{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:11:29Z","timestamp":1790730689613,"version":"4.1.0"},"reference-count":296,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00380","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T05:36:58Z","timestamp":1585633018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Development of a Bioinformatics Framework for Identification and Validation of Genomic Biomarkers and Key Immunopathology Processes and Controllers in Infectious and Non-infectious Severe Inflammatory Response Syndrome"],"prefix":"10.3389","volume":"11","author":[{"given":"Dong Ling","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Kempsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Szakmany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/anae.14062","article-title":"Defining sepsis on the wards: results of a multi-center point-prevalence study comparing two sepsis definitions","volume":"73","author":"Szakmany","year":"2018","journal-title":"Anesthesia"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1136\/bmjopen-2013-002586","article-title":"Sepsis-associated mortality in England: an analysis of multiple cause of death data from 2001 to (2010)","volume":"3","author":"McPherson","year":"2013","journal-title":"BMJ Open"},{"key":"B4","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"B5","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3238\/arztebl.2016.0159","article-title":"Hospital incidence and mortality rates of sepsis","volume":"113","author":"Fleischmann","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1016\/j.ejim.2018.03.005","article-title":"Admissions for certain conditions show explosive growth in England following a sudden and unexpected increase in deaths","volume":"54","author":"Jones","year":"2018","journal-title":"Eur J Intern Med"},{"key":"B9","first-page":"1317","article-title":"Goodbye to the SIRS, the reason why we do not need you","volume-title":"Am J Emerg Med","author":"Wu","year":"2017"},{"key":"B10","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1001\/jama.2016.20328","article-title":"Prognostic accuracy of the sofa score, sirs criteria, and qsofa score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit","volume":"317","author":"Raith","year":"2017","journal-title":"JAMA"},{"key":"B11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1089\/sur.2017.264","article-title":"Pathogen- and danger-associated molecular patterns and the cytokine response in sepsis","volume":"19","author":"Rajaee","year":"2018","journal-title":"Surg infect"},{"key":"B12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ccc.2017.08.002","article-title":"Immune activation in sepsis","volume":"34","author":"Conway-Morris","year":"2018","journal-title":"Critical care clinics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1182\/blood-2006-02-002477","article-title":"Gene expression patterns in blood leukocytes discriminate patients with acute infections","volume":"109","author":"Ramilo","year":"2007","journal-title":"Blood"},{"key":"B14","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1097\/CCM.0000000000003225","article-title":"Surviving sepsis campaign: research priorities for sepsis and septic shock","volume":"46","author":"Coopersmith","year":"2018","journal-title":"Crit Care Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/nm0509-496","article-title":"The sepsis seesaw: tilting toward immunosuppression","volume":"15","author":"Hotchkiss","year":"2009","journal-title":"Nat Med"},{"key":"B17","first-page":"178","article-title":"Sepsis and the systemic inflammatory response syndrome","volume":"45","author":"Paterson","year":"2000","journal-title":"J R Coll Surg Edinb"},{"key":"B18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.21037\/atm.2017.09.21","article-title":"Defects in innate and adaptive immunity in patients with sepsis and health care associated infection","volume":"5","author":"Ryan","year":"2017","journal-title":"Ann Transl Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3760\/cma.j.issn.1009-2587.2018.11.013","article-title":"Precision evaluation of immune status and its significance in sepsis after burns or trauma","volume":"34","author":"Yao","year":"2018","journal-title":"Zhonghua shao shang za zhi."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e0198555","DOI":"10.1371\/journal.pone.0198555","article-title":"The immunosuppressive face of sepsis early on intensive care unit-A large-scale microarray meta-analysis","volume":"13","author":"Schaack","year":"2018","journal-title":"PLoS ONE"},{"key":"B21","doi-asserted-by":"publisher","first-page":"287ra71","DOI":"10.1126\/scitranslmed.aaa5993","article-title":"A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set","volume":"7","author":"Sweeney","year":"2015","journal-title":"Sci Transl Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s41467-018-03078-2","article-title":"A community approach to mortality prediction in sepsis via gene expression analysis","volume":"9","author":"Sweeney","year":"2018","journal-title":"Nat Commun"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0154320","DOI":"10.1371\/journal.pone.0154320","article-title":"Temporal expression of peripheral blood leukocyte biomarkers in a macaca fascicularis infection model of tuberculosis; comparison with human datasets and analysis with parametric\/non-parametric tools for improved diagnostic biomarker identification","volume":"11","author":"Javed","year":"2016","journal-title":"PloS ONE"},{"key":"B24","doi-asserted-by":"publisher","first-page":"D987","DOI":"10.1093\/nar\/gks1174","article-title":"ArrayExpress update\u2013trends in database growth and links to data analysis tools","volume":"41","author":"Rustici","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1097\/CCM.0b013e3181aab5a3","article-title":"Gene-expression profiling of peripheral blood mononuclear cells in sepsis","volume":"37","author":"Payen","year":"2009","journal-title":"Crit Care Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1097\/CCM.0b013e31819b52fd","article-title":"Gene-expression profiling of peripheral blood mononuclear cells in sepsis","volume":"37","author":"Tang","year":"2009","journal-title":"Crit Care Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"R149","DOI":"10.1186\/cc10274","article-title":"Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis","volume":"15","author":"Sutherland","year":"2011","journal-title":"Crit Care"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1097\/CCM.0b013e31819fcc08","article-title":"Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum","volume":"37","author":"Wong","year":"2009","journal-title":"Crit Care Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10549-009-0378-1","article-title":"A validated gene expression profile for detecting clinical outcome in breast cancer using artificial neural networks","volume":"120","author":"Lancashire","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"D377","DOI":"10.1093\/nar\/gks1118","article-title":"PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees","volume":"41","author":"Mi","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-60761-175-2_7","article-title":"PANTHER pathway: an ontology-based pathway database coupled with data analysis tools","volume":"563","author":"Mi","year":"2009","journal-title":"Methods Mol Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/bioinformatics\/18.3.395","article-title":"An integrated approach utilizing artificial neural networks and SELDI mass spectrometry for the classification of human tumors and rapid identification of potential biomarkers","volume":"18","author":"Ball","year":"2002","journal-title":"Bioinformatics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1093\/bioinformatics\/bti368","article-title":"Classification of bacterial species from proteomic data using combinatorial approaches incorporating artificial neural networks, cluster analysis and principal components analysis","volume":"21","author":"Lancashire","year":"2005","journal-title":"Bioinformatics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/prca.200700022","article-title":"Diagnostic biomarkers differentiating metastatic melanoma patients from healthy controls identified by an integrated MALDI-TOF mass spectrometry\/bioinformatic approach","volume":"1","author":"Matharoo-Ball","year":"2007","journal-title":"Proteomics Clin Appl"},{"key":"B37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.artmed.2008.03.001","article-title":"Identification of gene transcript signatures predictive for estrogen receptor and lymph node status using a stepwise forward selection artificial neural network modelling approach","volume":"43","author":"Lancashire","year":"2008","journal-title":"Artif Intell Med"},{"key":"B38","volume-title":"Artificial neural network techniques to investigate potential interactions between biomarkers","author":"Lemetre","year":"2010"},{"key":"B39","first-page":"877","volume-title":"IWANN.","author":"Lemetre","year":"2009"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e102483","DOI":"10.1371\/journal.pone.0102483","article-title":"Artificial neural network inference (ANNI): a study on gene-gene interaction for biomarkers in childhood