title":"Arch Pathol Lab Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus","volume":"46","author":"Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0005048","DOI":"10.1371\/journal.pntd.0005048","article-title":"Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil","volume":"10","author":"Donald","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.biologicals.2005.09.005","article-title":"Molecular and phenotypic analysis of a working seed lot of yellow fever virus 17DD vaccine strain produced from the secondary seed lot 102\/84 with an additional passage in chicken embryos","volume":"34","author":"Marchevsky","year":"2006","journal-title":"Biologicals."},{"key":"B21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jim.2003.12.015","article-title":"Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system","volume":"286","author":"Crotty","year":"2004","journal-title":"J Immunol Methods."},{"key":"B22","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nprot.2009.3","article-title":"Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen","volume":"4","author":"Smith","year":"2009","journal-title":"Nat Protoc."},{"key":"B23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u0394\u0394CT method","volume":"25","author":"Kenneth","year":"2001","journal-title":"Methods."},{"key":"B24","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12985-016-0548-9","article-title":"Isolation of dengue virus serotype 4 genotype II from a patient with high viral load and a mixed Th1\/Th17 inflammatory cytokine profile in South Brazil","volume":"13","author":"Kuczera","year":"2016","journal-title":"Virol J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e0143391","DOI":"10.1371\/journal.pone.0143391","article-title":"Dengue virus directly stimulates polyclonal B cell activation","volume":"10","author":"Correa","year":"2015","journal-title":"PLoS ONE."},{"key":"B26","doi-asserted-by":"publisher","first-page":"eaan6809","DOI":"10.1126\/sciimmunol.aan6809","article-title":"Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors","volume":"2","author":"Rogers","year":"2017","journal-title":"Sci Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0006000","DOI":"10.1371\/journal.pntd.0006000","article-title":"Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-na\u00efve individual during the 2016 outbreak in Miami, FL","volume":"11","author":"Ricciardi","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.4049\/jimmunol.1700256","article-title":"Immune cell dynamics in rhesus macaques infected with a brazilian strain of Zika virus","volume":"199","author":"Silveira","year":"2017","journal-title":"J Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ebiom.2019.02.060","article-title":"Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model","volume":"41","author":"Nivarthi","year":"2019","journal-title":"EBioMedicine."},{"key":"B30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.chom.2014.06.001","article-title":"Dengue virus infection induces expansion of a CD14+CD16+monocyte population that stimulates plasmablast differentiation","volume":"16","author":"Kwissa","year":"2014","journal-title":"Cell Host Microbe."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/08916934.2014.993027","article-title":"B cell TLR1\/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses","volume":"48","author":"Pone","year":"2015","journal-title":"Autoimmunity."},{"key":"B32","doi-asserted-by":"publisher","first-page":"304ra142","DOI":"10.1126\/scitranslmed.aaa3863","article-title":"Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity","volume":"7","author":"Modhiran","year":"2015","journal-title":"Sci Transl Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/icb.2017.5","article-title":"Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6","volume":"95","author":"Modhiran","year":"2017","journal-title":"Immunol Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"22147","DOI":"10.1074\/jbc.M110.192500","article-title":"Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication","volume":"286","author":"McLean","year":"2011","journal-title":"J Biol Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/cdd.2015.149","article-title":"Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses","volume":"23","author":"Arnold","year":"2016","journal-title":"Cell Death Differ."},{"key":"B36","doi-asserted-by":"publisher","first-page":"M111","DOI":"10.1074\/mcp.M111.012187","article-title":"A physical interaction network of dengue virus and human proteins","volume":"10","author":"Khadka","year":"2011","journal-title":"Mol Cell Proteomics."},{"key":"B37","doi-asserted-by":"publisher","first-page":"31266","DOI":"10.1038\/srep31266","article-title":"Regulation of B cell differentiation by the ubiquitinbinding protein TAX1BP1","volume":"6","author":"Matsushita","year":"2016","journal-title":"Sci Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ebiom.2016.09.003","article-title":"Plasmablasts during acute dengue infection represent a small subset of a broader virus-specific memory B cell pool","volume":"12","author":"Appanna","year":"2016","journal-title":"EBioMedicine."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1126\/science.aad3439","article-title":"Visualizing antibody affinity maturation in germinal centers","volume":"351","author":"Tas","year":"2016","journal-title":"Science."},{"key":"B40","first-page":"38","article-title":"Obligatory role of macrophages in dengue virus antigen presentation to B lymphocytes","volume":"67","author":"Rizvi","year":"1989","journal-title":"Immunology."},{"key":"B41","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fimmu.2015.00188","article-title":"Germinal center reaction following cutaneous dengue virus infection in immune-competent mice","volume":"6","author":"Yam-Puc","year":"2015","journal-title":"Front Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/ana.21195","article-title":"Viral load determines the B-cell response in the cerebrospinal fluid during human immunodeficiency virus infection","volume":"62","author":"Cepok","year":"2007","journal-title":"Ann Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1016\/j.celrep.2018.05.053","article-title":"Progressive upregulation of oxidative metabolism facilitates plasmablast differentiation to a T-independent antigen","volume":"23","author":"Price","year":"2018","journal-title":"Cell Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.cell.2017.04.026","article-title":"Metabolic phenotypes of response to vaccination in humans","volume":"169","author":"Li","year":"2017","journal-title":"Cell."},{"key":"B45","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1515\/bchm3.1988.369.1.337","article-title":"Tryptophan degradation in patients infected by human immunodeficiency virus","volume":"369","author":"Werner","year":"1988","journal-title":"Biol Chem Hoppe Seyler."