{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:54Z","timestamp":1792099854419,"version":"4.4.0"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI 079705"],"award-info":[{"award-number":["R01 AI 079705"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI 105813"],"award-info":[{"award-number":["R01 AI 105813"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI138944"],"award-info":[{"award-number":["T32 AI138944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007820","name":"Alliance for Lupus Research","doi-asserted-by":"publisher","award":["ALR 641363"],"award-info":[{"award-number":["ALR 641363"]}],"id":[{"id":"10.13039\/100007820","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00491","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T04:34:59Z","timestamp":1585024499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a"],"prefix":"10.3389","volume":"11","author":[{"given":"Paolo","family":"Casali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Chupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.it.2013.03.006","article-title":"Epigenetics of the antibody response","volume":"34","author":"Li","year":"2013","journal-title":"Trends Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3389\/fimmu.2015.00631","article-title":"Epigenetics of peripheral B-cell differentiation and the antibody response","volume":"6","author":"Zan","year":"2015","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1172\/JCI0214873","article-title":"Estrogen alters thresholds for B cell apoptosis and activation","volume":"109","author":"Grimaldi","year":"2002","journal-title":"J Clin Invest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1177\/0961203308089402","article-title":"Hormonal regulation of B-cell function and systemic lupus erythematosus","volume":"17","author":"Cohen-Solal","year":"2008","journal-title":"Lupus"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1016\/j.vaccine.2008.04.054","article-title":"Sexual dimorphism of humoral immunity with human vaccines","volume":"26","author":"Cook","year":"2008","journal-title":"Vaccine"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1016\/j.vaccine.2011.01.080","article-title":"17beta-Estradiol restores antibody responses to an influenza vaccine in a postmenopausal mouse model","volume":"29","author":"Nguyen","year":"2011","journal-title":"Vaccine."},{"key":"B7","doi-asserted-by":"publisher","first-page":"J282","DOI":"10.1016\/j.jaut.2011.11.013","article-title":"Sex affects immunity","volume":"38","author":"Pennell","year":"2012","journal-title":"J Autoimmun"},{"key":"B8","doi-asserted-by":"publisher","first-page":"A479","DOI":"10.1016\/j.autrev.2011.11.022","article-title":"The influence of sex and gender on the immune response","volume":"11","author":"Oertelt-Prigione","year":"2012","journal-title":"Autoimmun Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3389\/fimmu.2015.00635","article-title":"The immune system is a natural target for estrogen action: opposing effects of estrogen in two prototypical autoimmune diseases","volume":"6","author":"Khan","year":"2015","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nrrheum.2014.144","article-title":"Modulation of autoimmune rheumatic diseases by oestrogen and progesterone","volume":"10","author":"Hughes","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3389\/fimmu.2015.00568","article-title":"Estrogen signaling modulates allergic inflammation and contributes to sex differences in asthma","volume":"6","author":"Keselman","year":"2015","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.3389\/fimmu.2018.02455","article-title":"Hormonal regulation of physiology, innate immunity and antibody response to H1N1 influenza virus infection during pregnancy","volume":"9","author":"Littauer","year":"2018","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.3389\/fimmu.2018.02302","article-title":"Sex-dependent outcome of hepatitis B and C viruses infections: synergy of sex hormones and immune responses?","volume":"9","author":"Ruggieri","year":"2018","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fimmu.2018.00478","article-title":"Our environment shapes us: the importance of environment and sex differences in regulation of autoantibody production","volume":"9","author":"Edwards","year":"2018","journal-title":"Front Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.3389\/fimmu.2018.01931","article-title":"Sex hormones determine immune response","volume":"9","author":"Taneja","year":"2018","journal-title":"Front Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.3389\/fimmu.2018.02279","article-title":"Sex hormones in acquired immunity and autoimmune disease","volume":"9","author":"Moulton","year":"2018","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nri3216","article-title":"Immunoglobulin class-switch DNA recombination: induction, targeting and beyond","volume":"12","author":"Xu","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Classs witch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)","volume":"102","author":"Revy","year":"2000","journal-title":"Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/08916934.2012.749244","article-title":"Regulation of Aicda expression and AID activity","volume":"46","author":"Zan","year":"2013","journal-title":"Autoimmunity"},{"key":"B22","doi-asserted-by":"crossref","first-page":"eaay2793","DOI":"10.1126\/sciadv.aay2793","article-title":"B cell Sirt1 deacetylates histone and non-histone proteins to modulate AID expression and the antibody response","volume":"6","author":"Gan","year":"2020","journal-title":"Sci Adv"},{"key":"B23","doi-asserted-by":"publisher","first-page":"5933","DOI":"10.4049\/jimmunol.1401702","article-title":"Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses","volume":"193","author":"White","year":"2014","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3389\/fimmu.2015.00627","article-title":"Genome-wide