sarcomas","volume":"9","author":"Tong","year":"2014","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization","volume":"27","author":"Smoot","year":"2011","journal-title":"Bioinformatics"},{"key":"B42","unstructured":""},{"key":"B43","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/0306-9877(95)90228-7","article-title":"Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus","volume":"45","author":"Klipper-Aurbach","year":"1995","journal-title":"Med hypotheses"},{"key":"B44","doi-asserted-by":"publisher","first-page":"120134","DOI":"10.1098\/rsob.120134","article-title":"Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity","volume":"2","author":"Beyrau","year":"2012","journal-title":"Open Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1183\/09031936.00104412","article-title":"Management-based risk prediction in community-acquired pneumonia by scores and biomarkers","volume":"41","author":"Kolditz","year":"2013","journal-title":"Eur Respir J"},{"key":"B46","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00540-012-1502-7","article-title":"Clinical application of sepsis biomarkers","volume":"27","author":"Sankar","year":"2013","journal-title":"J Anesth"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.2741\/e568","article-title":"Molecular mediators of polymicrobial sepsis","volume":"4","author":"Wintersteller","year":"2012","journal-title":"Front Biosci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/cc10537","article-title":"Clinical review: sepsis and septic shock\u2013the potential of gene arrays","volume":"16","author":"Wong","year":"2012","journal-title":"Crit Care"},{"key":"B49","doi-asserted-by":"publisher","first-page":"R7","DOI":"10.1186\/cc11145","article-title":"Clinical utility of biomarkers of endothelial activation in sepsis\u2013a systematic review","volume":"16","author":"Xing","year":"2012","journal-title":"Crit Care"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e6162","DOI":"10.1371\/journal.pone.0006162","article-title":"Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis","volume":"4","author":"Kwon","year":"2009","journal-title":"PLoS ONE"},{"key":"B51","first-page":"245","article-title":"Conventionally used reference genes are not outstanding for normalization of gene expression in human cancer research","volume-title":"BMC Bioinformatics","author":"Jo","year":"2019"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e113781","DOI":"10.1371\/journal.pone.0113781","article-title":"Identification of optimal reference genes for gene expression normalization in a wide cohort of endometrioid endometrial carcinoma tissues","volume":"9","author":"Romani","year":"2014","journal-title":"PLoS ONE"},{"key":"B53","doi-asserted-by":"publisher","first-page":"16923","DOI":"10.1038\/s41598-017-16916-y","article-title":"A simple method to assess group difference in RT-qPCR reference gene selection using GeNorm: the case of the placental sex","volume":"7","author":"St-Pierre","year":"2017","journal-title":"Sci Rep"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.3892\/ol.2017.5887","article-title":"Validation of reference genes for the normalization of RT-qPCR expression studies in human tongue carcinoma cell lines and tissue","volume":"13","author":"Wang","year":"2017","journal-title":"Oncol Lett"},{"key":"B55","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.genrep.2017.11.009","article-title":"Selection of reference genes for studies of human retinal endothelial cell gene expression by reverse transcription-quantitative real-time polymerase chain reaction","volume":"10","author":"Appukuttan","year":"2018","journal-title":"Gene Rep"},{"key":"B56","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fgene.2019.00097","article-title":"Pan-Cancer analysis of TCGA data revealed promising reference genes for qPCR normalization","volume":"10","author":"Krasnov","year":"2019","journal-title":"Front Genet"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1182\/blood-2017-03-768507","article-title":"CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation","volume":"130","author":"Bai","year":"2017","journal-title":"Blood"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1084\/jem.20161093","article-title":"Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets","volume":"214","author":"Eulenberg-Gustavus","year":"2017","journal-title":"J Exp Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.4049\/jimmunol.0903136","article-title":"Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1","volume":"184","author":"Bayat","year":"2010","journal-title":"J Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1600-0609.2012.01817.x","article-title":"Comparative evaluation of the role of the adhesion molecule CD177 in neutrophil interactions with platelets and endothelium","volume":"89","author":"Pliyev","year":"2012","journal-title":"Eur J Haematol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-1-4939-8949-2_5","article-title":"Determination of subset-restricted anti-neutrophil cytoplasmic antibodies (anca) by immunofluorescence cytochemistry","volume":"1901","author":"Amirbeagi","year":"2019","journal-title":"Methods Mol Biol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/MOH.0b013e32834babdd","article-title":"Developments in the definition and clinical impact of human neutrophil antigens","volume":"18","author":"Muschter","year":"2011","journal-title":"Curr Opin Hematol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"23603","DOI":"10.1074\/jbc.M701120200","article-title":"The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)","volume":"282","author":"Sachs","year":"2007","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.yjmcc.2017.01.009","article-title":"Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles","volume":"104","author":"Wang","year":"2017","journal-title":"J Mol Cell Cardiol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"7790","DOI":"10.1073\/pnas.1216412110","article-title":"Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis","volume":"110","author":"DeStefano","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.cell.2012.04.046","article-title":"Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration","volume":"149","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"B67","doi-asserted-by":"publisher","first-page":"17431","DOI":"10.1074\/jbc.M117.787788","article-title":"C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation","volume":"292","author":"Burel","year":"2017","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1161\/CIRCRESAHA.113.301215","article-title":"Fibroblast growth factor homologous factors modulate cardiac calcium channels","volume":"113","author":"Hennessey","year":"2013","journal-title":"Circ Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/cpr.12200","article-title":"FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating Spry1","volume":"48","author":"Lu","year":"2015","journal-title":"Cell Prolif"},{"key":"B70","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/onc.2017.373","article-title":"Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion","volume":"37","author":"Otani","year":"2018","journal-title":"Oncogene"},{"key":"B71","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s10517-015-2794-z","article-title":"In vitro effects of nanosized diamond particles on macrophages","volume":"158","author":"Shkurupy","year":"2015","journal-title":"Bull Exp Biol Med"},{"key":"B72","first-page":"806","article-title":"FGF13 selectively regulates heat nociception by interacting with nav1.7","volume-title":"Neuron","author":"Yang","year":"2017"},{"key":"B73","doi-asserted-by":"publisher","first-page":"17953","DOI":"10.1038\/s41598-017-18159-3","article-title":"Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84","volume":"7","author":"Mahmud","year":"2017","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","first-page":"10684","DOI":"10.1074\/jbc.M112.420042","article-title":"Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor","volume":"288","author":"Suzuki","year":"2013","journal-title":"J Biol Chem"},{"key":"B75","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.bbamcr.2018.02.008","article-title":"Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R","volume":"1865","author":"Sundqvist","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3389\/fimmu.2018.01419","article-title":"Activation of the immune-metabolic receptor GPR84 enhances inflammation and phagocytosis in macrophages","volume":"9","author":"Recio","year":"2018","journal-title":"Front Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/s41598-017-00828-y","article-title":"Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFalpha expression","volume":"7","author":"Muller","year":"2017","journal-title":"Sci Rep"},{"key":"B78","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.phrs.2018.02.021","article-title":"Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor","volume":"131","author":"Gaidarov","year":"2018","journal-title":"Pharmacol Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.prostaglandins.2009.05.003","article-title":"Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis","volume":"89","author":"Ichimura","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"B80","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1146\/annurev-immunol-051116-052235","article-title":"Metabolite-Sensing