{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:46:28Z","timestamp":1792813588438,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00103","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T05:11:35Z","timestamp":1581397895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups"],"prefix":"10.3389","volume":"11","author":[{"given":"Mariateresa","family":"Coppola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Villar-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista E.","family":"van Meijgaarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Latorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Muriel Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Garcia-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees L. M. C.","family":"Franken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"De Souza Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan-Pau","family":"Millet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Sabri\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"S\u00e1nchez-Montalva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Noguera-Julian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Geluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom H. M.","family":"Ottenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"B1","year":"2019","journal-title":"Global Tuberculosis Report 2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1002152","DOI":"10.1371\/journal.pmed.1002152","article-title":"The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling","volume":"13","author":"Houben","year":"2016","journal-title":"PLoS Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/resp.13272","article-title":"Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease","volume":"23","author":"Goletti","year":"2018","journal-title":"Respirology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41577-018-0025-3","article-title":"Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection","volume":"18","author":"Simmons","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1128\/IAI.70.5.2544-2548.2002","article-title":"Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis","volume":"70","author":"Geluk","year":"2002","journal-title":"Infect Immun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"S644","DOI":"10.1093\/infdis\/jix354","article-title":"Drivers of tuberculosis transmission","volume":"216","author":"Mathema","year":"2017","journal-title":"J Infect Dis"},{"key":"B7","unstructured":"Pipeline of vaccines 201931831000"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1056\/NEJMoa1803484","article-title":"Phase 2b controlled trial of M72\/AS01E vaccine to prevent tuberculosis","volume":"379","author":"Van Der Meeren","year":"2018","journal-title":"N Engl J Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1056\/NEJMoa1909953","article-title":"Final analysis of a trial of M72\/AS01E vaccine to prevent tuberculosis","volume":"381","author":"Tait","year":"2019","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.4049\/jimmunol.1201593","article-title":"An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection","volume":"190","author":"Commandeur","year":"2013","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"37793","DOI":"10.1038\/srep37793","article-title":"New genome-wide algorithm identifies novel in-vivo expressed Mycobacterium tuberculosis antigens inducing human T-cell responses with classical and unconventional cytokine profiles","volume":"6","author":"Coppola","year":"2016","journal-title":"Sci Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/s41591-019-0441-3","article-title":"IFN-gamma-independent immune markers of Mycobacterium tuberculosis exposure","volume":"25","author":"Lu","year":"2019","journal-title":"Nat Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.smim.2018.07.001","article-title":"Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination","volume":"39","author":"Coppola","year":"2018","journal-title":"Semin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1084\/jem.20030205","article-title":"Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program","volume":"198","author":"Voskuil","year":"2003","journal-title":"J Exp Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"8916","DOI":"10.1073\/pnas.95.15.8916","article-title":"A bacterial cytokine","volume":"95","author":"Mukamolova","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1016\/j.micinf.2006.03.018","article-title":"Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis","volume":"8","author":"Leyten","year":"2006","journal-title":"Microbes Infect"},{"key":"B17","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1086\/338833","article-title":"Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis","volume":"185","author":"Masungi","year":"2002","journal-title":"J Infect Dis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e926","DOI":"10.1371\/journal.pone.0000926","article-title":"Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis","volume":"2","author":"Hougardy","year":"2007","journal-title":"PLoS ONE"},{"key":"B19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fmicb.2014.00517","article-title":"Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis","volume":"5","author":"Serra-Vidal","year":"2014","journal-title":"Front Microbiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.3389\/fimmu.2018.02476","article-title":"A systematic review on novel Mycobacterium tuberculosis antigens and their discriminatory potential for the diagnosis of latent and active Tuberculosis","volume":"9","author":"Meier","year":"2018","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1002\/eji.201141602","article-title":"Double- and monofunctional CD4(+) and CD8(+) T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals","volume":"41","author":"Commandeur","year":"2011","journal-title":"Eur J Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1128\/CVI.00482-12","article-title":"Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis","volume":"19","author":"Kassa","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.cyto.2015.07.028","article-title":"Evaluation of cytokine and chemokine response elicited by Rv2204c and Rv0753c to detect latent tuberculosis infection","volume":"76","author":"Pathakumari","year":"2015","journal-title":"Cytokine"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e0124134","DOI":"10.1371\/journal.pone.0124134","article-title":"Pro- and anti-inflammatory cytokines against Rv2031 are elevated during latent tuberculosis: a study in cohorts of tuberculosis patients, household contacts and community controls in an endemic setting","volume":"10","author":"Belay","year":"2015","journal-title":"PLoS ONE"},{"key":"B25","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1128\/CVI.00217-16","article-title":"Multifunctional T cell response to DosR and Rpf antigens is associated with protection in long-term Mycobacterium tuberculosis-infected individuals in colombia","volume":"23","author":"Arroyo","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.3389\/fimmu.2017.01262","article-title":"Polyfunctional CD4(+) T cells as targets for tuberculosis vaccination","volume":"8","author":"Lewinsohn","year":"2017","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/s41586-018-0439-x","article-title":"A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes","volume":"560","author":"Roy Chowdhury","year":"2018","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s41586-019-1276-2","article-title":"Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis","volume":"570","author":"Ardain","year":"2019","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e0201205","DOI":"10.1371\/journal.pone.0201205","article-title":"Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies","volume":"13","author":"van Meijgaarden","year":"2018","journal-title":"PLoS ONE"},{"key":"B30","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cyto.2015.06.013","article-title":"The role of interleukin-32 against tuberculosis","volume":"76","author":"Bai","year":"2015","journal-title":"Cytokine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"250ra114","DOI":"10.1126\/scitranslmed.3009546","article-title":"IL-32 is a molecular marker of a host defense network in human tuberculosis","volume":"6","author":"Montoya","year":"2014","journal-title":"Sci Transl Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jim.2014.12.003","article-title":"Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T cell immunity by flow cytometry","volume":"417","author":"Kagina","year":"2015","journal-title":"J Immunol Methods"},{"key":"B33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jim.2004.06.010","article-title":"Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies","volume":"291","author":"Hanekom","year":"2004","journal-title":"J Immunol Methods"},{"key":"B34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jim.2011.11.011","article-title":"Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria","volume":"376","author":"Shey","year":"2012","journal-title":"J Immunol Methods"},{"key":"B35","unstructured":"C. L. phenotypicForest 0.2"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1038\/s41467-017-01689-9","article-title":"Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types","volume":"8","author":"van Unen","year":"2017","journal-title":"Nat Commun"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1007643","DOI":"10.1371\/journal.ppat.1007643","article-title":"A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates","volume":"15","author":"Rodo","year":"2019","journal-title":"PLoS Pathog"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1126\/science.280.5368.1435","article-title":"Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients","volume":"280","author":"de Jong","year":"1998","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/imm.12362","article-title":"Clinical implications of interferon-gamma genetic and epigenetic variants","volume":"143","author":"Smith","year":"2014","journal-title":"Immunology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1128\/CVI.00721-14","article-title":"Quest for correlates of protection against tuberculosis","volume":"22","author":"Bhatt","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e1005667","DOI":"10.1371\/journal.ppat.1005667","article-title":"CD4 T Cell-derived IFN-gamma plays a minimal role in control of pulmonary Mycobacterium tuberculosis infection and must be actively repressed by PD-1 to prevent lethal disease","volume":"12","author":"Sakai","year":"2016","journal-title":"PLoS Pathog"},{"key":"B42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.tube.2018.08.011","article-title":"Cytokine biomarkers for the diagnosis of tuberculosis infection and disease in adults in a low prevalence setting","volume":"114","author":"Clifford","year":"2019","journal-title":"Tuberculosis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.3389\/fimmu.2017.01252","article-title":"IL-17 production from T helper 17, mucosal-associated invariant T, and gammadelta cells in tuberculosis infection and disease","volume":"8","author":"Coulter","year":"2017","journal-title":"Front Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/cmi.2017.128","article-title":"The crucial roles of Th17-related cytokines\/signal pathways in M. tuberculosis infection","volume":"15","author":"Shen","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1038\/s41598-019-40778-1","article-title":"Use of IP-10 detection in dried plasma spots for latent tuberculosis infection diagnosis in contacts via mail","volume":"9","author":"Villar-Hernandez","year":"2019","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1172\/JCI97508","article-title":"Mycobacterial growth inhibition is associated with trained innate immunity","volume":"128","author":"Joosten","year":"2018","journal-title":"J Clin