{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:57:26Z","timestamp":1769738246954,"version":"3.49.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017-01409"],"award-info":[{"award-number":["2017-01409"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["2015-01505"],"award-info":[{"award-number":["2015-01505"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005701","name":"\u00c5hl\u00e9n-stiftelsen","doi-asserted-by":"publisher","award":["2018-2019"],"award-info":[{"award-number":["2018-2019"]}],"id":[{"id":"10.13039\/501100005701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2017-0063"],"award-info":[{"award-number":["FO2017-0063"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2019-0270"],"award-info":[{"award-number":["FO2019-0270"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00516","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T04:29:33Z","timestamp":1587443373000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female Mice"],"prefix":"10.3389","volume":"11","author":[{"given":"Giacomo","family":"Gravina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernilla","family":"Svedin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Ardalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Joakim","family":"Ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline C. Y.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1001\/jama.2013.3786","article-title":"Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden","volume":"309","author":"Serenius","year":"2013","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S1473-3099(14)70710-8","article-title":"Infection-induced inflammation and cerebral injury in preterm infants","volume":"14","author":"Strunk","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40748-017-0043-3","article-title":"Prevention and treatment of neonatal nosocomial infections","volume":"3","author":"Ramasethu","year":"2017","journal-title":"Matern Health Neonatol Perinatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-62703-736-5_1","article-title":"Clinical characteristics of infections in humans due to Staphylococcus epidermidis","volume":"1106","author":"Rupp","year":"2014","journal-title":"Methods Mol Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"F257","DOI":"10.1136\/archdischild-2014-306213","article-title":"Late-onset neonatal sepsis: recent developments","volume":"100","author":"Dong","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-1-62703-736-5_2","article-title":"Staphylococcus epidermidis pathogenesis","volume":"1106","author":"Otto","year":"2014","journal-title":"Methods Mol Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/nyas.13985","article-title":"Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury","volume":"1437","author":"Meneses","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/jp.2012.167","article-title":"Neurodevelopmental outcomes of very low birth weight infants with neonatal sepsis: systematic review and meta-analysis","volume":"33","author":"Alshaikh","year":"2013","journal-title":"J Perinatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1651-2227.2007.00618.x","article-title":"Cardiorespiratory development in extremely preterm infants: vulnerability to infection and persistence of events beyond term-equivalent age","volume":"97","author":"Hofstetter","year":"2008","journal-title":"Acta Paediatr"},{"key":"B11","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fped.2019.00142","article-title":"Neonatal encephalopathy: need for recognition of multiple etiologies for optimal management","volume":"7","author":"Aslam","year":"2019","journal-title":"Front Pediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1177\/0271678X17691292","article-title":"Systemic activation of toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain","volume":"37","author":"Mottahedin","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"B13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000487798","article-title":"Hypothermia is neuroprotective after severe hypoxic-ischaemic brain injury in neonatal rats pre-exposed to PAM3CSK4","volume":"40","author":"Falck","year":"2018","journal-title":"Dev Neurosci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e02003","DOI":"10.1128\/AAC.02003-19","article-title":"Vancomycin is protective in a neonatal mouse model of Staphylococcus epidermidis-potentiated hypoxic-ischemic brain injury","volume":"64","author":"Lai","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"B15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1203\/01.PDR.0000163513.03619.8D","article-title":"Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain","volume":"58","author":"Eklind","year":"2005","journal-title":"Pediatr Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1515\/jpm-2019-0175","article-title":"The role of complement in preterm birth and prematurity","volume":"47","author":"Galindo-Sevilla","year":"2019","journal-title":"J Perinat Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3389\/fimmu.2012.00368","article-title":"New insights for C5a and C5a receptors in sepsis","volume":"3","author":"Yan","year":"2012","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1096\/fj.11-202382","article-title":"Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis","volume":"26","author":"Pavlovski","year":"2012","journal-title":"FASEB J"},{"key":"B19","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/pr.2016.271","article-title":"Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy","volume":"81","author":"Shah","year":"2017","journal-title":"Pediatr Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1080\/14767058.2016.1251896","article-title":"Complement C5a is present in CSF of human newborns and is elevated in association with preterm birth","volume":"30","author":"Pataky","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12974-014-0153-z","article-title":"The immune response after hypoxia-ischemia in a mouse model of preterm brain injury","volume":"11","author":"Albertsson","year":"2014","journal-title":"J Neuroinflammation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1523\/JNEUROSCI.4391-06.2007","article-title":"Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia","volume":"27","author":"Svedin","year":"2007","journal-title":"J Neurosci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/sj.cdd.4401545","article-title":"The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia","volume":"12","author":"Zhu","year":"2005","journal-title":"Cell Death Differ"},{"key":"B24","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ijdevneu.2008.05.003","article-title":"A correlative light and electron microscopic study of postnatal myelination in the murine corpus callosum","volume":"26","author":"Vincze","year":"2008","journal-title":"Int J Dev Neurosci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"E2270","DOI":"10.3390\/ijms20092270","article-title":"Sex-dependent effects of perinatal inflammation on the brain: implication for neuro-psychiatric disorders","volume":"20","author":"Ardalan","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1093\/infdis\/jiv231","article-title":"Staphylococcus