{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:58:20Z","timestamp":1792497500532,"version":"4.5.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00225","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T08:29:02Z","timestamp":1582878542000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["TRPML Cation Channels in Inflammation and Immunity"],"prefix":"10.3389","volume":"11","author":[{"given":"Barbara","family":"Spix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kai","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Abrahamian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.chembiol.2017.05.025","article-title":"Small molecules for early endosome-specific patch clamping","volume":"24","author":"Chen","year":"2017","journal-title":"Cell Chem Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.celrep.2015.07.050","article-title":"Presenilin 1 Maintains lysosomal Ca(2+) homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification","volume":"12","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/nature07311","article-title":"The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel","volume":"455","author":"Dong","year":"2008","journal-title":"Nature."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1038\/ncomms5681","article-title":"A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV","volume":"5","author":"Chen","year":"2014","journal-title":"Nat Commun"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e39720","DOI":"10.7554\/eLife.39720","article-title":"Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells","volume":"7","author":"Plesch","year":"2018","journal-title":"Elife"},{"key":"B6","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1053\/j.gastro.2010.11.040","article-title":"A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice","volume":"140","author":"Chandra","year":"2011","journal-title":"Gastroenterology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.devcel.2017.04.003","article-title":"Gastric acid secretion from parietal cells is mediated by a Ca(2+) efflux channel in the tubulovesicle","volume":"41","author":"Sahoo","year":"2017","journal-title":"Dev Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1042\/BJ20130647","article-title":"Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?","volume":"457","author":"Coblentz","year":"2014","journal-title":"Biochem J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"12109","DOI":"10.1038\/ncomms12109","article-title":"MCOLN1 is a ROS sensor in lysosomes that regulates autophagy","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat Cell Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/nm.3611","article-title":"The intracellular Ca(2)(+) channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy","volume":"20","author":"Cheng","year":"2014","journal-title":"Nat Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"14994","DOI":"10.1073\/pnas.222425399","article-title":"Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice","volume":"99","author":"Di","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"B13","doi-asserted-by":"publisher","first-page":"19583","DOI":"10.1073\/pnas.0709846104","article-title":"A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse","volume":"104","author":"Grimm","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B14","doi-asserted-by":"publisher","first-page":"18321","DOI":"10.1073\/pnas.0709096104","article-title":"Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice","volume":"104","author":"Xu","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1073\/pnas.0707963105","article-title":"The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration","volume":"105","author":"Nagata","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"36138","DOI":"10.1074\/jbc.C700190200","article-title":"Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype","volume":"282","author":"Kim","year":"2007","journal-title":"J Biol Chem"},{"key":"B17","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.devcel.2013.08.003","article-title":"A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis","volume":"26","author":"Samie","year":"2013","journal-title":"Dev Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"eaak9573","DOI":"10.1126\/sciimmunol.aak9573","article-title":"Lysosome signaling controls the migration of dendritic cells","volume":"2","author":"Bretou","year":"2017","journal-title":"Sci Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41467-019-08384-x","article-title":"Remodeling of secretory lysosomes during education tunes functional potential in NK cells","volume":"10","author":"Goodridge","year":"2019","journal-title":"Nat Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4922","DOI":"10.4049\/jimmunol.1500163","article-title":"Novel Role of TRPML2 in the Regulation of the Innate Immune Response","volume":"195","author":"Sun","year":"2015","journal-title":"J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1111\/tra.12303","article-title":"The phosphoinositide-gated lysosomal Ca(2+) channel, TRPML1, is required for phagosome maturation","volume":"16","author":"Dayam","year":"2015","journal-title":"Traffic."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1111\/tra.12199","article-title":"PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages","volume":"15","author":"Kim","year":"2014","journal-title":"Traffic."