G protein-coupled receptors-facilitators of diet-related immune regulation","volume":"35","author":"Tan","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1763589","DOI":"10.1155\/2019\/1763589","article-title":"chlorpyrifos suppresses neutrophil extracellular traps in carp by promoting necroptosis and inhibiting respiratory burst caused by the PKC\/MAPK pathway","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.4049\/jimmunol.1600461","article-title":"NKG2D promotes b1a cell development and protection against bacterial infection","volume":"198","author":"Lenartic","year":"2017","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3389\/fimmu.2018.00441","article-title":"NKG2D: a master regulator of immune cell responsiveness","volume":"9","author":"Wensveen","year":"2018","journal-title":"Front Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1158\/2326-6066.CIR-15-0098","article-title":"NKG2D receptor and its ligands in host defense","volume":"3","author":"Lanier","year":"2015","journal-title":"Cancer Immunol Res"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1128\/MCB.01274-12","article-title":"NF-E2 p45 is important for establishing normal function of platelets","volume":"33","author":"Fujita","year":"2013","journal-title":"Mol Cell Biol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1182\/blood-2009-03-209932","article-title":"MAL\/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9","volume":"114","author":"Gilles","year":"2009","journal-title":"Blood"},{"key":"B87","doi-asserted-by":"publisher","first-page":"6037","DOI":"10.1182\/blood-2010-06-289850","article-title":"Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency","volume":"116","author":"Jalagadugula","year":"2010","journal-title":"Blood"},{"key":"B88","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0021-9290(91)90382-W","article-title":"The determinants of skeletal muscle force and power: their adaptability with changes in activity pattern","volume":"1","author":"Fitts","year":"1991","journal-title":"J Biomech"},{"key":"B89","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1540\/jsmr.48.137","article-title":"Surface CD3 expression proceeds through both myosin regulatory light chain 9 (MYL9)-dependent and MYL9-independent pathways in Jurkat cells","volume":"48","author":"Aoki","year":"2012","journal-title":"J Smooth Muscle Res"},{"key":"B90","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1540\/jsmr.44.29","article-title":"Smooth muscle type isoform of 20 kDa myosin light chain is expressed in monocyte\/macrophage cell lineage","volume":"44","author":"Higashihara","year":"2008","journal-title":"J Smooth Muscle Res"},{"key":"B91","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1540\/jsmr.37.113","article-title":"Myosin light chain phosphorylation is correlated with cold-induced changes in platelet shape","volume":"37","author":"Kawakami","year":"2001","journal-title":"J Smooth Muscle Res"},{"key":"B92","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1540\/jsmr.37.25","article-title":"Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells","volume":"37","author":"Watanabe","year":"2001","journal-title":"J Smooth Muscle Res"},{"key":"B93","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12864-017-3630-9","article-title":"Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients","volume":"18","author":"Adhikary","year":"2017","journal-title":"BMC genomics"},{"key":"B94","doi-asserted-by":"publisher","first-page":"49820","DOI":"10.1074\/jbc.M209891200","article-title":"PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1","volume":"277","author":"Steiglitz","year":"2002","journal-title":"J Biol Chem"},{"key":"B95","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jcb.20605","article-title":"Diverse biological functions of extracellular collagen processing enzymes","volume":"96","author":"Trackman","year":"2005","journal-title":"J Cell Biochem"},{"key":"B96","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/MOL.0000000000000211","article-title":"What does procollagen C-endopeptidase enhancer protein 2 have to do with HDL-cholesteryl ester uptake? Or how I learned to stop worrying and love reverse cholesterol transport? Current opinion in lipidology","volume":"26","author":"Sorci-Thomas","year":"2015"},{"key":"B97","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1093\/neuonc\/not243","article-title":"Lactate dehydrogenase a silencing in IDH mutant gliomas","volume":"16","author":"Chesnelong","year":"2014","journal-title":"Neuro-oncology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.mam.2012.05.003","article-title":"The SLC16 gene family - structure, role and regulation in health and disease","volume":"34","author":"Halestrap","year":"2013","journal-title":"Mol Aspects Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1021\/mp3007133","article-title":"Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery","volume":"10","author":"Kadam","year":"2013","journal-title":"Mol Pharmaceutics"},{"key":"B100","doi-asserted-by":"publisher","first-page":"66","DOI":"10.4149\/av_2017_01_66","article-title":"Genome-wide gene expression pattern underlying differential host response to high or low pathogenic H5N1 avian influenza virus in ducks","volume":"61","author":"Kumar","year":"2017","journal-title":"Acta virologica"},{"key":"B101","doi-asserted-by":"publisher","first-page":"E893","DOI":"10.1152\/ajpendo.00484.2013","article-title":"Hypoxia-mediated carbohydrate metabolism and transport promote early-stage murine follicle growth and survival","volume":"306","author":"Makanji","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B102","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s12177-009-9041-7","article-title":"Gene expression microarray analysis of early oxygen-induced retinopathy in the rat","volume":"2","author":"Tea","year":"2009","journal-title":"J Ocul Biol Dis Infor"},{"key":"B103","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1136\/jmedgenet-2017-104514","article-title":"Mutation in TDRD9 causes non-obstructive azoospermia in infertile men","volume":"54","author":"Arafat","year":"2017","journal-title":"J Med Genet"},{"key":"B104","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1134\/S0026893314010063","article-title":"Dead-box RNA helicases in animal gametogenesis","volume":"48","author":"Kotov","year":"2014","journal-title":"Mol Biol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.1242\/dev.099184","article-title":"The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles","volume":"140","author":"Lim","year":"2013","journal-title":"Development"},{"key":"B106","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.devcel.2009.10.012","article-title":"The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline","volume":"17","author":"Shoji","year":"2009","journal-title":"Dev Cell"},{"key":"B107","doi-asserted-by":"publisher","first-page":"e0217941","DOI":"10.1371\/journal.pone.0217941","article-title":"Expression of genome defence protein members in proliferating and quiescent rat male germ cells and the Nuage dynamics","volume":"14","author":"Rocha-da-Silva","year":"2019","journal-title":"PLoS ONE"},{"key":"B108","doi-asserted-by":"publisher","first-page":"9618","DOI":"10.18632\/oncotarget.22709","article-title":"Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage","volume":"9","author":"Guijo","year":"2018","journal-title":"Oncotarget"},{"key":"B109","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.devcel.2009.11.007","article-title":"Defending the genome in tudor style","volume":"17","author":"van der Heijden","year":"2009","journal-title":"Dev Cell"},{"key":"B110","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.idc.2010.02.001","article-title":"Infections in pediatric transplant recipients: not just small adults","volume":"24","author":"Michaels","year":"2010","journal-title":"Infect Dis Clin North Am"},{"key":"B111","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1586\/1744666X.2015.990440","article-title":"Important differences in the diagnostic spectrum of primary immunodeficiency in adults versus children","volume":"11","author":"Abolhassani","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1002\/eji.201242916","article-title":"Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes","volume":"43","author":"Steevels","year":"2013","journal-title":"Eur J Immunol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.4049\/jimmunol.0902039","article-title":"Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes","volume":"184","author":"Steevels","year":"2010","journal-title":"J Immunol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.4049\/jimmunol.1501650","article-title":"Signal inhibitory receptor on leukocytes-1 limits the formation of neutrophil extracellular traps, but preserves intracellular bacterial killing","volume":"196","author":"Van Avondt","year":"2016","journal-title":"J Immunol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"e78459","DOI":"10.1371\/journal.pone.0078459","article-title":"Ligation of signal inhibitory receptor