{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:18:09Z","timestamp":1777943889701,"version":"3.51.4"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00c3\u00ada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00390","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T05:14:19Z","timestamp":1584076459000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["A Proinflammatory Immune Response Might Determine Toxoplasma gondii Vertical Transmission and Severity of Clinical Features in Congenitally Infected Newborns"],"prefix":"10.3389","volume":"11","author":[{"given":"Fernando","family":"G\u00f3mez-Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Ca\u00f1edo-Solares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz Belinda","family":"Ortiz-Alegr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevel","family":"Flores-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Figueroa-Dami\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Luna-Past\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"G\u00f3mez-Toscano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"L\u00f3pez-Candiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Emmanuel","family":"Arce-Estrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Bonilla-R\u00edos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Mora-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Garc\u00eda-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/adc.2006.094870","article-title":"Newborn screening for congenital toxoplasmosis: feasible, but benefits are not established","volume":"91","author":"Gilbert","year":"2006","journal-title":"Arch Dis Child"},{"key":"B2","first-page":"119","volume-title":"Foodborne Parasites. Food Microbiology and Food Safety","author":"Hill","year":"2018"},{"key":"B3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0065-308X(08)60331-0","article-title":"The prevalence and source of Toxoplasma infection in the environment","volume":"28","author":"Jackson","year":"1989","journal-title":"Adv Parasitol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1016\/S0140-6736(98)08220-8","article-title":"Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling","volume":"353","author":"Dunn","year":"1999","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1556\/EuJMI.1.2011.1.3","article-title":"Parasite dissemination and the pathogenesis of toxoplasmosis","volume":"1","author":"Randall","year":"2011","journal-title":"Eur J Microbiol Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1462-5822.2009.01417.x","article-title":"Modelling parasite dissemination: host cell subversion and immune evasion by Toxoplasma gondii","volume":"12","author":"Lambert","year":"2010","journal-title":"Cell Microbiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","article-title":"Toxoplasmosis: a history of clinical observations","volume":"39","author":"Weiss","year":"2009","journal-title":"Int J Parasitol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-017-2565-8","article-title":"Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection","volume":"17","author":"Arce-Estrada","year":"2017","journal-title":"BMC Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.18233\/APM39No6pp321-3331730","article-title":"Toxoplasmosis cong\u00e9nita en el Valle de M\u00e9xico. Resultados de una serie de casos","volume":"39","author":"G\u00f3mez-Toscano","year":"2018","journal-title":"Acta Pediatr Mex"},{"key":"B10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/INF.0b013e31816591df","article-title":"Congenital toxoplasmosis: specific IgG subclasses in mother\/newborn pairs","volume":"27","author":"Ca\u00f1edo-Solares","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/gene.2010.21","article-title":"Congenital toxoplasmosis: candidate host immune genes relevant for vertical transmission and pathogenesis","volume":"11","author":"Ortiz-Alegr\u00eda","year":"2010","journal-title":"Genes Immun"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s10096-016-2656-2","article-title":"Is Toxoplasma gondii type related to clinical outcome in human congenital infection? Systematic and critical review","volume":"35","author":"Rico-Torres","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.micinf.2010.10.002","article-title":"Migratory responses of leukocytes infected with Toxoplasma gondii","volume":"13","author":"Lambert","year":"2011","journal-title":"Microbes Infect"},{"key":"B14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/pim.12163","article-title":"Toxoplasma gondii dissemination: a parasite's journey through the infected host","volume":"37","author":"Harker","year":"2015","journal-title":"Parasite Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1440-1711.2005.01356.x","article-title":"Toxoplasma gondii regulates ICAM-1 mediated monocyte adhesion to trophoblasts","volume":"83","author":"Pfaff","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1017\/S0031182007000200","article-title":"Cellular and molecular physiopathology of congenital toxoplasmosis: the dual role of IFN-gamma","volume":"134","author":"Pfaff","year":"2007","journal-title":"Parasitology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1128\/IAI.72.3.1397-1401.2004","article-title":"Role of NK cells and gamma interferon in transplacental passage of Toxoplasma gondii in a mouse model of primary infection","volume":"72","author":"Abou-Bacar","year":"2004","journal-title":"Infect Immun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.0141-9838.2004.00713.x","article-title":"Role of gamma interferon and T cells in congenital Toxoplasma transmission","volume":"26","author":"Abou-Bacar","year":"2004","journal-title":"Parasite Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2019.00285","article-title":"Maternal