},{"key":"B23","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1084\/jem.20030527","article-title":"Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+\/calmodulin-PI3K hVPS34 cascade","volume":"198","author":"Vergne","year":"2003","journal-title":"J Exp Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/j.cub.2016.05.070","article-title":"Phagocytosis enhances lysosomal and bactericidal properties by activating the transcription factor TFEB","volume":"26","author":"Gray","year":"2016","journal-title":"Curr Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e1001262","DOI":"10.1371\/journal.ppat.1001262","article-title":"A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci","volume":"7","author":"Bewley","year":"2011","journal-title":"PLoS Pathog."},{"key":"B26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/jb\/mvj132","article-title":"Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors","volume":"140","author":"Tsukuba","year":"2006","journal-title":"J Biochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1084\/jem.20151938","article-title":"Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection","volume":"213","author":"Qi","year":"2016","journal-title":"J Exp Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"43218","DOI":"10.1074\/jbc.M508210200","article-title":"TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage","volume":"280","author":"Kiselyov","year":"2005","journal-title":"J Biol Chem"},{"key":"B29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: a control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1600-0854.2009.00924.x","article-title":"The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy","volume":"10","author":"Kim","year":"2009","journal-title":"Traffic"},{"key":"B31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/15548627.2018.1518671","article-title":"Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3\/TRPML3 to regulate autophagy","volume":"15","author":"Kim","year":"2019","journal-title":"Autophagy."},{"key":"B32","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.1038\/s41467-019-13572-w","article-title":"TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKK\u03b2\/VPS34 pathway","volume":"10","author":"Scotto","year":"2019","journal-title":"Nat Commun"},{"key":"B33","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.chom.2017.05.002","article-title":"Lysosomal degradation is required for sustained phagocytosis of bacteria by macrophages","volume":"21","author":"Wong","year":"2017","journal-title":"Cell Host Microbe."},{"key":"B34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/bjc.2017.356","article-title":"TAMeless traitors: macrophages in cancer progression and metastasis","volume":"117","author":"Aras","year":"2017","journal-title":"Br J Cancer."},{"key":"B36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1083\/jcb.200612131","article-title":"Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFalpha","volume":"178","author":"Manderson","year":"2007","journal-title":"J Cell Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"9826","DOI":"10.1074\/jbc.M110.169185","article-title":"Mucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathway","volume":"286","author":"Lelouvier","year":"2011","journal-title":"J Biol Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ceca.2014.10.008","article-title":"The role of TRPMLs in endolysosomal trafficking and function","volume":"58","author":"Venkatachalam","year":"2015","journal-title":"Cell Calcium."},{"key":"B39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/jlb.63.1.108","article-title":"Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model","volume":"63","author":"Ajuebor","year":"1998","journal-title":"J Leukoc Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-pathol-020712-164023","article-title":"The multifaceted functions of neutrophils","volume":"9","author":"Mayadas","year":"2014","journal-title":"Annu Rev Pathol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/ni.2921","article-title":"Neutrophils at work","volume":"15","author":"Nauseef","year":"2014","journal-title":"Nat Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.micinf.2003.09.014","article-title":"Phagocytosis by neutrophils","volume":"5","author":"Lee","year":"2003","journal-title":"Microbes Infect."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.4049\/jimmunol.1601466","article-title":"The lipid kinase PIKfyve coordinates the neutrophil immune response through the activation of the rac GTPase","volume":"199","author":"Dayam","year":"2017","journal-title":"J Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature."},{"key":"B45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1152\/physrev.00023.2001","article-title":"Dendritic cells: immune regulators in health and disease","volume":"82","author":"Lipscomb","year":"2002","journal-title":"Physiol Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1084\/jem.182.2.389","article-title":"Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products","volume":"182","author":"Sallusto","year":"1995","journal-title":"J Exp Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1084\/jem.20030448","article-title":"Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming","volume":"198","author":"Martin-Fontecha","year":"2003","journal-title":"J Exp Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1158\/2326-6066.CIR-13-0102","article-title":"Dendritic cells: master regulators of the immune response","volume":"1","author":"Mellman","year":"2013","journal-title":"Cancer