{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:24:20Z","timestamp":1773854660933,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00450","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T14:10:18Z","timestamp":1584108618000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response"],"prefix":"10.3389","volume":"11","author":[{"given":"Sebastian","family":"Beck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zickler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius","family":"Pinho dos Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Grundhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick T.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak W.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Stanelle-Bertram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u015fah","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/82_2014_386","article-title":"Molecular determinants of pathogenicity in the polymerase complex","volume":"385","author":"Gabriel","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1371\/journal.ppat.0040011","article-title":"Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus","volume":"4","author":"Gabriel","year":"2008","journal-title":"PLoS Pathog"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1002488","DOI":"10.1371\/journal.ppat.1002488","article-title":"Human-like PB2 627K influenza virus polymerase activity is regulated by importin-alpha1 and -alpha7","volume":"8","author":"Hudjetz","year":"2012","journal-title":"PLoS Pathog"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1000136","DOI":"10.1371\/journal.ppat.1000136","article-title":"Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit","volume":"4","author":"Tarendeau","year":"2008","journal-title":"PLoS Pathog"},{"key":"B5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ejcb.2015.05.012","article-title":"Adaptive mutation PB2 D701N promotes nuclear import of influenza vRNPs in mammalian cells","volume":"94","author":"Sediri","year":"2015","journal-title":"Eur J Cell Biol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.ajpath.2016.12.017","article-title":"H7N9 Influenza A virus exhibits importin-alpha7-mediated replication in the mammalian respiratory tract","volume":"187","author":"Bertram","year":"2017","journal-title":"Am J Pathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/ncomms1158","article-title":"Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus","volume":"2","author":"Gabriel","year":"2011","journal-title":"Nat Commun"},{"key":"B8","doi-asserted-by":"publisher","first-page":"8166","DOI":"10.1128\/JVI.00270-14","article-title":"Importin-alpha7 is required for enhanced influenza A virus replication in the alveolar epithelium and severe lung damage in mice","volume":"88","author":"Resa-Infante","year":"2014","journal-title":"J Virol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1002\/bies.201400058","article-title":"Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications","volume":"36","author":"Reilly","year":"2014","journal-title":"Bioessays"},{"key":"B10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature16474","article-title":"Species difference in ANP32A underlies influenza A virus polymerase host restriction","volume":"529","author":"Long","year":"2016","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e08939","DOI":"10.7554\/eLife.08939","article-title":"pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA","volume":"4","author":"Sugiyama","year":"2015","journal-title":"Elife"},{"key":"B12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.chom.2008.06.007","article-title":"An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase","volume":"4","author":"Mehle","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e00217-19","DOI":"10.1128\/JVI.00217-19","article-title":"ANP32 proteins are essential for influenza virus replication in human cells","volume":"93","author":"Staller","year":"2019","journal-title":"J Virol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e00174-19","DOI":"10.1128\/JVI.00174-19","article-title":"Fundamental contribution and host range determination of ANP32A and ANP32B in influenza A virus polymerase activity","volume":"93","author":"Zhang","year":"2019","journal-title":"J Virol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/82_2014_388","article-title":"Molecular determinants of influenza virus pathogenesis in mice","volume":"385","author":"Kamal","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"4744","DOI":"10.1128\/JVI.03799-13","article-title":"TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice","volume":"88","author":"Tarnow","year":"2014","journal-title":"J Virol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e13597","DOI":"10.1371\/journal.pone.0013597","article-title":"Generation and characterization of the Anp32e-deficient mouse","volume":"5","author":"Reilly","year":"2010","journal-title":"PLoS ONE"},{"key":"B18","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.1038\/s41598-019-41269-z","article-title":"The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice","volume":"9","author":"Chemnitz","year":"2019","journal-title":"Sci Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ajpath.2011.03.041","article-title":"Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models","volume":"179","author":"Otte","year":"2011","journal-title":"Am J Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1074\/jbc.M608849200","article-title":"Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression","volume":"282","author":"Fries","year":"2007","journal-title":"J Biol Chem"},{"key":"B21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"4","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.chom.2010.05.008","article-title":"Cellular networks involved in the influenza virus life cycle","volume":"7","author":"Watanabe","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e01162-19","DOI":"10.1128\/mBio.01162-19","article-title":"Low polymerase activity attributed to PA drives the acquisition of the PB2 E627K mutation of H7N9 avian influenza virus in mammals","volume":"10","author":"Liang","year":"2019","journal-title":"MBio"},{"key":"B27","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.chom.2014.11.002","article-title":"Influenza virus-host interactome screen as a platform for antiviral drug development","volume":"16","author":"Watanabe","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1128\/MCB.01396-07","article-title":"Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5","volume":"28","author":"Munemasa","year":"2008","journal-title":"Mol Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e2082","DOI":"10.1038\/cddis.2016.8","article-title":"ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation","volume":"7","author":"Yang","year":"2016","journal-title":"Cell Death Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00450\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T14:10:21Z","timestamp":1584108621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00450\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":29,"alternative-id":["10.3389\/fimmu.2020.00450"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00450","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,13]]},"article-number":"450"}}