immune response during pregnancy and vertical transmission in human toxoplasmosis","volume":"10","author":"G\u00f3mez-Ch\u00e1vez","year":"2019","journal-title":"Front Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3855\/jidc.3858","article-title":"Diagnostic-test evaluation of immunoassays for anti-Toxoplasma gondii IgG antibodies in a random sample of Mexican population","volume":"8","author":"Caballero-Ortega","year":"2014","journal-title":"J Infect Dev Ctries"},{"key":"B21","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/jp.2009.79","article-title":"Toxoplasmosis in pregnancy: determination of IgM, IgG and avidity in filter paper-embedded blood","volume":"29","author":"Ca\u00f1edo-Solares","year":"2009","journal-title":"J Perinatol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/INF.0b013e318241f564","article-title":"Molecular diagnosis and genotyping of cases of perinatal toxoplasmosis in Mexico","volume":"31","author":"Rico-Torres","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"B23","doi-asserted-by":"crossref","first-page":"592 p","DOI":"10.1002\/0471725331","volume-title":"A User's Guide to Principal Components.","author":"Jackson","year":"1991"},{"key":"B24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cellimm.2017.04.004","article-title":"TGF-\u03b21 improving abnormal pregnancy outcomes induced by Toxoplasma gondii infection: regulating NKG2D\/DAP10 and killer subset of decidual NK cells","volume":"317","author":"Xu","year":"2017","journal-title":"Cell Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cyto.2016.07.002","article-title":"TGF-beta in toxoplasmosis: friend or foe?","volume":"86","author":"Zare-Bidaki","year":"2016","journal-title":"Cytokine"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2017.00901","article-title":"The effect of TGF-\u03b2 on Treg cells in adverse pregnancy outcome upon Toxoplasma gondii infection","volume":"8","author":"Zhao","year":"2017","journal-title":"Front Microbiol"},{"key":"B27","first-page":"33","article-title":"Role of TNF and IL-1 in infections with Toxoplasma gondii","volume":"69","author":"Chang","year":"1990","journal-title":"Immunology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1086\/315494","article-title":"Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens","volume":"181","author":"Yamamoto","year":"2000","journal-title":"J Infect Diseases"},{"key":"B29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41590-018-0250-8","article-title":"Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii","volume":"20","author":"Safronova","year":"2019","journal-title":"Nat Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/intimm\/dxy004","article-title":"Host immune responses to Toxoplasma gondii","volume":"30","author":"Sasai","year":"2018","journal-title":"Int Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/eji.200324038","article-title":"The role of interleukin-12 in human infectious diseases: only a faint signature","volume":"33","author":"Fieschi","year":"2003","journal-title":"Eur J Immunol"},{"key":"B32","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.4049\/jimmunol.135.6.4160","article-title":"In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii","volume":"135","author":"Sharma","year":"1985","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1084\/jem.184.1.131","article-title":"A role for CD4+ NK1","volume":"184","author":"Denkers","year":"1996","journal-title":". J Exp Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1084\/jem.179.2.757","article-title":"Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3","volume":"179","author":"Bri\u00e8re","year":"1994","journal-title":"J Exp Med"},{"key":"B35","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.4049\/jimmunol.163.9.4707","article-title":"Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation","volume":"163","author":"Deenick","year":"1999","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.micinf.2005.11.013","article-title":"Immunization with MIC1 and MIC4 induces protective immunity against Toxoplasma gondii","volume":"8","author":"Louren\u00e7o","year":"2006","journal-title":"Microbes Infect"},{"key":"B37","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/j.1365-3024.2007.00982.x","article-title":"Congenital and acquired toxoplasmosis: diversity and role of antibodies in different compartments of the host","volume":"29","author":"Correa","year":"2007","journal-title":"Parasite Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/infdis\/jiu189","article-title":"Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines","volume":"210","author":"Pernas","year":"2014","journal-title":"J Infect Dis"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e12660","DOI":"10.1111\/aji.12660","article-title":"Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor expression and cytokine\/chemokine profiles","volume":"78","author":"Castillo","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2019.00852","article-title":"Increased Toxoplasma gondii intracellular proliferation in human extravillous trophoblast cells (HTR8\/SVneo line) is sequentially triggered by MIF, ERK1\/2, and COX-2","volume":"10","author":"Milian","year":"2019","journal-title":"Front Microbiol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"12733","DOI":"10.1074\/jbc.M112.419911","article-title":"Biochemical and immunological characterization of Toxoplasma gondii macrophage migration inhibitory factor","volume":"288","author":"Sommerville","year":"2013","journal-title":"J Biol Chem"},{"key":"B42","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.placenta.2013.12.013","article-title":"Susceptibility