{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:15:31Z","timestamp":1792023331029,"version":"4.4.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202865\/Z\/16\/Z"],"award-info":[{"award-number":["202865\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00495","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T04:43:29Z","timestamp":1584679409000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The Impact of Type 1 Interferons on Alveolar Macrophage Tolerance and Implications for Host Susceptibility to Secondary Bacterial Pneumonia"],"prefix":"10.3389","volume":"11","author":[{"given":"Emma","family":"Connolly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hussell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1004923","DOI":"10.1371\/journal.ppat.1004923","article-title":"The lung microbiome: new principles for respiratory bacteriology in health and disease","volume":"11","author":"Dickson","year":"2015","journal-title":"PLoS Pathog."},{"key":"B2","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nature06245","article-title":"An ecological and evolutionary perspective on human-microbe mutualism and disease","volume":"449","author":"Dethlefsen","year":"2007","journal-title":"Nature."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.3389\/fimmu.2018.02345","article-title":"Resolving viral-induced secondary bacterial infection in COPD: a concise review","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.1128\/IAI.00298-15","article-title":"Influenza and bacterial superinfection: illuminating the immunologic mechanisms of disease","volume":"83","author":"Rynda-Apple","year":"2015","journal-title":"Infect Immun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/BF00917815","article-title":"Pulmonary inflammatory responses during viral pneumonia and secondary bacterial infection","volume":"7","author":"Warr","year":"1983","journal-title":"Inflammation."},{"key":"B6","doi-asserted-by":"publisher","first-page":"7435","DOI":"10.4049\/jimmunol.173.12.7435","article-title":"Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease","volume":"173","author":"Williams","year":"2004","journal-title":"J Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science."},{"key":"B8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.chom.2012.06.006","article-title":"Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes","volume":"12","author":"Quintin","year":"2012","journal-title":"Cell Host Microbe."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science."},{"key":"B10","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nri3759","article-title":"Macrophages: innate memory training","volume":"14","author":"Bordon","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science."},{"key":"B12","first-page":"517","article-title":"Results of BCG immunization in New York City","volume":"53","author":"Levine","year":"1946","journal-title":"Am Rev Tuberculosis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat Rev Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/nature05836","article-title":"Gene-specific control of inflammation by TLR-induced chromatin modifications","volume":"447","author":"Foster","year":"2007","journal-title":"Nature."},{"key":"B17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.immuni.2015.02.013","article-title":"Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals","volume":"42","author":"Lee","year":"2015","journal-title":"Immunity."},{"key":"B18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.immuni.2015.02.008","article-title":"Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function","volume":"42","author":"Schlums","year":"2015","journal-title":"Immunity."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.3389\/fmicb.2018.03225","article-title":"Trained immunity carried by non-immune cells","volume":"9","author":"Hamada","year":"2018","journal-title":"Front Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev.phyto.42.040803.140421","article-title":"Systemic acquired resistance","volume":"42","author":"Durrant","year":"2004","journal-title":"Ann Rev Phytopathol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.it.2005.02.001","article-title":"Specific memory within innate immune systems","volume":"26","author":"Kurtz","year":"2005","journal-title":"Trends Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2013.05.008","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity."},{"key":"B23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1084\/jem.20070891","article-title":"Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection","volume":"205","author":"Didierlaurent","year":"2008","journal-title":"J Exp Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1172\/JCI35412","article-title":"Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice","volume":"119","author":"Shahangian","year":"2009","journal-title":"J Clin Investig."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e00810","DOI":"10.1128\/mBio.00810-19","article-title":"Influenza trains the host for enhanced susceptibility to secondary bacterial infection","volume":"10","author":"Shirey","year":"2019","journal-title":"mBio."},{"key":"B27","doi-asserted-by":"publisher","first-page":"12304","DOI":"10.1128\/JVI.01269-12","article-title":"Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of gammadelta T cells","volume":"86","author":"Li","year":"2012","journal-title":"J Virol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1172\/JCI57762","article-title":"Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice","volume":"121","author":"Nakamura","year":"2011","journal-title":"J Clin Investig."},{"key":"B29","doi-asserted-by":"publisher","first-page":"5153","DOI":"10.4049\/jimmunol.1301237","article-title":"Influenza A exacerbates Staphylococcus aureus pneumonia by attenuating IL-1beta production in mice","volume":"191","author":"Robinson","year":"2013","journal-title":"J Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e00506","DOI":"10.1128\/mBio.00506-16","article-title":"Differential type I interferon signaling is a master regulator of susceptibility to postinfluenza bacterial superinfection","volume":"7","author":"Shepardson","year":"2016","journal-title":"mBio."