on leukocytes-1 suppresses the release of neutrophil extracellular traps in systemic lupus erythematosus","volume":"8","author":"Van Avondt","year":"2013","journal-title":"PLoS ONE"},{"key":"B116","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cellimm.2012.07.009","article-title":"VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells","volume":"278","author":"Guo","year":"2012","journal-title":"Cell Immunol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1182\/blood.V99.9.3293","article-title":"Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells","volume":"99","author":"Cambot","year":"2002","journal-title":"Blood"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1161\/ATVBAHA.115.305278","article-title":"Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis","volume":"35","author":"Lambden","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s13054-018-2277-5","article-title":"Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity","volume":"22","author":"Lambden","year":"2018","journal-title":"Crit Care"},{"key":"B120","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13054-017-1782-2","article-title":"Markers of nitric oxide are associated with sepsis severity: an observational study","volume":"21","author":"Winkler","year":"2017","journal-title":"Crit Care"},{"key":"B121","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1038\/sj.onc.1203586","article-title":"The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways","volume":"19","author":"Hernandez-Munoz","year":"2000","journal-title":"Oncogene"},{"key":"B122","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.bbamem.2010.01.002","article-title":"Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box","volume":"1798","author":"Baumgart","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"B123","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.imlet.2016.08.011","article-title":"Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients","volume":"178","author":"Demaret","year":"2016","journal-title":"Immunol Lett"},{"key":"B124","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1365-2141.2004.05027.x","article-title":"Neutrophil CD177 (NB1 gp, HNA-2a) expression is increased in severe bacterial infections and polycythaemia vera","volume":"126","author":"Gohring","year":"2004","journal-title":"Br J Haematol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1016\/S0301-472X(99)00100-9","article-title":"Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors","volume":"27","author":"Darley","year":"1999","journal-title":"Exp Hematol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1097\/CCM.0b013e318274647d","article-title":"Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome","volume":"41","author":"Drifte","year":"2013","journal-title":"Crit Care Med"},{"key":"B127","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/MOH.0000000000000303","article-title":"Consequences of extracellular trap formation in sepsis","volume":"24","author":"O'Brien","year":"2017","journal-title":"Curr Opin Hematol"},{"key":"B128","first-page":"1681S","article-title":"Arginine and immunity","volume-title":"J Nutr","author":"Popovic","year":"2007"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.2174\/0929867311320110006","article-title":"Myeloid derived suppressor cells and their role in diseases","volume":"20","author":"Kong","year":"2013","journal-title":"Curr Med Chem"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s00134-012-2574-4","article-title":"Myeloid-derived suppressor cells control microbial sepsis","volume":"38","author":"Derive","year":"2012","journal-title":"Intensive Care Med"},{"key":"B131","doi-asserted-by":"publisher","first-page":"R163","DOI":"10.1186\/cc14003","article-title":"Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients","volume":"18","author":"Darcy","year":"2014","journal-title":"Crit Care"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1158\/1535-7163.MCT-14-0849","article-title":"The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses","volume":"14","author":"Christiansson","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"B133","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1128\/IAI.00239-12","article-title":"Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response","volume":"80","author":"Brudecki","year":"2012","journal-title":"Infect Immun"},{"key":"B134","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1097\/SLA.0000000000001783","article-title":"Human myeloid-derived suppressor cells are associated with chronic immune suppression after severe sepsis\/septic shock","volume":"265","author":"Mathias","year":"2017","journal-title":"Ann Surg"},{"key":"B135","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1164\/rccm.201606-1143OC","article-title":"Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in patients with sepsis","volume":"196","author":"Uhel","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"B136","article-title":"A novel assay for neutrophil extracellular traps (nets) formation independently predicts disseminated intravascular coagulation and mortality in critically ill patients","volume-title":"Am J Respir Crit Care Med","author":"Abrams","year":"2019"},{"key":"B137","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/bjh.14077","article-title":"The role of extracellular histones in haematological disorders","volume":"173","author":"Alhamdi","year":"2016","journal-title":"Br J Haematol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood"},{"key":"B139","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00441-018-2790-5","article-title":"The enigmatic neutrophil: what we do not know","volume":"371","author":"Kubes","year":"2018","journal-title":"Cell Tissue Res"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The neutrophil's role during health and disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol Rev"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/JLB.3CE0419-130R","article-title":"Rise and shine: Open your eyes to produce anti-inflammatory NETs","volume":"105","author":"Thanabalasuriar","year":"2019","journal-title":"J Leukocyte Biol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3389\/fimmu.2017.01895","article-title":"Monocytic myeloid-derived suppressor cells in chronic infections","volume":"8","author":"Dorhoi","year":"2017","journal-title":"Front Immunol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat Immunol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/aps.2017.27","article-title":"The novel alpha-glucan YCP improves the survival rates and symptoms in septic mice by regulating myeloid-derived suppressor cells","volume":"38","author":"Liu","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"B145","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1007\/s10753-018-0852-1","article-title":"Arctigenin ameliorates inflammation by regulating accumulation and functional activity of mdscs in endotoxin shock","volume":"41","author":"Shi","year":"2018","journal-title":"Inflammation"},{"key":"B146","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jinf.2015.04.019","article-title":"Immunomodulation in sepsis-why blunting the response doesn't work?","volume":"71","author":"Szakmany","year":"2015","journal-title":"J Infect"},{"key":"B147","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.1038\/s41598-019-39764-4","article-title":"Discovery and validation of a novel neutrophil activation marker associated with obesity","volume":"9","author":"Pan","year":"2019","journal-title":"Sci Rep"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2019.1603547","article-title":"Emerging views of mitophagy in immunity and autoimmune diseases","volume":"2019","author":"Xu","year":"2019","journal-title":"Autophagy"},{"key":"B149","doi-asserted-by":"publisher","first-page":"5985209","DOI":"10.1155\/2017\/5985209","article-title":"Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies","volume":"2017","author":"Mantzarlis","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"B150","doi-asserted-by":"publisher","first-page":"66","DOI":"10.4161\/viru.26907","article-title":"The role of mitochondrial dysfunction in sepsis-induced multi-organ failure","volume":"5","author":"Singer","year":"2014","journal-title":"Virulence"},{"key":"B151","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.4049\/jimmunol.136.10.3779","article-title":"The human B cell-associated antigen CD24 is a single chain sialoglycoprotein","volume":"136","author":"Pirruccello","year":"1986","journal-title":"J Immunol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"L1102","DOI":"10.1152\/ajplung.00380.2014","article-title":"Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS","volume":"308","author":"Kangelaris","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B153","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1182\/blood-2016-01-688887","article-title":"Neutrophil heterogeneity: implications for homeostasis and pathogenesis","volume":"127","author":"Silvestre-Roig","year":"2016","journal-title":"Blood"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1189\/jlb.69.6.1045","article-title":"Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes","volume":"69","author":"Yousefi","year":"2001","journal-title":"J