to Toxoplasma gondii proliferation in BeWo human trophoblast cells is dose-dependent of macrophage migration inhibitory factor (MIF), via ERK1\/2 phosphorylation and prostaglandin E2 production","volume":"35","author":"Barbosa","year":"2014","journal-title":"Placenta"},{"key":"B43","doi-asserted-by":"publisher","first-page":"789","DOI":"10.2217\/imt.11.68","article-title":"The CD8 T-cell road to immunotherapy of toxoplasmosis","volume":"3","author":"Bhadra","year":"2011","journal-title":"Immunotherapy"},{"key":"B44","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.micinf.2005.08.008","article-title":"T cell mediated immune responses to Toxoplasma gondii in pregnant women with primary toxoplasmosis","volume":"8","author":"Abou-Bacar","year":"2006","journal-title":"Microbes Infect"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1016\/j.ajpath.2011.02.005","article-title":"Effect of macrophage migration inhibitory factor (MIF) in human placental explants infected with Toxoplasma gondii depends on gestational age","volume":"178","author":"Gomes","year":"2011","journal-title":"Am J Pathol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2353\/ajpath.2008.070432","article-title":"Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants","volume":"172","author":"Ferro","year":"2008","journal-title":"Am J Pathol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nri.2017.64","article-title":"The unique immunological and microbial aspects of pregnancy","volume":"17","author":"Mor","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B48","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/B0-72-160537-0\/50033-5","article-title":"Toxoplasmosis","volume-title":"Infectious Diseases of the Fetus and Newborn Infant","author":"Remington","year":"2006"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4966","DOI":"10.1128\/IAI.72.9.4966-4972.2004","article-title":"CD4+ T cells in the pathogenesis of murine ocular toxoplasmosis","volume":"72","author":"Lu","year":"2004","journal-title":"Infect Immun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1084\/jem.184.2.597","article-title":"Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii","volume":"184","author":"Liesenfeld","year":"1996","journal-title":"J Exp Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1001\/pubs.Ophthalmol.-ISSN-0003-9950-119-1-ecs90186","article-title":"Histopathological features of ocular toxoplasmosis in the fetus and infant","volume":"119","author":"Roberts","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"910621","DOI":"10.1155\/2014\/910621","article-title":"Biomarker analysis revealed distinct profiles of innate and adaptive immunity in infants with ocular lesions of congenital toxoplasmosis","volume":"2014","author":"Machado","year":"2014","journal-title":"Mediators Inflamm"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1093\/infdis\/jiw041","article-title":"Cytokine signatures associated with early onset, active lesions and late cicatricial events of retinochoroidal commitment in infants with congenital toxoplasmosis","volume":"213","author":"Carneiro","year":"2016","journal-title":"J Infect Dis"},{"key":"B54","doi-asserted-by":"publisher","first-page":"8357","DOI":"10.4049\/jimmunol.179.12.8357","article-title":"Death receptor ligation or exposure to perforin trigger rapid egress of the intracellular parasite Toxoplasma gondii","volume":"179","author":"Persson","year":"2007","journal-title":"J Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"8485","DOI":"10.4049\/jimmunol.181.12.8485","article-title":"Dendritic cells expressing plasmacytoid marker PDCA-1 are trojan horses during Toxoplasma gondii infection","volume":"181","author":"Bierly","year":"2008","journal-title":"J Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jneuroim.2010.10.029","article-title":"Intracellular transport of Toxoplasma gondii through the blood-brain barrier","volume":"232","author":"Lachenmaier","year":"2011","journal-title":"J Neuroimmunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/sj.icb.7100038","article-title":"Cytokine regulation of immunopathology in toxoplasmosis","volume":"85","author":"Gaddi","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"B58","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5375","DOI":"10.4049\/jimmunol.164.10.5375","article-title":"IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB\/c and susceptible C57BL\/6 mice following peroral infection with Toxoplasma gondii","volume":"164","author":"Suzuki","year":"2000","journal-title":"J Immunol"},{"key":"B60","first-page":"2591","article-title":"IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxin-induced uveitis","volume":"41","author":"Ohta","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/eji.200738109","article-title":"Critical role of IL-2 and TGF-\u03b2 in generation, function and stabilization of Foxp3+CD4+ Treg","volume":"38","author":"Horwitz","year":"2008","journal-title":"Eur J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3389\/fimmu.2018.00125","article-title":"Critical role of TGF-\u03b2 and IL-2 receptor signaling in Foxp3 induction by an inhibitor of DNA methylation","volume":"9","author":"Freudenberg","year":"2018","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00390\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T15:04:18Z","timestamp":1695913458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00390\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":62,"alternative-id":["10.3389\/fimmu.2020.00390"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00390","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,13]]},"article-number":"390"}}