analysis reveals selective modulation of microRNAs and mRNAs by histone deacetylase Inhibitor in B cells induced to undergo class-switch DNA recombination and plasma cell differentiation","volume":"6","author":"Shen","year":"2015","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41467-019-13603-6","article-title":"B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids","volume":"11","author":"Sanchez","year":"2020","journal-title":"Nat Commun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3109\/08916934.2014.915955","article-title":"MicroRNAs in lupus","volume":"47","author":"Zan","year":"2014","journal-title":"Autoimmunity"},{"key":"B27","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/ni.1725","article-title":"HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation","volume":"10","author":"Park","year":"2009","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"37797","DOI":"10.1074\/jbc.M110.169086","article-title":"Estrogen receptors bind to and activate the HOXC4\/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation","volume":"285","author":"Mai","year":"2010","journal-title":"J Biol Chem"},{"key":"B29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2119\/molmed.2010.00172","article-title":"Differential roles of estrogen receptors alpha and beta in control of B-cell maturation and selection","volume":"17","author":"Hill","year":"2011","journal-title":"Mol Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4161\/epi.23790","article-title":"Epigenetic regulation of estrogen signaling in breast cancer","volume":"8","author":"Hervouet","year":"2013","journal-title":"Epigenetics"},{"key":"B31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.tem.2012.03.002","article-title":"miRNAs and estrogen action","volume":"23","author":"Klinge","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"B32","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.mce.2015.01.035","article-title":"miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets","volume":"418","author":"Klinge","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"R40","DOI":"10.1186\/bcr3644","article-title":"Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2","volume":"16","author":"Tan","year":"2014","journal-title":"Breast Cancer Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"11162","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1084\/jem.20061952","article-title":"Regulation of AID expression in the immune response","volume":"204","author":"Crouch","year":"2007","journal-title":"J Exp Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.bbrc.2012.07.016","article-title":"Generation of ERalpha-floxed and knockout mice using the Cre\/LoxP system","volume":"424","author":"Antonson","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/sj.bjc.6603851","article-title":"Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial","volume":"97","author":"Atmaca","year":"2007","journal-title":"Br J Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1200\/JCO.2006.08.6165","article-title":"Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study","volume":"25","author":"Munster","year":"2007","journal-title":"J Clin Oncol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3109\/08916934.2011.577128","article-title":"AID dysregulation in lupus-prone MRL\/Fas(lpr\/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc\/IgH loci translocations: modulation by HoxC4","volume":"44","author":"White","year":"2011","journal-title":"Autoimmunity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.2741\/4073","article-title":"B cell TLRs and induction of immunoglobulin class-switch DNA recombination","volume":"17","author":"Pone","year":"2012","journal-title":"Front Biosci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"14244","DOI":"10.1038\/ncomms14244","article-title":"Rad52 competes with Ku70\/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination","volume":"8","author":"Zan","year":"2017","journal-title":"Nat Commun"},{"key":"B42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.exphem.2008.12.002","article-title":"Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL\/lpr(-\/-) murine model of autoimmune lymphoproliferative syndrome (ALPS)","volume":"37","author":"Dowdell","year":"2009","journal-title":"Exp Hematol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/ng.2007.30","article-title":"Wide spread microRNA repression by Myc contributes to tumorigenesis","volume":"40","author":"Chang","year":"2008","journal-title":"Nat Genet"},{"key":"B44","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1073\/pnas.1200677109","article-title":"Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A","volume":"109","author":"Chaudhuri","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/nsmb.1884","article-title":"14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination","volume":"17","author":"Xu","year":"2010","journal-title":"Nat Struct Mol Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.molmed.2011.07.005","article-title":"Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases","volume":"17","author":"Hedrich","year":"2011","journal-title":"Trends Mol Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"864","DOI":"10.4103\/1008-682X.129132","article-title":"Physiological normal levels of androgen inhibit proliferation of prostate cancer cells in vitro","volume":"16","author":"Song","year":"2014","journal-title":"Asian J Androl"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1210\/en.2003-0567","article-title":"Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype","volume":"144","author":"Frasor","year":"2003","journal-title":"Endocrinology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1677\/JME-08-0103","article-title":"Non-classical genomic estrogen receptor (ER)\/specificity protein and ER\/activating protein-1 signaling pathways","volume":"41","author":"Safe","year":"2008","journal-title":"J