Leukoc Biol"},{"key":"B155","first-page":"e00057","article-title":"The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis","volume-title":"Microbiol Mol Biol Rev","author":"Lawrence","year":"2018"},{"key":"B156","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.4049\/jimmunol.181.6.3761","article-title":"Resistin inhibits essential functions of polymorphonuclear leukocytes","volume":"181","author":"Cohen","year":"2008","journal-title":"J Immunol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nri1864","article-title":"CEACAM1: contact-dependent control of immunity","volume":"6","author":"Gray-Owen","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/bip.21447","article-title":"Two new synthetic peptides from the N-domain of CEACAM1 (CD66a) stimulate neutrophil adhesion to endothelial cells","volume":"96","author":"Skubitz","year":"2011","journal-title":"Biopolymers"},{"key":"B159","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.1096\/fj.201800331R","article-title":"Endothelial barrier function is differentially regulated by CEACAM1-mediated signaling","volume":"32","author":"Ghavampour","year":"2018","journal-title":"FASEB J"},{"key":"B160","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.bbrc.2012.11.107","article-title":"CEACAM1 inhibits cell-matrix adhesion and promotes cell migration through regulating the expression of N-cadherin","volume":"430","author":"Liu","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"B161","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10528-006-9038-x","article-title":"NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis","volume":"44","author":"Liu","year":"2006","journal-title":"Biochem Genet"},{"key":"B162","first-page":"30","article-title":"Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer","volume-title":"BMC Med Genomics","author":"Shivakumar","year":"2017"},{"key":"B163","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.gene.2016.02.048","article-title":"Structural and biological function of NYD-SP15 as a new member of cytidine deaminases","volume":"583","author":"Xu","year":"2016","journal-title":"Gene"},{"key":"B164","doi-asserted-by":"publisher","first-page":"774","DOI":"10.4049\/jimmunol.1103067","article-title":"Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine","volume":"190","author":"Kusu","year":"2013","journal-title":"J Immunol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3168\/jds.2013-7379","article-title":"Hepatic purinergic signaling gene network expression and its relationship with inflammation and oxidative stress biomarkers in blood from peripartal dairy cattle","volume":"97","author":"Seo","year":"2014","journal-title":"J Dairy Sci"},{"key":"B166","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1179\/1351000215Y.0000000005","article-title":"Sepsis, oxidative stress, and hypoxia: are there clues to better treatment?","volume":"20","author":"Bar-Or","year":"2015","journal-title":"Redox Rep"},{"key":"B167","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/1871529X15666150108115553","article-title":"Involvement of hypoxia-inducible factors in the dysregulation of oxygen homeostasis in sepsis","volume":"15","author":"Hirota","year":"2015","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1097\/ALN.0b013e31828baa67","article-title":"Hypoxia-inducible factor and target gene expression are decreased in patients with sepsis: prospective observational clinical and cellular studies","volume":"118","author":"Schafer","year":"2013","journal-title":"Anesthesiology"},{"key":"B169","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1097\/01.CCM.0000281639.42926.00","article-title":"Modulation of the sepsis inflammatory response by resuscitation: the missing link between cytopathic and hypoxic hypoxia?","volume":"35","author":"Trzeciak","year":"2007","journal-title":"Crit Care Med"},{"key":"B170","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.immuni.2015.02.001","article-title":"Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1alpha","volume":"42","author":"Shalova","year":"2015","journal-title":"Immunity"},{"key":"B171","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ygeno.2005.03.006","article-title":"Identification and expression of a new type II transmembrane protein in human mast cells","volume":"86","author":"Li","year":"2005","journal-title":"Genomics"},{"key":"B172","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.28937","article-title":"Lentiviral-mediated silencing of mast cell-expressed membrane protein 1 promotes angiogenesis of rats with cerebral ischemic stroke","volume-title":"J Cell Biochem","author":"Jian","year":"2019"},{"key":"B173","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1161\/STROKEAHA.115.011854","article-title":"Peripheral blood MCEMP1 gene expression as a biomarker for stroke prognosis","volume":"47","author":"Raman","year":"2016","journal-title":"Stroke"},{"key":"B174","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrneurol.2016.17","article-title":"Stroke: MCEMP1\u2013a new prognostic and diagnostic biomarker for stroke?","volume":"12","author":"Wood","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3171\/2017.4.JNS17284","article-title":"The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus","volume":"129","author":"Hassel","year":"2018","journal-title":"J Neurosurg"},{"key":"B176","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1074\/jbc.M007603200","article-title":"Three novel components of the human exosome","volume":"276","author":"Brouwer","year":"2001","journal-title":"J Biol Chem"},{"key":"B177","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature12967","article-title":"L-Myc expression by dendritic cells is required for optimal T-cell priming","volume":"507","author":"Kc","year":"2014","journal-title":"Nature"},{"key":"B178","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.bbrc.2012.02.120","article-title":"DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4\/6 and p21Cip1","volume":"420","author":"Lee","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B179","doi-asserted-by":"publisher","first-page":"e12018","DOI":"10.1097\/MD.0000000000012018","article-title":"Gene co-expression network analysis identifies the hub genes associated with immune functions for nocturnal hemodialysis in patients with end-stage renal disease","volume":"97","author":"Dai","year":"2018","journal-title":"Med"},{"key":"B180","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.biochi.2005.11.001","article-title":"Gene expression profiles of U937 human macrophages exposed to Chlamydophila pneumoniae and\/or low density lipoprotein in five study models using differential display and real-time RT-PCR","volume":"88","author":"Lim","year":"2006","journal-title":"Biochimie"},{"key":"B181","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/j.wneu.2019.04.125","article-title":"Analysis of peripheral blood cells' transcriptome in patients with subarachnoid hemorrhage from ruptured aneurysm reveals potential biomarkers","volume":"129","author":"Zhao","year":"2019","journal-title":"World Neurosurg"},{"key":"B182","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1038\/onc.2014.459","article-title":"IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy","volume":"34","author":"Dong","year":"2015","journal-title":"Oncogene"},{"key":"B183","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3389\/fimmu.2012.00426","article-title":"IRGM in autophagy and viral infections","volume":"3","author":"Petkova","year":"2012","journal-title":"Front Immunol"},{"key":"B184","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3390\/cells8020138","article-title":"Modulation of autophagy for controlling immunity","volume":"8","author":"Jang","year":"2019","journal-title":"Cells"},{"key":"B185","doi-asserted-by":"publisher","first-page":"e69575","DOI":"10.1371\/journal.pone.0069575","article-title":"The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro","volume":"8","author":"Welin","year":"2013","journal-title":"PLoS ONE"},{"key":"B186","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/1753425918817611","article-title":"Olfactomedin 4 marks a subset of neutrophils in mice","volume":"25","author":"Alder","year":"2019","journal-title":"Innate Immun"},{"key":"B187","doi-asserted-by":"publisher","first-page":"e426","DOI":"10.1097\/CCM.0000000000002102","article-title":"Olfactomedin-4 Is a candidate marker for a pathogenic neutrophil subset in septic shock","volume":"45","author":"Alder","year":"2017","journal-title":"Crit Care Med"},{"key":"B188","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/SLA.0000000000002406","article-title":"Quantification of immune dysregulation by next-generation polymerase chain reaction to improve sepsis diagnosis in surgical patients","volume":"269","author":"Almansa","year":"2019","journal-title":"Ann Surg"},{"key":"B189","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.4049\/jimmunol.1103179","article-title":"Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice","volume":"189","author":"Liu","year":"2012","journal-title":"J