},{"key":"B31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/ni.3046","article-title":"The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection","volume":"16","author":"Schliehe","year":"2015","journal-title":"Nat Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"101300","DOI":"10.1016\/j.smim.2019.101300","article-title":"Global virus outbreaks: Interferons as 1st responders","volume":"43","author":"Wang","year":"2019","journal-title":"Semin Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"8555","DOI":"10.1073\/pnas.87.21.8555","article-title":"ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains","volume":"87","author":"Fu","year":"1990","journal-title":"Proc Natl Acad Sci USA."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1073\/pnas.92.9.3829","article-title":"Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3","volume":"92","author":"Qureshi","year":"1995","journal-title":"Proc Natl Acad Sci USA."},{"key":"B35","doi-asserted-by":"publisher","first-page":"30127","DOI":"10.1074\/jbc.274.42.30127","article-title":"Activation of the p38 mitogen-activated protein kinase by type I interferons","volume":"274","author":"Uddin","year":"1999","journal-title":"J Biol Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.4049\/jimmunol.166.4.2658","article-title":"A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin","volume":"166","author":"Doughty","year":"2001","journal-title":"J Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e41879","DOI":"10.1371\/journal.pone.0041879","article-title":"Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria","volume":"7","author":"Tian","year":"2012","journal-title":"PLoS ONE."},{"key":"B38","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fcimb.2019.00042","article-title":"How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication","volume":"9","author":"Eisenreich","year":"2019","journal-title":"Front Cell Infect Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1089\/jir.2015.0072","article-title":"The role of virus infection in deregulating the cytokine response to secondary bacterial infection","volume":"35","author":"Mehta","year":"2015","journal-title":"J Interf Cytokine Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1601953","DOI":"10.1183\/13993003.01953-2016","article-title":"Tyk2 as a target for immune regulation in human viral\/bacterial pneumonia","volume":"50","author":"Berg","year":"2017","journal-title":"Eur Respir J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.3389\/fimmu.2018.02151","article-title":"STAT2 signaling regulates macrophage phenotype during influenza and bacterial super-infection","volume":"9","author":"Gopal","year":"2018","journal-title":"Front Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1097\/CCM.0b013e31827c0c8d","article-title":"Benzodiazepine augmented gamma-amino-butyric acid signaling increases mortality from pneumonia in mice","volume":"41","author":"Sanders","year":"2013","journal-title":"Crit Care Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1097\/ALN.0000000000000766","article-title":"Halothane modulates the type i interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model","volume":"123","author":"MacDonald","year":"2015","journal-title":"Anesthesiology."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetimm.2012.11.008","article-title":"SOCS proteins in infectious diseases of mammals","volume":"151","author":"Delgado-Ortega","year":"2013","journal-title":"Vet Immunol Immunopathol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/mi.2014.129","article-title":"The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung","volume":"8","author":"Fujimori","year":"2015","journal-title":"Mucosal Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.jaci.2017.03.024","article-title":"Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma","volume":"140","author":"Grabiec","year":"2017","journal-title":"J Allergy Clin Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00281-016-0555-3","article-title":"The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation","volume":"38","author":"Grabiec","year":"2016","journal-title":"Semin Immunopathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.matbio.2018.01.027","article-title":"Hyaluronan interactions with innate immunity in lung biology","volume":"79","author":"Tighe","year":"2019","journal-title":"Matrix Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.matbio.2018.06.006","article-title":"Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis","volume":"80","author":"Bell","year":"2019","journal-title":"Matrix Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"L1069","DOI":"10.1152\/ajplung.00353.2017","article-title":"Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs","volume":"313","author":"Chang","year":"2017","journal-title":"Am J Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1165\/rcmb.2005-0241OC","article-title":"Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation","volume":"35","author":"Maus","year":"2006","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41577-019-0151-6","article-title":"Epigenetic regulation of the innate immune response to infection","volume":"19","author":"Zhang","year":"2019","journal-title":"Nat Rev Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.2174\/1568026619666190619143706","article-title":"Epigenetic modification in macrophages: a promising target for tumor and inflammation-associated disease therapy","volume":"19","author":"Sun","year":"2019","journal-title":"Curr Top Med Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG Educates hematopoietic stem cells to generate protective innate immunity against tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell."},{"key":"B55","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of Myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.it.2018.11.002","article-title":"Immunometabolic crosstalk: an ancestral principle of trained immunity?","volume":"40","author":"Penkov","year":"2019","journal-title":"Trends Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41577-019-0124-9","article-title":"Immunometabolism at the interface between macrophages and pathogens","volume":"19","author":"Russell","year":"2019","journal-title":"Nat Rev Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/ni.3257","article-title":"The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory","volume":"16","author":"Yoshida","year":"2015","journal-title":"Nat Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41590-019-0568-x","article-title":"Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection","volume":"21","author":"Aegerter","year":"2020","journal-title":"Nat Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/ni.3818","article-title":"Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation","volume":"18","author":"Park","year":"2017","journal-title":"Nat Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"E9162","DOI":"10.1073\/pnas.1720930115","article-title":"Interferon stimulation creates chromatin marks and establishes transcriptional memory","volume":"115","author":"Kamada","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"B62","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nri3210","article-title":"Interferon-inducible effector mechanisms in cell-autonomous immunity","volume":"12","author":"MacMicking","year":"2012","journal-title":"Nat Rev Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev-cellbio-092910-153958","article-title":"Emerging roles for lipid droplets in immunity and host-pathogen interactions","volume":"28","author":"Saka","year":"2012","journal-title":"Ann Rev Cell Dev Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1089\/jir.2010.0126","article-title":"Systems biology of interferon responses","volume":"31","author":"Hertzog","year":"2011","journal-title":"J Interf Cytokine Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41564-019-0421-x","article-title":"Decoding type I and III interferon signalling during viral infection","volume":"4","author":"Mesev","year":"2019","journal-title":"Nat Microbiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and type III interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity."},{"key":"B67","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.biopha.2018.12.103","article-title":"Downregulation of miR-146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo","volume":"111","author":"Zhang","year":"2019","journal-title":"Biomed Pharmacother."},{"key":"B68","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s12250-017-4004-9","article-title":"Influenza A virus-induced downregulation of miR-26a contributes to reduced IFNalpha\/beta production","volume":"32","author":"Gao","year":"2017","journal-title":"Virol Sinica."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.bbrc.2016.08.142","article-title":"Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-alpha receptor","volume":"478","author":"Zhang","year":"2016","journal-title":"Biochem Biophys Res Commun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.cell.2016.09.034","article-title":"\u03b2-Glucan reverses the epigenetic state of lps-induced immunological tolerance","volume":"167","author":"Novakovic","year":"2016","journal-title":"Cell."},{"key":"B71","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1165\/rcmb.2015-0057OC","article-title":"Epigenetic regulation of tolerance to Toll-like receptor ligands in alveolar epithelial cells","volume":"53","author":"Neagos","year":"2015","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"L158","DOI":"10.1152\/ajplung.00338.2014","article-title":"Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice","volume":"309","author":"Lee","year":"2015","journal-title":"Am J Physiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.4049\/jimmunol.1002194","article-title":"Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice","volume":"186","author":"Kudva","year":"2011","journal-title":"J Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.chom.2011.05.006","article-title":"Viral infection augments Nod1\/2 signaling to potentiate lethality associated with secondary bacterial infections","volume":"9","author":"Kim","year":"2011","journal-title":"Cell Host Microbe."},{"key":"B75","doi-asserted-by":"publisher","first-page":"7107","DOI":"10.1073\/pnas.0901162106","article-title":"Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections","volume":"106","author":"Navarini","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B76","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1089\/jir.2013.0158","article-title":"How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms","volume":"34","author":"Reder","year":"2014","journal-title":"J Interf Cytok Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nrrheum.2009.237","article-title":"Type I interferons: crucial participants in disease amplification in autoimmunity","volume":"6","author":"Hall","year":"2010","journal-title":"Nat Rev Rheumatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.semnephrol.2015.08.012","article-title":"Lessons learned from the clinical trials of novel biologics and small molecules in lupus nephritis","volume":"35","author":"Furie","year":"2015","journal-title":"Semin Nephrol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1056\/NEJM199707243370402","article-title":"Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French chronic myeloid leukemia study group","volume":"337","author":"Guilhot","year":"1997","journal-title":"N Engl J Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.it.2017.05.005","article-title":"Type I interferon in chronic virus infection and cancer","volume":"38","author":"Snell","year":"2017","journal-title":"Trends Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ygyno.2005.07.117","article-title":"Randomized trial of adjuvant intraperitoneal alpha-interferon in stage III ovarian cancer patients who have no evidence of disease after primary surgery and chemotherapy: an intergroup study","volume":"100","author":"Alberts","year":"2006","journal-title":"Gynecol Oncol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.cell.2016.11.022","article-title":"Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade","volume":"167","author":"Benci","year":"2016","journal-title":"Cell."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1136\/annrheumdis-2015-208562","article-title":"Sifalimumab, an anti-interferon-alpha monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study","volume":"75","author":"Khamashta","year":"2016","journal-title":"Ann Rheumat Dis."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00495\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T04:43:31Z","timestamp":1584679411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00495\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":83,"alternative-id":["10.3389\/fimmu.2020.00495"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00495","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,20]]},"article-number":"495"}}