Mol Endocrinol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1210\/me.2003-0217","article-title":"An activator protein 1-like motif mediates 17beta-estradiol repression of gonadotropin-releasing hormone receptor promoter via an estrogen receptor alpha-dependent mechanism in ovarian and breast cancer cells","volume":"17","author":"Cheng","year":"2003","journal-title":"Mol Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"16272","DOI":"10.1074\/jbc.M513405200","article-title":"Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter","volume":"281","author":"Stossi","year":"2006","journal-title":"J Biol Chem"},{"key":"B52","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1210\/mend.12.7.0133","article-title":"FRA-1 expression level modulates regulation of activator protein-1 activity by estradiol in breast cancer cells","volume":"12","author":"Philips","year":"1998","journal-title":"Mol Endocrinol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"13615","DOI":"10.1074\/jbc.M008384200","article-title":"Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway","volume":"276","author":"Jakacka","year":"2001","journal-title":"J Biol Chem"},{"key":"B54","doi-asserted-by":"publisher","first-page":"48479","DOI":"10.1074\/jbc.C200570200","article-title":"Mutationsin the estrogen receptor DNA-binding domain discriminate between the classical mechanism of action and cross-talk with Stat5b and activating protein 1 (AP-1)","volume":"277","author":"Bjornstrom","year":"2002","journal-title":"J Biol Chem"},{"key":"B55","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1210\/me.2004-0486","article-title":"Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes","volume":"19","author":"Bjornstrom","year":"2005","journal-title":"Mol Endocrinol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"13444","DOI":"10.1074\/jbc.M109.062430","article-title":"Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex","volume":"285","author":"Suzuki","year":"2010","journal-title":"J Biol Chem"},{"key":"B57","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2174\/138920206779315737","article-title":"Estrogen signaling multiple pathways to impact gene transcription","volume":"7","author":"Marino","year":"2006","journal-title":"Curr Genomics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mce.2008.04.003","article-title":"New insights into the classical and non-classical actions of estrogen: evidence from estrogen receptor knock-out and knock-in mice","volume":"290","author":"McDevitt","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1210\/me.2011-1037","article-title":"Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor","volume":"25","author":"Wang","year":"2011","journal-title":"Mol Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.4049\/jimmunol.1601166","article-title":"Sex drives dimorphic immune responses to viral infections","volume":"198","author":"Ghosh","year":"2017","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1093\/ije\/23.5.1078","article-title":"Sex differences in the humoral antibody response to live measles vaccine in young adults","volume":"23","author":"Green","year":"1994","journal-title":"Int J Epidemiol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1056\/NEJMoa011915","article-title":"GlaxoSmithKline herpes vaccine efficacy study. Glycoprotein-D-adjuvant vaccine to prevent genital herpes","volume":"347","author":"Stanberry","year":"2002","journal-title":"N Engl J Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.humimm.2004.07.001","article-title":"The contribution of HLA class I antigens in immune status following two doses of rubella vaccination","volume":"65","author":"Ovsyannikova","year":"2004","journal-title":"Hum Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.0141-9838.2004.00710.x","article-title":"Hormonal and immunological mechanisms mediating sex differences in parasite infection","volume":"26","author":"Klein","year":"2004","journal-title":"Parasite Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2893.2005.00658.x","article-title":"Response to hepatitis a vaccine in HIV-positive patients","volume":"13","author":"Weissman","year":"2006","journal-title":"J Viral Hepat"},{"key":"B66","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1399-0039.2008.01097.x","article-title":"Associations between cytokine\/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population","volume":"72","author":"Dhiman","year":"2008","journal-title":"Tissue Antigens"},{"key":"B67","doi-asserted-by":"publisher","first-page":"6165","DOI":"10.1016\/j.vaccine.2008.08.045","article-title":"Intranasaland subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone","volume":"26","author":"Bhavanam","year":"2008","journal-title":"Vaccine"},{"key":"B68","doi-asserted-by":"publisher","first-page":"5830","DOI":"10.1016\/j.vaccine.2009.07.052","article-title":"Estradiol improves genital herpes vaccine efficacy in mice","volume":"27","author":"Pennock","year":"2009","journal-title":"Vaccine"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.1016\/j.vaccine.2009.01.086","article-title":"Gender effects on humoral immune responses to smallpox vaccine","volume":"27","author":"Kennedy","year":"2009","journal-title":"Vaccine"},{"key":"B70","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S1473-3099(10)70049-9","article-title":"The Xs and Y of immune responses to viral vaccines","volume":"10","author":"Klein","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1002\/bies.201200099","article-title":"Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases","volume":"34","author":"Klein","year":"2012","journal-title":"Bioessays"},{"key":"B72","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.it.2013.10.006","article-title":"SeXX matters in immunity","volume":"35","author":"Markle","year":"2014","journal-title":"Trends Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/trstmh\/tru167","article-title":"Sex-based