Immunol"},{"key":"B190","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.1172\/JCI68453","article-title":"Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease","volume":"123","author":"Liu","year":"2013","journal-title":"J Clin Invest"},{"key":"B191","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1189\/jlb.0811417","article-title":"Olfactomedin 4 defines a subset of human neutrophils","volume":"91","author":"Clemmensen","year":"2012","journal-title":"J Leukoc Biol"},{"key":"B192","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nature23669","article-title":"Identification of CMTM6 and CMTM4 as PD-L1 protein regulators","volume":"549","author":"Mezzadra","year":"2017","journal-title":"Nature"},{"key":"B193","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/ijerph2006030018","article-title":"Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses","volume":"3","author":"Ayensu","year":"2006","journal-title":"Int J Environ Res Public Health"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.3390\/nu10121920","article-title":"Effects of millimolar steady-state hydrogen peroxide exposure on inflammatory and redox gene expression in immune cells from humans with metabolic syndrome","volume":"10","author":"Busquets-Cortes","year":"2018","journal-title":"Nutrients"},{"key":"B195","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.3389\/fimmu.2018.01644","article-title":"The many and varied roles of tetraspanins in immune cell recruitment and migration","volume":"9","author":"Yeung","year":"2018","journal-title":"Front Immunol"},{"key":"B196","doi-asserted-by":"publisher","first-page":"e0184317","DOI":"10.1371\/journal.pone.0184317","article-title":"Differential expression of tetraspanin superfamily members in dendritic cell subsets","volume":"12","author":"Zuidscherwoude","year":"2017","journal-title":"PLoS ONE"},{"key":"B197","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/j.1399-0039.2004.00271.x","article-title":"Expression of tetraspanins in peripheral blood leukocytes: a comparison between normal and infectious conditions","volume":"64","author":"Tohami","year":"2004","journal-title":"Tissue Antigens"},{"key":"B198","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.celrep.2018.06.026","article-title":"The circadian clock controls immune checkpoint pathway in sepsis","volume":"24","author":"Deng","year":"2018","journal-title":"Cell Rep"},{"key":"B199","doi-asserted-by":"publisher","first-page":"7283","DOI":"10.1074\/jbc.H116.772434","article-title":"Into the linker's DENN: a tyrosine's control of autophagy","volume":"292","author":"Caplan","year":"2017","journal-title":"J Biol Chem"},{"key":"B200","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1074\/jbc.H118.002041","article-title":"A new actin-binding domain glues autophagy together","volume":"293","author":"Wojnacki","year":"2018","journal-title":"J Biol Chem"},{"key":"B201","doi-asserted-by":"publisher","first-page":"4566","DOI":"10.1074\/jbc.RA117.001446","article-title":"A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy","volume":"293","author":"Xu","year":"2018","journal-title":"J Biol Chem"},{"key":"B202","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.1074\/jbc.M116.772434","article-title":"Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction","volume":"292","author":"Xu","year":"2017","journal-title":"J Biol Chem"},{"key":"B203","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1002\/pmic.201400013","article-title":"MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain","volume":"14","author":"Baymaz","year":"2014","journal-title":"Proteomics"},{"key":"B204","doi-asserted-by":"publisher","first-page":"e11982","DOI":"10.1371\/journal.pone.0011982","article-title":"The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA","volume":"5","author":"Laget","year":"2010","journal-title":"PLoS ONE"},{"key":"B205","first-page":"515","article-title":"Host-parasite responses outcome regulate the expression of antimicrobial peptide genes in the skin of balb\/c and c57bl\/6 murine strains following leishmania major mrho\/ir\/75\/er infection","volume":"13","author":"Daneshvar","year":"2018","journal-title":"Iran J Parasitol"},{"key":"B206","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41398-018-0240-5","article-title":"Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus","volume":"8","author":"Luo","year":"2018","journal-title":"Transl Psychiatry"},{"key":"B207","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.4049\/jimmunol.0803577","article-title":"Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2","volume":"183","author":"Lawson","year":"2009","journal-title":"J Immunol"},{"key":"B208","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S1044-579X(03)00022-1","article-title":"HLA-G modulates immune responses by diverse receptor interactions","volume":"13","author":"Hofmeister","year":"2003","journal-title":"Semin Cancer Biol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1096\/fj.04-1617fje","article-title":"HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells","volume":"19","author":"LeMaoult","year":"2005","journal-title":"FASEB J"},{"key":"B210","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1093\/intimm\/dxs082","article-title":"A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4","volume":"24","author":"Li","year":"2012","journal-title":"Int Immunol"},{"key":"B211","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1182\/blood-2010-12-325753","article-title":"A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells","volume":"118","author":"Solito","year":"2011","journal-title":"Blood"},{"key":"B212","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cellimm.2018.07.003","article-title":"IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development","volume":"332","author":"Bah","year":"2018","journal-title":"Cell Immunol"},{"key":"B213","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1007\/s00134-012-2575-3","article-title":"Myeloid-derived suppressor cells in sepsis: friend or foe?","volume":"38","author":"Cuenca","year":"2012","journal-title":"Intensive Care Med"},{"key":"B214","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1177\/1753425917742956","article-title":"Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis","volume":"24","author":"Dai","year":"2018","journal-title":"Innate Immun"},{"key":"B215","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/eji.201847805","article-title":"Impaired antigen-specific lymphocyte priming in mice after Toll-like receptor 4 activation via induction of monocytic myeloid-derived suppressor cells","volume":"49","author":"Tsukamoto","year":"2019","journal-title":"Eur J Immunol"},{"key":"B216","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1471-2156-13-74","article-title":"Characterization of bovine FUT7 furthers understanding of FUT7 evolution in mammals","volume":"13","author":"Laporte","year":"2012","journal-title":"BMC Genet"},{"key":"B217","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.lfs.2017.11.017","article-title":"The alpha1,3-fucosyltransferase FUT7 regulates IL-1beta-induced monocyte-endothelial adhesion via fucosylation of endomucin","volume":"192","author":"Zhang","year":"2018","journal-title":"Life Sci"},{"key":"B218","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1006\/smim.1993.1029","article-title":"T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2","volume":"5","author":"Bierer","year":"1993","journal-title":"Semin Immunol"},{"key":"B219","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0167-5699(96)80617-7","article-title":"The structure and ligand interactions of CD2: implications for T-cell function","volume":"17","author":"Davis","year":"1996","journal-title":"Immunol Today"},{"key":"B220","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1615\/CritRevImmunol.v37.i2-6.130","article-title":"T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles","volume":"37","author":"Wingren","year":"2017","journal-title":"Crit Rev Immunol"},{"key":"B221","first-page":"130","article-title":"Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming","volume-title":"J Clin Invest","author":"Merino","year":"2019"},{"key":"B222","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-immunol-032712-095951","article-title":"Regulation of ligands for the NKG2D activating receptor","volume":"31","author":"Raulet","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/3-540-27743-9_6","article-title":"Immunobiology of human NKG2D and its ligands","volume":"298","author":"Gonzalez","year":"2006","journal-title":"Cur Top Microbiol Immunol"},{"key":"B224","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nri2144","article-title":"Promiscuity and the single receptor: NKG2D","volume":"7","author":"Eagle","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B225","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.4049\/jimmunol.1701618","article-title":"Sepsis-Induced T Cell immunoparalysis: the ins and outs of impaired t cell immunity","volume":"200","author":"Jensen","year":"2018","journal-title":"J Immunol"},{"key":"B226","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1182\/blood-2005-11-4616","article-title":"Gimap4 accelerates T-cell