Invest"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e02087","DOI":"10.1128\/mBio.02087-17","article-title":"T cell production of GM-CSF protects the host during experimental tuberculosis","volume":"8","author":"Robinson","year":"2017","journal-title":"mBio"},{"key":"B48","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3389\/fimmu.2019.00431","article-title":"Mycobacteria-specific mono- and polyfunctional CD4+ T cell profiles in children with latent and active tuberculosis: a prospective proof-of-concept study","volume":"10","author":"Tebruegge","year":"2019","journal-title":"Front Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12967-018-1572-x","article-title":"Screening and identification of a six-cytokine biosignature for detecting TB infection and discriminating active from latent TB","volume":"16","author":"Wang","year":"2018","journal-title":"J Transl Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.tube.2018.08.006","article-title":"Diagnostic performance of GM-CSF and IL-2 in response to long-term specific-antigen cell stimulation in patients with active and latent tuberculosis infection","volume":"112","author":"Balcells","year":"2018","journal-title":"Tuberculosis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.jinf.2014.06.013","article-title":"IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children","volume":"69","author":"Latorre","year":"2014","journal-title":"J Infection"},{"key":"B52","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nm.2299","article-title":"Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease","volume":"17","author":"Harari","year":"2011","journal-title":"Nat Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O'Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/joim.12212","article-title":"Recent advances towards tuberculosis control: vaccines and biomarkers","volume":"275","author":"Weiner","year":"2014","journal-title":"J Internal Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nm.2285","article-title":"A multistage tuberculosis vaccine that confers efficient protection before and after exposure","volume":"17","author":"Aagaard","year":"2011","journal-title":"Nat Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7513","DOI":"10.1016\/j.vaccine.2012.10.045","article-title":"A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice","volume":"30","author":"Geluk","year":"2012","journal-title":"Vaccine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nm.4473","article-title":"Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine","volume":"24","author":"Hansen","year":"2018","journal-title":"Nat Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1128\/IAI.67.6.2941-2950.1999","article-title":"Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family","volume":"67","author":"Dillon","year":"1999","journal-title":"Infection Immunity"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1128\/IAI.67.8.3998-4007.1999","article-title":"Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis","volume":"67","author":"Skeiky","year":"1999","journal-title":"Infection Immunity"},{"key":"B60","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1365-2249.2004.02609.x","article-title":"In vitro cellular immune responses to complex and newly defined recombinant antigens of Mycobacterium tuberculosis","volume":"138","author":"Al-Attiyah","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/187152809787582543","article-title":"TNF-alpha in tuberculosis: a cytokine with a split personality","volume":"8","author":"Mootoo","year":"2009","journal-title":"Inflamm Allergy Drug Targets"},{"key":"B62","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"key":"B63","year":"2018","journal-title":"WHO Preferred Product Characteristics for New Tuberculosis Vaccine"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3389\/fimmu.2017.01059","article-title":"Age-stratified T cell responses in children infected with Mycobacterium tuberculosis","volume":"8","author":"Dreesman","year":"2017","journal-title":"Front Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.4049\/jimmunol.168.7.3536","article-title":"The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF","volume":"168","author":"Belge","year":"2002","journal-title":"J Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1172\/JCI38482","article-title":"Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans","volume":"119","author":"Bruns","year":"2009","journal-title":"J Clin Invest"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1002\/eji.201243262","article-title":"Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease","volume":"43","author":"Rozot","year":"2013","journal-title":"Eur J Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/jmp.12399","article-title":"CD4CD8 double positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques","volume":"48","author":"Diedrich","year":"2019","journal-title":"J Med Primatol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cell.2016.04.019","article-title":"Mass cytometry: single cells, many features","volume":"65","author":"Spitzer","year":"2016","journal-title":"Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4049\/jimmunol.0903856","article-title":"Understanding latent tuberculosis: a moving target","volume":"185","author":"Lin","year":"2010","journal-title":"J Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nri.2017.69","article-title":"Heterogeneity in tuberculosis","volume":"17","author":"Cadena","year":"2017","journal-title":"Nat Rev Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00103\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T05:11:39Z","timestamp":1581397899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00103\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":71,"alternative-id":["10.3389\/fimmu.2020.00103"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00103","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"article-number":"103"}}