Immunol Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev.immunol.24.021605.090552","article-title":"Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large","volume":"24","author":"Beutler","year":"2006","journal-title":"Annu Rev Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jaci.2006.02.023","article-title":"Toll-like receptor function and signaling","volume":"117","author":"Kaisho","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/intimm\/dxu086","article-title":"Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes","volume":"27","author":"Li","year":"2015","journal-title":"Int Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/nrc928","article-title":"New aspects of natural-killer-cell surveillance and therapy of cancer","volume":"2","author":"Smyth","year":"2002","journal-title":"Nat Rev Cancer."},{"key":"B54","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.it.2007.04.001","article-title":"Keeping NK cells in highly regulated antiviral warfare","volume":"28","author":"Lee","year":"2007","journal-title":"Trends Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nri2381","article-title":"Formation and function of the lytic NK-cell immunological synapse","volume":"8","author":"Orange","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3389\/fimmu.2013.00390","article-title":"Activation of lymphocyte cytolytic machinery: where are we?","volume":"4","author":"Galandrini","year":"2013","journal-title":"Front Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or adaptive immunity?","volume":"331","author":"Vivier","year":"2011","journal-title":". Science."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1126\/science.1103478","article-title":"Natural killer cell signaling pathways","volume":"306","author":"Vivier","year":"2004","journal-title":"Science."},{"key":"B59","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ni1581","article-title":"Up on the tightrope: natural killer cell activation and inhibition","volume":"9","author":"Lanier","year":"2008","journal-title":"Nat Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev.immunol.19.1.291","article-title":"Regulation of the natural killer cell receptor repertoire","volume":"19","author":"Raulet","year":"2001","journal-title":"Annu Rev Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nri1570","article-title":"MHC class I molecules and KIRs in human history, health and survival","volume":"5","author":"Parham","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nri2604","article-title":"Oncogenic stress sensed by the immune system: role of natural killer cell receptors","volume":"9","author":"Raulet","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.immuni.2006.06.013","article-title":"Human NK cell education by inhibitory receptors for MHC class I","volume":"25","author":"Anfossi","year":"2006","journal-title":"Immunity."},{"key":"B64","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0167-5699(94)90267-4","article-title":"The B-cell antigen receptor complex: structure and signal transduction","volume":"15","author":"Pleiman","year":"1994","journal-title":"Immunol Today."},{"key":"B65","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.biocel.2004.09.007","article-title":"B cells","volume":"37","author":"Ollila","year":"2005","journal-title":"Int J Biochem Cell Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.ejcb.2006.08.004","article-title":"TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes","volume":"85","author":"Song","year":"2006","journal-title":"Eur J Cell Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"R402","DOI":"10.1016\/j.cub.2008.02.068","article-title":"Multivesicular bodies","volume":"18","author":"Clague","year":"2008","journal-title":"Curr Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fimmu.2014.00092","article-title":"Early BCR events and antigen capture, processing, and loading on MHC class II on B Cells","volume":"5","author":"Avalos","year":"2014","journal-title":"Front Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cellimm.2005.07.001","article-title":"Differential expression and molecular characterisation of Lmo7, Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells","volume":"235","author":"Lindvall","year":"2005","journal-title":"Cell Immunol."},{"key":"B70","unstructured":"Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain5873\n            MohamedAJ\n            YuL\n            BackesjoCM\n            VargasL\n            FaryalR\n            AintsA\n          10.1111\/j.1600-065X.2008.00741.x19290921Immunol Rev.2282009"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of genetic polymorphisms on human immune cell gene expression","volume":"175","author":"Schmiedel","year":"2018","journal-title":"Cell."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.celrep.2019.01.041","article-title":"RNA-Seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types","volume":"26","author":"Monaco","year":"2019","journal-title":"Cell Rep."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00225\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T08:29:05Z","timestamp":1582878545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00225\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":72,"alternative-id":["10.3389\/fimmu.2020.00225"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00225","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]},"article-number":"225"}}