},{"key":"B46","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/clinchem\/44.4.858","article-title":"Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients","volume":"44","author":"Huengsberg","year":"1998","journal-title":"Clin Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T cell proliferation by macrophage tryptophan catabolism","volume":"189","author":"Munn","year":"1999","journal-title":"J Exp Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.4049\/jimmunol.164.7.3596","article-title":"Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation","volume":"164","author":"Hwu","year":"2000","journal-title":"J Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/ni846","article-title":"CTLA-4-Ig regulates tryptophan catabolism in vivo","volume":"3","author":"Grohmann","year":"2002","journal-title":"Nat Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1172\/JCI115457","article-title":"Activation of T lymphocytes in dengue virus infections","volume":"88","author":"Kurane","year":"1991","journal-title":"J Clin Invest."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1093\/infdis\/jiy360","article-title":"Activation of peripheral T follicular helper cells during acute dengue virus infection","volume":"218","author":"Haltaufderhyde","year":"2018","journal-title":"J Infect Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/COH.0000000000000242","article-title":"Role of immune activation in progression to AIDS","volume":"11","author":"Utay","year":"2016","journal-title":"Curr Opin HIV AIDS."},{"key":"B53","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1097\/COH.0000000000000243","article-title":"Immune activation in the central nervous system throughout the course of HIV infection","volume":"11","author":"Spudich","year":"2016","journal-title":"Curr Opin HIV AIDS."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1126\/science.1217550","article-title":"Natural SIV hosts: showing AIDS the door","volume":"335","author":"Chahroudi","year":"2012","journal-title":"Science."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1001\/jama.1983.03330410031024","article-title":"Immune deficiency syndrome in children","volume":"249","author":"Oleske","year":"1983","journal-title":"JAMA J Am Med Assoc."},{"key":"B56","first-page":"148","article-title":"Serum immunoglobulin elevations in the acquired immunodeficiency syndrome (AIDS): IgG, IgA, IgM, and IgD","volume":"2","author":"Chess","year":"1984","journal-title":"Diagn Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1093\/ajcp\/84.4.425","article-title":"The bone marrow in AIDS. A histologic, hematologic, and microbiologic study","volume":"84","author":"Castella","year":"1985","journal-title":"Am J Clin Pathol."},{"key":"B58","first-page":"5","article-title":"Serum IgD elevation is an early marker of B cell activation during infection with the human immunodeficiency viruses","volume":"68","author":"Mizuma","year":"1987","journal-title":"Clin Exp Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1056\/NEJM198308253090803","article-title":"Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome","volume":"309","author":"Lane","year":"1983","journal-title":"N Engl J Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"5800","DOI":"10.1128\/JVI.00094-13","article-title":"Characterization of plasmablasts in the blood of HIV-infected viremic individuals: evidence for nonspecific immune activation","volume":"87","author":"Buckner","year":"2013","journal-title":"J Virol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1178646917691938","DOI":"10.1177\/1178646917691938","article-title":"Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects","volume":"10","author":"Badawy","year":"2017","journal-title":"Int J Tryptophan Res."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402854","article-title":"Indoleamine 2,3-dioxygenase inhibits B cell immune response to T independent antigens (IRM8P.710)","volume":"192","author":"Shinde","year":"2014","journal-title":"J Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1128\/IAI.00193-08","article-title":"Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis","volume":"76","author":"Harrington","year":"2008","journal-title":"Infect Immun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"5768","DOI":"10.4049\/jimmunol.0803480","article-title":"Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase","volume":"183","author":"Barnes","year":"2009","journal-title":"J Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1038\/s41467-018-04366-7","article-title":"Single cell analysis of kynurenine and system L amino acid transport in T cells","volume":"9","author":"Sinclair","year":"2018","journal-title":"Nat Commun."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e1486353","DOI":"10.1080\/2162402X.2018.1486353","article-title":"Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation","volume":"7","author":"Adam","year":"2018","journal-title":"Oncoimmunology."},{"key":"B67","unstructured":"Blood Atlas: WARS - Monaco Scaled Dataset2019"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1182\/blood.V112.11.2812.2812","article-title":"Serum concentration of L-kynurenine can determine clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP","volume":"112","author":"Ninomiya","year":"2008","journal-title":"Blood."},{"key":"B69","doi-asserted-by":"publisher","first-page":"5100","DOI":"10.1182\/blood.V130.Suppl_1.5100.5100","article-title":"Utilization of metabolomics to identify biomarkers in hematological malignancies: role of IDO and the tryptophan pathway","volume":"130","author":"Finger","year":"2017","journal-title":"Blood."},{"key":"B70","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0609.2009.01393.x","article-title":"Serum concentration of L-kynurenine predicts the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP","author":"Yoshikawa","year":"2010","journal-title":"Eur J Haematol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41598-018-37273-4","article-title":"Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma","volume":"9","author":"Fornecker","year":"2019","journal-title":"Sci Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4511","DOI":"10.1182\/blood-2018-99-116447","article-title":"Tryptophan deprivation promotes an adaptive response and contributes to bioenergetics in multiple myeloma","volume":"132","author":"Romano","year":"2018","journal-title":"Blood."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1002\/eji.201343822","article-title":"Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts","volume":"44","author":"Heine","year":"2014","journal-title":"Eur J Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1172\/JCI18025","article-title":"BAFF selectively enhances the survival of plasmablasts generated from human memory B cells","volume":"112","author":"Avery","year":"2003","journal-title":"J Clin Invest."},{"key":"B75","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/intimm\/dxv034","article-title":"Regulatory B cells in anti-tumor immunity","volume":"27","author":"Zhang","year":"2015","journal-title":"Int Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00020\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T05:08:19Z","timestamp":1581397699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00020\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":75,"alternative-id":["10.3389\/fimmu.2020.00020"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00020","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"article-number":"20"}}