differences in immune function and responses to vaccination","volume":"109","author":"Klein","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"B74","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cophys.2018.03.010","article-title":"The evolution of greater humoral immunity in females than males: implications for vaccine efficacy","volume":"6","author":"Fink","year":"2018","journal-title":"Curr Opin Physiol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00281-018-0726-5","article-title":"Sex differences in vaccine-induced humoral immunity","volume":"41","author":"Fischinger","year":"2019","journal-title":"Semin Immunopathol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"6699","DOI":"10.1016\/j.vaccine.2007.07.015","article-title":"Effect of influenza vaccine status on winter mortality in Spanish community-dwelling elderly people during 2002-2005 influenza periods","volume":"25","author":"Vila-Corcoles","year":"2007","journal-title":"Vaccine"},{"key":"B77","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1016\/S0264-410X(02)00181-0","article-title":"Efficacy and cost-effectiveness of influenza vaccination of the elderly in a densely populated and unvaccinated community","volume":"20","author":"Wang","year":"2002","journal-title":"Vaccine"},{"key":"B78","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1017\/S095026880005874X","article-title":"Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989-90 using a general practice database","volume":"115","author":"Fleming","year":"1995","journal-title":"Epidemiol Infect"},{"key":"B79","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1532-5415.1999.tb04574.x","article-title":"Effectiveness of inactivated influenza vaccine among nursing home residents during an influenza type A (H3N2) epidemic","volume":"47","author":"Ohmit","year":"1999","journal-title":"J Am Geriatr Soc"},{"key":"B80","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1053\/ajkd.2002.34521","article-title":"Southwest pediatric nephrology study. Response to recombinant hepatitis B vaccine in children and adolescents with chronic renal failure","volume":"40","author":"Watkins","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1016\/S0140-6736(02)08764-0","article-title":"Hepatitis A vaccine failure","volume":"359","author":"Elliott","year":"2002","journal-title":"Lancet"},{"key":"B82","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/hep.20006","article-title":"Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination","volume":"39","author":"Chen","year":"2004","journal-title":"Hepatology"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1001\/archinternmed.2008.513","article-title":"Half- vs full-dose trivalent inactivated influenza vaccine. (2004-2005): age, dose, and sex effects on immune responses","volume":"168","author":"Engler","year":"2008","journal-title":"Arch Intern Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-cellbio-100616-060718","article-title":"Sex and gender differences in the outcomes of vaccination over the life course","volume":"33","author":"Flanagan","year":"2017","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41586-019-1873-0","article-title":"AGPR174-CCL21 module imparts sexual dimorphism to humoral immunity","volume":"577","author":"Zhao","year":"2020","journal-title":"Nature"},{"key":"B86","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1191\/0961203304lu1094oa","article-title":"Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity","volume":"13","author":"Cutolo","year":"2004","journal-title":"Lupus"},{"key":"B87","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1136\/ard.42.4.471","article-title":"Systemic lupus erythematosus and Klinefelter's syndrome","volume":"42","author":"French","year":"1983","journal-title":"Ann Rheum Dis"},{"key":"B88","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/01.rhu.0000256169.05087.ad","article-title":"New onset systemic lupus erythematosus in a transgender man: possible role of feminizing sex hormones","volume":"13","author":"Santos-Ocampo","year":"2007","journal-title":"J Clin Rheumatol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1177\/0961203313500550","article-title":"Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited","volume":"22","author":"Chan","year":"2013","journal-title":"Lupus"},{"key":"B90","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/0961203317734921","article-title":"Significant symptomatic improvement of subacute cutaneous lupus after testosterone therapy in a female-to-male transgender subject","volume":"27","author":"Ocon","year":"2018","journal-title":"Lupus"},{"key":"B91","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1006\/cimm.1998.1372","article-title":"Estrogen increases the number of plasma cells and enhances their autoantibody production in nonautoimmune C57BL\/6 mice","volume":"189","author":"Verthelyi","year":"1998","journal-title":"Cell Immunol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/iid3.37","article-title":"Effects of lasofoxifene and bazedoxifene on B cell development and function","volume":"2","author":"Bernardi","year":"2014","journal-title":"Immun Inflamm Dis"},{"key":"B93","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/S0091-6749(99)70503-8","article-title":"Estrogen enhances immunoglobulin production by human PBMCs","volume":"103","author":"Kanda","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1177\/0961203314559636","article-title":"17-\u03b2-estradiol affects BLyS serum levels and the nephritogenic autoantibody network accelerating glomerulonephritis in NZB\/WF1 mice","volume":"24","author":"Bassi","year":"2015","journal-title":"Lupus."