death","volume":"108","author":"Schnell","year":"2006","journal-title":"Blood"},{"key":"B227","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1074\/mcp.M800139-MCP200","article-title":"Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation","volume":"8","author":"Filen","year":"2009","journal-title":"Mol Cell Proteomics : MCP"},{"key":"B228","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/icb.2014.86","article-title":"Tubulin- and actin-associating GIMAP4 is required for IFN-gamma secretion during Th cell differentiation","volume":"93","author":"Heinonen","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"B229","doi-asserted-by":"publisher","first-page":"246","DOI":"10.4049\/jimmunol.1403238","article-title":"The tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages","volume":"195","author":"Tampella","year":"2015","journal-title":"J Immunol"},{"key":"B230","doi-asserted-by":"publisher","first-page":"45935","DOI":"10.1038\/srep45935","article-title":"T-Bet independent development of IFNgamma secreting natural T helper 1 cell population in the absence of Itk","volume":"7","author":"Kannan","year":"2017","journal-title":"Sci Rep"},{"key":"B231","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.4049\/jimmunol.176.3.1571","article-title":"Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help","volume":"176","author":"Atherly","year":"2006","journal-title":"J Immunol"},{"key":"B232","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2006.05.012","article-title":"The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells","volume":"25","author":"Atherly","year":"2006","journal-title":"Immunity"},{"key":"B233","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.immuni.2006.05.011","article-title":"Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk","volume":"25","author":"Broussard","year":"2006","journal-title":"Immunity"},{"key":"B234","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.4049\/jimmunol.180.5.3007","article-title":"The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival","volume":"180","author":"Felices","year":"2008","journal-title":"J Immunol"},{"key":"B235","doi-asserted-by":"publisher","first-page":"5923","DOI":"10.4049\/jimmunol.175.9.5923","article-title":"Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion","volume":"175","author":"Finkelstein","year":"2005","journal-title":"J Immunol"},{"key":"B236","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.4049\/jimmunol.1102475","article-title":"A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice","volume":"188","author":"Qi","year":"2012","journal-title":"J Immunol"},{"key":"B237","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.4049\/jimmunol.181.9.6125","article-title":"Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses","volume":"181","author":"Sahu","year":"2008","journal-title":"J Immunol"},{"key":"B238","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3121\/cmr.4.2.147","article-title":"Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease","volume":"4","author":"Suzuki","year":"2006","journal-title":"Clin Med Res"},{"key":"B239","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.4049\/jimmunol.168.5.2365","article-title":"Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription","volume":"168","author":"Takeba","year":"2002","journal-title":"J Immunol"},{"key":"B240","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.4049\/jimmunol.178.6.3575","article-title":"Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk","volume":"178","author":"Khurana","year":"2007","journal-title":"J Immunol"},{"key":"B241","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejcb.2018.12.003","article-title":"Natural killer cells in sepsis: underprivileged innate immune cells","volume":"98","author":"Kumar","year":"2018","journal-title":"Eur J Cell Biol"},{"key":"B242","doi-asserted-by":"publisher","first-page":"e1007405","DOI":"10.1371\/journal.ppat.1007405","article-title":"Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections","volume":"14","author":"Jensen","year":"2018","journal-title":"PLoS Pathog"},{"key":"B243","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/imm.12854","article-title":"The biology of natural killer cells during sepsis","volume":"153","author":"Guo","year":"2018","journal-title":"Immunology"},{"key":"B244","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12929-018-0455-z","article-title":"IL-33 receptor (ST2) deficiency downregulates myeloid precursors, inflammatory NK and dendritic cells in early phase of sepsis","volume":"25","author":"Babic","year":"2018","journal-title":"J Biomed Sci"},{"key":"B245","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/jhg.2017.76","article-title":"2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio","volume":"62","author":"Lin","year":"2017","journal-title":"J Hum Genet"},{"key":"B246","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1182\/blood-2009-04-214601","article-title":"RUNX1\/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency","volume":"115","author":"Kaur","year":"2010","journal-title":"Blood"},{"key":"B247","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.4103\/0366-6999.209889","article-title":"Effect of platelet-derived p-selectin on neutrophil recruitment in a mouse model of sepsis-induced acute kidney injury","volume":"130","author":"Li","year":"2017","journal-title":"Chinese Med J"},{"key":"B248","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1080\/08820139.2017.1413113","article-title":"Modification of immunological features in human platelets during sepsis","volume":"47","author":"Raque","year":"2018","journal-title":"Immunol Investig"},{"key":"B249","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.21873\/invivo.11169","article-title":"Role for neutrophil extracellular traps (nets) and platelet aggregation in early sepsis-induced hepatic dysfunction","volume":"31","author":"Sakurai","year":"2017","journal-title":"In Vivo"},{"key":"B250","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1080\/09537104.2016.1252837","article-title":"Higher platelet reactivity and platelet-monocyte complex formation in gram-positive sepsis compared to gram-negative sepsis","volume":"28","author":"Tunjungputri","year":"2017","journal-title":"Platelets"},{"key":"B251","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/MBC.0000000000000528","article-title":"Ascorbate inhibits platelet-endothelial adhesion in an in-vitro model of sepsis via reduced endothelial surface P-selectin expression","volume":"28","author":"Secor","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"B252","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3390\/antiox6030049","article-title":"Vitamin C and microvascular dysfunction in systemic inflammation","volume":"6","author":"Tyml","year":"2017","journal-title":"Antioxidants"},{"key":"B253","unstructured":"Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity9059 LiuTF ZhangJW ChenXH FengXR BaiZS LiuML 26679648Beijing Da Xue Xue Bao Yi Xue Ban472015"},{"key":"B254","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.gene.2017.04.041","article-title":"Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function","volume":"624","author":"Zhang","year":"2017","journal-title":"Gene"},{"key":"B255","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/09537104.2018.1428739","article-title":"Platelets and vascular integrity","volume":"29","author":"Deppermann","year":"2018","journal-title":"Platelets"},{"key":"B256","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.smim.2016.10.005","article-title":"Platelets and infection","volume":"28","author":"Deppermann","year":"2016","journal-title":"Semin Immunol"},{"key":"B257","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3109\/09537104.2016.1148129","article-title":"Human platelet activation by Escherichia coli: roles for FcgammaRIIA and integrin alphaIIbbeta3","volume":"27","author":"Watson","year":"2016","journal-title":"Platelets"},{"key":"B258","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1182\/blood-2014-05-575878","article-title":"Platelet 12-LOX is essential for FcgammaRIIa-mediated platelet activation","volume":"124","author":"Yeung","year":"2014","journal-title":"Blood"},{"key":"B259","first-page":"59","article-title":"Clinical studies support a role for trem-like transcript-1 during the progression of sepsis","volume":"102","author":"Esponda","year":"2010","journal-title":"Boletin Asoc Medica Puerto Rico"},{"key":"B260","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1089\/mab.2017.0063","article-title":"The characterization of monoclonal antibodies to mouse tlt-1 suggests that tlt-1 plays a role in wound healing","volume":"37","author":"Manfredi","year":"2018","journal-title":"Monoclo Antib Immunodiagn Immunother"},{"key":"B261","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1172\/JCI36175","article-title":"TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans","volume":"119","author":"Washington","year":"2009","journal-title":"J Clin Invest"},{"key":"B262","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.4049\/jimmunol.1102674","article-title":"Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis","volume":"188","author":"Derive","year":"2012","journal-title":"J