{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:44:47Z","timestamp":1788835487414,"version":"build-2803163510"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR57"],"award-info":[{"award-number":["TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1382"],"award-info":[{"award-number":["CRC1382"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["668031"],"award-info":[{"award-number":["668031"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["731875"],"award-info":[{"award-number":["731875"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["825694"],"award-info":[{"award-number":["825694"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3n Cellex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00354","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T04:30:30Z","timestamp":1583901030000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Alexander","family":"Queck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"Uschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J.","family":"Brol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schierwagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann E.","family":"Wasmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luise","family":"Berres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jhep.2018.10.023","article-title":"Inflammatory pathways in alcoholic steatohepatitis","volume":"70","author":"Gao","year":"2019","journal-title":"J Hepatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.jhep.2015.07.004","article-title":"Mechanisms of decompensation and organ failure in cirrhosis: from peripheral arterial vasodilation to systemic inflammation hypothesis","volume":"63","author":"Bernardi","year":"2015","journal-title":"J Hepatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1 + monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"Karlmark","year":"2009","journal-title":"Hepatology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1159\/000495276","article-title":"The spleen promotes the secretion of CCL2 and supports an M1 dominant phenotype in hepatic macrophages during liver fibrosis","volume":"51","author":"Li","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B6","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3389\/fimmu.2019.00476","article-title":"Addressing profiles of systemic inflammation across the different clinical phenotypes of acutely decompensated cirrhosis","volume":"10","author":"Trebicka","year":"2019","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.3389\/fimmu.2018.02948","article-title":"The role of monocytes and macrophages in acute and acute-on-chronic liver failure","volume":"9","author":"Triantafyllou","year":"2018","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1002\/hep.29612","article-title":"Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality","volume":"67","author":"Jansen","year":"2018","journal-title":"Hepatol Baltim Md"},{"key":"B9","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.humimm.2018.07.233","article-title":"The portal vein as a distinct immunological compartment - A comprehensive immune phenotyping study","volume":"79","author":"Queck","year":"2018","journal-title":"Hum Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319044","article-title":"Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS","author":"Queck","year":"2019","journal-title":"Gut"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"G182","DOI":"10.1152\/ajpgi.00361.2018","article-title":"Combination of CCl 4 with alcoholic and metabolic injuries mimics human liver fibrosis","volume":"317","author":"Brol","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/liv.13610","article-title":"Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality","volume":"38","author":"Lehmann","year":"2018","journal-title":"Liver Int"},{"key":"B14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1136\/gutjnl-2015-309600","article-title":"Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis","volume":"66","author":"Klein","year":"2017","journal-title":"Gut"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1002\/hep.23222","article-title":"Role of \u03b23-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis","volume":"50","author":"Trebicka","year":"2009","journal-title":"Hepatology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/hep.21673","article-title":"Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA\/Rho-kinase and activation of endothelial nitric oxide synthase","volume":"46","author":"Trebicka","year":"2007","journal-title":"Hepatology"},{"key":"B17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-7113-8_7","article-title":"Mouse rat models of induction of hepatic fibrosis assessment of portal hypertension","volume-title":"Fibrosis.","author":"Klein","year":"2017"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1097\/MEG.0b013e32834a75dc","article-title":"Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt","volume":"23","author":"Trebicka","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e83341","DOI":"10.1371\/journal.pone.0083341","article-title":"Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension","volume":"8","author":"Trebicka","year":"2013","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/liv.12922","article-title":"Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt","volume":"36","author":"Berres","year":"2016","journal-title":"Liver Int"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1136\/gutjnl-2013-306294","article-title":"CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis","volume":"63","author":"Ehling","year":"2014","journal-title":"Gut"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/hep.30249","article-title":"Pharmacological inhibition of CCR2\/5 signaling prevents and reverses alcohol-induced liver damage, steatosis, and inflammation in mice","volume":"69","author":"Ambade","year":"2019","journal-title":"Hepatology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/hep.26783","article-title":"Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C + macrophage infiltration in mice","volume":"59","author":"Baeck","year":"2014","journal-title":"Hepatology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1007\/s10620-016-4132-3","article-title":"Dysfunction of circulating polymorphonuclear leukocytes and monocytes in ambulatory cirrhotics predicts patient outcome","volume":"61","author":"Sargenti","year":"2016","journal-title":"Dig Dis Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1136\/gutjnl-2018-316227","article-title":"Circulating microbiome in blood of different circulatory compartments","volume":"68","author":"Schierwagen","year":"2019","journal-title":"Gut"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1002\/hep.28740","article-title":"Systemic inflammation in decompensated cirrhosis: characterization and role in acute-on-chronic liver failure","volume":"64","author":"Cl\u00e0ria","year":"2016","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cyto.2015.10.006","article-title":"Immune dysfunction in cirrhosis: distinct cytokines phenotypes according to cirrhosis severity","volume":"77","author":"Dirchwolf","year":"2016","journal-title":"Cytokine"},{"key":"B28","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/hep4.1317","article-title":"Serum albumin is inversely associated with portal vein thrombosis in cirrhosis","volume":"3","author":"Basili","year":"2019","journal-title":"Hepatol Commun"},{"key":"B29","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/MEG.0000000000001526","article-title":"Systemic inflammation and portal vein thrombosis in cirrhotic patients with gastroesophageal varices","volume":"32","author":"Huang","year":"2020","journal-title":"Eur J Gastroenterol Hepatol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00354\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T04:30:33Z","timestamp":1583901033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00354\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":29,"alternative-id":["10.3389\/fimmu.2020.00354"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00354","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,11]]},"article-number":"354"}}