epidermidis bacteremia induces brain injury in neonatal mice via toll-like receptor 2-dependent and -independent pathways","volume":"212","author":"Bi","year":"2015","journal-title":"J Infect Dis"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e10111","DOI":"10.1371\/journal.pone.0010111","article-title":"TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia","volume":"5","author":"Strunk","year":"2010","journal-title":"PLoS ONE"},{"key":"B28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/pr.2012.48","article-title":"Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation","volume":"72","author":"Strunk","year":"2012","journal-title":"Pediatr Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1093\/cercor\/bht333","article-title":"Preferential detachment during human brain development: age- and sex-specific structural connectivity in diffusion tensor imaging (DTI) data","volume":"25","author":"Lim","year":"2015","journal-title":"Cereb Cortex"},{"key":"B30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrn1909","article-title":"Why sex matters for neuroscience","volume":"7","author":"Cahill","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.placenta.2012.11.007","article-title":"Fetal sex and preterm birth","volume":"34","author":"Challis","year":"2013","journal-title":"Placenta"},{"key":"B32","doi-asserted-by":"publisher","first-page":"E61","DOI":"10.3390\/ijms19010061","article-title":"Sexually dimorphic outcomes after neonatal stroke and hypoxia-ischemia","volume":"19","author":"Charriaut-Marlangue","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1001\/jama.2017.17812","article-title":"Prevalence of autism spectrum disorder among US children and adolescents, 2014-2016","volume":"319","author":"Xu","year":"2018","journal-title":"JAMA"},{"key":"B34","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1176\/ajp.2007.164.6.942","article-title":"The worldwide prevalence of ADHD: a systematic review and metaregression analysis","volume":"164","author":"Polanczyk","year":"2007","journal-title":"Am J Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.psc.2010.01.006","article-title":"Gender differences in attention-deficit\/hyperactivity disorder","volume":"33","author":"Rucklidge","year":"2010","journal-title":"Psychiatr Clin North Am"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1016\/j.celrep.2018.05.048","article-title":"Sex-Specific features of microglia from adult mice","volume":"23","author":"Villa","year":"2018","journal-title":"Cell Rep"},{"key":"B37","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12974-019-1569-2","article-title":"Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain","volume":"16","author":"Bruce","year":"2019","journal-title":"J Neuroinflammation"},{"key":"B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13293-018-0187-5","article-title":"Sexual dimorphism in bacterial infections","volume":"9","author":"Vazquez-Martinez","year":"2018","journal-title":"Biol Sex Differ"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00011-013-0661-9","article-title":"Inflammatory mediators of systemic inflammation in neonatal sepsis","volume":"62","author":"Sugitharini","year":"2013","journal-title":"Inflamm Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"272","DOI":"10.5604\/17322693.1198990","article-title":"Evaluation of serum chemokine RANTES concentration as a biomarker in the diagnosis of early-onset severe infections in neonates","volume":"70","author":"Stojewska","year":"2016","journal-title":"Postepy Hig Med Dosw"},{"key":"B41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.cyto.2010.11.003","article-title":"T cell cytokines and the risk of blood stream infection in extremely low birth weight infants","volume":"53","author":"Schelonka","year":"2011","journal-title":"Cytokine"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e12800","DOI":"10.1111\/aji.12800","article-title":"IL-17 in neonatal health and disease","volume":"79","author":"Lawrence","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/pr.2016.267","article-title":"Utility of cytokines to predict neonatal sepsis","volume":"81","author":"Ye","year":"2017","journal-title":"Pediatr Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1080\/14767058.2018.1449828","article-title":"Cytokine profile as diagnostic and prognostic factor in neonatal sepsis","volume":"32","author":"Leal","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/pr.2015.280","article-title":"Association of brain injury and neonatal cytokine response during therapeutic hypothermia in newborns with hypoxic-ischemic encephalopathy","volume":"79","author":"Orrock","year":"2016","journal-title":"Pediatr Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1189\/jlb.3A1215-568R","article-title":"TLR2-mediated leukocyte trafficking to the developing brain","volume":"101","author":"Mottahedin","year":"2017","journal-title":"J Leukoc Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","article-title":"Immune responses in neonates","volume":"10","author":"Basha","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"363246","DOI":"10.1155\/2012\/363246","article-title":"Factors of the lectin pathway of complement activation and their clinical associations in neonates","volume":"2012","author":"Cedzynski","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e000217","DOI":"10.1136\/tsaco-2018-000217","article-title":"Early complementopathy predicts the outcomes of patients with trauma","volume":"4","author":"Li","year":"2019","journal-title":"Trauma Surg Acute Care Open"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1515\/BC.2001.192","article-title":"Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis","volume":"382","author":"Dubin","year":"2001","journal-title":"Biol Chem"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1515\/BC.2001.138","article-title":"Isolation and characterization of a highly specific serine endopeptidase from an oral strain of Staphylococcus epidermidis","volume":"382","author":"Moon","year":"2001","journal-title":"Biol Chem"},{"key":"B52","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1096\/fj.08-110595","article-title":"Functions of the complement components C3 and C5 during sepsis","volume":"22","author":"Flierl","year":"2008","journal-title":"FASEB J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"63","DOI":"10.29399\/npa.23212","article-title":"Association between inflammatory markers and cognitive outcome in patients with acute brain dysfunction due to sepsis","volume":"56","author":"Orhun","year":"2019","journal-title":"Noro Psikiyatr Ars"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00516\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T04:29:36Z","timestamp":1587443376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00516\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":53,"alternative-id":["10.3389\/fimmu.2020.00516"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00516","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"article-number":"516"}}