Immunol"},{"key":"B263","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/MBC.0b013e3283358116","article-title":"Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization","volume":"21","author":"Morales","year":"2010","journal-title":"Blood Coagul Fibrinolysis"},{"key":"B264","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/cvr\/cvv003","article-title":"Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis","volume":"105","author":"Arita-Okubo","year":"2015","journal-title":"Cardiovasc Res"},{"key":"B265","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1210\/me.2014-1403","article-title":"Selective coregulator function and restriction of steroid receptor chromatin occupancy by Hic-5","volume":"29","author":"Chodankar","year":"2015","journal-title":"Mol Endocrinol"},{"key":"B266","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1091\/mbc.E18-02-0092","article-title":"Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices","volume":"29","author":"Gulvady","year":"2018","journal-title":"Mol Biol Cell"},{"key":"B267","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1096\/fj.14-269894","article-title":"Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-beta","volume":"29","author":"Hornigold","year":"2015","journal-title":"FASEB J"},{"key":"B268","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/j.biopha.2018.04.191","article-title":"TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells","volume":"103","author":"Jiang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B269","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/mi.2017.53","article-title":"IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5","volume":"11","author":"Paul","year":"2018","journal-title":"Mucosal Immunol"},{"key":"B270","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.compbiolchem.2016.07.006","article-title":"An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation","volume":"64","author":"Sahu","year":"2016","journal-title":"Comput Biol Chem"},{"key":"B271","doi-asserted-by":"publisher","first-page":"82506","DOI":"10.18632\/oncotarget.19714","article-title":"Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFbeta1-independent manner","volume":"8","author":"Sheta","year":"2017","journal-title":"Oncotarget"},{"key":"B272","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1021\/acs.jproteome.8b00218","article-title":"Quantitative proteomics implicates rictor\/mtorc2 in cell adhesion","volume":"17","author":"Wang","year":"2018","journal-title":"J Proteome Res"},{"key":"B273","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.biopha.2018.06.127","article-title":"Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells by inhibiting expression of miR-124","volume":"106","author":"Yu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B274","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1055\/s-0037-1616534","article-title":"Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb\/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity","volume":"86","author":"Dicker","year":"2001","journal-title":"Thromb Haemost"},{"key":"B275","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1172\/JCI115468","article-title":"von Willebrand factor binding to platelet GpIb initiates signals for platelet activation","volume":"88","author":"Kroll","year":"1991","journal-title":"J Clin Invest"},{"key":"B276","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1538-7836.2009.03656.x","article-title":"The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules","volume":"8","author":"Munday","year":"2010","journal-title":"J Thromb Haemost : JTH"},{"key":"B277","doi-asserted-by":"publisher","first-page":"5365","DOI":"10.1016\/j.biomaterials.2011.04.011","article-title":"Delineating the roles of the GPIIb\/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin","volume":"32","author":"Sivaraman","year":"2011","journal-title":"Biomaterials"},{"key":"B278","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1055\/s-0038-1648955","article-title":"Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV","volume":"72","author":"Takafuta","year":"1994","journal-title":"Thromb Haemost"},{"key":"B279","first-page":"246","article-title":"The genetics of common variation affecting platelet development, function and pharmaceutical targeting","volume-title":"J Thromb Haemost: JTH","author":"Johnson","year":"2011"},{"key":"B280","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1182\/blood-2004-08-3109","article-title":"Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation","volume":"105","author":"Kanaji","year":"2005","journal-title":"Blood"},{"key":"B281","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/MOH.0b013e3283567526","article-title":"Genetic variants that affect platelet function","volume":"19","author":"Kunicki","year":"2012","journal-title":"Curr Opin Hematol"},{"key":"B282","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/rth2.12033","article-title":"Anti-glycoprotein VI mediated immune thrombocytopenia: an under-recognized and significant entity?","volume":"1","author":"Rabbolini","year":"2017","journal-title":"Res Pract Thromb Haemost"},{"key":"B283","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.numecd.2009.12.002","article-title":"Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians","volume":"21","author":"Shaffer","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis: NMCD"},{"key":"B284","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3324\/haematol.2018.198853","article-title":"High-throughput elucidation of thrombus formation reveals sources of platelet function variability","volume":"104","author":"van Geffen","year":"2019","journal-title":"Haematologica"},{"key":"B285","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1046\/j.1432-1033.2003.03846.x","article-title":"Oxygen tension regulates the expression of a group of procollagen hydroxylases","volume":"270","author":"Hofbauer","year":"2003","journal-title":"Eur J Biochem"},{"key":"B286","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbagrm.2014.10.006","article-title":"Genome-wide identification of hypoxia-inducible factor-1 and\u22122 binding sites in hypoxic human macrophages alternatively activated by IL-10","volume":"1849","author":"Tausendschon","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B287","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/rth2.12058","article-title":"Correlates of plasma and platelet tissue factor pathway inhibitor, factor V, and protein S","volume":"2","author":"Ellery","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"key":"B288","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1182\/blood.V66.6.1452.1452","article-title":"Identification and quantitation of protein S in human platelets","volume":"66","author":"Schwarz","year":"1985","journal-title":"Blood"},{"key":"B289","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.thromres.2014.04.031","article-title":"Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C","volume":"134","author":"Somajo","year":"2014","journal-title":"Thromb Res"},{"key":"B290","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1160\/TH12-08-0622","article-title":"Platelet protein S directly inhibits procoagulant activity on platelets and microparticles","volume":"109","author":"Stavenuiter","year":"2013","journal-title":"Thromb Haemost"},{"key":"B291","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/oxfordjournals.jbchem.a134857","article-title":"Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va","volume":"96","author":"Suzuki","year":"1984","journal-title":"J Biochem"},{"key":"B292","doi-asserted-by":"publisher","first-page":"12769","DOI":"10.1021\/bi00166a009","article-title":"Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles","volume":"31","author":"Dahlback","year":"1992","journal-title":"Biochemistry"},{"key":"B293","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/0268-960X(93)90024-X","article-title":"Platelet alpha-granules","volume":"7","author":"Harrison","year":"1993","journal-title":"Blood reviews"},{"key":"B294","doi-asserted-by":"publisher","first-page":"e0151088","DOI":"10.1371\/journal.pone.0151088","article-title":"Blockade of thrombopoietin reduces organ damage in experimental endotoxemia and polymicrobial sepsis","volume":"11","author":"Cuccurullo","year":"2016","journal-title":"PLoS ONE"},{"key":"B295","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00395-010-0103-6","article-title":"Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum","volume":"105","author":"Lupia","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"B296","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102200","article-title":"Platelets and multi-organ failure in sepsis","volume-title":"Int J Mol Sci","author":"Greco","year":"2017"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00380\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:15:41Z","timestamp":1695978941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00380\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":296,"alternative-id":["10.3389\/fimmu.2020.00380"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00380","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,31]]},"article-number":"380"}}