},{"key":"B95","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/sj.gene.6364458","article-title":"Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice","volume":"9","author":"Bynote","year":"2008","journal-title":"Genes Immun"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1002\/art.24548","article-title":"Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB\/NZW mice","volume":"60","author":"Hughes","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B97","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"e72503","DOI":"10.1371\/journal.pone.0072503","article-title":"Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination","volume":"8","author":"Tang","year":"2013","journal-title":"PLoS ONE"},{"key":"B99","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.molcel.2009.10.006","article-title":"Hormonal regulation of microRNA biogenesis","volume":"36","author":"Macias","year":"2009","journal-title":"Mol Cell"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/ni.3519","article-title":"Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation","volume":"17","author":"Barwick","year":"2016","journal-title":"Nat Immunol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cell.2013.12.019","article-title":"ReversingDNA methylation: mechanisms, genomics, and biological functions","volume":"156","author":"Wu","year":"2014","journal-title":"Cell"},{"key":"B102","doi-asserted-by":"publisher","first-page":"17892","DOI":"10.1073\/pnas.1317397110","article-title":"MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation","volume":"110","author":"Fu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B103","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.celrep.2013.08.050","article-title":"Anextensive network of TET2-targeting microRNAs regulates malignant hematopoiesis","volume":"5","author":"Cheng","year":"2013","journal-title":"Cell Rep"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1158\/2159-8290.CD-18-0657","article-title":"Melnick. TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation, and promotes B-cell lymphomagenesis","volume":"8","author":"Dominguez","year":"2018","journal-title":"Cancer Discov"},{"key":"B105","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.semcancer.2011.07.001","article-title":"MicroRNA and DNA methylation alterations mediating retinoic acid induced neuroblastoma cell differentiation","volume":"21","author":"Stallings","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s12885-015-1495-3","article-title":"Estrogen receptor alpha enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner","volume":"15","author":"Cao","year":"2015","journal-title":"BMC Cancer"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1101\/gad.1777409","article-title":"The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo","volume":"23","author":"Huse","year":"2009","journal-title":"Genes Dev"},{"key":"B108","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1084\/jem.20021101","article-title":"Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination","volume":"197","author":"Suzuki","year":"2003","journal-title":"J Exp Med"},{"key":"B109","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.immuni.2006.08.015","article-title":"Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling","volume":"25","author":"Omori","year":"2006","journal-title":"Immunity"},{"key":"B110","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ni.2640","article-title":"Commensal bacteria at the interface of host metabolism and the immune system","volume":"14","author":"Brestoff","year":"2013","journal-title":"Nat Immunol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"B112","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/imr.12556","article-title":"The nutrition-gut microbiome-physiology axis and allergic diseases","volume":"278","author":"McKenzie","year":"2017","journal-title":"Immunol Rev"},{"key":"B113","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.tem.2016.08.001","article-title":"Estrogen and microbiota crosstalk: should we pay attention?","volume":"27","author":"Chen","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"B114","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.maturitas.2017.06.025","article-title":"Estrogen-gut microbiome axis: physiological and clinical implications","volume":"103","author":"Baker","year":"2017","journal-title":"Maturitas"},{"key":"B115","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41385-019-0192-y","article-title":"The antibody\/microbiota interface in health and disease","volume":"13","author":"Sterlin","year":"2020","journal-title":"Mucosal Immunol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3389\/fimmu.2018.00439","article-title":"Interrelation of diet, gut microbiome, and autoantibody production","volume":"9","author":"Petta","year":"2018","journal-title":"Front Immunol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1210\/endo.143.8.8974","article-title":"Gastric parietal cells: potent endocrine role in secreting estrogen as a possible regulator of gastro-hepatic axis","volume":"143","author":"Ueyama","year":"2002","journal-title":"Endocrinology"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1016\/j.lfs.2003.10.005","article-title":"Estrogen-producing steroidogenic pathways in parietal cells of the rat gastric mucosa","volume":"74","author":"Ueyama","year":"2004","journal-title":"Life Sci"},{"key":"B119","doi-asserted-by":"publisher","first-page":"159845","DOI":"10.1155\/2009\/159845","article-title":"Sex disparity in food allergy: evidence from the PubMed database","volume":"2009","author":"Kelly","year":"2009","journal-title":"J Allergy"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00491\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T20:00:39Z","timestamp":1614974439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00491\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":119,"alternative-id":["10.3389\/fimmu.2020.00491"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00491","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]},"article-number":"491"}}